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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2018 Volume 18 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)

Zhen Zhang, Li Yao, Jinhua Yang, Zhenkang Wang, Gang Du
Pages: 3547-3554
Published online on: 09 August 2018

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Article Open Access

Isolation and characterization of minipig perivascular stem cells for bone tissue engineering

Zhen Cui, Chenshuang Li, Nan Jiang, Ci Zhang, Yiran Wang, Hongyun Gao, Yanheng Zhou
Pages: 3555-3562
Published online on: 21 August 2018

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Article Open Access

Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α

Kun Han, Qing‑Yi Wang, Cai‑Xia Wang, Shao‑Yong Luan, Wen‑Peng Tian, Yue Wang, Rui‑Yun Zhang
Pages: 3563-3568
Published online on: 10 August 2018

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Article Open Access

Identification of protein complexes associated with myocardial infarction using a bioinformatics approach

Nianhui Jiao, Yongjie Qi, Changli Lv, Hongjun Li, Fengyong Yang
Pages: 3569-3576
Published online on: 21 August 2018

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Article Open Access

MicroRNA‑34b promotes proliferation, migration and invasion of Ewing's sarcoma cells by downregulating Notch1

Qunshan Lu, Mei Lu, Dong Li, Shuai Zhang
Pages: 3577-3588
Published online on: 09 August 2018

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Article Open Access

Establishment of a SVM classifier to predict recurrence of ovarian cancer

Jinting Zhou, Lin Li, Liling Wang, Xiaofang Li, Hui Xing, Li Cheng
Pages: 3589-3598
Published online on: 08 August 2018

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Article Open Access

Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis

Weiwei Qi, Libin Sun, Ning Liu, Shufen Zhao, Jing Lv, Wensheng Qiu
Pages: 3599-3610
Published online on: 08 August 2018

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Article Open Access

Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway

Xiaohui Ye, Lingling He, Jiali Ma, Yufeng Li, Manka Zhang, Junru Yang, Jian Zhang, Fan Xiao, Hongshan Wei
Pages: 3611-3618
Published online on: 16 August 2018

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Article

Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway

Qiang Fu, Yuzhong Gao, Hui Zhao, Zaijun Wang, Jian Wang
Pages: 3619-3624
Published online on: 22 August 2018

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Article

Renoprotection of dapagliflozin in human renal proximal tubular cells via the inhibition of the high mobility group box 1‑receptor for advanced glycation end products‑nuclear factor‑κB signaling pathway

Di Yao, Suyu Wang, Min Wang, Weiping Lu
Pages: 3625-3630
Published online on: 17 August 2018

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Article Open Access

MicroRNA‑675‑3p promotes esophageal squamous cell cancer cell migration and invasion

Qi Xiao, Tianming Chen, Yao Wu, Wenxiu Wu, Yandi Xu, Zhunan Gong, Shilin Chen
Pages: 3631-3640
Published online on: 09 August 2018

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Article Open Access

Oleanolic acid protects against oxidative stress‑induced human umbilical vein endothelial cell injury by activating AKT/eNOS signaling

Wei Zhang, Jian Feng, Biao Cheng, Qing Lu, Xiaoping Chen
Pages: 3641-3648
Published online on: 03 August 2018

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Article Open Access

Hydroxysafflor yellow A protects against angiotensin II‑induced hypertrophy

Bin Ni, Donglai Zhou, Yunyan Jing, Shanxin Liu
Pages: 3649-3656
Published online on: 17 August 2018

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Article Open Access

Dysregulation of lncRNAs GM5524 and GM15645 involved in high‑glucose‑induced podocyte apoptosis and autophagy in diabetic nephropathy

Yamin Feng, Sheng Chen, Jiarong Xu, Qun Zhu, Xiaolong Ye, Dafa Ding, Weihao Yao, Yibing Lu
Pages: 3657-3664
Published online on: 21 August 2018

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Article Open Access

Absence of Sirt3 aggravates cisplatin nephrotoxicity via enhanced renal tubular apoptosis and inflammation

Dal Kim, Woong Park, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang
Pages: 3665-3672
Published online on: 03 August 2018

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Article Open Access

Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma

Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhang
Pages: 3673-3682
Published online on: 09 August 2018

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Article Open Access

In vitro and in vivo study of the expression of the Syk/Ras/c‑Fos pathway in chronic glomerulonephritis

Jiarong Gao, Liangbing Wei, Junmei Song, Hui Jiang, Yachen Gao, Xi Wu, Shuangzhi Xu
Pages: 3683-3690
Published online on: 03 August 2018

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Article Open Access

Sinomenine alleviates dextran sulfate sodium‑induced colitis via the Nrf2/NQO‑1 signaling pathway

Yan Zhou, Hanyang Liu, Jun Song, Liang Cao, Liming Tang, Chunjian Qi
Pages: 3691-3698
Published online on: 10 August 2018

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Article Open Access

Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells

Delong Tian, Yanhai Li, Xinxin Li, Zhenzhen Tian
Pages: 3699-3710
Published online on: 22 August 2018

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Article Open Access

Therapeutic effects of bee venom on experimental atopic dermatitis

Hyemin Gu, Woon‑Hae Kim, Hyun‑Jin An, Jung‑Yeon Kim, Mi‑Gyeong Gwon, Sang Mi Han, Jaechan Leem, Kwan‑Kyu Park
Pages: 3711-3718
Published online on: 17 August 2018

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Article Open Access

PDGF‑BB promotes the differentiation and proliferation of MC3T3‑E1 cells through the Src/JAK2 signaling pathway

Qi Liu, Yunfeng Zhou, Zubing Li
Pages: 3719-3726
Published online on: 03 August 2018

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Article Open Access

Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG

Shijie Duan, Baocheng Gong, Pengliang Wang, Hanwei Huang, Lei Luo, Funan Liu
Pages: 3727-3736
Published online on: 09 August 2018

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Article Open Access

Bioinformatics analysis to screen for critical genes between survived and non‑survived patients with sepsis

Yanfeng Wu, Lei Zhang, Ying Zhang, Yong Zhen, Shouyue Liu
Pages: 3737-3743
Published online on: 21 August 2018

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Article Open Access

Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Pages: 3744-3750
Published online on: 06 August 2018

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Article Open Access

ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT

Qingsong Zuo, Jie Wang, Chao Chen, Yong Zhang, Dian‑Xu Feng, Ronghua Zhao, Teng Chen
Pages: 3751-3759
Published online on: 08 August 2018

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Article Open Access

Salidroside mitigates hypoxia/reoxygenation injury by alleviating endoplasmic reticulum stress‑induced apoptosis in H9c2 cardiomyocytes Retraction in /10.3892/mmr.2024.13320

Meng‑Yao Sun, Da‑Shi Ma, Song Zhao, Lei Wang, Chun‑Ye Ma, Yang Bai
Pages: 3760-3768
Published online on: 20 August 2018

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Article Open Access

EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma

Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhang
Pages: 3769-3779
Published online on: 08 August 2018

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Article Open Access

C‑C chemokine receptor type 3 gene knockout alleviates inflammatory responses in allergic rhinitis model mice by regulating the expression of eosinophil granule proteins and immune factors

Xinhua Zhu, Ke Liu, Jialin Wang, Haisen Peng, Qibin Pan, Shuhong Wu, Yinli Jiang, Yuehui Liu
Pages: 3780-3790
Published online on: 10 August 2018

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Article Open Access

Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells via downregulation of the mitogen‑activated protein kinase pathway

Zheng Wang, Hesheng Luo, Hong Xia
Pages: 3791-3799
Published online on: 03 August 2018

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Article Open Access

Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway

Zhen Wang, Gang Han, Qinghong Liu, Wenyuan Zhang, Jinshan Wang
Pages: 3800-3808
Published online on: 14 August 2018

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Article Open Access

proBDNF inhibits the proliferation and migration of OLN‑93 oligodendrocytes

Shen Liu, Wei Guo, Hengxing Zhou, Liang Tang, Shiqing Feng, Jin‑Hua Zhong, Xin‑Fu Zhou
Pages: 3809-3817
Published online on: 21 August 2018

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Article Open Access

Effects of Toll‑like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate‑induced acute pancreatitis rats

Liang Sun, Yuanhua Li, Huayou Luo, Kunhua Wang, Li Li, Yujian Zeng
Pages: 3818-3824
Published online on: 03 August 2018

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Article Open Access

Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method

Ming Ding, Ting‑Jin Guan, Chuan‑Yin Wei, Bo‑Hua Chen
Pages: 3825-3833
Published online on: 17 August 2018

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Article Open Access

Effects of Panax ginseng C.A. Meyer extract on the offspring of adult mice with maternal immune activation

Hak‑Jae Kim, Hansol Won, Jiyun Im, Hwayoung Lee, Jiwoo Park, Sanghyun Lee, Young‑Ock Kim, Hyung‑Ki Kim, Jun‑Tack Kwon
Pages: 3834-3842
Published online on: 22 August 2018

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Article Open Access

Overexpression of KLF5 inhibits puromycin‑induced apoptosis of podocytes

Yang Li, Xiaoni Sui, Xueqing Hu, Zhao Hu
Pages: 3843-3849
Published online on: 09 August 2018

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Article Open Access

Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis

Jie Liu, Qi Wang, Rongrong Zhang, Chu Zhang, Jihui Lin, Xiaojie Huang
Pages: 3850-3858
Published online on: 14 August 2018

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Article Open Access

Correlation between DEC1/DEC2 and epithelial‑mesenchymal transition in human prostate cancer PC‑3 cells

Qiang Liu, Yunyan Wu, Hiroko Seino, Toshihiro Haga, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima
Pages: 3859-3865
Published online on: 09 August 2018

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Article Open Access

Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation

Yan Feng, Xing Guo, Xinping Huang, Manya Wu, Xin Li, Shushu Wu, Xiaoling Luo
Pages: 3866-3872
Published online on: 03 August 2018

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Article Open Access

Cellular and molecular changes to chondrocytes in an in vitro model of developmental dysplasia of the hip‑an experimental model of DDH with swaddling position

Bo Ning, Rui Jin, Lin Wan, Dahui Wang
Pages: 3873-3881
Published online on: 13 August 2018

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Article Open Access

Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy

Yang‑Ling Li, Xiu Hu, Qing‑Yu Li, Fei Wang, Bo Zhang, Ke Ding, Bi‑Qin Tan, Neng‑Ming Lin, Chong Zhang
Pages: 3882-3890
Published online on: 03 August 2018

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Article Open Access

Investigation of key autophagy-and mitophagy-related proteins and gene expression in BALF cells from patients with IPF and RA-ILD

Eirini Vasarmidi, Stella Sarantoulaki, Athina Trachalaki, George Margaritopoulos, Eleni Bibaki, Demetrios A. Spandidos, Nikolaos Tzanakis, Katerina Antoniou
Pages: 3891-3897
Published online on: 06 August 2018

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Article Open Access

A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion

Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Ji Young Sul, Jun Beom Park, Young Bok Ko
Pages: 3898-3906
Published online on: 09 August 2018

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Article Open Access

Pirfenidone suppresses TGF‑β1‑induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway

Yanwu Sun, Yiyi Zhang, Pan Chi
Pages: 3907-3913
Published online on: 22 August 2018

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Article Open Access

Elevated expression of PTCD3 correlates with tumor progression and predicts poor prognosis in patients with prostate cancer

Yiqiao Huang, Ganggang Jiang, Xue Liang, Ziquan Lan, Zhengming Su, Hualing Wu, Jinsheng Weng, Xianhan Jiang
Pages: 3914-3922
Published online on: 20 August 2018

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Article Open Access

Cold exposure promotes obesity and impairs glucose homeostasis in mice subjected to a high‑fat diet

Ping Zhu, Zhi‑Hui Zhang, Xu‑Feng Huang, Yan‑Chuan Shi, Neeta Khandekar, He‑Qin Yang, Shi‑Yu Liang, Zhi‑Yuan Song, Shu Lin
Pages: 3923-3931
Published online on: 10 August 2018

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Article Open Access

Downregulation of Krüppel‑like factor 1 inhibits the metastasis and invasion of cervical cancer cells

Bisheng Zhu, Qisheng Liu, Qi Han, Bohang Zeng, Jingqi Chen, Qiuju Xiao
Pages: 3932-3940
Published online on: 20 August 2018

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Article

Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study

Akifumi Tsuruta, Takumi Horiike, Masafumi Yoshimura, Isao Nagaoka
Pages: 3941-3948
Published online on: 17 August 2018

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Article

Immunohistochemical detection of E7 human papillomavirus protein in pre‑malignant and malignant lesions of the uterine cervix

Lijun Shi, Fengli Han, Chenglong Shi, Yan Huang, Yan Liu, Xiaojia Chang
Pages: 3949-3956
Published online on: 22 August 2018

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Article

Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK

Zhenhong Wang, Wei Zhou, Haiping Dong, Xiaoxiao Ma, Zhenzhou He
Pages: 3957-3964
Published online on: 03 August 2018

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Article

miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma

Xiaobo Hui, Shiming Zhang, Yanping Wang
Pages: 3965-3972
Published online on: 14 August 2018

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Article

Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes

Ruifang Wu, Yuan Liao, Weiyun Shen, Yu Liu, Jianzhong Zhang, Min Zheng, Genghui Chen, Yuwen Su, Ming Zhao, Qianjin Lu
Pages: 3973-3982
Published online on: 16 August 2018

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Article

Antifibrotic potential of bone marrow‑derived mesenchymal stem cells in biliary atresia mice

Jun Lei, Yong Chai, Juhua Xiao, Huakun Hu, Zhiqiang Liu, Yu Xiao, Lijun Yi, Jinshi Huang, Tianxin Xiang, Shouhua Zhang
Pages: 3983-3988
Published online on: 03 August 2018

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Article

Cell‑to‑cell communication via extracellular vesicles among human pancreatic cancer cells derived from the same patient

Mitsuru Chiba, Shiori Kubota, Ayaka Sakai, Satoru Monzen
Pages: 3989-3996
Published online on: 09 August 2018

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Article

Hypoxia‑inducible factor 1α and ROCK1 regulate proliferation and collagen synthesis in hepatic stellate cells under hypoxia

Yibing Hu, Danping Hu, Huanhuan Yu, Wangwang Xu, Rongquan Fu
Pages: 3997-4003
Published online on: 17 August 2018

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Case Report

Two novel mutations in the ANTXR2 gene in a Chinese patient suffering from hyaline fibromatosis syndrome: A case report

Ying Gao, Jinli Bai, Jiancai Wang, Xiaoyan Liu
Pages: 4004-4008
Published online on: 22 August 2018

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Article

Long non‑coding RNA lnc‑GNAT1‑1 inhibits gastric cancer cell proliferation and invasion through the Wnt/β‑catenin pathway in Helicobacter pylori infection

Liping Liu, Tiankui Shuai, Bin Li, Lei Zhu, Xun Li
Pages: 4009-4015
Published online on: 20 August 2018

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Article

Immune thrombocytopenia induces autophagy and suppresses apoptosis in megakaryocytes

Zhanshu Liu, Tonghua Mei
Pages: 4016-4022
Published online on: 09 August 2018

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Article

Geranylgeranyl transferase 1 inhibitor GGTI‑298 enhances the anticancer effect of gefitinib

Bi‑Sheng Liu, Xin‑Yu Dai, Hong‑Wei Xia, Huan‑Ji Xu, Qiu‑Lin Tang, Qi‑Yong Gong, Yong‑Zhan Nie, Feng Bi
Pages: 4023-4029
Published online on: 09 August 2018

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Article

Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling

Xuezhi Zhao, Xiaohan Guo, Junhua Shen, Dingchao Hua
Pages: 4030-4036
Published online on: 22 August 2018

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Article

Estrogen receptor antagonist fulvestrant inhibits proliferation and promotes apoptosis of prolactinoma cells by regulating the IRE1/XBP1 signaling pathway

Chao Wang, Minghan Bai, Xin Wang, Chunlei Tan, Dongzhi Zhang, Liang Chang, Guofu Li, Lingyu Xie, Jun Su, Yuan Wen
Pages: 4037-4041
Published online on: 10 August 2018

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Article

MicroRNA‑16 inhibits interleukin‑13‑induced inflammatory cytokine secretion and mucus production in nasal epithelial cells by suppressing the IκB kinase β/nuclear factor‑κB pathway

Yueqiu Gao, Zhengzheng Yu
Pages: 4042-4050
Published online on: 17 August 2018

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Article

Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats Corrigendum in /10.3892/mmr.2019.10758

Jiangtao Zhou, Yina Zhao, Guangwen Wu, Bingbing Lin, Zuanfang Li, Xianxiang Liu
Pages: 4051-4057
Published online on: 13 August 2018

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Article

Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

Hisaya K. Ono, Sayuri Yoshimura, Shouhei Hirose, Kouji Narita, Makoto Tsuboi, Krisana Asano, Akio Nakane
Pages: 4058-4064
Published online on: 08 August 2018

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Article

MicroRNA‑424 suppresses the proliferation of hemangioma‑derived endothelial cells by targeting VEGFR‑2

Zhewei Fei, Mingke Qiu, Xianqin Qi, Yuxin Dai, Shuqing Wang, Zhiwei Quan, Yingbin Liu, Jingmin Ou
Pages: 4065-4071
Published online on: 21 August 2018

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Selective activation of inflammation factors by human parvovirus B19 and human bocavirus VP1 unique region on H9c2 cardiomyocyte

Hiong‑Ping Hii, Chun‑Ching Chiu, Di‑Wei Lin, Ya‑Fang Shi, Tsai‑Ching Hsu, Bor‑Show Tzang
Pages: 4072-4078
Published online on: 09 August 2018

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A microRNA‑125a variant, which affects its mature processing, increases the risk of radiation‑induced pneumonitis in patients with non‑small‑cell lung cancer

Hong‑Yan Quan, Tian Yuan, Jian‑Feng Hao
Pages: 4079-4086
Published online on: 20 August 2018

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Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression

Wei Yu, Jinjin Qin, Chunjuan Chen, Yucai Fu, Wei Wang
Pages: 4087-4094
Published online on: 16 August 2018

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Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model

Er‑Cui Feng, Li Jiang
Pages: 4095-4102
Published online on: 14 August 2018

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Corticosteroid therapy in IgA nephropathy with minimal proteinuria and high renal pathological score: A single‑center cohort study

Yuyan Tang, Haidong He, Weiqian Sun, Pin Hu, Xia Chen, Xudong Xu
Pages: 4103-4112
Published online on: 21 August 2018

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MicroRNA‑152 regulates insulin secretion and pancreatic β cell proliferation by targeting PI3Kα

Li Chen, Haiyun Qian, Junli Xue, Juan Zhang, Hao Chen
Pages: 4113-4121
Published online on: 08 August 2018

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Overexpression of miR‑21 is involved in acute monocytic leukemia‑associated angiogenesis by targeting IL‑12

Xue‑Peng He, Peng Chen, Kai Yang, Bing Liu, Yuan Zhang, Fang Wang, Zhi Guo, Xiao‑Dong Liu, Jin‑Xing Lou, Hui‑Ren Chen
Pages: 4122-4128
Published online on: 06 August 2018

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miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes

Shuyue Wang, Linfang Li, Xiehui Chen, Xiuqing Huang, Jin Liu, Xuelin Sun, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Weiqing Tang, Lin Dou, Jian Li
Pages: 4129-4137
Published online on: 17 August 2018

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Identification of genes and genetic networks associated with BAG3‑dependent cell proliferation and cell survival in human cervical cancer HeLa cells

Yukihiro Furusawa, Tatsuya Yunoki, Tetsushi Hirano, Satsuki Minagawa, Hironori Izumi, Hisashi Mori, Atsushi Hayashi, Yoshiaki Tabuchi
Pages: 4138-4146
Published online on: 10 August 2018

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Microarray and pattern miner analysis of AXL and VIM gene networks in MDA‑MB‑231 cells

Sudhakar Natarajan, Venil N. Sumantran, Mohan Ranganathan, Suresh Madheswaran
Pages: 4147-4155
Published online on: 20 August 2018

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[Retracted] Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion

Tao Fan, Guozhi Huang, Wen Wu, Rong Guo, Qing Zeng
Pages: 4156-4156
Published online on: 09 August 2018

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[Corrigendum] Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU

Bo Tang, Zhigao Hu, Yang Li, Shengguang Yuan, Zhenran Wang, Shuiping Yu, Songqing He
Pages: 4157-4157
Published online on: 21 August 2018

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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