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Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma

  • Authors:
    • Shoubao Gao
    • Xiaohong Xu
    • Yue Wang
    • Wei Zhang
    • Xingye Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161021, P.R. China, Department of Clinical Laboratory, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161021, P.R. China, Medical School of Nanchang University, Nanchang, Jiangxi 330031, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3305-3313
    |
    Published online on: July 30, 2018
       https://doi.org/10.3892/mmr.2018.9336
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Abstract

Long non‑coding RNAs (lncRNAs) offer great potential as cancer biomarkers. Owing to the limited sensitivity and specificity of α‑fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC), the present study used an lncRNA microarray to screen aberrantly expressed lncRNAs in HCC tissues. Subsequently, the expression profile of the target lncRNAs was investigated in plasma from patients with HCC or hepatitis B virus‑positive chronic hepatitis and cirrhosis (HCH), as well as from healthy volunteers. A total of six aberrantly expressed lncRNAs were identified in HCC tissues and corresponding normal tissues, from which only small nucleolar RNA host gene 1 (SNHG1) expression in HCC tissues demonstrated a good correlation with those in plasma from HCC patients. Subsequent analysis revealed that high plasma SNHG1 expression levels were correlated with tumor size, TNM stage and AFP levels. Receiver operating characteristic analysis demonstrated that SNHG1 yields an excellent diagnostic ability to differentiate between patients with HCC and unaffected control patients, which was superior to that of AFP. The combination of SNHG1 with AFP may be able to distinguish HCC from HCH or healthy volunteers with the area under the curve values of 0.86 and 0.97, respectively. In summary, it was demonstrated that plasma SNHG1 has great potential as a sensitive and reliable biomarker for the diagnosis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Gao S, Xu X, Wang Y, Zhang W and Wang X: Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma. Mol Med Rep 18: 3305-3313, 2018.
APA
Gao, S., Xu, X., Wang, Y., Zhang, W., & Wang, X. (2018). Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma. Molecular Medicine Reports, 18, 3305-3313. https://doi.org/10.3892/mmr.2018.9336
MLA
Gao, S., Xu, X., Wang, Y., Zhang, W., Wang, X."Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma". Molecular Medicine Reports 18.3 (2018): 3305-3313.
Chicago
Gao, S., Xu, X., Wang, Y., Zhang, W., Wang, X."Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma". Molecular Medicine Reports 18, no. 3 (2018): 3305-3313. https://doi.org/10.3892/mmr.2018.9336
Copy and paste a formatted citation
x
Spandidos Publications style
Gao S, Xu X, Wang Y, Zhang W and Wang X: Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma. Mol Med Rep 18: 3305-3313, 2018.
APA
Gao, S., Xu, X., Wang, Y., Zhang, W., & Wang, X. (2018). Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma. Molecular Medicine Reports, 18, 3305-3313. https://doi.org/10.3892/mmr.2018.9336
MLA
Gao, S., Xu, X., Wang, Y., Zhang, W., Wang, X."Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma". Molecular Medicine Reports 18.3 (2018): 3305-3313.
Chicago
Gao, S., Xu, X., Wang, Y., Zhang, W., Wang, X."Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma". Molecular Medicine Reports 18, no. 3 (2018): 3305-3313. https://doi.org/10.3892/mmr.2018.9336
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