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Case Report

Sarcomatoid carcinoma of the pancreas: A case report and review of the literature

  • Authors:
    • Yingjun Xie
    • Yien Xiang
    • Dan Zhang
    • Xiaoxiao Yao
    • Jiyao Sheng
    • Yongsheng Yang
    • Xuewen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
  • Pages: 4716-4724
    |
    Published online on: September 14, 2018
       https://doi.org/10.3892/mmr.2018.9489
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Abstract

Sarcomatoid carcinoma (SC) is an extremely rare and complicated malignant neoplasm that consists of both malignant epithelial components and atypical spindle cells that express an epithelial phenotype. The presents study reported a case of SC of the pancreas (SCP), along with a brief review of the literature. A 63‑year‑old man was admitted to The Second Hospital of Jilin University hospital with complaints of epigastralgia and jaundice of one month in duration. Based on preoperative laboratory blood tests and radiography, a mass at the distal common bile duct was suspected. Intraoperative examination discovered a 2.5x2x1.8‑cm mass in the pancreatic head, with invasion of the distal bile duct. Pancreaticoduodectomy was performed. Histopathology and immunohistochemistry of the specimen confirmed the diagnosis of SCP. The patient succumbed 18 months after surgery due to multiple hepatic metastases.
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1 

De la Riva S, Muñoz-Navas MA, Betés M, Súbtil JC, Carretero C and Sola JJ: Sarcomatoid carcinoma of the pancreas and congenital choledochal cyst. Gastrointest Endosc. 64:1005–1006. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Kane JR, Laskin WB, Matkowskyj KA, Villa C and Yeldandi AV: Sarcomatoid (spindle cell) carcinoma of the pancreas: A case report and review of the literature. Oncol Lett. 7:245–249. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Fang XH: New arguments on carcinosarcoma (CS) and sarcomatoid carcinoma (SC). Cancer Res Clinic. 17:138–139. 2005.(In Chinese).

4 

Alguacil-Garcia A and Weiland LH: The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer. 39:1181–1189. 1977. View Article : Google Scholar : PubMed/NCBI

5 

Fukushima N, Hruban RH and Kato Y: Ductal adenocarcinoma variants and mixed neoplasms of the pancreas. WHO Classific Tumors Digest System. 1–299. 2010.

6 

Hruban RH, Pitman MB and Klimstra DS: Adenocarcinoma variantsTumors of the Pancreas. (AFIP Atlas of Tumor Pathology: Series 4). American Registry of Pathology; Washington, DC: pp. 165–190. 2007

7 

Ren CL, Jin P, Han CX, Xiao Q, Wang DR, Shi L, Wang DX and Chen H: Unusual early-stage pancreatic sarcomatoid carcinoma. World J Gastroenterol. 19:7820–7824. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Shirobe T, Yamamoto T and Mori T: A case of spindle cell carcinoma of the pancreas. Suizo. 10:387–392. 1995.

9 

Wolfman NT, Karstaedt N and Kawamoto EH: Pleomorphic carcinoma of the pancreas: Computed-tomographic, sonographic, and pathologic findings. Radiology. 154:329–332. 1985. View Article : Google Scholar : PubMed/NCBI

10 

Mszyco S, Teng L, Annunziata J and Hartman MS: Pancreatic carcinosarcoma: A case report highlighting computed tomography characteristics. Curr Probl Diagn Radiol. 46:342–345. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Husain AN, Colby TV, Ordóñez NG, Krausz T, Borczuk A, Cagle PT, Chirieac LR, Churg A, Galateau-Salle F, Gibbs AR, et al: Guidelines for pathologic diagnosis of malignant mesothelioma: A consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med. 133:1317–1331. 2009.PubMed/NCBI

12 

Lu BC, Wang C, Yu JH, Shen ZH and Yang JH: A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: An unusual case report. World J Gastroenterol. 20:16381–16386. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Jia Z, Zhang K, Huang R, Zhou X and Jiang L: Pancreatic carcinosarcoma with rare long-term survival: Case report and review of the literature. Medicine (Baltimore). 96:e59662017. View Article : Google Scholar : PubMed/NCBI

14 

Yu W, Wang Y, Jiang Y, Zhang W and Li Y: Distinct immunophenotypes and prognostic factors in renal cell carcinoma with sarcomatoid differentiation: A systematic study of 19 immunohistochemical markers in 42 cases. BMC Cancer. 17:2932017. View Article : Google Scholar : PubMed/NCBI

15 

Inoue H, Takahashi H, Hashimura M, Eshima K, Akiya M, Matsumoto T and Saegusa M: Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma. BMC Cancer. 16:532016. View Article : Google Scholar : PubMed/NCBI

16 

Ding HY and Liao SL: Carcinosarcoma (CS) and sarcomatoid carcinoma (SC). Chin J Diagn Pathol. 6:56–57. 1999.(In Chinese).

17 

Lichtiger B, Mackay B and Tessmer CF: Spindle-cell variant of squamous carcinoma. A light and electron microscopic study of 13 cases. Cancer. 26:1311–1320. 1970. View Article : Google Scholar : PubMed/NCBI

18 

Kim KH, Kang DY, Lee MK, Yang HW and Han HY: Sarcomatoid carcinoma of the pancreas: A case report. Kor J Pathol. 40:306–310. 2006.

19 

Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N and Perucho M: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 53:549–554. 1988. View Article : Google Scholar : PubMed/NCBI

20 

Dall'Oglio MF, Lieberknecht M, Gouveia V, Sant'Anna AC, Leite KR and Srougi M: Sarcomatoid differentiation in renal cell carcinoma: Prognostic implications. Int Braz J Urol. 31:10–16. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Lee J, Hyun JJ and Lee HS: A Rare cause of abdominal pain by pancreatic mass in a young female patient. Carcinosarcoma of the pancreas. Gastroenterology. 149:e3–e5. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Goto T, Hirotsu Y, Mochizuki H, Nakagomi T, Oyama T, Amemiya K and Omata M: Stepwise addition of genetic changes correlated with histological change from ‘well-differentiated’ to ‘sarcomatoid’ phenotypes: A case report. BMC Cancer. 17:652017. View Article : Google Scholar : PubMed/NCBI

23 

Schaefer IM, Sahlmann CO, Overbeck T, Schweyer S and Menke J: Blastomatoid pulmonary carcinosarcoma: Report of a case with a review of the literature. BMC Cancer. 12:4242012. View Article : Google Scholar : PubMed/NCBI

24 

Kurihara K, Nagai H, Kasahara K, Kawai T, Saito K and Kanazawa K: Pleomorphic carcinoma of the pancreas with massive lymphocytic stromal infiltration and long-term survival after resection. Int J Pancreatol. 27:241–248. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Tschang TP, Garza-Garza R and Kissane JM: Pleomorphic carcinoma of the pancreas: An analysis of 15 cases. Cancer. 39:2114–2126. 1977. View Article : Google Scholar : PubMed/NCBI

26 

Kamisawa T, Tabata I, Isawa T, Tsuruta K, Okamoto A and Koike M: A case of pleomorphic carcinoma of the pancreas showing sequential histological change by immunohistochemical study. Int J Pancreatol. 18:67–70. 1995.PubMed/NCBI

27 

Gelos M, Behringer D, Philippou S and Mann B: Pancreatic carcinosarcoma. Case report of multimodal therapy and review of the literature. JOP. 9:50–55. 2008.PubMed/NCBI

28 

Cresson DH and Reddick RL: Sarcomatoid carcinoma of the pancreas presenting as gastric carcinoma: Clinicopathologic and ultrastructural findings. J Surg Oncol. 36:268–274. 1987. View Article : Google Scholar : PubMed/NCBI

29 

Higashi M, Takao S and Sato E: Sarcomatoid carcinoma of the pancreas: A case report with immunohistochemical study. Pathol Int. 49:453–456. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Darvishian F, Sullivan J, Teichberg S and Basham K: Carcinosarcoma of the pancreas: A case report and review of the literature. Arch Pathol Lab Med. 126:1114–1117. 2002.PubMed/NCBI

31 

Barkatullah SA, Deziel DJ, Jakate SM, Kluskens L and Komanduri S: Pancreatic carcinosarcoma with unique triphasic histological pattern. Pancreas. 31:291–292. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Bloomston M, Chanona-Vilchis J, Ellison EC, Ramirez NC and Frankel WL: Carcinosarcoma of the pancreas arising in a mucinous cystic neoplasm. Am Surg. 72:351–355. 2006.PubMed/NCBI

33 

Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E and Hanazaki K: Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma. Pathol Int. 58:672–677. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Kim HS, Joo SH, Yang DM, Lee SH, Choi SH and Lim SJ: Carcinosarcoma of the pancreas: A unique case with emphasis on metaplastic transformation and the presence of undifferentiated pleomorphic high-grade sarcoma. J Gastrointestin Liver Dis. 20:197–200. 2011.PubMed/NCBI

35 

Shen ZL, Wang S, Ye YJ, Wang YL, Sun KK, Yang XD and Jiang KW: Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: Is there a good prognosis with the complete resection? Eur J Cancer Care (Engl). 19:118–123. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhu WY, Liu TG and Zhu H: Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review. Med Oncol. 29:140–143. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Yao J, Qian JJ, Zhu CR, Bai DS and Miao Y: Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature. Oncol Lett. 6:568–570. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Oymaci E, Argon A, Coşkun A, Uçar AD, Carti E, Erkan N and Yildirim M: Pancreatic carcinosarcoma: Case report of a rare type of pancreatic neoplasia. JOP. 14:212–215. 2013.PubMed/NCBI

39 

Shi HY, Xie J and Miao F: Pancreatic carcinosarcoma: First literature report on computed tomography imaging. World J Gastroenterol. 21:1357–1361. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Salibay CJ, Rewerska J, Gupta S and Ree N: Primary carcinosarcoma of the pancreas with CD10-positive sarcoma component. J Investig Med High Impact Case Rep. 5:23247096177409062017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Xiang Y, Zhang D, Yao X, Sheng J, Yang Y and Zhang X: Sarcomatoid carcinoma of the pancreas: A case report and review of the literature. Mol Med Rep 18: 4716-4724, 2018.
APA
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., & Zhang, X. (2018). Sarcomatoid carcinoma of the pancreas: A case report and review of the literature. Molecular Medicine Reports, 18, 4716-4724. https://doi.org/10.3892/mmr.2018.9489
MLA
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., Zhang, X."Sarcomatoid carcinoma of the pancreas: A case report and review of the literature". Molecular Medicine Reports 18.5 (2018): 4716-4724.
Chicago
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., Zhang, X."Sarcomatoid carcinoma of the pancreas: A case report and review of the literature". Molecular Medicine Reports 18, no. 5 (2018): 4716-4724. https://doi.org/10.3892/mmr.2018.9489
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Xiang Y, Zhang D, Yao X, Sheng J, Yang Y and Zhang X: Sarcomatoid carcinoma of the pancreas: A case report and review of the literature. Mol Med Rep 18: 4716-4724, 2018.
APA
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., & Zhang, X. (2018). Sarcomatoid carcinoma of the pancreas: A case report and review of the literature. Molecular Medicine Reports, 18, 4716-4724. https://doi.org/10.3892/mmr.2018.9489
MLA
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., Zhang, X."Sarcomatoid carcinoma of the pancreas: A case report and review of the literature". Molecular Medicine Reports 18.5 (2018): 4716-4724.
Chicago
Xie, Y., Xiang, Y., Zhang, D., Yao, X., Sheng, J., Yang, Y., Zhang, X."Sarcomatoid carcinoma of the pancreas: A case report and review of the literature". Molecular Medicine Reports 18, no. 5 (2018): 4716-4724. https://doi.org/10.3892/mmr.2018.9489
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