Open Access

The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)

  • Authors:
    • Magdalenia Bałkowiec
    • Radosław B. Maksym
    • Paweł K. Włodarski
  • View Affiliations

  • Published online on: July 23, 2018     https://doi.org/10.3892/mmr.2018.9303
  • Pages: 3123-3136
  • Copyright: © Bałkowiec et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aberrant regulation of matrix metalloproteinases (MMPs) may be the primary cause of endometrial lesion formation in a group of predisposed women. Prospect for the genuine origin of endometriosis is ongoing, since retrograde menstruation leads to presence of endometrial debris in peritoneal cavity of many women, which do not experience endometriosis. Tissue remodeling is regulated precisely by a balance of MMPs and their inhibitors. Interplay between factors enhancing and suppressing matrix turnover is crucial for cyclic preparation of endometrium for embryo implantation, and endometrial shedding and renewal in physiology of primates. Disorders of the regulation of matrix remodeling leads to augmentation of implantation and invasive growth of ectopic endometrial tissue. Moreover, endometriosis‑induced changes in the matrix balance leads to adhesion formation, ovulatory dysfunction and fertility impairment. The review summarizes the current knowledge regarding the regulation of extracellular matrix turnover in the physiology of the endometrial cycle and in the development of endometriosis, as well as the pathophysiology of ovulatory dysfunction in endometriotic women. Therapeutic modalities utilizing modulation of tissue remodeling were discussed.
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September-2018
Volume 18 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Bałkowiec M, Maksym RB and Włodarski PK: The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review). Mol Med Rep 18: 3123-3136, 2018
APA
Bałkowiec, M., Maksym, R.B., & Włodarski, P.K. (2018). The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review). Molecular Medicine Reports, 18, 3123-3136. https://doi.org/10.3892/mmr.2018.9303
MLA
Bałkowiec, M., Maksym, R. B., Włodarski, P. K."The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)". Molecular Medicine Reports 18.3 (2018): 3123-3136.
Chicago
Bałkowiec, M., Maksym, R. B., Włodarski, P. K."The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)". Molecular Medicine Reports 18, no. 3 (2018): 3123-3136. https://doi.org/10.3892/mmr.2018.9303