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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2018 Volume 18 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1

Wenbiao Zheng, Junhui Guan
Pages: 2523-2530
Published online on: 09 July 2018

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Article Open Access

Investigation of the role of cullin 4A overexpression in human liver cancer

Gang Chen, Xiongqi Zhao, Zedan Tan, Dongdong Wang, Ding Luo, Peiyao Zhang, Jun Cao, Fan Wang, Qiyu Liu, Li Li
Pages: 2531-2540
Published online on: 29 June 2018

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Article Open Access

Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells

Changjiang Li, Lei Cheng, Haitao Wu, Peijie He, Yanping Zhang, Yue Yang, Jian Chen, Min Chen
Pages: 2541-2550
Published online on: 16 July 2018

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Article Open Access

Protective effects of compound ammonium glycyrrhizin, L‑arginine, silymarin and glucurolactone against liver damage induced by ochratoxin A in primary chicken hepatocytes

Zugong Yu, Feng Wu, Jing Tian, Xuewen Guo, Ran An
Pages: 2551-2560
Published online on: 16 July 2018

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Article Open Access

Aucubin suppresses Titanium particles‑mediated apoptosis of MC3T3‑E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway

Ziguan Zhu, Qingping Xie, Yazeng Huang, Shuijun Zhang, Yu Chen
Pages: 2561-2570
Published online on: 16 July 2018

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Article Open Access

miR‑200b‑3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1

Lijuan Chen, Xiangqun Wang, Yunhua Zhu, Jian Zhu, Qingzhong Lai
Pages: 2571-2580
Published online on: 16 July 2018

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Article Open Access

Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis

Jing Li, Zhongjun Ding, Yue Yang, Baohong Mao, Yanxia Wang, Xiaoying Xu
Pages: 2581-2588
Published online on: 12 July 2018

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Article

Protection of mouse pancreatic islet function by co‑culture with hypoxia pre‑treated mesenchymal stromal cells

Cheng Xiang, Qiu‑Ping Xie
Pages: 2589-2598
Published online on: 29 June 2018

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Article Open Access

Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats

Tingyu Yang, Yani Liu, Xixi Huang, Rui Zhang, Chunxiao Yang, Jiali Zhou, Yu Zhang, Jing Wan, Shaojun Shi
Pages: 2599-2612
Published online on: 03 July 2018

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Article Open Access

SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway

Jiang Yuan, Lei Zeng, Yanpeng Sun, Na Wang, Qiang Sun, Zhaohui Cheng, Yunfu Wang
Pages: 2613-2620
Published online on: 09 July 2018

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Article Open Access

miR‑185‑5p inhibits F‑actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE

Chonggao Yin, Guoxin Zhang, Ruimei Sun, Xinting Pan, Xuewen Wang, Hongli Li, Yunbo Sun
Pages: 2621-2630
Published online on: 16 July 2018

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Article Open Access

Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing

Dong‑Yue Wen, Deng‑Hua Pan, Peng Lin, Qiu‑Yan Mo, Yun‑Peng Wei, Yi‑Huan Luo, Gang Chen, Yun He, Jun‑Qiang Chen, Hong Yang
Pages: 2631-2642
Published online on: 03 July 2018

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Article Open Access

Comprehensive analysis of gene expression profiles provides insight into the pathogenesis of Crohn's disease

Lumin Bo, Hongyu Fu, Junchi Yang
Pages: 2643-2650
Published online on: 09 July 2018

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Article Open Access

Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis

Guangda Xin, Rui Chen, Xiaofei Zhang
Pages: 2651-2660
Published online on: 16 July 2018

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Article Open Access

MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10

Jinhui Liu, Yi Jiang, Yicong Wan, Shulin Zhou, Sunita Thapa, Wenjun Cheng
Pages: 2661-2668
Published online on: 05 July 2018

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Article Open Access

Analysis of non‑alcoholic fatty liver disease microRNA expression spectra in rat liver tissues

Jiao Nie, Chang‑Ping Li, Jue‑Hong Li, Xia Chen, Xiaoling Zhong
Pages: 2669-2680
Published online on: 09 July 2018

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Article Open Access

Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway

Xiao‑Ying Wang, Li‑Yan Jiao, Jing‑Lan He, Zhi‑An Fu, Ru‑Jun Guo
Pages: 2681-2688
Published online on: 27 June 2018

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Article Open Access

MiR‑500a‑5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5

Zhiyong Liu, Danying Su, Xiuying Qi, Jing Ma
Pages: 2689-2696
Published online on: 09 July 2018

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Article Open Access

Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways

Xiaojian Huang, Qiyong Pan, Zekai Mao, Pengcheng Wang, Rui Zhang, Xiaohu Ma, Jingyuan Chen, Hongbo You
Pages: 2697-2704
Published online on: 16 July 2018

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Article Open Access

Effect of cellular mass on chondrogenic differentiation during embryoid body formation

Michał Stefan Lach, Katarzyna Kulcenty, Karolina Jankowska, Tomasz Trzeciak, Magdalena Richter, Wiktoria Maria Suchorska
Pages: 2705-2714
Published online on: 10 July 2018

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Article Open Access

Candidate genes and microRNAs for glioma pathogenesis and prognosis based on gene expression profiles

Chen Xie, Meng Xu, Dejuan Lu, Weiguang Zhang, Laizang Wang, Hongwei Wang, Jianhua Li, Fubin Ren, Chao Wang
Pages: 2715-2723
Published online on: 29 June 2018

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Article Open Access

Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway

Haige Li, Chen Chen, Dehang Wang
Pages: 2724-2732
Published online on: 12 July 2018

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Article Open Access

‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways

Wen Sun, Yang Gao, Xianhua Yu, Yuan Yuan, Jun Yi, Zhen Zhang, Yuxing Cheng, Yong Li, Xing Peng, Xushan Cha
Pages: 2733-2743
Published online on: 09 July 2018

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Article Open Access

ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity

Guanghao Xia, Tiehong Zhu, Xiaotong Li, Yujing Jin, Jing Zhou, Jinfeng Xiao
Pages: 2744-2752
Published online on: 03 July 2018

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Article Open Access

miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer

Bin Wang, Liwei Sun, Jinduo Li, Rong Jiang
Pages: 2753-2761
Published online on: 16 July 2018

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Article Open Access

Comparison of target volume and clinical effects of four radiotherapy plans for acute lymphoblastic leukemia prior to hematopoietic stem cell transplantation

Yalei Lin, Fanyang Kong, Hongfei Li, Dandan Xu, Fei Jia, Xudong Zhang, Baohong Wang, Guowen Li
Pages: 2762-2770
Published online on: 27 June 2018

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Article Open Access

Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells

Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Dai
Pages: 2771-2779
Published online on: 05 July 2018

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Article Open Access

Short‑term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice

Qi Yu, Fang Wang, Xiaodong Meng, Yiren Gong, Yanli Wang, Cangbao Xu, Siwang Wang
Pages: 2780-2788
Published online on: 03 July 2018

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Article Open Access

Integrative analysis of promising molecular biomarkers and pathways for coronary artery disease using WGCNA and MetaDE methods

Shilin Yan
Pages: 2789-2797
Published online on: 16 July 2018

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Article Open Access

MicroRNA‑155 promotes ox‑LDL‑induced autophagy in human umbilical vein endothelial cells by targeting the PI3K/Akt/mTOR pathway

Shuangshuang Yin, Shaonan Yang, Xudong Pan, Aijun Ma, Juanjuan Ma, Haotian Pei, Yi Dong, Shu Li, Wei Li, Xinran Bi
Pages: 2798-2806
Published online on: 29 June 2018

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Article Open Access

Alterations in necroptosis during ALDH2‑mediated protection against high glucose‑induced H9c2 cardiac cell injury

Tingting Fang, Ruiping Cao, Wenlian Wang, Hongwei Ye, Lin Shen, Zhenghong Li, Junfeng Hu, Qin Gao
Pages: 2807-2815
Published online on: 09 July 2018

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Article Open Access

Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p.G296C, in the FRMD7 gene

Yanghui Xiu, Yihua Yao, Tanchu Yang, Meihua Pan, Hui Yang, Weifang Fang, Feng Gu, Junzhao Zhao, Yihua Zhu
Pages: 2816-2822
Published online on: 09 July 2018

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Article Open Access

Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia

Yan‑Fei Li, Xiao‑Yan Chen, Tie‑Chi Lei
Pages: 2823-2831
Published online on: 09 July 2018

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Article Open Access

Eotaxin‑1 and MCP‑1 serve as circulating indicators in response to power frequency electromagnetic field exposure in mice

Hualiang Li, Lin Lin, Li Li, Liang Zhou, Shuai Hao, Ying Zhang, Zhenhua Ding
Pages: 2832-2840
Published online on: 29 June 2018

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Article Open Access

Bioinformatics approach reveals the key role of C‑X‑C motif chemokine receptor 2 in endometriosis development

Aili Tan, Ruoyu Luo, Hua Liang, Mengru Li, Peng Ruan
Pages: 2841-2849
Published online on: 12 July 2018

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Article Open Access

Long non‑coding RNA HR1 participates in the expression of SREBP‑1c through phosphorylation of the PDK1/AKT/FoxO1 pathway Corrigendum in /10.3892/mmr.2024.13161

Duan Li, Liwei Guo, Baoguo Deng, Min Li, Tingting Yang, Fan Yang, Zhijun Yang
Pages: 2850-2856
Published online on: 16 July 2018

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Article Open Access

Bioinformatic analysis of microRNA expression in Huntington's disease

Xiaoyu Dong, Shuyan Cong
Pages: 2857-2865
Published online on: 29 June 2018

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Article Open Access

miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA

Peixia Yang, Jie Xiong, Lin Zuo, Kequn Liu, Houbin Zhang
Pages: 2866-2872
Published online on: 16 July 2018

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Article Open Access

RBP4 regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway

Hongxia Li, Guangming Cao, Nawei Zhang, Tong Lou, Qiushi Wang, Zhenyu Zhang, Chongdong Liu
Pages: 2873-2879
Published online on: 03 July 2018

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Article Open Access

Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK

Jun Beom Park, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Soyeon Kim, Ji Young Sul
Pages: 2880-2888
Published online on: 03 July 2018

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Article Open Access

Rapid diagnosis of human adenovirus B, C and E in the respiratory tract using multiplex quantitative polymerase chain reaction

Yuhong Dou, Yuxia Li, Caifeng Ma, Huijun Zhu, Jikun Du, Helu Liu, Qiong Liu, Rui Chen, Ying Tan
Pages: 2889-2897
Published online on: 05 July 2018

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Article Open Access

Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress

Yanli Wang, Peng Zhang, Xingli Su, Qi Yu, Yulong Chen, Hua Guan, Enqi Liu, Jianglin Fan
Pages: 2898-2904
Published online on: 06 July 2018

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Article Open Access

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

Jun Song, Yan Zhou, Yu Gong, Hanyang Liu, Liming Tang
Pages: 2905-2913
Published online on: 16 July 2018

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Article

Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia

Binbo Fang, Xuehai Chen, Minmin Wu, Hongru Kong, Guanyu Chu, Zhenxu Zhou, Chunwu Zhang, Bicheng Chen
Pages: 2914-2922
Published online on: 03 July 2018

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Article

Sevoflurane attenuates ventilator‑induced lung injury by regulating c‑PLA2 expression

Yong Yang, Wen‑Fa Wang, Yan‑Hua Li, Li‑Sha Li, Xin Guo, Rui Liu
Pages: 2923-2928
Published online on: 03 July 2018

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Article

Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest

Dong Wang, Xinjie Zhang, Daoxu Qu, Jichun Han, Fanqing Meng, Minglei Xu, Qiusheng Zheng
Pages: 2929-2936
Published online on: 05 July 2018

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Article

Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions

Chunhong Liu, Feng Xing, Yuanying He, Shanshan Zong, Chengfeng Luo, Chunqing Li, Tao Duan, Kai Wang, Qian Zhou
Pages: 2937-2944
Published online on: 16 July 2018

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Article

MicroRNA‑29a contributes to intracranial aneurysm by regulating the mitochondrial apoptotic pathway

Wenjing Zhao, Haifang Zhang, Jin‑Ying Su
Pages: 2945-2954
Published online on: 06 July 2018

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Article

Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats

Yanxia Wang, Huajie Wu, Wen Niu, Jian Chen, Manlin Liu, Xin Sun, Zhichao Li
Pages: 2955-2962
Published online on: 16 July 2018

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Article

Expression of transmembrane protein 41A is associated with metastasis via the modulation of E‑cadherin in radically resected gastric cancer

Bin Lin, Yingming Xue, Chao Qi, Xiangjie Chen, Weizheng Mao
Pages: 2963-2972
Published online on: 03 July 2018

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Article

PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway

Meng Li, Xiang Yang, Shouchuan Wang
Pages: 2973-2986
Published online on: 09 July 2018

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Article

Spilanthol inhibits TNF‑α‑induced ICAM‑1 expression and pro‑inflammatory responses by inducing heme oxygenase‑1 expression and suppressing pJNK in HaCaT keratinocytes

Chun‑Hsun Huang, Li‑Chun Chang, Sindy Hu, Chien‑Yu Hsiao, Shu‑Ju Wu
Pages: 2987-2994
Published online on: 03 July 2018

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Article

Associations of CXCL16, miR‑146a and miR‑146b in atherosclerotic apolipoprotein E‑knockout mice

Ai‑Jun Ma, Xiao‑Yan Zhu, Shao‑Nan Yang, Xu‑Dong Pan, Ting Wang, Yuan Wang, Xing Xiao, Shi‑Hai Liu
Pages: 2995-3002
Published online on: 10 July 2018

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Article

Network‑based gene function inference method to predict optimal gene functions associated with fetal growth restriction

Ke‑Jun Ye, Jie Dai, Ling‑Yun Liu, Meng‑Jia Peng
Pages: 3003-3010
Published online on: 29 June 2018

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Article

Obtusifolin inhibits high glucose‑induced mitochondrial apoptosis in human umbilical vein endothelial cells

Yu Tang, Zhi‑Ying Zhong, Yan‑Feng Liu, Gou‑Tai Sheng
Pages: 3011-3019
Published online on: 05 July 2018

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Article

Decreased expression of TROAP suppresses cellular proliferation, migration and invasion in gastric cancer

Ke Jing, Qinsheng Mao, Peng Ma
Pages: 3020-3026
Published online on: 27 June 2018

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Article

P2X7 receptor regulates EMMPRIN and MMP‑9 expression through AMPK/MAPK signaling in PMA‑induced macrophages

Lu Lin, Shanjun Huang, Zhouyang Zhu, Jibo Han, Zhengxian Wang, Weijian Huang, Zhouqing Huang
Pages: 3027-3033
Published online on: 16 July 2018

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Article

Differential responses of GC‑1 spermatogonia cells to high and low doses of bisphenol A

Yuhua Li, Fei Duan, Xiaoyu Zhou, Hongjie Pan, Runsheng Li
Pages: 3034-3040
Published online on: 06 July 2018

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Article

Triptolide exhibits antitumor effects by reversing hypermethylation of WIF‑1 in lung cancer cells

Xiaoliang Mao, Jichun Tong, Yong Wang, Zheng Zhu, Yajun Yin, Yeming Wang
Pages: 3041-3049
Published online on: 09 July 2018

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Article

Prevalence of hyperuricemia among the Chinese population of the southeast coastal region and association with single nucleotide polymorphisms in urate‑anion exchanger genes: SLC22A12, ABCG2 and SLC2A9

Xinran Yang, Yingxiu Xiao, Kaixi Liu, Xiaoyang Jiao, Xiaozhe Lin, Yongni Wang, Qiaoxin Zhang
Pages: 3050-3058
Published online on: 16 July 2018

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Article

Long non‑coding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR‑204‑mediated BRD4 activation

Dong Li, Chuanyou Cui, Jing Chen, Zhifang Hu, Yonghui Wang, Dongyu Hu
Pages: 3059-3067
Published online on: 03 July 2018

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Article

Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR‑135a‑mediated c‑myc activation

Yonghui Wang, Zhengguang Hou, Dong Li
Pages: 3068-3076
Published online on: 16 July 2018

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Article

MicroRNA‑130a inhibits the proliferation, migration and invasive ability of hepatocellular carcinoma cells by downregulating Rho‑kinase 2

Yansong Zheng, Liangguang Xiang, Mingliu Chen, Chunhui Xiang
Pages: 3077-3084
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Qiang Wang, Longkun Lv, Yuan Li, Honghai Ji
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Qiu Liu, Xueke Li, Liang Li, Zhiliang Xu, Jun Zhou, Wei Xiao
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Dingwen Qin, Haige Li, Honglin Xie
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Feng Liu, Jing Zhang, Jianmin Qian, Gang Wu, Zhenyu Ma
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Wen‑Da Wang, Rui Sun, Yue‑Xin Chen
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Xiu‑Rong Zhang, Shi‑Yao Wang, Wen Sun, Chao Wei
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Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats

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Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/β‑catenin signalling pathway

Yue Wang, Ran Wang, Fengqiu Zhang
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Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR‑29c in chronic hypoxia

Yun Zhu, Zezhou Feng, Zhao Jian, Yingbin Xiao
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Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes

Ji‑Hyun Lee, Hyeon‑Hui Ki, Dae‑Ki Kim, Young‑Mi Lee
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Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo

Miaoni Zhou, Fuquan Lin, Wen Xu, Rong Jin, Aie Xu
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Shikonin‑mediated inhibition of nestin affects hypoxia‑induced proliferation of pulmonary artery smooth muscle cells

Susu He, Jian Lin, Ling Lin, Youzu Xu, Jiaxi Feng
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Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling

Xiaoyun Li, Bojia Peng, Yanbin Pan, Panpan Wang, Kehuan Sun, Xiaotong Lei, Ling Ou, Zhidi Wu, Xiaoguang Liu, Haixia Wang, Haibin He, Shu Mo, Ya Tian, Xunqian Peng, Xiaofeng Zhu, Ronghua Zhang, Li Yang
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shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth

Juan Liu, Jing Sun, Qian Zhang, Zhaochong Zeng
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Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway

Yan Zhang, Baoguang Qiao, Fei Gao, Haifeng Wang, Shaohua Miao, Huan Zhao
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Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone

Darshna Yagnik, Frank Hills
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NSD2 is downregulated in T2DM and promotes β cell proliferation and insulin secretion through the transcriptionally regulation of PDX1

Suqin Shi, Lu Zhao, Lili Zheng
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MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

Guanghong Zhou, Hao Jiang, Liping Ma
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Increased mitochondrial common deletion in platelets from patients with type 2 diabetes is not associated with abnormal platelet activity or mitochondrial function

Ayla Karimova, Yalçin Hacioğlu, Nurten Bahtiyar, Mutlu Niyazoğlu, Fahri Akbaş, Erkan Yilmaz, Turgut Ulutin, Ilhan Onaran
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Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF‑α‑induced HaCaT cell proliferation and the underlying mechanism in psoriasis

Hong Leng, Li Pu, Longjiang Xu, Xin Shi, Jiang Ji, Kun Chen
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Yuejiao Zhang, Zhongshun Mao, Yong Diao
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Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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