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Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia

  • Authors:
    • Yan‑Fei Li
    • Xiao‑Yan Chen
    • Tie‑Chi Lei
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pathology, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2823-2831
    |
    Published online on: July 9, 2018
       https://doi.org/10.3892/mmr.2018.9266
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Abstract

The aim of the present study wasto investigate the potential inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia. In rabbits, flumethasone ointment was used to induce skin telangiectasia in the inner ear. Subsequently, timolol maleate (0.5%) eye drops (TMEDs) were administered twice daily for 4 weeks. Expression of the antibacterial peptides 37‑amino acid peptide (LL‑37) and kallikrein‑5 (KLK5) was detected using quantitative polymerase chain reaction (PCR) and semi‑quantitative reverse transcription‑PCR. In patients with facial skin telangiectasia, one cheek of each patient was assigned to a treatment group and the other to a control group. For the treatment group cheeks, topical application of TMEDs was combined with 0.1% tacrolimus ointment once or twice daily for 8 weeks. The control group cheeks were administered with 0.1% tacrolimus ointment alone. Alterations in lesions were recorded by dermoscopy, and the L, a and b values of lesions were measured, based on the Commission Internationale de l'Éclairage system, with a chromameter prior to and at 1, 2, 4 and 8 weeks following treatment. The results indicated that erythema, papules and telangiectasia were significantly diminished following 4 weeks of treatment with TMEDs in rabbits. Notably, the expression of LL‑37 and KLK5 mRNA was increased in the negative control group; however, it was decreased in the trial and blank groups. Clinical and dermoscopy images demonstrated that erythema was reduced in the 2 groups for 1 week, and that telangiectasia in the treatment group was markedly reduced compared with the control group at 4 weeks. The difference of the L and a values of lesions between the treatment and control group was significant (P<0.05). Overall, the present results suggested that the abnormal expression of LL‑37 may be one of the mechanisms underlying the pathogenesis of facial corticosteroid addiction dermatitis (FCAD) and TMEDs may inhibit the mRNA expression of LL‑37 by downregulating KLK5; in this regard, TMEDs may serve a role in attenuating telangiectasia, which may be beneficial in improving the telangiectasia symptoms of FCAD.
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Copy and paste a formatted citation
Spandidos Publications style
Li YF, Chen XY and Lei TC: Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia. Mol Med Rep 18: 2823-2831, 2018.
APA
Li, Y., Chen, X., & Lei, T. (2018). Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia. Molecular Medicine Reports, 18, 2823-2831. https://doi.org/10.3892/mmr.2018.9266
MLA
Li, Y., Chen, X., Lei, T."Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia". Molecular Medicine Reports 18.3 (2018): 2823-2831.
Chicago
Li, Y., Chen, X., Lei, T."Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia". Molecular Medicine Reports 18, no. 3 (2018): 2823-2831. https://doi.org/10.3892/mmr.2018.9266
Copy and paste a formatted citation
x
Spandidos Publications style
Li YF, Chen XY and Lei TC: Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia. Mol Med Rep 18: 2823-2831, 2018.
APA
Li, Y., Chen, X., & Lei, T. (2018). Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia. Molecular Medicine Reports, 18, 2823-2831. https://doi.org/10.3892/mmr.2018.9266
MLA
Li, Y., Chen, X., Lei, T."Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia". Molecular Medicine Reports 18.3 (2018): 2823-2831.
Chicago
Li, Y., Chen, X., Lei, T."Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia". Molecular Medicine Reports 18, no. 3 (2018): 2823-2831. https://doi.org/10.3892/mmr.2018.9266
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