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Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma

  • Authors:
    • Lingqi Zhou
    • Hai Tang
    • Fang Wang
    • Lizhi Chen
    • Shanshan Ou
    • Tong Wu
    • Jie Xu
    • Kaihua Guo
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Molecular Diagnostics, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4185-4196
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    Published online on: August 21, 2018
       https://doi.org/10.3892/mmr.2018.9411
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Abstract

Glioblastoma (GBM) is the most common type of malignant tumor of the central nervous system. The prognosis of patients with GBM is very poor, with a survival time of ~15 months. GBM is highly heterogeneous and highly aggressive. Surgical removal of intracranial tumors does provide a good advantage for patients as there is a high rate of recurrence. The understanding of this type of cancer needs to be strengthened, and the aim of the present study was to identify gene signatures present in GBM and uncover their potential mechanisms. The gene expression profiles of GSE15824 and GSE51062 were downloaded from the Gene Expression Omnibus database. Normalization of the data from primary GBM samples and normal samples in the two databases was conducted using R software. Then, joint analysis of the data was performed. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, and the protein‑protein interaction (PPI) network of the differentially expressed genes (DEGs) was constructed using Cytoscape software. Identification of prognostic biomarkers was conducted using UALCAN. In total, 9,341 DEGs were identified in the GBM samples, including 9,175 upregulated genes and 166 downregulated genes. The top 1,000 upregulated DEGs and all of the downregulated DEGs were selected for GO, KEGG and prognostic biomarker analyses. The GO results showed that the upregulated DEGs were significantly enriched in biological processes (BP), including immune response, cell division and cell proliferation, and the downregulated DEGs were also significantly enriched in BP, including cell growth, intracellular signal transduction and signal transduction by protein phosphorylation. KEGG pathway analysis showed that the upregulated DEGs were enriched in circadian entrainment, cytokine‑cytokine receptor interaction and maturity onset diabetes of the young, while the downregulated DEGs were enriched in the TGF‑β signaling pathway, MAPK signaling pathway and pathways in cancer. All of the downregulated genes and the top 1,000 upregulated genes were selected to establish the PPI network, and the sub‑networks revealed that these genes were involved in significant pathways, including olfactory transduction, neuroactive ligand‑receptor interaction and viral carcinogenesis. In total, seven genes were identified as good prognostic biomarkers. In conclusion, the identified DEGs and hub genes contribute to the understanding of the molecular mechanisms underlying the development of GBM and they may be used as diagnostic and prognostic biomarkers and molecular targets for the treatment of patients with GBM in the future.
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1 

Steiner HH, Herold-Mende C, Bonsanto M, Geletneky K and Kunze S: Prognosis of brain tumors: Epidemiology, survival time and clinical course. Versicherungsmedizin. 50:173–179. 1998.(In French). PubMed/NCBI

2 

Fisher JL, Schwartzbaum JA, Wrensch M and Wiemels JL: Epidemiology of brain tumors. Neurol Clin. 25:867–890. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Asthagiri AR, Pouratian N, Sherman J, Ahmed G and Shaffrey ME: Advances in brain tumor surgery. Neurol Clin. 25:975–1003. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Grzmil M, Morin P Jr, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G and Hemmings BA: MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. Cancer Res. 71:2392–2402. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Martinez-Lage M, Simon MC, O'Rourke DM and Lazzara MJ: Sprouty2 drives drug resistance and proliferation in glioblastoma. Mol Cancer Res. 13:1227–1237. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Gerber NK, Goenka A, Turcan S, Reyngold M, Makarov V, Kannan K, Beal K, Omuro A, Yamada Y, Gutin P, et al: Transcriptional diversity of long-term glioblastoma survivors. Neuro Oncol. 16:1186–1195. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Barrett T, Troup DB, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, et al: NCBI GEO: Archive for functional genomics data sets-10 years on. Nucleic Acids Res. 39:D1005–D1010. 2011. View Article : Google Scholar : PubMed/NCBI

9 

NIH: The Cancer Genome Atlas, . TCGA Data Portal. https://tcga-data.nci.nih.gov/docs/publications/tcga/?June 30–2016

10 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Diboun I, Wernisch L, Orengo CA and Koltzenburg M: Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 7:2522006. View Article : Google Scholar : PubMed/NCBI

12 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Gene Ontology Consortium, . The gene ontology (GO) project in 2006. Nucleic Acids Res. 34:D322–D336. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nature Genetics. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

18 

Franceschini A, Szklarezyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Liu TT, Achrol AS, Mitchell LA, Rodriguez SA, Feroze A, Iv M, Kim C, Chaudhary N, Gevaert O, Stuart JM, et al: Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment. Neuro Oncol. 19:997–1007. 2017.PubMed/NCBI

22 

Brandes A, Franceschi E, Tosoni A, Fioravanti A, Agati R, Andreoli A, Mazzocchi V, Morandi L, Bartolini S and Ermani M: Change in MGMT methylation status between first and second surgery for recurrence: Clinical implications. Eur J Cancer Suppl. 7:4952009. View Article : Google Scholar

23 

Akbari A, Farahnejad Z, Akhtari J, Abastabar M, Mobini GR and Mehbod AS: Staphylococcus aureus enterotoxin B down-regulates the expression of transforming growth factor-beta (TGF-β). Signaling Transducers in Human Glioblastoma. Jundishapur J Microbiol. 9:e272972016. View Article : Google Scholar : PubMed/NCBI

24 

Jiang C, Shen F, Du J, Hu Z, Li X, Su J, Wang X and Huang X: MicroRNA-564 is downregulated in glioblastoma and inhibited proliferation and invasion of glioblastoma cells by targeting TGF-β1. Oncotarget. 7:56200–56208. 2016.PubMed/NCBI

25 

Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y and Xu Y: Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J Neuro Oncol. 132:15–26. 2017. View Article : Google Scholar

26 

Kim EH, Song HS, Yoo SH and Yoon M: Tumor treating fields inhibit glioblastoma cell migration, invasion and angiogenesis. Oncotarget. 7:65125–65136. 2016.PubMed/NCBI

27 

Firat E and Niedermann G: FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition. Oncotarget. 7:54883–54896. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, et al: mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab. 18:726–739. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Al-Khafaji AS, Davies MP, Risk JM, Marcus MW, Koffa M, Gosney JR, Shaw RJ, Field JK and Liloglou T: Aurora B expression modulates paclitaxel response in non-small cell lung cancer. Br J Cancer. 116:592–599. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Borges KS, Castro-Gamero AM, Moreno DA, da Silva Silveira V, Brassesco MS, de Paula Queiroz RG, de Oliveira HF, Carlotti CG Jr, Scrideli CA and Tone LG: Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. J Cancer Res Clin Oncol. 138:405–414. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Bornschein J, Nielitz J, Drozdov I, Selgrad M, Wex T, Jechorek D, Link A, Vieth M and Malfertheiner P: Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer. Cancer Med. 5:516–526. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Yousef EM, Furrer D, Laperriere DL, Tahir MR, Mader S, Diorio C and Gaboury LA: MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation. Mod Pathol. 30:682–697. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Su Z, Zheng X, Zhang X, Wang Y, Zhu S, Lu F, Qu J and Hou L: Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5. J Dermatol Sci. 85:216–225. 2017. View Article : Google Scholar : PubMed/NCBI

34 

He X, Liu Z, Peng Y and Yu C: MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-β pathway. Biochem Biophys Res Commun. 469:1041–1085. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Wu ZB, Cai L, Lin SJ, Lu JL, Yao Y and Zhou LF: The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. Brain Res. 1529:16–25. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W and Lo HW: The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Oncotarget. 6:22653–22655. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Sheik Y, Qureshi SF, Mohhammed B and Nallari P: FOXC2 and FLT4 gene variants in lymphatic filariasis. Lymphat Res Biol. 13:112–119. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P and Hutchinson L: The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol. 46:868–875. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Rani N, Aichem A, Schmidtke G, Kreft SG and Groettrup M: FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nat Commun. 3:7492012. View Article : Google Scholar : PubMed/NCBI

40 

Zhang J, Yan B, Späth SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van Waes C, Chen Z, et al: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. Cell Biosci. 5:532015. View Article : Google Scholar : PubMed/NCBI

41 

Liau CT, Chou WC, Wei KC, Chang CN, Toh CH and Jung SM: Female sex, good performance status and bevacizumab-induced hypertension associated with survival benefit in Asian patients with recurrent glioblastoma treated with bevacizumab. Asia Pac J Clin Oncol. 14:e8–e14. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou L, Tang H, Wang F, Chen L, Ou S, Wu T, Xu J and Guo K: Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Mol Med Rep 18: 4185-4196, 2018.
APA
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T. ... Guo, K. (2018). Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Molecular Medicine Reports, 18, 4185-4196. https://doi.org/10.3892/mmr.2018.9411
MLA
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T., Xu, J., Guo, K."Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma". Molecular Medicine Reports 18.5 (2018): 4185-4196.
Chicago
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T., Xu, J., Guo, K."Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma". Molecular Medicine Reports 18, no. 5 (2018): 4185-4196. https://doi.org/10.3892/mmr.2018.9411
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou L, Tang H, Wang F, Chen L, Ou S, Wu T, Xu J and Guo K: Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Mol Med Rep 18: 4185-4196, 2018.
APA
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T. ... Guo, K. (2018). Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Molecular Medicine Reports, 18, 4185-4196. https://doi.org/10.3892/mmr.2018.9411
MLA
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T., Xu, J., Guo, K."Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma". Molecular Medicine Reports 18.5 (2018): 4185-4196.
Chicago
Zhou, L., Tang, H., Wang, F., Chen, L., Ou, S., Wu, T., Xu, J., Guo, K."Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma". Molecular Medicine Reports 18, no. 5 (2018): 4185-4196. https://doi.org/10.3892/mmr.2018.9411
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