Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways

  • Authors:
    • Wen Sun
    • Yang Gao
    • Xianhua Yu
    • Yuan Yuan
    • Jun Yi
    • Zhen Zhang
    • Yuxing Cheng
    • Yong Li
    • Xing Peng
    • Xushan Cha
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Department of Anesthesiology, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Department of Vascular Surgery, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Department of Spine Surgery, Shenzhen Baoan Shajing People's Hospital, Shenzhen, Guangdong 518104, P.R. China, Department of Surgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Department of Dermatology, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2733-2743
    |
    Published online on: July 9, 2018
       https://doi.org/10.3892/mmr.2018.9262
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

‘Psoriasis 1’, a Chinese herbal medicine (CHM) formulation, is extensively used to treat psoriasis in China. Although this CHM formulation yields good therapeutic effect, the underlying mechanism of how this works remains unknown. The present study aimed to test the hypothesis that the CHM formulation ‘psoriasis 1’ inhibits vitamin D receptor (VDR)‑mediated inflammation in psoriasis. To test this, a model of psoriasis was established by stimulating keratinocytes (HaCaT cells) with tumor necrosis factor (TNF)‑α; these cells were subsequently transfected with a lentiviral VDR RNA interference expression vector. The expression levels of 25‑hydroxyvitamin D3 (25HVD3), TNF‑α, interleukin (IL)‑4, IL‑1, IL‑17C, IL‑23 and IL‑6 were measured using ELISA, and the expression levels of VDR, inhibitor of nuclear factor (NF)‑κB (IKK), NF‑κB, signal transducer and activator of transcription (STAT) 3 and STAT4 were measured using reverse transcription‑quantitative polymerase chain reaction analysis and western blotting. It was observed that ‘psoriasis 1’ downregulated the concentrations of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and upregulated the concentration of 25HVD3; furthermore, ‘psoriasis 1’ downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level of VDR in TNF‑α‑induced HaCaT cells. These results suggested that ‘psoriasis 1’ suppressed the inflammatory response and the activation of the NF‑κB and STAT signaling pathways. In addition, it was identified that silencing VDR expression decreased the levels of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and increased the level of 25HVD3; silencing VDR expression additionally downregulated the expression levels of NF‑кB, p‑NF‑кB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the level of VDR in TNF‑α‑induced HaCaT cells. It was concluded that ‘psoriasis 1’ exerts inflammation‑suppressive effects in psoriasis by suppressing the NF‑кB and STAT signaling pathways.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Nickoloff BJ and Nestle FO: Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest. 113:1664–1675. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Mak RK, Hundhausen C and Nestle FO: Progress in understanding the immunopathogenesis of psoriasis. Actas Dermosifiliogr. 100 Suppl 2:S2–S13. 2009. View Article : Google Scholar

3 

Di Cesare A, Di Meglio P and Nestle FO: The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 129:1339–1350. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR and Nair RP: Molecular dissection of psoriasis: Integrating genetics and biology. J Invest Dermatol. 130:1213–1226. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Nestle FO, Kaplan DH and Barker J: Psoriasis. N Engl J Med. 361:496–509. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Li R, Wang J, Wang X, Zhou J, Wang M, Ma H and Xiao S: Increased βTrCP are associated with imiquimod-induced psoriasis-like skin inflammation in mice via NF-κB signaling pathway. Gene. 592:164–171. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Tsuruta D: NF-kappaB links keratinocytes and lymphocytes in the pathogenesis of psoriasis. Recent Pat Inflamm Allergy Drug Discov. 3:40–48. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Ivanenkov YA, Balakin KV and Lavrovsky Y: Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics. Mini Rev Med Chem. 11:55–78. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Fan Y, Mao R and Yang J: NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 4:176–185. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Tse TW: Use of common Chinese herbs in the treatment of psoriasis. Clin Exp Dermatol. 28:469–475. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lin YK, Yen HR, Wong WR, Yang SH and Pang JH: Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. Pediatr Dermatol. 23:507–510. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zhang GZ, Wang JS, Wang P, Jiang CY, Deng BX, Li P, Zhao YM, Liu WL, Qu X, Chen WW, et al: Distribution and development of the TCM syndromes in psoriasis vulgaris. J Tradit Chin Med. 29:195–200. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Lu C, Deng J, Li L, Wang D and Li G: Application of metabolomics on diagnosis and treatment of patients with psoriasis in traditional Chinese medicine. Biochim Biophys Acta. 1844:280–288. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Lu CJ, Yu JJ and Deng JW: Disease-syndrome combination clinical study of psoriasis: Present status, advantages, and prospects. Chin J Integr Med. 18:166–171. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Yu JJ, Zhang CS, Zhang AL, May B, Xue CC and Lu C: Add-on effect of chinese herbal medicine bath to phototherapy for psoriasis vulgaris: A systematic review. Evid Based Complement Alternat Med. 2013:6730782013. View Article : Google Scholar : PubMed/NCBI

16 

Lu L, Xuan M, Yan Y, Li G, Zhou L, Wen Z and Lu C: A statistical analysis plan for the efficiency and safety of Chinese herbal medicine used concurrently with topical therapy for psoriasis vulgaris. Trials. 17:4822016. View Article : Google Scholar : PubMed/NCBI

17 

Tse WP, Che CT, Liu K and Lin ZX: Evaluation of the anti-proliferative properties of selected psoriasis-treating Chinese medicines on cultured HaCaT cells. J Ethnopharmacol. 108:133–141. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Jiang L, Lai YK, Zhang JF, Chan CY, Lu G, Lin MC, He ML, Li JC and Kung HF: Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells. World J Gastroenterol. 18:2035–2042. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Dong L, Wang F, Yin X, Chen L, Li G, Lin F, Ni W, Wu J, Jin R and Jiang L: Overexpression of S100P promotes colorectal cancer metastasis and decreases chemosensitivity to 5-FU in vitro. Mol Cell Biochem. 389:257–264. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T and Verkman AS: Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis. Nat Commun. 6:74542015. View Article : Google Scholar : PubMed/NCBI

22 

Kim BH, Lee JM, Jung YG, Kim S and Kim TY: Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice. J Invest Dermatol. 134:1023–1032. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A and Hunninghake GW: Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 184:965–974. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Wang Q, Li H, Xie H, Fu M, Guo B, Ding Y, Li W and Yu H: 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 135:43–50. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Dhawan P, Peng X, Sutton AL, MacDonald PN, Croniger CM, Trautwein C, Centrella M, McCarthy TL and Christakos S: Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase. Mol Cell Biol. 25:472–487. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Aggarwal BB, Shishodia S, Takada Y, Jackson-Bernitsas D, Ahn KS, Sethi G and Ichikawa H: TNF blockade: An inflammatory issue. Ernst Schering Res Found Workshop. 161–186. 2006.PubMed/NCBI

27 

Rozieres A, Hennino A and Nicolas JF: TNF alpha in the physiopathology of psoriasis. Ann Dermatol Venereol. 133:174–180. 2006.(In French). View Article : Google Scholar : PubMed/NCBI

28 

Weng SW, Chen BC, Wang YC, Liu CK, Sun MF, Chang CM, Lin JG and Yen HR: Traditional Chinese medicine use among patients with psoriasis in Taiwan: A Nationwide population-based study. Evid Based Complement Alternat Med. 2016:31641052016. View Article : Google Scholar : PubMed/NCBI

29 

Cho JW, Lee KS and Kim CW: Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int J Mol Med. 19:469–474. 2007.PubMed/NCBI

30 

Cassano N, Loconsole F, Coviello C and Vena GA: Infliximab in recalcitrant severe atopic eczema associated with contact allergy. Int J Immunopathol Pharmacol. 19:237–240. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Piérard-Franchimont C and Piérard GE: Etanercept (Enbrel) for the treatment of moderate to severe plaque type psoriasis. Rev Med Liege. 61:201–205. 2006.(In French). PubMed/NCBI

32 

Ritchlin C, Haas-Smith SA, Hicks D, Cappuccio J, Osterland CK and Looney RJ: Patterns of cytokine production in psoriatic synovium. J Rheumatol. 25:1544–1552. 1998.PubMed/NCBI

33 

Teschke R, Larrey D, Melchart D and Danan G: Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the role of novel diagnostic biomarkers such as MicroRNAs. Medicines (Basel). 3:pii: E18. 2016.PubMed/NCBI

34 

Xutian S, Zhang J and Louise W: New exploration and understanding of traditional Chinese medicine. Am J Chin Med. 37:411–426. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Huang CY, Lai WY, Sun MF, Lin CC, Chen BC, Lin HJ, Chang CM, Yang CH, Huang KC and Yen HR: Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study. J Ethnopharmacol. 176:311–320. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Xuan ML, Lu CJ, Han L and Xiang Y: Circulating levels of inflammatory cytokines in patients with psoriasis vulgaris of different Chinese medicine syndromes. Chin J Integr Med. 21:108–114. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Landis ET, Davis SA, Feldman SR and Taylor S: Complementary and alternative medicine use in dermatology in the United States. J Altern Complement Med. 20:392–398. 2014. View Article : Google Scholar : PubMed/NCBI

38 

May BH, Zhang AL, Zhou W, Lu CJ, Deng S and Xue CC: Oral herbal medicines for psoriasis: A review of clinical studies. Chin J Integr Med. 18:172–178. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lu CJ, Xiang Y, Xie XL, Xuan ML and He ZH: A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula. Chin J Integr Med. 18:186–191. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Wu Y and Zhou BP: TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer. 102:639–644. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, et al: Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 117:889–901. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Greten FR and Karin M: The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 206:193–199. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Grivennikov SI and Karin M: Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 21:11–19. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Ma D, Zhang RN, Wen Y, Yin WN, Bai D, Zheng GY, Li JS, Zheng B and Wen JK: 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation. Biochem Biophys Res Commun. 482:366–374. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Fekrmandi F, Wang TT and White JH: The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits. Sci Rep. 5:130022015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun W, Gao Y, Yu X, Yuan Y, Yi J, Zhang Z, Cheng Y, Li Y, Peng X, Cha X, Cha X, et al: ‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways. Mol Med Rep 18: 2733-2743, 2018.
APA
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z. ... Cha, X. (2018). ‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways. Molecular Medicine Reports, 18, 2733-2743. https://doi.org/10.3892/mmr.2018.9262
MLA
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z., Cheng, Y., Li, Y., Peng, X., Cha, X."‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways". Molecular Medicine Reports 18.3 (2018): 2733-2743.
Chicago
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z., Cheng, Y., Li, Y., Peng, X., Cha, X."‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways". Molecular Medicine Reports 18, no. 3 (2018): 2733-2743. https://doi.org/10.3892/mmr.2018.9262
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W, Gao Y, Yu X, Yuan Y, Yi J, Zhang Z, Cheng Y, Li Y, Peng X, Cha X, Cha X, et al: ‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways. Mol Med Rep 18: 2733-2743, 2018.
APA
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z. ... Cha, X. (2018). ‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways. Molecular Medicine Reports, 18, 2733-2743. https://doi.org/10.3892/mmr.2018.9262
MLA
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z., Cheng, Y., Li, Y., Peng, X., Cha, X."‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways". Molecular Medicine Reports 18.3 (2018): 2733-2743.
Chicago
Sun, W., Gao, Y., Yu, X., Yuan, Y., Yi, J., Zhang, Z., Cheng, Y., Li, Y., Peng, X., Cha, X."‘Psoriasis 1’ reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways". Molecular Medicine Reports 18, no. 3 (2018): 2733-2743. https://doi.org/10.3892/mmr.2018.9262
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team