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Article

MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1

  • Authors:
    • Guanghong Zhou
    • Hao Jiang
    • Liping Ma
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Nursing, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 3521-3528
    |
    Published online on: August 1, 2018
       https://doi.org/10.3892/mmr.2018.9344
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Abstract

Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑376a‑3p expression was downregulated in OS tissues and cell lines. Additionally, decreased miR‑376a expression was associated with tumor size and lymph node infiltration. Restoration of miR‑376a expression reduced cell proliferation and invasion of OS. Furthermore, special AT‑rich sequence‑binding protein 1 (SATB1) was identified as a direct target gene of miR‑376a in OS cells. Furthermore, SATB1 was overexpressed in OS tissues and SATB1 overexpression was inversely correlated with the expression level of miR‑376a. In addition, ectopic SATB1 expression counteracted the inhibitory effects of miR‑376a overexpression on the proliferation and invasion of OS cells. All these results identified that reduced miR‑376a expression may be implicated in the mechanism underlying OS progression, suggesting that the miR‑376a/SATB1 axis may be a promising novel target for potential therapeutic methods for the effective treatment of patients with OS.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou G, Jiang H and Ma L: MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1. Mol Med Rep 18: 3521-3528, 2018.
APA
Zhou, G., Jiang, H., & Ma, L. (2018). MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1. Molecular Medicine Reports, 18, 3521-3528. https://doi.org/10.3892/mmr.2018.9344
MLA
Zhou, G., Jiang, H., Ma, L."MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1". Molecular Medicine Reports 18.3 (2018): 3521-3528.
Chicago
Zhou, G., Jiang, H., Ma, L."MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1". Molecular Medicine Reports 18, no. 3 (2018): 3521-3528. https://doi.org/10.3892/mmr.2018.9344
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou G, Jiang H and Ma L: MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1. Mol Med Rep 18: 3521-3528, 2018.
APA
Zhou, G., Jiang, H., & Ma, L. (2018). MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1. Molecular Medicine Reports, 18, 3521-3528. https://doi.org/10.3892/mmr.2018.9344
MLA
Zhou, G., Jiang, H., Ma, L."MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1". Molecular Medicine Reports 18.3 (2018): 3521-3528.
Chicago
Zhou, G., Jiang, H., Ma, L."MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1". Molecular Medicine Reports 18, no. 3 (2018): 3521-3528. https://doi.org/10.3892/mmr.2018.9344
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