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Article

Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes

  • Authors:
    • Ji‑Hyun Lee
    • Hyeon‑Hui Ki
    • Dae‑Ki Kim
    • Young‑Mi Lee
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, Jeonbuk 54907, Republic of Korea, Department of Oriental Pharmacy, College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeollabuk 54538, Republic of Korea
  • Pages: 3461-3468
    |
    Published online on: July 31, 2018
       https://doi.org/10.3892/mmr.2018.9339
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Abstract

Atopic dermatitis (AD) is a common chronic, recurring, inflammatory skin disease. A number of researchers have been seeking safe AD therapies for a long time. Triticum aestivum sprouts (TAEE), known as wheatgrass, are one of the most widely used health foods worldwide. They show numerous beneficial effects, including anticancer, anti‑inflammatory, anti‑oxidant, anti‑obesity, anti‑colitis and anti‑allergy effects; however, their effect on AD is unknown. In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells). Oral administration of 200 mg/kg TAEE for 10 days significantly decreased the skin thickness, transepidermal water loss and serum immunoglobulin E levels in DNCB‑treated mice. In addition, TAEE reduced the secretion of inflammatory chemokines via regulation of the signal transducer and activator of transcription 1 and suppressor of cytokine signaling pathways in TNF‑α‑ and IFN‑γ‑stimulated HaCaT cells. These results indicate that TAEE may have beneficial effects in the treatment and prevention of AD and associated skin diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Lee JH, Ki HH, Kim DK and Lee YM: Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes. Mol Med Rep 18: 3461-3468, 2018.
APA
Lee, J., Ki, H., Kim, D., & Lee, Y. (2018). Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes. Molecular Medicine Reports, 18, 3461-3468. https://doi.org/10.3892/mmr.2018.9339
MLA
Lee, J., Ki, H., Kim, D., Lee, Y."Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes". Molecular Medicine Reports 18.3 (2018): 3461-3468.
Chicago
Lee, J., Ki, H., Kim, D., Lee, Y."Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes". Molecular Medicine Reports 18, no. 3 (2018): 3461-3468. https://doi.org/10.3892/mmr.2018.9339
Copy and paste a formatted citation
x
Spandidos Publications style
Lee JH, Ki HH, Kim DK and Lee YM: Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes. Mol Med Rep 18: 3461-3468, 2018.
APA
Lee, J., Ki, H., Kim, D., & Lee, Y. (2018). Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes. Molecular Medicine Reports, 18, 3461-3468. https://doi.org/10.3892/mmr.2018.9339
MLA
Lee, J., Ki, H., Kim, D., Lee, Y."Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes". Molecular Medicine Reports 18.3 (2018): 3461-3468.
Chicago
Lee, J., Ki, H., Kim, D., Lee, Y."Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes". Molecular Medicine Reports 18, no. 3 (2018): 3461-3468. https://doi.org/10.3892/mmr.2018.9339
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