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Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis

  • Authors:
    • Jing Li
    • Zhongjun Ding
    • Yue Yang
    • Baohong Mao
    • Yanxia Wang
    • Xiaoying Xu
  • View Affiliations / Copyright

    Affiliations: Department of Women and Children's Medical Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu 730050, P.R. China, Reproduction Medicine Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu 730050, P.R. China, Discipline of Physiology, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China, Perinatal Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu 730050, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2581-2588
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    Published online on: July 12, 2018
       https://doi.org/10.3892/mmr.2018.9274
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Abstract

Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects of LBP in trophoblast HTR8/SVneo cells injured with H2O2 were examined. A cell counting kit‑8 assay was performed to detect the effect of LBP at different concentrations on the proliferative ability of H2O2 injured trophoblast cells. Flow cytometry was used to determine the levels of reactive oxygen species (ROS), mitochondria membrane potential (MMP) disruption and apoptosis. Superoxide dismutase (SOD) activity and lactate dehydrogenase (LDH) leakage into the supernatant was detected by ultraviolet spectrophotometry. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to detect the expression of apoptosis‑associated factors, including survivin, hypoxia inducible factor 1‑α (HIF1‑α), Bcl‑2 apoptosis regulator (Bcl‑2), Bcl‑2 associated X apoptosis regulator (Bax). The results revealed that LBP protected the proliferative ability of trophoblast cells injured with H2O2 in a dose‑dependent manner. LBP inhibited the oxidative stress induced by H2O2, by reducing ROS and LDH levels and increasing SOD activity. Additionally, LBP decreased MMP disruption and cell apoptosis induced by H2O2, by increasing the mRNA and protein expression of survivin, HIF1‑α and Bcl‑2 and decreasing Bax expression. Therefore, it was concluded that LBP protected human trophoblast cells from H2O2‑induced oxidative stress and cell apoptosis via regulation of apoptosis‑associated factor expression. It will provide a novel strategy for the treatment of pregnancy complications.
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1 

Kim YM, Chaiworapongsa T, Gomez R, Bujold E, Yoon BH, Rotmensch S, Thaler HT and Romero R: Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol. 187:1137–1142. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Pardi G, Marconi AM and Cetin I: Pathophysiology of intrauterine growth retardation: Role of the placenta. Acta Paediatr Suppl. 423:170–172. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Hauspurg A, Ying W, Hubel CA, Michos ED and Ouyang P: Adverse pregnancy outcomes and future maternal cardiovascular disease. Clin Cardiol. 41:239–246. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Hannan NJ, Binder NK, Beard S, Nguyen TV, Kaitu'u-Lino TJ and Tong S: Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia. PLoS One. 13:e01870822018. View Article : Google Scholar : PubMed/NCBI

5 

Wan J, Hu Z, Zeng K, Yin Y, Zhao M, Chen M and Chen Q: The reduction in circulating levels of estrogen and progesterone in women with preeclampsia. Pregnancy Hypertens. 11:18–25. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Nagai R, Watanabe K, Wakatsuki A, Hamada F, Shinohara K, Hayashi Y, Imamura R and Fukaya T: Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta. J Pineal Res. 45:271–276. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Okatani Y, Wakatsuki A, Shinohara K, Taniguchi K and Fukaya T: Melatonin protects against oxidative mitochondrial damage induced in rat placenta by ischemia and reperfusion. J Pineal Res. 31:173–178. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Aris A, Benali S, Ouellet A, Moutquin JM and Leblanc S: Potential biomarkers of preeclampsia: Inverse correlation between hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia. Placenta. 30:342–347. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Straszewski-Chavez SL, Abrahams VM and Mor G: The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev. 26:877–897. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Fukushima K, Miyamoto S, Tsukimori K, Kobayashi H, Seki H, Takeda S, Kensuke E, Ohtani K, Shibuya M and Nakano H: Tumor necrosis factor and vascular endothelial growth factor induce endothelial integrin repertories, regulating endovascular differentiation and apoptosis in a human extravillous trophoblast cell line. Biol Reprod. 73:172–179. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Huppertz B, Frank HG, Kingdom JC, Reister F and Kaufmann P: Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol. 110:495–508. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Lewis MP, Clements M, Takeda S, Kirby PL, Seki H, Lonsdale LB, Sullivan MH, Elder MG and White JO: Partial characterization of an immortalized human trophoblast cell-line, TCL-1, which possesses a CSF-1 autocrine loop. Placenta. 17:137–146. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Smith SC, Baker PN and Symonds EM: Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol. 177:1395–1401. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Crocker IP, Cooper S, Ong SC and Baker PN: Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol. 162:637–643. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T and Maruo T: Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol. 186:158–166. 2002. View Article : Google Scholar : PubMed/NCBI

16 

DiFederico E, Genbacev O and Fisher SJ: Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol. 155:293–301. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Moindjie H, Santos ED, Gouesse RJ, Swierkowski-Blanchard N, Serazin V, Barnea ER, Vialard F and Dieudonne MN: Preimplantation factor is an anti-apoptotic effector in human trophoblasts involving p53 signaling pathway. Cell Death Dis. 7:e25042016. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Liu Y, Sun Y, Mou Q, Wang B, Zhang Y and Huang L: Structural characterization of LbGp1 from the fruits of Lycium barbarum L. Food Chem. 159:137–142. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Varoni MV, Gadau SD, Pasciu V, Baralla E, Serra E, Palomba D and Demontis MP: Investigation of the effects of Lycium barbarum polysaccharides against cadmium induced damage in testis. Exp Mol Pathol. 103:26–32. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Po KK, Leung JW, Chan JN, Fung TK, Sánchez-Vidaña DI, Sin EL, So KF, Lau BW and Siu AM: Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced mood impairment and neurogenesis suppression. Brain Res Bull. 134:10–17. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Liu WJ, Jiang HF, Rehman FU, Zhang JW, Chang Y, Jing L and Zhang JZ: Lycium barbarum polysaccharides decrease hyperglycemia-aggravated ischemic brain injury through maintaining mitochondrial fission and fusion balance. Int J Biol Sci. 13:901–910. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Liu L, Lao W, Ji QS, Yang ZH, Yu GC and Zhong JX: Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis. Int J Ophthalmol. 8:11–16. 2015.PubMed/NCBI

23 

Zhang XJ, Yu HY, Cai YJ and Ke M: Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway. Oncotarget. 8:5936–5942. 2017.PubMed/NCBI

24 

Tian JY, Chen WW, Cui J, Wang H, Chao C, Lu ZY and Bi YY: Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Exp Ther Med. 12:683–689. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Datta S and Chakrabarti N: Age related rise in lactate and its correlation with lactate dehydrogenase (LDH) status in post-mitochondrial fractions isolated from different regions of brain in mice. Neurochem Int. 118:23–33. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Shan T, Shan T, Liu F, Zheng H and Li G: Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide. Mol Med Rep. 15:879–884. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Gao Y, Wei Y, Wang Y, Gao F and Chen Z: Lycium barbarum: A traditional chinese herb and a promising anti-aging agent. Aging Dis. 8:778–791. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Lin CL, Wang CC, Chang SC, Inbaraj BS and Chen BH: Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int J Biol Macromol. 45:146–151. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Bittner L, Wyck S, Herrera C, Siuda M, Wrenzycki C, van Loon B and Bollwein H: Negative effects of oxidative stress in bovine spermatozoa on in vitro development and DNA integrity of embryos. Reprod Fertil Dev. May 1–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

31 

Che X, Zhao Q and Li D: Expression of thioredoxin-2 in human lens epithelial cells with oxidative damage and its significance. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 43:253–259. 2018.(In Chinese). PubMed/NCBI

32 

Kupsco A and Schlenk D: Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol. 317:1–66. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA and Chappell LC: Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 94 6 Suppl:1980S–1985S. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Deepa D, Jayakumari N and Thomas SV: Oxidative stress is increased in women with epilepsy: Is it a potential mechanism of anti-epileptic drug-induced teratogenesis? Ann Indian Acad Neurol. 15:281–286. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Kovacic P and Somanathan R: Mechanism of teratogenesis: Electron transfer, reactive oxygen species, and antioxidants. Birth Defects Res C Embryo Today. 78:308–325. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Burton GJ and Jauniaux E: Placental oxidative stress: From miscarriage to preeclampsia. J Soc Gynecol Investig. 11:342–352. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Su Y, Han W and Cao Y: Association between activities of SOD, MDA and Na+-K+-ATPase in peripheral blood of patients with acute myocardial infarction and the complication of varying degrees of arrhythmia. Hellenic J Cardiol. Apr 24–2018.(Epub ahead of print).

38 

Schoppet M, Tailhades J, Kulkarni K and Cryle MJ: Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade? J Org Chem. Apr 30–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

39 

Chen L, Li W, Qi D and Wang D: Lycium barbarum polysaccharide protects against LPS-induced ARDS by inhibiting apoptosis, oxidative stress, and inflammation in pulmonary endothelial cells. Free Radic Res. 52:480–490. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Varoni MV, Pasciu V, Gadau SD, Baralla E, Serra E, Palomba D and Demontis MP: Possible antioxidant effect of Lycium barbarum polysaccharides on hepatic cadmium-induced oxidative stress in rats. Environ Sci Pollut Res Int. 24:2946–2955. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Sinha K, Das J, Pal PB and Sil PC: Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol. 87:1157–1180. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Chen S, Lv X, Hu B, Zhao L, Li S, Li Z, Qing X, Liu H, Xu J and Shao Z: Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis. Apoptosis. Apr 28–2018.(Epub ahead of print). View Article : Google Scholar

43 

Ahmadian E, Khosroushahi AY, Eftekhari A, Farajnia S, Babaei H and Eghbal MA: Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2. Biomed Pharmacother. 99:939–946. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Liang J, Wu S, Xie W and He H: Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway. Drug Des Devel Ther. 12:845–853. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Sarvestani Namazi N, Firouzi Saberi S, Falak R, Karimi MY, Gholami Davoodzadeh M, Rangbar A and Hosseini A: Phosphodiesterase 4 and 7 inhibitors produce protective effects against high glucose-induced neurotoxicity in PC12 cells via modulation of the oxidative stress, apoptosis and inflammation pathways. Metab Brain Dis. Apr 30–2018.(Epub ahead of print).

46 

Zhang Z, Wang H, Jin Z, Cai X, Gao N, Cui X, Liu P, Zhang J, Yang S and Yang X: Downregulation of survivin regulates adult hippocampal neurogenesis and apoptosis, and inhibits spatial learning and memory following traumatic brain injury. Neuroscience. 300:219–228. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI

48 

Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T and Tanigawa N: Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res. 58:5071–5074. 1998.PubMed/NCBI

49 

Adida C, Crotty PL, McGrath J, Berrebi D, Diebold J and Altieri DC: Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol. 152:43–49. 1998.PubMed/NCBI

50 

Magnon C, Opolon P, Ricard M, Connault E, Ardouin P, Galaup A, Métivier D, Bidart JM, Germain S, Perricaudet M and Schlumberger M: Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1alpha-mediated tumor apoptotic switch. J Clin Invest. 117:1844–1855. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Fujiwara S, Nakagawa K, Harada H, Nagato S, Furukawa K, Teraoka M, Seno T, Oka K, Iwata S and Ohnishi T: Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int J Oncol. 30:793–802. 2007.PubMed/NCBI

52 

Unruh A, Ressel A, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, Katschinski DM and Wenger RH: The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene. 22:3213–3220. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW and Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression. Cancer. 88:2606–2618. 2000. View Article : Google Scholar : PubMed/NCBI

54 

Li X, Liu X, Xu Y, Liu J, Xie M, Ni W and Chen S: KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α. Int J Oncol. 45:1507–1514. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Mitselou A, Peschos D, Dallas P, Charalabopoulos K, Agnantis NJ and Vougiouklakis T: Immunohistochemical analysis of expression of bcl-2 protein in papillary carcinomas and papillary microcarcinomas of the thyroid gland. Exp Oncol. 26:282–286. 2004.PubMed/NCBI

56 

Basolo F, Pollina L, Fontanini G, Fiore L, Pacini F and Baldanzi A: Apoptosis and proliferation in thyroid carcinoma: Correlation with bcl-2 and p53 protein expression. Br J Cancer. 75:537–541. 1997. View Article : Google Scholar : PubMed/NCBI

57 

Yoo NJ, Kim MS and Lee SH: Expression and mutation analyses of Fas, FLIP and Bcl-2 in granulosa cell tumor of ovary. Tumori. 98:118e–121e. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Yildirim M, Suren D, Goktas S, Dilli UD, Kaya C, Copuroglu R, Yildiz M and Sezer C: The predictive role of Bcl-2 expression in operable locally advanced or metastatic gastric carcinoma. J BUON. 17:106–109. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Ding Z, Yang Y, Mao B, Wang Y and Xu X: Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Mol Med Rep 18: 2581-2588, 2018.
APA
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., & Xu, X. (2018). Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Molecular Medicine Reports, 18, 2581-2588. https://doi.org/10.3892/mmr.2018.9274
MLA
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., Xu, X."Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis". Molecular Medicine Reports 18.3 (2018): 2581-2588.
Chicago
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., Xu, X."Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis". Molecular Medicine Reports 18, no. 3 (2018): 2581-2588. https://doi.org/10.3892/mmr.2018.9274
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Spandidos Publications style
Li J, Ding Z, Yang Y, Mao B, Wang Y and Xu X: Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Mol Med Rep 18: 2581-2588, 2018.
APA
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., & Xu, X. (2018). Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Molecular Medicine Reports, 18, 2581-2588. https://doi.org/10.3892/mmr.2018.9274
MLA
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., Xu, X."Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis". Molecular Medicine Reports 18.3 (2018): 2581-2588.
Chicago
Li, J., Ding, Z., Yang, Y., Mao, B., Wang, Y., Xu, X."Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis". Molecular Medicine Reports 18, no. 3 (2018): 2581-2588. https://doi.org/10.3892/mmr.2018.9274
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