search button
Open Access

Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis

  • Authors:
    • Jie Liu
    • Qi Wang
    • Rongrong Zhang
    • Chu Zhang
    • Jihui Lin
    • Xiaojie Huang

  • View Affiliations

  • Published online on: August 14, 2018     https://doi.org/10.3892/mmr.2018.9387
  • Pages: 3850-3858

  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Endometriosis affects 6‑10% of women of reproductive age. Though a significant amount of research has explored the pathogenesis of endometriosis, little is clear. Elucidating the mechanisms is urgently required for improving the therapeutic efficiency of endometriosis treatment. Long non‑coding RNAs (lncRNAs) have recently acquired extensive attention as regulatory components in a variety of biological processes and diseases. However, the functions of many lncRNAs in endometriosis are poorly understood. Therefore, the exploration of the dysregulated genes in endometriosis, particularly lncRNAs, is of importance. In the present study, datasets for endometriosis, including GSE7305, GSE7846, GSE29981 and E‑MTAB‑694, were downloaded from Gene Expression Omnibus and ArrayExpress. Then, the limma and Affy packages were used to analyze the CEL file. The RankProd method was used to conduct meta‑analysis. Long intergenic non‑protein coding RNA 1279 (LINC01279) was significantly upregulated in the three datasets, and was the most upregulated lncRNA as determined by the RankProd method. Gene set enrichment and Gene Ontology analyses were conducted, which revealed that LINC01279 is likely to function as a cell cycle mediator in endometriosis. Finally, it was identified that LINC01279 is strongly associated with certain previously identified key factors in the development of endometriosis, including cyclin‑dependent kinase 14 and C‑X‑C motif chemokine ligand 12. Thus, it was demonstrated that LINC01279 may be associated with the pathogenesis of endometriosis. This may potentially represent a target in the therapy of endometriosis.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 18 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Wang Q, Zhang R, Zhang C, Lin J and Huang X: Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis. Mol Med Rep 18: 3850-3858, 2018
APA
Liu, J., Wang, Q., Zhang, R., Zhang, C., Lin, J., & Huang, X. (2018). Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis. Molecular Medicine Reports, 18, 3850-3858. https://doi.org/10.3892/mmr.2018.9387
MLA
Liu, J., Wang, Q., Zhang, R., Zhang, C., Lin, J., Huang, X."Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis". Molecular Medicine Reports 18.4 (2018): 3850-3858.
Chicago
Liu, J., Wang, Q., Zhang, R., Zhang, C., Lin, J., Huang, X."Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis". Molecular Medicine Reports 18, no. 4 (2018): 3850-3858. https://doi.org/10.3892/mmr.2018.9387