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Article

Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e

  • Authors:
    • Leilei Yang
    • Qian Shen
    • Yanqiong Xia
    • Xueheng Lei
    • Jian Peng
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, Hubei 430060, P.R. China
  • Pages: 4657-4665
    |
    Published online on: September 3, 2018
       https://doi.org/10.3892/mmr.2018.9442
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Abstract

Sevoflurane is a common anesthetic agent used in surgical settings and previous studies have indicated that it exerts a neurotoxic effect. However, the molecular mechanism underlying this side effect is unknown. In addition, the human microRNA‑302 (hsa‑miR‑302) family members have been reported to be involved in neuronal cell development and biology. Thus, the present study aimed to investigate the potential implication of hsa‑miR‑302e in the sevoflurane‑induced cytotoxicity on human hippocampal cells (HN‑h). HN‑h cells were transfected with hsa‑miR‑302e mimic, hsa‑miR‑302e inhibitor or negative controls and subsequently exposed to different concentrations of sevoflurane. An MTT assay was used to assess the cytotoxicity of sevoflurane on HN‑h cells. Cell apoptosis was determined by flow cytometry. The levels of lactate dehydrogenase release, reactive oxygen species, lipid peroxidation and intracellular calcium (Ca2+) were additionally detected. Reverse transcription‑quantitative polymerase chain reaction and western blotting were conducted to determine mRNA and protein expression, respectively. A luciferase assay was performed for validating the targeting of OXR1 by hsa‑miR‑302e. The results indicated that sevoflurane induced a decrease in cell viability, malondialdehyde and reactive oxygen species production, lactate dehydrogenase release, intracellular Ca2+ production, calcium/calmodulin‑dependent protein kinase II phosphorylation and apoptosis. In addition, treatment with sevoflurane induced the expression of hsa‑miR‑302e while the expression of its target, oxidation resistance gene 1 (OXR1), was significantly downregulated. Inhibition of hsa‑miR‑302e expression protected neuronal cells from sevoflurane cytotoxicity. Mechanistic studies demonstrated that OXR1 was a direct target of hsa‑miR‑302e. Furthermore, the overexpression of OXR1 abolished the effect of sevoflurane on neuronal cells. The results of the present study indicated that sevoflurane exerts its neurotoxic effect by regulating the hsa‑miR‑302e/OXR1 axis. Therefore, the manipulation of the hsa‑miR‑302e/OXR1 pathway will be useful for preventing sevoflurane‑induced neurotoxicity.
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1 

Freiermuth D, Mets B, Bolliger D, Reuthebuch O, Doebele T, Scholz M, Gregor M, Haschke M, Seeberger MD and Fassl J: Sevoflurane and isoflurane-pharmacokinetics, hemodynamic stability, and cardioprotective effects during cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 30:1494–1501. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Likhvantsev VV, Landoni G, Levikov DI, Grebenchikov OA, Skripkin YV and Cherpakov RA: Sevoflurane vs. total intravenous anesthesia for isolated coronary artery bypass surgery with cardiopulmonary bypass: A randomized trial. J Cardiothorac Vasc Anesth. 30:1221–1227. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Ružman T, Šimurina T, Gulam D, Ružman N and Miškulin M: Sevoflurane preserves regional cerebral oxygen saturation better than propofol: Randomized controlled trial. J Clin Anesth. 36:110–117. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Walia H, Ruda J and Tobias JD: Sevoflurane and bradycardia in infants with trisomy 21: A case report and review of the literature. Int J Pediatr Otorhinolaryngol. 80:5–7. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Conreux F, Best O, Preckel MP, Lhopitault C, Beydon L, Pouplard F and Granry JC: Effets électroencéphalographiques du sévoflurane à l'induction chez le jeune enfant: Étude prospective sur 20 cas. Ann Fr Anesth Réanim. 20:438–445. 2001.(In French). View Article : Google Scholar

6 

Geng YJ, Wu QH and Zhang RQ: Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. J Clin Anesth. 38:165–171. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Xiao H, Liu B, Chen Y and Zhang J: Learning, memory and synaptic plasticity in hippocampus in rats exposed to sevoflurane. Int J Dev Neurosci. 48:38–49. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hu N, Wang M, Xie K, Wang H, Wang C, Wang C, Wang C, Li Y, Yu Y and Wang G: Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane. Neurotoxicol. 49:94–103. 2015. View Article : Google Scholar

9 

Shen X, Liu Y, Xu S, Zhao Q, Guo X, Shen R and Wang F: Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. Neurotoxicol. 39:45–56. 2013. View Article : Google Scholar

10 

Wu Y, Gu C and Huang X: Sevoflurane protects against hepatic ischemia/reperfusion injury by modulating microRNA-200c regulation in mice. Biomed Pharmacother. 84:1126–1136. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sun Y, Li Y, Liu L, Wang Y, Xia Y, Zhang L and Ji X: Identification of miRNAs involved in the protective effect of sevoflurane preconditioning against hypoxic injury in PC12 cells. Cell Mol Neurobiol. 35:1117–1125. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Yi W, Li D, Guo Y, Zhang Y, Huang B and Li X: Sevoflurane inhibits the migration and invasion of glioma cells by upregulating microRNA-637. Int J Mol Med. 38:1857–1863. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ye J, Zhang Z, Wang Y, Chen C, Xu X, Yu H and Peng M: Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis. Exp Ther Med. 12:1299–1310. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Fujimoto S, Ishikawa M, Nagano M and Sakamoto A: Influence of neonatal sevoflurane exposure on nerve development-related microRNAs and behavior of rats. Biomed Res. 36:347–355. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Friedman R, Farh K, Burge C and Bartel D: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Winter J, Jung S, Keller S, Gregory R and Diederichs S: Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat Cell Biol. 11:228–234. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Wang Q, Li G, Li B, Chen Q, Lv D, Liu J, Ma J, Sun N, Yang L, Fei X and Song Q: Sevoflurane represses the self-renewal ability by regulating miR-7a,7b/Klf4 signalling pathway in mouse embryonic stem cells. Cell Prolif. 49:609–617. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zhou C, Gu H, Fan R, Wang B and Lou J: MicroRNA 302/367 cluster effectively facilitates direct reprogramming from human fibroblasts into functional neurons. Stem Cells Dev. 24:2746–2755. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Z, Hong Y, Xiang D, Zhu P, Wu E, Li W, Mosenson J and Wu WS: MicroRNA-302/367 cluster governs hESC self-renewal by dually regulating cell cycle and apoptosis pathways. Stem Cell Reports. 4:645–657. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Li HL, Wei JF, Fan LY, Wang SH, Zhu L, Li TP, Lin G, Sun Y, Sun ZJ, Ding J, et al: miR-302 regulates pluripotency, teratoma formation and differentiation in stem cells via an AKT1/OCT4-dependent manner. Cell Death Dis. 7:e20782016. View Article : Google Scholar : PubMed/NCBI

21 

Gao Z, Zhu X and Dou Y: The miR-302/367 cluster: A comprehensive update on its evolution and functions. Open Biol. 5:1501382015. View Article : Google Scholar : PubMed/NCBI

22 

Yang CM, Chiba T, Brill B, Delis N, von Manstein V, Vafaizadeh V, Oellerich T and Groner B: Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. Int J Cancer. 137:2296–2309. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Maadi H, Moshtaghian A, Taha MF, Mowla SJ, Kazeroonian A, Haass NK and Javeri A: Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer. Int J Biochem Cell Biol. 81:121–132. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA and Blelloch R: miR-302 is required for timing of neural differentiation, neural tube closure, and embryonic viability. Cell Rep. 12:760–773. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Suresh B, Kumar AM, Jeong HS, Cho YH, Ramakrishna S and Kim KS: Regulation of Fanconi anemia protein FANCD2 monoubiquitination by miR-302. Biochem Biophys Res Commun. 466:180–185. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yang SL, Yang M, Herrlinger S, Liang C, Lai F and Chen JF: MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 408:140–150. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Li HH, Lin SL, Huang CN, Lu FJ, Chiu PY, Huang WN, Lai TJ and Lin CL: miR-302 attenuates amyloid-beta-induced neurotoxicity through activation of Akt signaling. J Alzheimers Dis. 50:1083–1098. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Fang YC and Yeh CH: Inhibition of miR-302 suppresses hypoxia-reoxygenation-induced H9c2 cardiomyocyte death by regulating Mcl-1 expression. Oxid Med Cell Longev. 2017:79689052017. View Article : Google Scholar : PubMed/NCBI

29 

Ghasemi-Kasman M, Baharvand H and Javan M: Enhanced neurogenesis in degenerated hippocampi following pretreatment with miR-302/367 expressing lentiviral vector in mice. Biomed Pharmacother. 96:1222–1229. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Ghasemi-Kasman M, Shojaei A, Gol M, Moghadamnia AA, Baharvand H and Javan M: miR-302/367-induced neurons reduce behavioral impairment in an experimental model of Alzheimer's disease. Mol Cell Neurosci. 86:50–57. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Zhou YF, Wang QX, Zhou HY and Chen G: Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells. Acta Pharmacol Sin. 37:580–588. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Altuntas TG, Zager RA and Kharasch ED: Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. Toxicol Appl Pharmacol. 193:55–65. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Manoharan S, Guillemin GJ, Abiramasundari RS, Essa MM, Akbar M and Akbar MD: The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and Huntington's disease: A mini review. Oxid Med Cell Longev. 2016:85905782016. View Article : Google Scholar : PubMed/NCBI

35 

Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE and Oliver PL: Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain. 138:1167–1181. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Oliver PL, Finelli MJ, Edwards B, Bitoun E, Butts DL, Becker EB, Cheeseman MT, Davies B and Davies KE: Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. PLoS Genet. 7:e10023382011. View Article : Google Scholar : PubMed/NCBI

37 

Finelli MJ, Sanchez-Pulido L, Liu KX, Davies KE and Oliver PL: The evolutionarily conserved Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) domain is neuroprotective against oxidative stress. J Biol Chem. 291:2751–2763. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wu Y, Davies KE and Oliver PL: The antioxidant protein Oxr1 influences aspects of mitochondrial morphology. Free Radic Biol Med. 95:255–267. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Chen X, Xu Y, Liao X, Liao R, Zhang L, Niu K, Li T, Li D, Chen Z, Duan Y and Sun J: Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer. Tumour Biol. 37:11927–11936. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Shen Q, Xia Y, Lei X and Peng J: Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e. Mol Med Rep 18: 4657-4665, 2018.
APA
Yang, L., Shen, Q., Xia, Y., Lei, X., & Peng, J. (2018). Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e. Molecular Medicine Reports, 18, 4657-4665. https://doi.org/10.3892/mmr.2018.9442
MLA
Yang, L., Shen, Q., Xia, Y., Lei, X., Peng, J."Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e". Molecular Medicine Reports 18.5 (2018): 4657-4665.
Chicago
Yang, L., Shen, Q., Xia, Y., Lei, X., Peng, J."Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e". Molecular Medicine Reports 18, no. 5 (2018): 4657-4665. https://doi.org/10.3892/mmr.2018.9442
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Shen Q, Xia Y, Lei X and Peng J: Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e. Mol Med Rep 18: 4657-4665, 2018.
APA
Yang, L., Shen, Q., Xia, Y., Lei, X., & Peng, J. (2018). Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e. Molecular Medicine Reports, 18, 4657-4665. https://doi.org/10.3892/mmr.2018.9442
MLA
Yang, L., Shen, Q., Xia, Y., Lei, X., Peng, J."Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e". Molecular Medicine Reports 18.5 (2018): 4657-4665.
Chicago
Yang, L., Shen, Q., Xia, Y., Lei, X., Peng, J."Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e". Molecular Medicine Reports 18, no. 5 (2018): 4657-4665. https://doi.org/10.3892/mmr.2018.9442
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