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Article Open Access

Therapeutic effects of bee venom on experimental atopic dermatitis

  • Authors:
    • Hyemin Gu
    • Woon‑Hae Kim
    • Hyun‑Jin An
    • Jung‑Yeon Kim
    • Mi‑Gyeong Gwon
    • Sang Mi Han
    • Jaechan Leem
    • Kwan‑Kyu Park
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea, Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea, Department of Agricultural Biology, National Academy of Agricultural Science, Wanju, Jeollabuk-do 55365, Republic of Korea, Department of Immunology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea
    Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3711-3718
    |
    Published online on: August 17, 2018
       https://doi.org/10.3892/mmr.2018.9398
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Abstract

Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by recurrent eczema and itching. It is caused by a poorly controlled immune response and damage to the skin barrier. Purified bee venom (BV) is a natural toxin produced by honeybees (Apis mellifera L.), and is well known for its anti‑inflammatory, analgesic and anti‑cancer effects against various types of disease. However, treatment strategies based on anti‑inflammatory properties have not been adequately studied in AD. Thus, the present study examined the progression of AD‑like skin lesions induced by ovalbumin (OVA) and the mechanism of action of BV. BV, administered by intraperitoneal inoculation, was observed to reduce the symptoms of AD, in addition to the serum immunoglobulin E levels, according to dorsal skin thickness and histopathologic analysis. The treatment also inhibited the infiltration of eosinophils and mast cells. These results suggested that it is possible to develop novel AD alternative therapy using BV by effectively suppressing allergic skin inflammation in AD.
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Copy and paste a formatted citation
Spandidos Publications style
Gu H, Kim WH, An HJ, Kim JY, Gwon MG, Han SM, Leem J and Park KK: Therapeutic effects of bee venom on experimental atopic dermatitis. Mol Med Rep 18: 3711-3718, 2018.
APA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S.M. ... Park, K. (2018). Therapeutic effects of bee venom on experimental atopic dermatitis. Molecular Medicine Reports, 18, 3711-3718. https://doi.org/10.3892/mmr.2018.9398
MLA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18.4 (2018): 3711-3718.
Chicago
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18, no. 4 (2018): 3711-3718. https://doi.org/10.3892/mmr.2018.9398
Copy and paste a formatted citation
x
Spandidos Publications style
Gu H, Kim WH, An HJ, Kim JY, Gwon MG, Han SM, Leem J and Park KK: Therapeutic effects of bee venom on experimental atopic dermatitis. Mol Med Rep 18: 3711-3718, 2018.
APA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S.M. ... Park, K. (2018). Therapeutic effects of bee venom on experimental atopic dermatitis. Molecular Medicine Reports, 18, 3711-3718. https://doi.org/10.3892/mmr.2018.9398
MLA
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18.4 (2018): 3711-3718.
Chicago
Gu, H., Kim, W., An, H., Kim, J., Gwon, M., Han, S. M., Leem, J., Park, K."Therapeutic effects of bee venom on experimental atopic dermatitis". Molecular Medicine Reports 18, no. 4 (2018): 3711-3718. https://doi.org/10.3892/mmr.2018.9398
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