Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats

  • Authors:
    • Xiaofeng Ou
    • Yusi Hua
    • Xuelian Liao
    • Cansheng Gong
    • Yan Kang
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 3437-3444
    |
    Published online on: July 24, 2018
       https://doi.org/10.3892/mmr.2018.9313
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cognitive impairments induced by severe acute pancreatitis (SAP) are severe complications, for which there are a lack of effective pharmacological treatment strategies. Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, which exhibits numerous biological effects on gastrointestinal disorders. However, the effects of berberine on SAP‑induced cognitive impairments remain unknown. The present study aimed to investigate the effects of berberine on cognitive impairments associated with SAP. Wistar rats were randomly divided into Sham, Sham + berberine, SAP and SAP + berberine groups. Rats were intraperitoneally injected with L‑arginine (3 g/kg) to induce SAP. Subsequently, selected rats were intragastrically administered berberine (100 mg/kg) once daily for 6 consecutive days. Disease severities of rats were investigated 48 h post‑induction of SAP via determination of serum amylase levels and hematoxylin and eosin staining. Survival rates, performance of behavioral tests (automated rotarod and fear conditioning tests), blood brain barrier (BBB) permeability, and the expression levels of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β in hippocampal tissues were also determined. Proteins associated with apoptosis and necroptosis in the hippocampal tissues of SAP rats, including caspase‑3, receptor‑interacting protein kinase (RIP)1 and RIP3, were detected via western blotting. The results revealed that treatment with L‑arginine induced SAP, which subsequently resulted in increased BBB permeability, mortality rates and cognitive deficits in rats. The expression levels of TNF‑α, IL‑1β, caspase‑3, RIP1 and RIP3 were significantly increased in the hippocampal tissues of SAP rats, thus suggesting that neuroinflammation, apoptosis and necroptosis may be involved in neurodegeneration associated with the development of SAP. Notably, administration of berberine protected the integrity of the BBB, decreased levels of brain inflammation and mortality rates, and attenuated increased levels of proteins associated with apoptosis and necroptosis and cognitive deficits associated with SAP in rats. The results of the present study demonstrated that daily treatment with berberine may attenuate cognitive deficits and reduce associated mortality via exhibition of anti‑neuroinflammatory effects and attenuation of neuronal apoptosis and necroptosis in the hippocampal tissues of SAP rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Estrada RV, Moreno J, Martinez E, Hernandez MC, Gilsanz G and Gilsanz V: Pancreatic encephalopathy. Acta Neurol Scand. 59:135–139. 1979. View Article : Google Scholar : PubMed/NCBI

2 

Menza MA and Murray GB: Pancreatic encephalopathy. Biol Psychiatry. 25:781–784. 1989. View Article : Google Scholar : PubMed/NCBI

3 

Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P and Chevali L: Pathophysiology of acute pancreatitis. Pancreatology. 5:132–144. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Xiong J, Wang K, Yuan C, Xing R, Ni J, Hu G, Chen F and Wang X: Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects. Int J Mol Med. 39:113–125. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chen P, Sun B, Chen H, Wang G, Pan S, Kong R, Bai X and Wang S: Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats. Cytokine. 49:15–23. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Vezzani A, Aronica E, Mazarati A and Pittman QJ: Epilepsy and brain inflammation. Exp Neurol. 244:11–21. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yang Y, Wang Q, Xie M, Liu P, Qi X, Liu X and Li Z: Berberine exerts an anti-inflammatory role in ocular Behcet's disease. Mol Med Rep. 15:97–102. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Huang M, Chen S, Liang Y and Guo Y: The role of berberine in the multi-target treatment of senile dementia. Curr Top Med Chem. 16:867–873. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Kim M, Cho KH, Shin MS, Lee JM, Cho HS, Kim CJ, Shin DH and Yang HJ: Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease. Int J Mol Med. 33:870–878. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zhou J, Du X, Long M, Zhang Z, Zhou S, Zhou J and Qian G: Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats. Eur J Pharmacol. 774:87–94. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sedaghat R, Taab Y, Kiasalari Z, Afshin-Majd S, Baluchnejadmojarad T and Roghani M: Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. Biomed Pharmacother. 87:200–208. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Daviu N, Andero R, Armario A and Nadal R: Sex differences in the behavioural and hypothalamic-pituitary-adrenal response to contextual fear conditioning in rats. Horm Behav. 66:713–723. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Shoji H, Takao K, Hattori S and Miyakawa T: Contextual and cued fear conditioning test using a video analyzing system in mice. J Vis Exp. e508712014.

14 

Zhang CL, Lin ZQ, Luo RJ, Zhang XX, Guo J, Wu W, Shi N, Deng LH, Chen WW, Zhang XY, et al: Chai-Qin-Cheng-Qi decoction and carbachol improve intestinal motility by regulating protein kinase C-mediated Ca2+ release in colonic smooth muscle cells in rats with acute necrotising pancreatitis. Evid Based Complement Alternat Med. 2017:58649452017. View Article : Google Scholar : PubMed/NCBI

15 

Feng AW, Gao W, Zhou GR, Yu R, Li N, Huang XL, Li QR and Li JS: Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia. Int Immunopharmacol. 12:182–188. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Schmidt J, Rattner DW, Lewandrowski K, Compton CC, Mandavilli U, Knoefel WT and Warshaw AL: A better model of acute pancreatitis for evaluating therapy. Ann Surg. 215:44–56. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Rau BM, Kruger CM, Hasel C, Oliveira V, Rubie C, Beger HG and Schilling MK: Effects of immunosuppressive and immunostimulative treatment on pancreatic injury and mortality in severe acute experimental pancreatitis. Pancreas. 33:174–183. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Fanselow MS and Poulos AM: The neuroscience of mammalian associative learning. Annu Rev Psychol. 56:207–234. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Vajtr D, Benada O, Kukacka J, Prusa R, Houstava L, Toupalik P and Kizek R: Correlation of ultrastructural changes of endothelial cells and astrocytes occurring during blood brain barrier damage after traumatic brain injury with biochemical markers of BBB leakage and inflammatory response. Physiol Res. 58:263–268. 2009.PubMed/NCBI

20 

Ning Q, Liu Z, Wang X, Zhang R, Zhang J, Yang M, Sun H, Han F, Zhao W and Zhang X: Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice. Neurol Res. 39:357–366. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Chavez-Valdez R, Martin LJ, Flock DL and Northington FJ: Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience. 219:192–203. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Guo Q, Li A, Xia Q, Liu X, Tian B, Mai G, Huang Z, Chen G, Tang W, Jin X, et al: The role of organ failure and infection in necrotizing pancreatitis: A prospective study. Ann Surg. 259:1201–1207. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Wichmann MA, Cruickshanks KJ, Carlsson CM, Chappell R, Fischer ME, Klein BE, Klein R, Tsai MY and Schubert CR: Long-term systemic inflammation and cognitive impairment in a population-based cohort. J Am Geriatr Soc. 62:1683–1691. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Calsavara AC, Rodrigues DH, Miranda AS, Costa PA, Lima CX, Vilela MC, Rachid MA and Teixeira AL: Late anxiety-like behavior and neuroinflammation in mice subjected to sublethal polymicrobial sepsis. Neurotox Res. 24:103–108. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Nicoletti F, Mancuso G, Cusumano V, Di Marco R, Zaccone P, Bendtzen K and Teti G: Prevention of endotoxin-induced lethality in neonatal mice by interleukin-13. Eur J Immunol. 27:1580–1583. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Dujmovic I, Mangano K, Pekmezovic T, Quattrocchi C, Mesaros S, Stojsavljevic N, Nicoletti F and Drulovic J: The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy. J Neuroimmunol. 207:101–106. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Li G, Wu XJ, Yang L, He YX, Liu Y, Jin X and Yuan H: TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis. Int J Mol Med. 37:99–107. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Li J, Csakai A, Jin J, Zhang F and Yin H: Therapeutic developments targeting toll-like receptor-4-mediated neuroinflammation. ChemMedChem. 11:154–165. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Kniesel U and Wolburg H: Tight junctions of the blood-brain barrier. Cell Mol Neurobiol. 20:57–76. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Toklu HZ, Uysal MK, Kabasakal L, Sirvanci S, Ercan F and Kaya M: The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. J Surg Res. 152:238–248. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Hotchkiss RS and Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 6:813–822. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Linkermann A and Green DR: Necroptosis. N Engl J Med. 370:455–465. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, et al: The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150:339–350. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, et al: RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 353:603–608. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, et al: Activation of necroptosis in multiple sclerosis. Cell Rep. 10:1836–1849. 2015. View Article : Google Scholar : PubMed/NCBI

36 

You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA and Whalen MJ: Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 28:1564–1573. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Huang W, Szatmary P, Wan M, Bharucha S, Awais M, Tang W, Criddle DN, Xia Q and Sutton R: Translational insights into peroxisome proliferator-activated receptors in experimental acute pancreatitis. Pancreas. 45:167–178. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ou X, Hua Y, Liao X, Gong C and Kang Y: Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Mol Med Rep 18: 3437-3444, 2018.
APA
Ou, X., Hua, Y., Liao, X., Gong, C., & Kang, Y. (2018). Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular Medicine Reports, 18, 3437-3444. https://doi.org/10.3892/mmr.2018.9313
MLA
Ou, X., Hua, Y., Liao, X., Gong, C., Kang, Y."Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats". Molecular Medicine Reports 18.3 (2018): 3437-3444.
Chicago
Ou, X., Hua, Y., Liao, X., Gong, C., Kang, Y."Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats". Molecular Medicine Reports 18, no. 3 (2018): 3437-3444. https://doi.org/10.3892/mmr.2018.9313
Copy and paste a formatted citation
x
Spandidos Publications style
Ou X, Hua Y, Liao X, Gong C and Kang Y: Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Mol Med Rep 18: 3437-3444, 2018.
APA
Ou, X., Hua, Y., Liao, X., Gong, C., & Kang, Y. (2018). Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular Medicine Reports, 18, 3437-3444. https://doi.org/10.3892/mmr.2018.9313
MLA
Ou, X., Hua, Y., Liao, X., Gong, C., Kang, Y."Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats". Molecular Medicine Reports 18.3 (2018): 3437-3444.
Chicago
Ou, X., Hua, Y., Liao, X., Gong, C., Kang, Y."Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats". Molecular Medicine Reports 18, no. 3 (2018): 3437-3444. https://doi.org/10.3892/mmr.2018.9313
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team