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Article Open Access

miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA

  • Authors:
    • Peixia Yang
    • Jie Xiong
    • Lin Zuo
    • Kequn Liu
    • Houbin Zhang
  • View Affiliations / Copyright

    Affiliations: Respiratory Department of Internal Medicine, Linyi Central Hospital, Linyi, Shandong 276000, P.R. China, Department of Internal Medicine, Health Service Center of Lanshan District, Linyi, Shandong 276000, P.R. China, Department of Hemodialysis, People's Hospital of Yishui County, Linyi, Shandong 276000, P.R. China, Department of Thoracic Surgery, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2866-2872
    |
    Published online on: July 16, 2018
       https://doi.org/10.3892/mmr.2018.9291
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Abstract

Lung cancer is the most common type of cancer worldwide, the most prevalent form of which is non‑small cell lung cancer (NSCLC). MicroRNAs (miRs) are involved in the progression of NSCLC; however, the specific function of miR‑140‑5p in NSCLC remains unclear. The present study demonstrated that miR‑140‑5p was downregulated in the tumor tissues of patients with NSCLC, and it was associated with a poor prognosis. Furthermore, miR‑140‑5p significantly suppressed cell migration and invasion of the NSCLC cell line A549. In addition, the direct regulatory effect of miR‑140‑5p on vascular endothelial growth factor‑A (VEGFA) was predicted by TargetScan and verified using a luciferase reporter gene assay. The present study also hypothesized that miR‑140‑5p may inhibit the expression of phosphorylated‑protein kinase B by targeting VEGFA. In conclusion, miR‑140‑5p may be a potential target for the development of anti‑neoplastic therapies in lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yang P, Xiong J, Zuo L, Liu K and Zhang H: miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA. Mol Med Rep 18: 2866-2872, 2018.
APA
Yang, P., Xiong, J., Zuo, L., Liu, K., & Zhang, H. (2018). miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA. Molecular Medicine Reports, 18, 2866-2872. https://doi.org/10.3892/mmr.2018.9291
MLA
Yang, P., Xiong, J., Zuo, L., Liu, K., Zhang, H."miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA". Molecular Medicine Reports 18.3 (2018): 2866-2872.
Chicago
Yang, P., Xiong, J., Zuo, L., Liu, K., Zhang, H."miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA". Molecular Medicine Reports 18, no. 3 (2018): 2866-2872. https://doi.org/10.3892/mmr.2018.9291
Copy and paste a formatted citation
x
Spandidos Publications style
Yang P, Xiong J, Zuo L, Liu K and Zhang H: miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA. Mol Med Rep 18: 2866-2872, 2018.
APA
Yang, P., Xiong, J., Zuo, L., Liu, K., & Zhang, H. (2018). miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA. Molecular Medicine Reports, 18, 2866-2872. https://doi.org/10.3892/mmr.2018.9291
MLA
Yang, P., Xiong, J., Zuo, L., Liu, K., Zhang, H."miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA". Molecular Medicine Reports 18.3 (2018): 2866-2872.
Chicago
Yang, P., Xiong, J., Zuo, L., Liu, K., Zhang, H."miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA". Molecular Medicine Reports 18, no. 3 (2018): 2866-2872. https://doi.org/10.3892/mmr.2018.9291
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