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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2018 Volume 18 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)

Zhen Zhang, Li Yao, Jinhua Yang, Zhenkang Wang, Gang Du
Pages: 3547-3554
Published online on: 09 August 2018

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Article Open Access

Isolation and characterization of minipig perivascular stem cells for bone tissue engineering

Zhen Cui, Chenshuang Li, Nan Jiang, Ci Zhang, Yiran Wang, Hongyun Gao, Yanheng Zhou
Pages: 3555-3562
Published online on: 21 August 2018

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Article Open Access

Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α

Kun Han, Qing‑Yi Wang, Cai‑Xia Wang, Shao‑Yong Luan, Wen‑Peng Tian, Yue Wang, Rui‑Yun Zhang
Pages: 3563-3568
Published online on: 10 August 2018

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Article Open Access

Identification of protein complexes associated with myocardial infarction using a bioinformatics approach

Nianhui Jiao, Yongjie Qi, Changli Lv, Hongjun Li, Fengyong Yang
Pages: 3569-3576
Published online on: 21 August 2018

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Article Open Access

MicroRNA‑34b promotes proliferation, migration and invasion of Ewing's sarcoma cells by downregulating Notch1

Qunshan Lu, Mei Lu, Dong Li, Shuai Zhang
Pages: 3577-3588
Published online on: 09 August 2018

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Article Open Access

Establishment of a SVM classifier to predict recurrence of ovarian cancer

Jinting Zhou, Lin Li, Liling Wang, Xiaofang Li, Hui Xing, Li Cheng
Pages: 3589-3598
Published online on: 08 August 2018

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Article Open Access

Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis

Weiwei Qi, Libin Sun, Ning Liu, Shufen Zhao, Jing Lv, Wensheng Qiu
Pages: 3599-3610
Published online on: 08 August 2018

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Article Open Access

Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway

Xiaohui Ye, Lingling He, Jiali Ma, Yufeng Li, Manka Zhang, Junru Yang, Jian Zhang, Fan Xiao, Hongshan Wei
Pages: 3611-3618
Published online on: 16 August 2018

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Article

Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway

Qiang Fu, Yuzhong Gao, Hui Zhao, Zaijun Wang, Jian Wang
Pages: 3619-3624
Published online on: 22 August 2018

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Article

Renoprotection of dapagliflozin in human renal proximal tubular cells via the inhibition of the high mobility group box 1‑receptor for advanced glycation end products‑nuclear factor‑κB signaling pathway

Di Yao, Suyu Wang, Min Wang, Weiping Lu
Pages: 3625-3630
Published online on: 17 August 2018

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Article Open Access

MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion

Qi Xiao, Tianming Chen, Yao Wu, Wenxiu Wu, Yandi Xu, Zhunan Gong, Shilin Chen
Pages: 3631-3640
Published online on: 09 August 2018

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Article Open Access

Oleanolic acid protects against oxidative stress‑induced human umbilical vein endothelial cell injury by activating AKT/eNOS signaling

Wei Zhang, Jian Feng, Biao Cheng, Qing Lu, Xiaoping Chen
Pages: 3641-3648
Published online on: 03 August 2018

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Article Open Access

Hydroxysafflor yellow A protects against angiotensin II‑induced hypertrophy

Bin Ni, Donglai Zhou, Yunyan Jing, Shanxin Liu
Pages: 3649-3656
Published online on: 17 August 2018

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Article Open Access

Dysregulation of lncRNAs GM5524 and GM15645 involved in high‑glucose‑induced podocyte apoptosis and autophagy in diabetic nephropathy

Yamin Feng, Sheng Chen, Jiarong Xu, Qun Zhu, Xiaolong Ye, Dafa Ding, Weihao Yao, Yibing Lu
Pages: 3657-3664
Published online on: 21 August 2018

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Article Open Access

Absence of Sirt3 aggravates cisplatin nephrotoxicity via enhanced renal tubular apoptosis and inflammation

Dal Kim, Woong Park, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang
Pages: 3665-3672
Published online on: 03 August 2018

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Article Open Access

Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma

Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhang
Pages: 3673-3682
Published online on: 09 August 2018

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Article Open Access

In vitro and in vivo study of the expression of the Syk/Ras/c‑Fos pathway in chronic glomerulonephritis

Jiarong Gao, Liangbing Wei, Junmei Song, Hui Jiang, Yachen Gao, Xi Wu, Shuangzhi Xu
Pages: 3683-3690
Published online on: 03 August 2018

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Article Open Access

Sinomenine alleviates dextran sulfate sodium‑induced colitis via the Nrf2/NQO‑1 signaling pathway

Yan Zhou, Hanyang Liu, Jun Song, Liang Cao, Liming Tang, Chunjian Qi
Pages: 3691-3698
Published online on: 10 August 2018

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Article Open Access

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Delong Tian, Yanhai Li, Xinxin Li, Zhenzhen Tian
Pages: 3699-3710
Published online on: 22 August 2018

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Article Open Access

Therapeutic effects of bee venom on experimental atopic dermatitis

Hyemin Gu, Woon‑Hae Kim, Hyun‑Jin An, Jung‑Yeon Kim, Mi‑Gyeong Gwon, Sang Mi Han, Jaechan Leem, Kwan‑Kyu Park
Pages: 3711-3718
Published online on: 17 August 2018

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Article Open Access

PDGF‑BB promotes the differentiation and proliferation of MC3T3‑E1 cells through the Src/JAK2 signaling pathway

Qi Liu, Yunfeng Zhou, Zubing Li
Pages: 3719-3726
Published online on: 03 August 2018

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Article Open Access

Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG

Shijie Duan, Baocheng Gong, Pengliang Wang, Hanwei Huang, Lei Luo, Funan Liu
Pages: 3727-3736
Published online on: 09 August 2018

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Article Open Access

Bioinformatics analysis to screen for critical genes between survived and non‑survived patients with sepsis

Yanfeng Wu, Lei Zhang, Ying Zhang, Yong Zhen, Shouyue Liu
Pages: 3737-3743
Published online on: 21 August 2018

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Article Open Access

Tumor promoter role of miR‑647 in gastric cancer via repression of TP73 Retraction in /10.3892/mmr.2026.13980

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Pages: 3744-3750
Published online on: 06 August 2018

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Article Open Access

ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT

Qingsong Zuo, Jie Wang, Chao Chen, Yong Zhang, Dian‑Xu Feng, Ronghua Zhao, Teng Chen
Pages: 3751-3759
Published online on: 08 August 2018

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Article Open Access

Salidroside mitigates hypoxia/reoxygenation injury by alleviating endoplasmic reticulum stress‑induced apoptosis in H9c2 cardiomyocytes Retraction in /10.3892/mmr.2024.13320

Meng‑Yao Sun, Da‑Shi Ma, Song Zhao, Lei Wang, Chun‑Ye Ma, Yang Bai
Pages: 3760-3768
Published online on: 20 August 2018

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Article Open Access

EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma

Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhang
Pages: 3769-3779
Published online on: 08 August 2018

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Article Open Access

C‑C chemokine receptor type 3 gene knockout alleviates inflammatory responses in allergic rhinitis model mice by regulating the expression of eosinophil granule proteins and immune factors

Xinhua Zhu, Ke Liu, Jialin Wang, Haisen Peng, Qibin Pan, Shuhong Wu, Yinli Jiang, Yuehui Liu
Pages: 3780-3790
Published online on: 10 August 2018

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Article Open Access

Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway

Zheng Wang, Hesheng Luo, Hong Xia
Pages: 3791-3799
Published online on: 03 August 2018

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Article Open Access

Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway

Zhen Wang, Gang Han, Qinghong Liu, Wenyuan Zhang, Jinshan Wang
Pages: 3800-3808
Published online on: 14 August 2018

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Article Open Access

proBDNF inhibits the proliferation and migration of OLN‑93 oligodendrocytes

Shen Liu, Wei Guo, Hengxing Zhou, Liang Tang, Shiqing Feng, Jin‑Hua Zhong, Xin‑Fu Zhou
Pages: 3809-3817
Published online on: 21 August 2018

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Article Open Access

Effects of Toll‑like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate‑induced acute pancreatitis rats

Liang Sun, Yuanhua Li, Huayou Luo, Kunhua Wang, Li Li, Yujian Zeng
Pages: 3818-3824
Published online on: 03 August 2018

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Article Open Access

Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method

Ming Ding, Ting‑Jin Guan, Chuan‑Yin Wei, Bo‑Hua Chen
Pages: 3825-3833
Published online on: 17 August 2018

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Article Open Access

Effects of Panax ginseng C.A. Meyer extract on the offspring of adult mice with maternal immune activation

Hak‑Jae Kim, Hansol Won, Jiyun Im, Hwayoung Lee, Jiwoo Park, Sanghyun Lee, Young‑Ock Kim, Hyung‑Ki Kim, Jun‑Tack Kwon
Pages: 3834-3842
Published online on: 22 August 2018

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Article Open Access

Overexpression of KLF5 inhibits puromycin‑induced apoptosis of podocytes

Yang Li, Xiaoni Sui, Xueqing Hu, Zhao Hu
Pages: 3843-3849
Published online on: 09 August 2018

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Article Open Access

Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis

Jie Liu, Qi Wang, Rongrong Zhang, Chu Zhang, Jihui Lin, Xiaojie Huang
Pages: 3850-3858
Published online on: 14 August 2018

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Article Open Access

Correlation between DEC1/DEC2 and epithelial‑mesenchymal transition in human prostate cancer PC‑3 cells

Qiang Liu, Yunyan Wu, Hiroko Seino, Toshihiro Haga, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima
Pages: 3859-3865
Published online on: 09 August 2018

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Article Open Access

Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation

Yan Feng, Xing Guo, Xinping Huang, Manya Wu, Xin Li, Shushu Wu, Xiaoling Luo
Pages: 3866-3872
Published online on: 03 August 2018

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Article Open Access

Cellular and molecular changes to chondrocytes in an in vitro model of developmental dysplasia of the hip‑an experimental model of DDH with swaddling position

Bo Ning, Rui Jin, Lin Wan, Dahui Wang
Pages: 3873-3881
Published online on: 13 August 2018

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Article Open Access

Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy

Yang‑Ling Li, Xiu Hu, Qing‑Yu Li, Fei Wang, Bo Zhang, Ke Ding, Bi‑Qin Tan, Neng‑Ming Lin, Chong Zhang
Pages: 3882-3890
Published online on: 03 August 2018

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Article Open Access

Investigation of key autophagy-and mitophagy-related proteins and gene expression in BALF cells from patients with IPF and RA-ILD

Eirini Vasarmidi, Stella Sarantoulaki, Athina Trachalaki, George Margaritopoulos, Eleni Bibaki, Demetrios A. Spandidos, Nikolaos Tzanakis, Katerina Antoniou
Pages: 3891-3897
Published online on: 06 August 2018

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Article Open Access

A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion

Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Ji Young Sul, Jun Beom Park, Young Bok Ko
Pages: 3898-3906
Published online on: 09 August 2018

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Article Open Access

Pirfenidone suppresses TGF‑β1‑induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway

Yanwu Sun, Yiyi Zhang, Pan Chi
Pages: 3907-3913
Published online on: 22 August 2018

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Article Open Access

Elevated expression of PTCD3 correlates with tumor progression and predicts poor prognosis in patients with prostate cancer

Yiqiao Huang, Ganggang Jiang, Xue Liang, Ziquan Lan, Zhengming Su, Hualing Wu, Jinsheng Weng, Xianhan Jiang
Pages: 3914-3922
Published online on: 20 August 2018

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Article Open Access

Cold exposure promotes obesity and impairs glucose homeostasis in mice subjected to a high‑fat diet

Ping Zhu, Zhi‑Hui Zhang, Xu‑Feng Huang, Yan‑Chuan Shi, Neeta Khandekar, He‑Qin Yang, Shi‑Yu Liang, Zhi‑Yuan Song, Shu Lin
Pages: 3923-3931
Published online on: 10 August 2018

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Article Open Access

Downregulation of Krüppel‑like factor 1 inhibits the metastasis and invasion of cervical cancer cells

Bisheng Zhu, Qisheng Liu, Qi Han, Bohang Zeng, Jingqi Chen, Qiuju Xiao
Pages: 3932-3940
Published online on: 20 August 2018

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Article

Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study

Akifumi Tsuruta, Takumi Horiike, Masafumi Yoshimura, Isao Nagaoka
Pages: 3941-3948
Published online on: 17 August 2018

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Article

Immunohistochemical detection of E7 human papillomavirus protein in pre‑malignant and malignant lesions of the uterine cervix

Lijun Shi, Fengli Han, Chenglong Shi, Yan Huang, Yan Liu, Xiaojia Chang
Pages: 3949-3956
Published online on: 22 August 2018

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Article

Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK

Zhenhong Wang, Wei Zhou, Haiping Dong, Xiaoxiao Ma, Zhenzhou He
Pages: 3957-3964
Published online on: 03 August 2018

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Article

miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma

Xiaobo Hui, Shiming Zhang, Yanping Wang
Pages: 3965-3972
Published online on: 14 August 2018

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Article

Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes

Ruifang Wu, Yuan Liao, Weiyun Shen, Yu Liu, Jianzhong Zhang, Min Zheng, Genghui Chen, Yuwen Su, Ming Zhao, Qianjin Lu
Pages: 3973-3982
Published online on: 16 August 2018

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Article

Antifibrotic potential of bone marrow‑derived mesenchymal stem cells in biliary atresia mice

Jun Lei, Yong Chai, Juhua Xiao, Huakun Hu, Zhiqiang Liu, Yu Xiao, Lijun Yi, Jinshi Huang, Tianxin Xiang, Shouhua Zhang
Pages: 3983-3988
Published online on: 03 August 2018

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Article

Cell‑to‑cell communication via extracellular vesicles among human pancreatic cancer cells derived from the same patient

Mitsuru Chiba, Shiori Kubota, Ayaka Sakai, Satoru Monzen
Pages: 3989-3996
Published online on: 09 August 2018

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Article

Hypoxia‑inducible factor 1α and ROCK1 regulate proliferation and collagen synthesis in hepatic stellate cells under hypoxia

Yibing Hu, Danping Hu, Huanhuan Yu, Wangwang Xu, Rongquan Fu
Pages: 3997-4003
Published online on: 17 August 2018

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Case Report

Two novel mutations in the ANTXR2 gene in a Chinese patient suffering from hyaline fibromatosis syndrome: A case report

Ying Gao, Jinli Bai, Jiancai Wang, Xiaoyan Liu
Pages: 4004-4008
Published online on: 22 August 2018

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Article

Long non‑coding RNA lnc‑GNAT1‑1 inhibits gastric cancer cell proliferation and invasion through the Wnt/β‑catenin pathway in Helicobacter pylori infection

Liping Liu, Tiankui Shuai, Bin Li, Lei Zhu, Xun Li
Pages: 4009-4015
Published online on: 20 August 2018

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Article

Immune thrombocytopenia induces autophagy and suppresses apoptosis in megakaryocytes

Zhanshu Liu, Tonghua Mei
Pages: 4016-4022
Published online on: 09 August 2018

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Article

Geranylgeranyl transferase 1 inhibitor GGTI‑298 enhances the anticancer effect of gefitinib

Bi‑Sheng Liu, Xin‑Yu Dai, Hong‑Wei Xia, Huan‑Ji Xu, Qiu‑Lin Tang, Qi‑Yong Gong, Yong‑Zhan Nie, Feng Bi
Pages: 4023-4029
Published online on: 09 August 2018

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Article

Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling

Xuezhi Zhao, Xiaohan Guo, Junhua Shen, Dingchao Hua
Pages: 4030-4036
Published online on: 22 August 2018

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Article

Estrogen receptor antagonist fulvestrant inhibits proliferation and promotes apoptosis of prolactinoma cells by regulating the IRE1/XBP1 signaling pathway

Chao Wang, Minghan Bai, Xin Wang, Chunlei Tan, Dongzhi Zhang, Liang Chang, Guofu Li, Lingyu Xie, Jun Su, Yuan Wen
Pages: 4037-4041
Published online on: 10 August 2018

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Article

MicroRNA‑16 inhibits interleukin‑13‑induced inflammatory cytokine secretion and mucus production in nasal epithelial cells by suppressing the IκB kinase β/nuclear factor‑κB pathway

Yueqiu Gao, Zhengzheng Yu
Pages: 4042-4050
Published online on: 17 August 2018

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Article

Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats Corrigendum in /10.3892/mmr.2019.10758

Jiangtao Zhou, Yina Zhao, Guangwen Wu, Bingbing Lin, Zuanfang Li, Xianxiang Liu
Pages: 4051-4057
Published online on: 13 August 2018

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Article

Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

Hisaya K. Ono, Sayuri Yoshimura, Shouhei Hirose, Kouji Narita, Makoto Tsuboi, Krisana Asano, Akio Nakane
Pages: 4058-4064
Published online on: 08 August 2018

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Article

MicroRNA‑424 suppresses the proliferation of hemangioma‑derived endothelial cells by targeting VEGFR‑2

Zhewei Fei, Mingke Qiu, Xianqin Qi, Yuxin Dai, Shuqing Wang, Zhiwei Quan, Yingbin Liu, Jingmin Ou
Pages: 4065-4071
Published online on: 21 August 2018

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Selective activation of inflammation factors by human parvovirus B19 and human bocavirus VP1 unique region on H9c2 cardiomyocyte

Hiong‑Ping Hii, Chun‑Ching Chiu, Di‑Wei Lin, Ya‑Fang Shi, Tsai‑Ching Hsu, Bor‑Show Tzang
Pages: 4072-4078
Published online on: 09 August 2018

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A microRNA‑125a variant, which affects its mature processing, increases the risk of radiation‑induced pneumonitis in patients with non‑small‑cell lung cancer

Hong‑Yan Quan, Tian Yuan, Jian‑Feng Hao
Pages: 4079-4086
Published online on: 20 August 2018

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Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression

Wei Yu, Jinjin Qin, Chunjuan Chen, Yucai Fu, Wei Wang
Pages: 4087-4094
Published online on: 16 August 2018

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Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Er‑Cui Feng, Li Jiang
Pages: 4095-4102
Published online on: 14 August 2018

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Corticosteroid therapy in IgA nephropathy with minimal proteinuria and high renal pathological score: A single‑center cohort study

Yuyan Tang, Haidong He, Weiqian Sun, Pin Hu, Xia Chen, Xudong Xu
Pages: 4103-4112
Published online on: 21 August 2018

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MicroRNA‑152 regulates insulin secretion and pancreatic β cell proliferation by targeting PI3Kα

Li Chen, Haiyun Qian, Junli Xue, Juan Zhang, Hao Chen
Pages: 4113-4121
Published online on: 08 August 2018

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Overexpression of miR‑21 is involved in acute monocytic leukemia‑associated angiogenesis by targeting IL‑12

Xue‑Peng He, Peng Chen, Kai Yang, Bing Liu, Yuan Zhang, Fang Wang, Zhi Guo, Xiao‑Dong Liu, Jin‑Xing Lou, Hui‑Ren Chen
Pages: 4122-4128
Published online on: 06 August 2018

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miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes

Shuyue Wang, Linfang Li, Xiehui Chen, Xiuqing Huang, Jin Liu, Xuelin Sun, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Weiqing Tang, Lin Dou, Jian Li
Pages: 4129-4137
Published online on: 17 August 2018

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Identification of genes and genetic networks associated with BAG3‑dependent cell proliferation and cell survival in human cervical cancer HeLa cells

Yukihiro Furusawa, Tatsuya Yunoki, Tetsushi Hirano, Satsuki Minagawa, Hironori Izumi, Hisashi Mori, Atsushi Hayashi, Yoshiaki Tabuchi
Pages: 4138-4146
Published online on: 10 August 2018

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Microarray and pattern miner analysis of AXL and VIM gene networks in MDA‑MB‑231 cells

Sudhakar Natarajan, Venil N. Sumantran, Mohan Ranganathan, Suresh Madheswaran
Pages: 4147-4155
Published online on: 20 August 2018

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Retraction Open Access

[Retracted] Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion

Tao Fan, Guozhi Huang, Wen Wu, Rong Guo, Qing Zeng
Pages: 4156-4156
Published online on: 09 August 2018

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[Corrigendum] Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU

Bo Tang, Zhigao Hu, Yang Li, Shengguang Yuan, Zhenran Wang, Shuiping Yu, Songqing He
Pages: 4157-4157
Published online on: 21 August 2018

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October-2026 Volume 34 Issue 4

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Resurrection biology: Melatonin as a modulator of anastasis (Review)

Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
Published online on: 02 September 2026

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[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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Article Open Access

POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
Published online on: 24 August 2026

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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
Published online on: 21 August 2026

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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Article Open Access

Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Article Open Access

Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Article Open Access

Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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Article Open Access

STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Review Open Access

Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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Retraction Open Access

[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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Article Open Access

A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Review Open Access

Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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