Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats

  • Authors:
    • Tingyu Yang
    • Yani Liu
    • Xixi Huang
    • Rui Zhang
    • Chunxiao Yang
    • Jiali Zhou
    • Yu Zhang
    • Jing Wan
    • Shaojun Shi
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2599-2612
    |
    Published online on: July 3, 2018
       https://doi.org/10.3892/mmr.2018.9249
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Quercetin is a flavonoid compound that is widely present in food and drink. Quercetin‑3‑O‑β‑D‑glucoside (Q3GA) is a major metabolite of quercetin. The aim of the present study was to investigate the effect of Q3GA on the pharmacokinetics of orally and intravenously administered cyclosporin A (CsA) in rats, and to assess the effect of Q3GA on drug‑metabolizing enzymes (DMEs), drug transporters (DTs) and nuclear receptors (NRs). The pharmacokinetic parameters of CsA were measured following oral (10 mg/kg) and intravenous (2.5 mg/kg) administration of CsA in the presence or absence of Q3GA. The mRNA and protein expression levels of DMEs, DTs and NRs in the liver and small intestine were detected by quantitative polymerase chain reaction and western blot analysis. The results indicated that the intravenous administration of Q3GA (2.5, 5 or 10 mg/kg) for 7 consecutive days reduced the bioavailability of oral CsA. By contrast, the pharmacokinetics of the intravenous administration of CsA were not affected by Q3GA. However, the mRNA and protein expression levels of DMEs and DTs were inhibited by Q3GA. The activation of DMEs and DTs by NRs, and the interplay between DMEs and DTs, may explain these results. The present study identified a novel flavonoid‑drug interaction, which may have implications for patients taking CsA and quercetin supplements or on a quercetin‑containing diet.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Mlcek J, Jurikova T, Skrovankova S and Sochor J: Quercetin and its anti-allergic immune response. Molecules. 21:pii: E623. 2016. View Article : Google Scholar

2 

Miclaus MO, Filip X, Filip C, Martin FA and Grosu IG: Highly sensitive solid forms discrimination on the whole tablet of the active ingredients in quercetin dietary supplements by NMR crystallography approaches. J Pharm Biomed Anal. 124:274–280. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Manach C, Scalbert A, Morand C, Rémésy C and Jiménez L: Polyphenols: Food sources and bioavailability. Am J Clin Nutr. 79:727–747. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Cai X, Fang Z, Dou J, Yu A and Zhai G: Bioavailability of quercetin: Problems and promises. Curr Med Chem. 20:2572–2582. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Russo M, Spagnuolo C, Tedesco I, Bilotto S and Russo GL: The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochem Pharmacol. 83:6–15. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Yang F, Song L, Wang H, Wang J, Xu Z and Xing N: Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review). Oncol Rep. 33:2659–2668. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kawabata K, Mukai R and Ishisaka A: Quercetin and related polyphenols: New insights and implications for their bioactivity and bioavailability. Food Funct. 6:1399–1417. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Galindo P, Rodriguez-Gómez I, González-Manzano S, Dueñas M, Jiménez R, Menéndez C, Vargas F, Tamargo J, Santos-Buelga C, Pérez-Vizcaíno F and Duarte J: Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One. 7:e326732012. View Article : Google Scholar : PubMed/NCBI

9 

Ishizawa K, Yoshizumi M, Kawai Y, Terao J, Kihira Y, Ikeda Y, Tomita S, Minakuchi K, Tsuchiya K and Tamaki T: Pharmacology in health food: Metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J Pharmacol Sci. 115:466–470. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Fan D, Zhou X, Zhao C, Chen H, Zhao Y and Gong X: Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in polygonum perfoliatum L. Fitoterapia. 82:805–810. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Yokoyama A, Sakakibara H, Crozier A, Kawai Y, Matsui A, Terao J, Kumazawa S and Shimoi K: Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radic Res. 43:913–921. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Derlindati E, Dall'Asta M, Ardigò D, Brighenti F, Zavaroni I, Crozier A and Del Rio D: Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects. Food Funct. 3:1144–1152. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Arinç E, Yilmaz D and Bozcaarmutlu A: Mechanism of inhibition of CYP1A1 and glutathione S-transferase activities in fish liver by quercetin, resveratrol, naringenin, hesperidin, and rutin. Nutr Cancer. 67:137–144. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Rastogi H and Jana S: Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome p450 activities. Phytother Res. 28:1873–1878. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Stachel N and Skopp G: Formation and inhibition of ethyl glucuronide and ethyl sulfate. Forensic Sci Int. 265:61–64. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Li Y, Revalde J and Paxton JW: The effects of dietary and herbal phytochemicals on drug transporters. Adv Drug Deliv Rev. 116:45–62. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Shi M, Liu Y, Bian JL, Jin M and Gui CS: The interactions between natural products and OATP1B1. Yao Xue Xue Bao. 50:848–853. 2015.(In Chinese). PubMed/NCBI

18 

Li L, Stanton JD, Tolson AH, Luo Y and Wang H: Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 26:872–882. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Tolson AH and Wang H: Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Adv Drug Deliv Rev. 62:1238–1249. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Chang YZ, Lin HC, Chan ST and Yeh SL: Effects of quercetin metabolites on the enhancing effect of β-carotene on DNA damage and cytochrome P1A1/2 expression in benzo[a]pyrene-exposed A549 cells. Food Chem. 133:445–450. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC and Hsieh YW: Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 46:677–682. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Dupuis R, Yuen A and Innocenti F: The influence of UGT polymorphisms as biomarkers in solid organ transplantation. Clin Chim Acta. 413:1318–1325. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kato R, Nishide M, Kozu C, Iwamoto A, Urashima K, Suzuki K, Ijiri Y, Hayashi T and Tanaka K: Is cyclosporine a transport inhibited by pravastatin via multidrug resistant protein 2? Eur J Clin Pharmacol. 66:153–158. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Ouwerkerk-Mahadevan S, Snoeys J, Peeters M, Beumont-Mauviel M and Simion A: Drug-drug interactions with the NS3/4A protease inhibitor simeprevir. Clin Pharmacokinet. 55:197–208. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, et al: Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem. 57:8503–8516. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Choi JS, Choi BC and Choi KE: Effect of quercetin on the pharmacokinetics of oral cyclosporine. Am J Health Syst Pharm. 61:2406–2409. 2004.PubMed/NCBI

27 

Zal F, Mostafavi-Pour Z and Vessal M: Comparison of the effects of vitamin E and/or quercetin in attenuating chronic cyclosporine A-induced nephrotoxicity in male rats. Clin Exp Pharmacol Physiol. 34:720–724. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Liu Y, Luo X, Yang C, Yang T, Zhou J and Shi S: Impact of quercetin-induced changes in drug-metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats. Mol Med Rep. 14:3073–3085. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Chiou WL: Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm. 6:539–546. 1978. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Lai Q, Wei J, Mahmoodurrahman M, Zhang C, Quan S, Li T and Yu Y: Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime. Drug Des Devel Ther. 9:4997–5018. 2015.PubMed/NCBI

32 

Zhu H, Zhu SC, Shakya S, Mao Q, Ding CH, Long MH and Li SL: Study on the pharmacokinetics profiles of polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method. J Pharm Biomed Anal. 107:119–124. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Yu CP, Wu PP, Hou YC, Lin SP, Tsai SY, Chen CT and Chao PD: Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. J Agric Food Chem. 59:4644–4648. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Shi S and Klotz U: Drug interactions with herbal medicines. Clin Pharmacokinet. 51:77–104. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Li L, Yao QQ, Xu SY, Hu HH, Shen Q, Tian Y, Pan LY, Zhou H, Jiang HD, Lu C, et al: Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP. Eur J Pharm Biopharm. 88:759–767. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Hsu PW, Shia CS, Lin SP, Chao PD, Juang SH and Hou YC: Potential risk of mulberry-drug interaction: Modulation on P-glycoprotein and cytochrome P450 3A. J Agric Food Chem. 61:4464–4469. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Hsiu SL, Hou YC, Wang YH, Tsao CW, Su SF and Chao PD: Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci. 72:227–235. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Jiang W and Hu M: Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways. RSC Adv. 2:7948–7963. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Dong H, Lin W, Wu J and Chen T: Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. BMC Biochem. 11:232010. View Article : Google Scholar : PubMed/NCBI

40 

Satsu H, Hiura Y, Mochizuki K, Hamada M and Shimizu M: Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. J Agric Food Chem. 56:5366–5373. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Urquhart BL, Tirona RG and Kim RB: Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs. J Clin Pharmacol. 47:566–578. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Lau AJ and Chang TK: 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. Pharmacol Res. 100:64–72. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Benet LZ, Cummins CL and Wu CY: Transporter-enzyme interactions: Implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 4:393–398. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Benet LZ, Cummins CL and Wu CY: Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm. 277:3–9. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Shi S and Li Y: Interplay of drug-metabolizing enzymes and transporters in drug absorption and disposition. Curr Drug Metab. 15:915–941. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Li Y, Zhou J, Ramsden D, Taub ME, O'Brien D, Xu J, Busacca CA, Gonnella N and Tweedie DJ: Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation. Drug Metab Dispos. 42:384–393. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Jiang W, Xu B, Wu B, Yu R and Hu M: UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Drug Metab Dispos. 40:336–345. 2012. View Article : Google Scholar : PubMed/NCBI

48 

van Zanden JJ, van der Woude H, Vaessen J, Usta M, Wortelboer HM, Cnubben NH and Rietjens IM: The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential. Biochem Pharmacol. 74:345–351. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Wong CC and Williamson G: Inhibition of hydroxycinnamic acid sulfation by flavonoids and their conjugated metabolites. Biofactors. 39:644–651. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang T, Liu Y, Huang X, Zhang R, Yang C, Zhou J, Zhang Y, Wan J and Shi S: Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Mol Med Rep 18: 2599-2612, 2018.
APA
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J. ... Shi, S. (2018). Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Molecular Medicine Reports, 18, 2599-2612. https://doi.org/10.3892/mmr.2018.9249
MLA
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J., Zhang, Y., Wan, J., Shi, S."Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats". Molecular Medicine Reports 18.3 (2018): 2599-2612.
Chicago
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J., Zhang, Y., Wan, J., Shi, S."Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats". Molecular Medicine Reports 18, no. 3 (2018): 2599-2612. https://doi.org/10.3892/mmr.2018.9249
Copy and paste a formatted citation
x
Spandidos Publications style
Yang T, Liu Y, Huang X, Zhang R, Yang C, Zhou J, Zhang Y, Wan J and Shi S: Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Mol Med Rep 18: 2599-2612, 2018.
APA
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J. ... Shi, S. (2018). Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Molecular Medicine Reports, 18, 2599-2612. https://doi.org/10.3892/mmr.2018.9249
MLA
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J., Zhang, Y., Wan, J., Shi, S."Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats". Molecular Medicine Reports 18.3 (2018): 2599-2612.
Chicago
Yang, T., Liu, Y., Huang, X., Zhang, R., Yang, C., Zhou, J., Zhang, Y., Wan, J., Shi, S."Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats". Molecular Medicine Reports 18, no. 3 (2018): 2599-2612. https://doi.org/10.3892/mmr.2018.9249
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team