1
|
Hernandez-Gea V and Friedman SL:
Pathogenesis of liver fibrosis. Annu Rev Pathol. 6:425–456. 2011.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Rockey DC: Translating an understanding of
the pathogenesis of hepatic fibrosis to novel therapies. Clin
Gastroenterol Hepatol. 11:224–231.e1-5. 2013. View Article : Google Scholar : PubMed/NCBI
|
3
|
Lee UE and Friedman SL: Mechanisms of
hepatic fibrogenesis. Best Pract Res Clin Gastroenterol.
25:195–206. 2011. View Article : Google Scholar : PubMed/NCBI
|
4
|
Corpechot C, Barbu V, Wendum D, Kinnman N,
Rey C, Poupon R, Housset C and Rosmorduc O: Hypoxia-induced VEGF
and collagen I expressions are associated with angiogenesis and
fibrogenesis in experimental cirrhosis. Hepatology. 35:1010–1021.
2002. View Article : Google Scholar : PubMed/NCBI
|
5
|
Poli G: Pathogenesis of liver fibrosis:
Role of oxidative stress. Mol Aspects Med. 21:49–98. 2000.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Moon JO, Welch TP, Gonzalez FJ and Copple
BL: Reduced liver fibrosis in hypoxia-inducible
factor-1alpha-deficient mice. Am J Physiol Gastrointest Liver
Physiol. 296:G582–G592. 2009. View Article : Google Scholar : PubMed/NCBI
|
7
|
Novo E, Povero D, Busletta C, Paternostro
C, di Bonzo LV, Cannito S, Compagnone A, Bandino A, Marra F,
Colombatto S, et al: The biphasic nature of hypoxia-induced
directional migration of activated human hepatic stellate cells. J
Pathol. 226:588–597. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Wang GL, Jiang BH, Rue EA and Semenza GL:
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci
USA. 92:pp. 5510–5514. 1995; View Article : Google Scholar : PubMed/NCBI
|
9
|
Copple BL, Bai S, Burgoon LD and Moon JO:
Hypoxia-inducible factor-1α regulates the expression of genes in
hypoxic hepatic stellate cells important for collagen deposition
and angiogenesis. Liver Int. 31:230–244. 2011. View Article : Google Scholar : PubMed/NCBI
|
10
|
Novo E, Cannito S, Zamara E, Valfrè di
Bonzo L, Caligiuri A, Cravanzola C, Compagnone A, Colombatto S,
Marra F, Pinzani M and Parola M: Proangiogenic cytokines as
hypoxia-dependent factors stimulating migration of human hepatic
stellate cells. Am J Pathol. 170:1942–1953. 2007. View Article : Google Scholar : PubMed/NCBI
|
11
|
Wang Y, Huang Y, Guan F, Xiao Y, Deng J,
Chen H, Chen X, Li J, Huang H and Shi C: Hypoxia-inducible
factor-1alpha and MAPK co-regulate activation of hepatic stellate
cells upon hypoxia stimulation. PLoS One. 8:e740512013. View Article : Google Scholar : PubMed/NCBI
|
12
|
Kato M, Iwamoto H, Higashi N, Sugimoto R,
Uchimura K, Tada S, Sakai H, Nakamuta M and Nawata H: Role of Rho
small GTP binding protein in the regulation of actin cytoskeleton
in hepatic stellate cells. J Hepatol. 31:91–99. 1999. View Article : Google Scholar : PubMed/NCBI
|
13
|
Iwamoto H, Nakamuta M, Tada S, Sugimoto R,
Enjoji M and Nawata H: A p160ROCK-specific inhibitor, Y-27632,
attenuates rat hepatic stellate cell growth. J Hepatol. 32:762–770.
2000. View Article : Google Scholar : PubMed/NCBI
|
14
|
Gilkes DM, Xiang L, Lee SJ, Chaturvedi P,
Hubbi ME, Wirtz D and Semenza GL: Hypoxia-inducible factors mediate
coordinated RhoA-ROCK1 expression and signaling in breast cancer
cells. Proc Natl Acad Sci USA. 111:pp. E384–E393. 2014; View Article : Google Scholar : PubMed/NCBI
|
15
|
Matoba K, Kawanami D, Okada R, Tsukamoto
M, Kinoshita J, Ito T, Ishizawa S, Kanazawa Y, Yokota T, Murai N,
et al: Rho-kinase inhibition prevents the progression of diabetic
nephropathy by downregulating hypoxia-inducible factor 1α. Kidney
Int. 84:545–554. 2013. View Article : Google Scholar : PubMed/NCBI
|
16
|
Ohta T, Takahashi T, Shibuya T, Amita M,
Henmi N, Takahashi K and Kurachi H: Inhibition of the Rho/ROCK
pathway enhances the efficacy of cisplatin through the blockage of
hypoxia-inducible factor-1α in human ovarian cancer cell. Cancer
Biol Ther. 13:25–33. 2012. View Article : Google Scholar : PubMed/NCBI
|
17
|
van den Beucken T, Koch E, Chu K,
Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL,
Buffa FM, Haider S, et al: Hypoxia promotes stem cell phenotypes
and poor prognosis through epigenetic regulation of DICER. Nat
Commun. 5:52032014. View Article : Google Scholar : PubMed/NCBI
|
18
|
Barsoum IB, Smallwood CA, Siemens DR and
Graham CH: A mechanism of hypoxia-mediated escape from adaptive
immunity in cancer cells. Cancer Res. 74:665–674. 2014. View Article : Google Scholar : PubMed/NCBI
|
19
|
Bataller R and Brenner DA: Liver fibrosis.
J Clin Invest. 115:209–218. 2005. View Article : Google Scholar : PubMed/NCBI
|
20
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar : PubMed/NCBI
|
21
|
Ji RC: Hypoxia and lymphangiogenesis in
tumor microenvironment and metastasis. Cancer Lett. 346:6–16. 2014.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Wigerup C, Påhlman S and Bexell D:
Therapeutic targeting of hypoxia and hypoxia-inducible factors in
cancer. Pharmacol Ther. 164:152–169. 2016. View Article : Google Scholar : PubMed/NCBI
|
23
|
Krishnamachary B, Berg-Dixon S, Kelly B,
Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P
and Semenza GL: Regulation of colon carcinoma cell invasion by
hypoxia-inducible factor 1. Cancer Res. 63:1138–1143.
2003.PubMed/NCBI
|
24
|
Ball MK, Waypa GB, Mungai PT, Nielsen JM,
Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK,
Steinhorn RH, et al: Regulation of hypoxia-induced pulmonary
hypertension by vascular smooth muscle hypoxia-inducible factor-1α.
Am J Respir Crit Care Med. 189:314–324. 2014. View Article : Google Scholar : PubMed/NCBI
|
25
|
He G, Jiang Y, Zhang B and Wu G: The
effect of HIF-1α on glucose metabolism, growth and apoptosis of
pancreatic cancerous cells. Asia Pac J Clin Nutr. 23:174–180.
2014.PubMed/NCBI
|
26
|
Birner P, Schindl M, Obermair A,
Breitenecker G and Oberhuber G: Expression of hypoxia-inducible
factor 1alpha in epithelial ovarian tumors: Its impact on prognosis
and on response to chemotherapy. Clin Cancer Res. 7:1661–1668.
2001.PubMed/NCBI
|
27
|
Zhan L, Huang C, Meng XM, Song Y, Wu XQ,
Yang Y and Li J: Hypoxia-inducible factor-1alpha in hepatic
fibrosis: A promising therapeutic target. Biochimie. 108:1–7. 2015.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Murata T, Arii S, Nakamura T, Mori A,
Kaido T, Furuyama H, Furumoto K, Nakao T, Isobe N and Imamura M:
Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of
rat liver fibrosis in association with inactivation of hepatic
stellate cells. J Hepatol. 35:474–481. 2001. View Article : Google Scholar : PubMed/NCBI
|
29
|
Tada S, Iwamoto H, Nakamuta M, Sugimoto R,
Enjoji M, Nakashima Y and Nawata H: A selective ROCK inhibitor,
Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in
rats. J Hepatol. 34:529–536. 2001. View Article : Google Scholar : PubMed/NCBI
|
30
|
Kutscher C, Lampert FM, Kunze M,
Markfeld-Erol F, Stark GB and Finkenzeller G: Overexpression of
hypoxia-inducible factor-1 alpha improves vasculogenesis-related
functions of endothelial progenitor cells. Microvasc Res.
105:85–92. 2016. View Article : Google Scholar : PubMed/NCBI
|
31
|
Hu F, Liu H, Xu L, Li Y, Liu X, Shi L, Su
Y, Qiu X, Zhang X, Yang Y, et al: Hypoxia-inducible factor-1α
perpetuates synovial fibroblast interactions with T cells and B
cells in rheumatoid arthritis. Eur J Immunol. 46:742–751. 2016.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Marhold M, Tomasich E, El-Gazzar A, Heller
G, Spittler A, Horvat R, Krainer M and Horak P: HIF1α Regulates
mTOR signaling and viability of prostate cancer stem cells. Mol
Cancer Res. 13:556–564. 2015. View Article : Google Scholar : PubMed/NCBI
|
33
|
Wojciak-Stothard B, Zhao L, Oliver E,
Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA,
Harrington LS, et al: Role of RhoB in the regulation of pulmonary
endothelial and smooth muscle cell responses to hypoxia. Circ Res.
110:1423–1434. 2012. View Article : Google Scholar : PubMed/NCBI
|
34
|
Knipe RS, Tager AM and Liao JK: The Rho
kinases: Critical mediators of multiple profibrotic processes and
rational targets for new therapies for pulmonary fibrosis.
Pharmacol Rev. 67:103–117. 2015. View Article : Google Scholar : PubMed/NCBI
|
35
|
Wang C, Song S, Zhang Y, Ge Y, Fang X,
Huang T, Du J and Gao J: Inhibition of the Rho/Rho kinase pathway
prevents lipopolysaccharide-induced hyperalgesia and the release of
TNF-α and IL-1β in the mouse spinal cord. Sci Rep. 5:145532015.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Dyck SM, Alizadeh A, Santhosh KT, Proulx
EH, Wu CL and Karimi-Abdolrezaee S: Chondroitin sulfate
proteoglycans negatively modulate spinal cord neural precursor
cells by signaling through LAR and RPTPσ and modulation of the
Rho/ROCK pathway. Stem Cells. 33:2550–2563. 2015. View Article : Google Scholar : PubMed/NCBI
|
37
|
Yin CP, Guan SH, Zhang B, Wang XX and Yue
SW: Upregulation of HIF-1α protects neuroblastoma cells from
hypoxia-induced apoptosis in a RhoA-dependent manner. Mol Med Rep.
12:7123–7131. 2015. View Article : Google Scholar : PubMed/NCBI
|