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Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis

  • Authors:
    • Qi‑Feng Chen
    • Jin‑Guo Xia
    • Wang Li
    • Lu‑Jun Shen
    • Tao Huang
    • Peihong Wu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging and Interventional Radiology, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4940-4950
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/mmr.2018.9494
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Abstract

To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs were identified, including 1,803 upregulated and 42 downregulated genes. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein‑protein interaction (PPI) network analyses were performed. It was identified that the ‘cell cycle’ and ‘progesterone‑mediated oocyte maturation’ KEGG pathways were significantly enriched in the DEGs. In addition, the high expression of the hub genes from the PPI network (including cyclin dependent kinase 1, cyclin B1, cyclin B2, mitotic arrest deficient 2 like 1, BUB1 mitotic checkpoint serine/threonine kinase and cyclin A2; P=0.00116, 0.00021, 0.04889, 0.00222, 0.00015 and 0.00647, respectively) was associated with a decrease in overall survival for patients with HCC as identified using survival and expression data from The Cancer Genome Atlas. The identified hub genes and pathways may help to elucidate the molecular mechanisms of HCC progression from HBV‑positive liver cirrhosis. Additionally, they may be useful as therapeutic targets or serve as novel biomarkers for HCC prognosis prediction.
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View References

1 

Chen QF, Jia ZY, Yang ZQ, Fan WL and Shi HB: Transarterial chemoembolization monotherapy versus combined transarterial chemoembolization-microwave ablation therapy for hepatocellular carcinoma tumors ≤5 cm: A propensity analysis at a single center. Cardiovasc Intervent Radiol. 40:1748–1755. 2017. View Article : Google Scholar : PubMed/NCBI

2 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273, e1. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Levrero M and Zucman-Rossi J: Mechanisms of HBV-induced hepatocellular carcinoma. J Hepatol. 64 1 Suppl:S84–S101. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Parkin DM: The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 118:3030–3044. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Zhou HY, Luo Y, Chen WD and Gong GZ: Hepatitis B virus mutation may play a role in hepatocellular carcinoma recurrence: A systematic review and meta-regression analysis. J Gastroenterol Hepatol. 30:977–983. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Intaraprasong P, Siramolpiwat S and Vilaichone RK: Advances in management of hepatocellular carcinoma. Asian Pac J Cancer Prev. 17:3697–3703. 2016.PubMed/NCBI

7 

Sherman M: Hepatocellular carcinoma: Epidemiology, surveillance, and diagnosis. Semin Liver Dis. 30:3–16. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yildiz G, Arslan-Ergul A, Bagislar S, Konu O, Yuzugullu H, Gursoy-Yuzugullu O, Ozturk N, Ozen C, Ozdag H, Erdal E, et al: Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis. PLoS One. 8:e640162013. View Article : Google Scholar : PubMed/NCBI

9 

He B, Yin J, Gong S, Gu J, Xiao J, Shi W, Ding W and He Y: Bioinformatics analysis of key genes and pathways for hepatocellular carcinoma transformed from cirrhosis. Medicine (Baltimore). 96:e69382017. View Article : Google Scholar : PubMed/NCBI

10 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

14 

Zhu Y, Qiu P and Ji Y: TCGA-assembler: Open-source software for retrieving and processing TCGA data. Nat Methods. 11:599–600. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Garnier D, Loyer P, Ribault C, Guguen-Guillouzo C and Corlu A: Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration. Hepatology. 50:1946–1956. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Nhieu JT, Renard CA, Wei Y, Cherqui D, Zafrani ES and Buendia MA: Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol. 155:703–710. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Y, Huang W, Ran Y, Xiong Y, Zhong Z, Fan X, Wang Z and Ye Q: miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3. Tumour Biol. 36:8309–8316. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Masaki T, Shiratori Y, Rengifo W, Igarashi K, Yamagata M, Kurokohchi K, Uchida N, Miyauchi Y, Yoshiji H, Watanabe S, et al: Cyclins and cyclin-dependent kinases: Comparative study of hepatocellular carcinoma versus cirrhosis. Hepatology. 37:534–543. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Wang X, Quail E, Hung NJ, Tan Y, Ye H and Costa RH: Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver. Proc Natl Acad Sci USA. 98:11468–11473. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Wang G, Chen H, Huang M, Wang N, Zhang J, Zhang Y, Bai G, Fong WF, Yang M and Yao X: Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 241:102–109. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sze KM, Ching YP, Jin DY and Ng IO: Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer. Cancer Res. 68:9194–9201. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Sze KM, Ching YP, Jin DY and Ng IO: Association of MAD2 expression with mitotic checkpoint competence in hepatoma cells. J Biomed Sci. 11:920–927. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Wills ES, Cnossen WR, Veltman JA, Woestenenk R, Steehouwer M, Salomon J, Morsche Te RH, Huch M, Hehir-Kwa JY, Banning MJ, et al: Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes. Eur J Hum Genet. 24:1707–1714. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Wang L, Huang J, Jiang M, Lin H, Qi L and Diao H: Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network in human hepatocellular carcinoma by systems-theoretic analysis. ScientificWorldJournal. 2012:4289792012. View Article : Google Scholar : PubMed/NCBI

25 

Rinaudo Spiewak JA and Thorgeirsson SS: Detection of a tyrosine-phosphorylated form of cyclin A during liver regeneration. Cell Growth Differ. 8:301–309. 1997.PubMed/NCBI

26 

Kim DH, Park SE, Kim M, Ji YI, Kang MY, Jung EH, Ko E, Kim Y, Kim S, Shim YM and Park J: A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers. Cancer. 117:4080–4091. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Simile MM, De Miglio MR, Muroni MR, Frau M, Asara G, Serra S, Muntoni MD, Seddaiu MA, Daino L, Feo F and Pascale RM: Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. Carcinogenesis. 25:333–341. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Wang J, Chenivesse X, Henglein B and Brechot C: Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature. 343:555–557. 1990. View Article : Google Scholar : PubMed/NCBI

29 

Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, et al: Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet. 47:1187–1193. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Yang F, Hu Y, Liu HX and Wan YJ: MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. J Biol Chem. 290:6507–6515. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Olson DC and Levine AJ: The properties of p53 proteins selected for the loss of suppression of transformation. Cell Growth Differ. 5:61–71. 1994.PubMed/NCBI

32 

Vaughan C, Pearsall I, Yeudall A, Deb SP and Deb S: p53: Its mutations and their impact on transcription. Subcell Biochem. 85:71–90. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Hussain SP, Schwank J, Staib F, Wang XW and Harris CC: TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer. Oncogene. 26:2166–2176. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Olivier M, Hollstein M and Hainaut P: TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2:a0010082010. View Article : Google Scholar : PubMed/NCBI

35 

Wong YH, Chen RH and Chen BS: Core and specific network markers of carcinogenesis from multiple cancer samples. J Theor Biol. 362:17–34. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Elledge SJ: Cell cycle checkpoints: Preventing an identity crisis. Science. 274:1664–1672. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Wong YH, Li CW and Chen BS: Evolution of network biomarkers from early to late stage bladder cancer samples. Biomed Res Int. 2014:1590782014. View Article : Google Scholar : PubMed/NCBI

38 

Cheung KF, Zhao J, Hao Y, Li X, Lowe AW, Cheng AS, Sung JJ and Yu J: CITED2 is a novel direct effector of peroxisome proliferator-activated receptor γ in suppressing hepatocellular carcinoma cell growth. Cancer. 119:1217–1226. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Dituri F, Mazzocca A, Lupo L, Edling CE, Azzariti A, Antonaci S, Falasca M and Giannelli G: PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma. Int J Cancer. 130:2505–2513. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Furuta M, Kozaki K, Tanimoto K, Tanaka S, Arii S, Shimamura T, Niida A, Miyano S and Inazawa J: The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One. 8:e601552013. View Article : Google Scholar : PubMed/NCBI

41 

Yang Y, Zheng B, Han Q, Zhang C, Tian Z and Zhang J: Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma. Cancer Biol. 17:449–456. 2016. View Article : Google Scholar

42 

Jin B, Wang W, Du G, Huang GZ, Han LT, Tang ZY, Fan DG, Li J and Zhang SZ: Identifying hub genes and dysregulated pathways in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 19:592–601. 2015.PubMed/NCBI

43 

Duckworth BC, Weaver JS and Ruderman JV: G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. Proc Natl Acad Sci USA. 99:16794–16799. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen QF, Xia JG, Li W, Shen LJ, Huang T and Wu P: Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis. Mol Med Rep 18: 4940-4950, 2018.
APA
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., & Wu, P. (2018). Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis. Molecular Medicine Reports, 18, 4940-4950. https://doi.org/10.3892/mmr.2018.9494
MLA
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., Wu, P."Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis". Molecular Medicine Reports 18.6 (2018): 4940-4950.
Chicago
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., Wu, P."Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis". Molecular Medicine Reports 18, no. 6 (2018): 4940-4950. https://doi.org/10.3892/mmr.2018.9494
Copy and paste a formatted citation
x
Spandidos Publications style
Chen QF, Xia JG, Li W, Shen LJ, Huang T and Wu P: Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis. Mol Med Rep 18: 4940-4950, 2018.
APA
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., & Wu, P. (2018). Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis. Molecular Medicine Reports, 18, 4940-4950. https://doi.org/10.3892/mmr.2018.9494
MLA
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., Wu, P."Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis". Molecular Medicine Reports 18.6 (2018): 4940-4950.
Chicago
Chen, Q., Xia, J., Li, W., Shen, L., Huang, T., Wu, P."Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis". Molecular Medicine Reports 18, no. 6 (2018): 4940-4950. https://doi.org/10.3892/mmr.2018.9494
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