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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2018 Volume 18 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mangiferin: An effective therapeutic agent against several disorders (Review)

Suya Du, Huirong Liu, Tiantian Lei, Xiaofang Xie, Hailian Wang, Xia He, Rongsheng Tong, Yi Wang
Pages: 4775-4786
Published online on: 02 October 2018

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Review Open Access

Peripheral artery disease and osteoporosis: Not only age‑related (Review)

Agostino Gaudio, Anastasia Xourafa, Rosario Rapisarda, Pietro Castellino , Salvatore Santo Signorelli
Pages: 4787-4792
Published online on: 27 September 2018

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Review Open Access

Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)

Lingjuan Wu, Liqun Chen
Pages: 4793-4801
Published online on: 27 September 2018

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Article Open Access

Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils

Ji Hyeon Ahn, Yoohun Noh, Bich Na Shin, Sung‑Su Kim, Joon Ha Park, Tae‑Kyeong Lee, Minah Song, Hyunjung Kim, Jae‑Chul Lee, Jun‑Hwan Yong, Il Jun Kang, Yun Lyul Lee, Moo‑Ho Won, Jong Dai Kim
Pages: 4802-4812
Published online on: 21 September 2018

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Article Open Access

(‑)Epigallocatechin‑3‑gallate attenuates anesthesia‑induced memory deficit in young mice via modulation of nitric oxide expression

Li Ding, Xiang Gao, Jianlei Hu, Shenghui Yu
Pages: 4813-4820
Published online on: 10 October 2018

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Article Open Access

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

Zhengxin Huang, Yingfeng Liu, Xianping Huang
Pages: 4821-4830
Published online on: 10 October 2018

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Article Open Access

Inhibition of microRNA‑939 suppresses the development of human non‑small cell lung cancer via the upregulation of tissue inhibitor of metalloproteinases 2

Aidong Chen, Shengping Liu, Xiaohu Lu, Lei Wei, Yijiang Chen
Pages: 4831-4838
Published online on: 20 September 2018

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Article Open Access

miR‑127 aggravates myocardial failure by promoting the TGF‑β1/Smad3 signaling Retraction in /10.3892/mmr.2019.10442

Hainian Xu, Fengmei Li
Pages: 4839-4846
Published online on: 27 September 2018

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Article Open Access

miR‑3666 suppresses cellular proliferation and invasion in colorectal cancer by targeting SATB2

Daqing Yang, Rizeng Li, Jianfu Xia, Wencai Li, Hong Zhou
Pages: 4847-4854
Published online on: 09 October 2018

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Article Open Access

S100B regulates inflammatory response during osteoarthritis via fibroblast growth factor receptor 1 signaling

Lifan Zhu, Zhen Weng, Pengcheng Shen, Jianxin Zhou, Jincai Zeng, Fengbiao Weng, Xiaojian Zhang, Huilin Yang
Pages: 4855-4864
Published online on: 01 October 2018

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Article Open Access

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma

Hyuk Soo Eun, Sang Yeon Cho, Byung Seok Lee, In‑Ock Seong, Kyung‑Hee Kim
Pages: 4865-4876
Published online on: 01 October 2018

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Article Open Access

Overexpression of small ubiquitin‑like modifier 2 ameliorates high glucose‑induced reductions in cardiomyocyte proliferation via the transforming growth factor‑β/Smad pathway

Chen Zhao, Qile Shen
Pages: 4877-4885
Published online on: 01 October 2018

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Article Open Access

Knockdown of BRCC3 exerts an anti‑tumor effect on cervical cancer in vitro

Feifang Zhang, Qun Zhou
Pages: 4886-4894
Published online on: 26 September 2018

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Article Open Access

Oral microbial flora of patients with Sicca syndrome

Shuang Zhou, Ye Cai, Min Wang, Wei‑Dong Yang, Ning Duan
Pages: 4895-4903
Published online on: 27 September 2018

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Article Open Access

A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations

Jianhua Sun, Lizhi Sun, Weijie Chen, Xiao Yin, Yong Lu, Qiang Jiang
Pages: 4904-4912
Published online on: 20 September 2018

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Article Open Access

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo

Hucheng Chen, Jiyu Xu, Yuan Lv, Ping He, Chunyan Liu, Jie Jiao, Shiwei Li, Xuhua Mao, Xue Xue
Pages: 4913-4921
Published online on: 25 September 2018

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Article Open Access

Electroacupuncture inhibits sodium nitroprusside‑mediated chondrocyte apoptosis through the mitochondrial pathway

Jie Lin, Guangwen Wu, Jun Chen, Changlong Fu, Xiue Hong, Li Li, Xianxiang Liu, Mingxia Wu
Pages: 4922-4930
Published online on: 20 September 2018

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Article Open Access

Synonymous mutation adenomatous polyposis coliΔ486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation‑negative familial adenomatous polyposis

Wei Qing Liu, Jian Dong, Yan Xia Peng, Wen Liang Li, Jun Yang
Pages: 4931-4939
Published online on: 20 September 2018

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Article Open Access

Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis

Qi‑Feng Chen, Jin‑Guo Xia, Wang Li, Lu‑Jun Shen, Tao Huang, Peihong Wu
Pages: 4940-4950
Published online on: 19 September 2018

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Article Open Access

MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells

Taisuke Murakami, Kaori Suzuki, Francois Niyonsaba, Hiroyuki Tada, Johannes Reich, Hiroshi Tamura, Isao Nagaoka
Pages: 4951-4959
Published online on: 02 October 2018

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Article Open Access

Expression of long non‑coding RNA and mRNA in the hippocampus of mice with type 2 diabetes

Li‑Ya Ci, De‑Shan Liu, Jing‑Qing Yang, Yu Zhao Liu, Chang Ling Li, Xi Zhang, Chun Mei Ma, Rui Ting Hu
Pages: 4960-4968
Published online on: 21 September 2018

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Article Open Access

Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord Corrigendum in /10.3892/mmr.2022.12919 Corrigendum in /10.3892/mmr.2022.12920

Jing Li, Shi‑Qing Xu, Yu‑Ming Zhao, Shi Yu, Li‑Hong Ge, Bao‑Hua Xu
Pages: 4969-4977
Published online on: 20 September 2018

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Article Open Access

Mechanism of HN‑3 cell apoptosis induced by carboplatin: Combination of mitochondrial pathway associated with Ca2+ and the nucleus pathways

Bo Shen, Wenjing Mao, Jin‑Chul Ahn, Phil‑Sang Chung, Peijie He
Pages: 4978-4986
Published online on: 24 September 2018

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Article Open Access

The possible association between AQP9 in the intestinal epithelium and acute liver injury‑induced intestinal epithelium damage

Tianxin Xiang, Shanfei Ge, Jiangxiong Wen, Junfeng Xie, Lixia Yang, Xiaoping Wu, Na Cheng
Pages: 4987-4993
Published online on: 10 October 2018

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Article Open Access

Upregulated miR‑203a‑3p and its potential molecular mechanism in breast cancer: A study based on bioinformatics analyses and a comprehensive meta‑analysis

Kai‑Teng Cai, Cai‑Xia Feng, Jin‑Che Zhao, Rong‑Quan He, Jie Ma, Jin‑Cai Zhong
Pages: 4994-5008
Published online on: 10 October 2018

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Article Open Access

Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease

Jinrong Fu, Jinjing Zou, Cheng Chen, Hongying Li, Lei Wang, Yanli Zhou
Pages: 5009-5015
Published online on: 10 October 2018

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Article Open Access

Compound pathogenic mutation in the USH2A gene in Chinese RP families detected by whole‑exome sequencing

Yue‑Chuan Fu, Na Chen, Zi‑Long Qiu, Lin Liu, Jie Shen
Pages: 5016-5022
Published online on: 02 October 2018

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Article Open Access

Abnormal expression of miR‑133a in patients with acute myocardial infarction following radical surgery for gastric cancer and the underlying mechanism

Jing Yu, Xufen Cao, Ye Zheng, Liqiu Yan, Jiawang Wang
Pages: 5023-5029
Published online on: 10 October 2018

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Article Open Access

Berberine promotes nerve regeneration through IGFR‑mediated JNK‑AKT signal pathway

Hai‑Na Zhang, Ya‑Juan Sun, Huai‑Qiang He, Hong‑Yan Li, Qiu‑Li Xue, Zhong‑Min Liu, Guang‑Meng Xu, Li‑Hua Dong
Pages: 5030-5036
Published online on: 24 September 2018

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Article Open Access

Ketamine destabilizes growth of dendritic spines in developing hippocampal neurons in vitro via a Rho‑dependent mechanism

Sufang Jiang, Zimiao Hao, Xuze Li, Lijun Bo, Rui Zhang, Ying Wang, Xiaofeng Duan, Rongtian Kang, Lining Huang
Pages: 5037-5043
Published online on: 02 October 2018

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Article Open Access

Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro

Ganming Deng, Kaiqun Li, Siwei Chen, Peisheng Chen, Haonan Zheng, Bin Yu, Kairui Zhang
Pages: 5044-5052
Published online on: 10 October 2018

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Article Open Access

Co-existence of endometriosis with 13 non-gynecological co-morbidities: Mutation analysis by whole exome sequencing

Charoula Matalliotaki, Michail Matalliotakis, Maria I. Zervou, Alexandra Trivli, Ioannis Matalliotakis, George Mavromatidis, Demetrios A. Spandidos, Hans M. Albertsen, Rakesh Chettier, Kenneth Ward, George N. Goulielmos
Pages: 5053-5057
Published online on: 01 October 2018

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Article Open Access

Microarray analysis reveals long non‑coding RNA SOX2OT as a novel candidate regulator in diabetic nephropathy

Xiaoxue Zhang, Jin Shang, Xiaoyang Wang, Genyang Cheng, Yumin Jiang, Dong Liu, Jing Xiao, Zhanzheng Zhao
Pages: 5058-5068
Published online on: 04 October 2018

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Article Open Access

Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis

Wendong Wang, Zhiwei Xu, Xiaobo Zhu, Xiaotong Chang
Pages: 5069-5075
Published online on: 10 October 2018

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Article

Biomarkers associated with binaprofen‑induced liver injury

Qiuping Guo, Jianmin Guo, Guiying Chen, Zhong Han, Baiquan Xiao, Ruomin Jin, Chun Liang, Wei Yang
Pages: 5076-5086
Published online on: 10 October 2018

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Article

ROR1 is highly expressed in circulating tumor cells and promotes invasion of pancreatic cancer

Gui‑Li Xu, Jian Shen, Yun‑Hua Xu, Wan‑Sheng Wang, Cai‑Fang Ni
Pages: 5087-5094
Published online on: 20 September 2018

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Article

Whole exome sequencing identification of a novel insertion mutation in the phospholipase C ε‑1 gene in a family with steroid resistant inherited nephrotic syndrome

Jamil Amjad Hashmi, Ramziah Ahmed Safar, Sibtain Afzal, Alia M. Albalawi, Feroz Abdu‑Samad, Zafar Iqbal, Sulman Basit
Pages: 5095-5100
Published online on: 02 October 2018

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Article

CXCL12 modulates the radiosensitivity of cervical cancer by regulating CD44

Zhichao Fu, Pei Zhang, Huachun Luo, Huijuan Huang, Fengmei Wang
Pages: 5101-5108
Published online on: 12 October 2018

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Article

Construction of an miRNA‑gene regulatory network in colorectal cancer through integrated analysis of mRNA and miRNA microarrays

Jun Hu, Xin Yue, Jianzhong Liu, Dalu Kong
Pages: 5109-5116
Published online on: 24 September 2018

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Article

Endoplasmic reticulum stress associated apoptosis as a novel mechanism in indoxyl sulfate‑induced cardiomyocyte toxicity

Xiao Tan, Xue‑Sen Cao, Pan Zhang, Fang‑Fang Xiang, Jie Teng, Jian‑Zhou Zou, Xiao‑Qiang Ding
Pages: 5117-5122
Published online on: 20 September 2018

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Article

Identification of miRNA and mRNA expression profiles by PCR microarray in hepatitis B virus‑associated hepatocellular carcinoma

Xiong‑Wei Cui, Zhi‑Ling Qian, Cong Li, Shi‑Chang Cui
Pages: 5123-5132
Published online on: 27 September 2018

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Article

Salmonella‑induced miR‑155 enhances necroptotic death in macrophage cells via targeting RIP1/3

Young‑Tae Ro, Guk‑Heui Jo, Sun‑Ah Jung, Eunjoo H. Lee, Jongdae Shin, Joon H. Lee
Pages: 5133-5140
Published online on: 01 October 2018

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Article

EP4 knockdown alleviates glomerulosclerosis through Smad and MAPK pathways in mesangial cells

Yingjie Cao, Tianyi Pan, Xiaolan Chen, Jianhua Wu, Naifeng Guo, Bicheng Wang
Pages: 5141-5150
Published online on: 12 October 2018

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Article

Synergistic effects of vemurafenib and fingolimod (FTY720) in vemurafenib‑resistant melanoma cell lines

Tomoko Takahashi, Naoko Abe, Hiroyuki Kanoh, Yoshiko Banno, Mariko Seishima
Pages: 5151-5158
Published online on: 08 October 2018

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Article

Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family

Yong Cui, Duan‑Jun He
Pages: 5159-5165
Published online on: 27 September 2018

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Article

An effective range of polydeoxyribonucleotides is critical for wound healing quality

Kyu‑Hee Hwang, Ji‑Hee Kim, Eun Young Park, Seung‑Kuy Cha
Pages: 5166-5172
Published online on: 08 October 2018

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Article

Long non‑coding RNA CASC2 inhibits progression and predicts favorable prognosis in epithelial ovarian cancer

Zhuowei Xue, Xiaolu Zhu, Yincheng Teng
Pages: 5173-5181
Published online on: 10 October 2018

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Article

Lutein protects human retinal pigment epithelial cells from oxidative stress‑induced cellular senescence

Seon Yeong Chae, Sun Young Park, Geuntae Park
Pages: 5182-5190
Published online on: 08 October 2018

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Article

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in vivo and in vitro

Guo‑Hua Shi, Lin Zhou
Pages: 5191-5197
Published online on: 26 September 2018

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Article

Astragalus root induces ovarian β‑oxidation and suppresses estrogen‑dependent uterine proliferation

Banzragchgarav Orkhon, Kyoko Kobayashi, Batkhuu Javzan, Kenroh Sasaki
Pages: 5198-5206
Published online on: 19 September 2018

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Article

LncRNA SRA deregulation contributes to the development of atherosclerosis by causing dysfunction of endothelial cells through repressing the expression of adipose triglyceride lipase

Shuguo Yang, Jingang Sun
Pages: 5207-5214
Published online on: 20 September 2018

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Article

Aloe emodin suppresses EGF‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways

Juan Zhang, Lihua Guo, Quanwu Zhang, Kangdong Liu, Ziming Dong
Pages: 5215-5220
Published online on: 27 September 2018

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Article

MicroRNA‑944 targets vascular endothelial growth factor to inhibit cell proliferation and invasion in osteosarcoma

Tingzhen Yan, Shiyong Zhu, Jing Zhang, Gongbiao Lu, Chaoliang Lv, Yanchun Wei, Minghua Luo
Pages: 5221-5228
Published online on: 01 October 2018

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Article

Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage

Ya‑Wen Cheng, Wen‑Juan Li, Xiang‑Jun Dou, Rui Jia, Hua Yang, Xin‑Guang Liu, Cang‑Bao Xu, Jing Liu, Yong‑Xiao Cao, Guo‑Gang Luo
Pages: 5229-5236
Published online on: 27 September 2018

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Article

Role of JNK signalling pathway and platelet‑lymphocyte aggregates in myocardial ischemia‑reperfusion injury and the cardioprotective effect of ischemic postconditioning in rats

Faxin Ren, Nan Mu, Mingxiao Gao, Jing Sun, Chuanhuan Zhang, Xiaojian Sun, Liudong Li, Jun Li, Tong Liu, Gary Tse, Mei Dong
Pages: 5237-5242
Published online on: 10 October 2018

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Article

Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea

Ana P. Azevedo, Susana N. Silva, Alice Reichert, Fernando Lima, Esmeraldina Júnior, José Rueff
Pages: 5243-5255
Published online on: 08 October 2018

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Article

Suppressing cell growth and inducing apoptosis by inhibiting miR‑23a‑5p in human bladder cancer

Yifan Li, Jing Quan, Xiang Pan, Jingcheng Zhou, Anbang He, Yongqing Lai, Guangchen Zhou
Pages: 5256-5260
Published online on: 02 October 2018

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Article

MicroRNA‑339‑5p inhibits cell proliferation of acute myeloid leukaemia by directly targeting SOX4

Xueming Sun, Huaqiang Liu, Tingting Li, Laiying Qin
Pages: 5261-5269
Published online on: 10 October 2018

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Article

miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer

Jianyu Fan, Wenjing Zhang, Yanting Wu, Ping Wan, Qiang Guo, Yu Zhang
Pages: 5270-5278
Published online on: 27 September 2018

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Article

NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model

Hitomi Fukatsu, Naoki Koide, Saeko Tada‑Oikawa, Kiyora Izuoka, Akihiko Ikegami, Sahoko Ichihara, Tamami Ukaji, Naoko Morita, Yoshikazu Naiki, Takayuki Komatsu, Kazuo Umezawa
Pages: 5279-5285
Published online on: 03 October 2018

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Article

Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer

Yoshiaki Sato, Hironori Yoshino, Yuka Kazama, Ikuo Kashiwakura
Pages: 5286-5294
Published online on: 08 October 2018

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Article

LncRNA‑p21 promotes chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR‑451

Luping Tang, Jianbo Ding, Guangju Zhou, Zhihai Liu
Pages: 5295-5301
Published online on: 24 September 2018

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Correction Open Access

[Corrigendum] High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE‑NOXs pathway

Yuan‑Fan Liao, Sui Yin, Zi‑Qi Chen, Fan Li, Bo Zhao
Pages: 5302-5302
Published online on: 12 October 2018

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Review

Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review)

Xiang‑Hua Yu, Xiao‑Hua Ren, Xin‑Hua Liang, Ya‑Ling Tang
Pages: 5307-5316
Published online on: 23 October 2018

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Article Open Access

Lentivirus‑mediated microRNA‑26a overexpression in bone mesenchymal stem cells facilitates bone regeneration in bone defects of calvaria in mice

Zhi Liu, Hong Chang, Yihong Hou, Yu Wang, Zhiqiang Zhou, Ming Wang, Zhidong Huang, Bin Yu
Pages: 5317-5326
Published online on: 25 October 2018

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Article Open Access

High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer

Yao He, Hui Wang, Meina Yan, Xinxin Yang, Rong Shen, Xiaoge Ni, Xiaokun Chen, Peifang Yang, Miao Chen, Xiaodong Lu, Genbao Shao, Xiaoming Zhou, Qixiang Shao
Pages: 5327-5336
Published online on: 16 October 2018

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Article Open Access

Effects of compound 21, a non‑peptide angiotensin II type 2 receptor agonist, on general anesthesia‑induced cerebral injury in neonatal rats

Jun Yong, Li Yan, Jing Wang, Hongmei Xiao, Qingfan Zeng
Pages: 5337-5344
Published online on: 26 October 2018

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Article Open Access

Dexamethasone inhibits NF‑кBp65 and HMGB1 expression in the pancreas of rats with severe acute pancreatitis

Shangping Zhao, Jinming Yang, Ting Liu, Juanxian Zeng, Liangliang Mi, Kaimin Xiang
Pages: 5345-5352
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Pilose antler polypeptide protects against sevoflurane‑mediated neurocyte injury

Shuping Li, Jiaxuan He
Pages: 5353-5360
Published online on: 24 October 2018

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Article Open Access

Identification of recurrent and novel mutations by whole‑genome sequencing of colorectal tumors from the Han population in Shanghai, eastern China

Hongfei Teng, Renyuan Gao, Nan Qin, Xun Jiang, Min Ren, Yu Wang, Shouxin Wu, Ning Li, Jiangman Zhao, Huanlong Qin
Pages: 5361-5370
Published online on: 17 October 2018

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Protective effect of polysaccharide peptide on cerebral ischemia‑reperfusion injury in rats

Pengcheng Xing, Ke Ma, Jun Wu, Wei Long, Donglian Wang
Pages: 5371-5378
Published online on: 23 October 2018

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Article Open Access

Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell

Ran Wu, Hui Yang, Jiangbo Wan, Xiaohui Deng, Linjun Chen, Siguo Hao, Liyuan Ma
Pages: 5379-5388
Published online on: 15 October 2018

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Article Open Access

Selenocysteine mimics the effect of dietary restriction on lifespan via SKN‑1 and retards age‑associated pathophysiological changes in Caenorhabditis elegans

So‑Hyeon Kim, Bo‑Kyoung Kim, Sang‑Kyu Park
Pages: 5389-5398
Published online on: 24 October 2018

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Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Zhenyu Qiu, Hongxia Yuan, Na Li, Xinjuan Yang, Xuemei Hu, Fengtai Su, Baiyi Chen
Pages: 5399-5408
Published online on: 22 October 2018

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Article Open Access

Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT‑8/5‑Fu human colorectal cancer cell line

Chao Zhang, Lian‑Jun He, Hai‑Zhu Ye, Ding‑Feng Liu, Yi‑Bao Zhu, Dong‑Dong Miao, Sheng‑Peng Zhang, Yun‑Yu Chen, Yuan‑Wei Jia, Jie Shen, Xiao‑Ping Liu
Pages: 5409-5416
Published online on: 24 October 2018

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Article Open Access

miR‑27a promotes human breast cancer cell migration by inducing EMT in a FBXW7‑dependent manner

Guobin Jiang, Weiwu Shi, Hongyan Fang, Xiaohua Zhang
Pages: 5417-5426
Published online on: 24 October 2018

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Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway

Lilian Zhang, Qi Chen, Haoli Wang, Jian Yang, Sunren Sheng
Pages: 5427-5436
Published online on: 25 October 2018

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Overexpression of long non‑coding RNA n346372 in bladder cancer tissues is associated with a poor prognosis

Anwei Liu, Zhensheng Zhang, Weidong Xu, Shengfei Qin, Meimian Hua, Shuxiong Zeng, Chuanliang Xu
Pages: 5437-5444
Published online on: 25 October 2018

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Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway

Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang
Pages: 5445-5454
Published online on: 24 October 2018

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Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage

Kana Sase, Yasushi Kitaoka, Chihiro Tsukahara, Hitoshi Takagi
Pages: 5455-5460
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FAK regulates epithelial‑mesenchymal transition in adenomyosis

Dexuan Zheng, Hua Duan, Sha Wang, Qian Xu, Lu Gan, Jinjiao Li, Qianjing Dong
Pages: 5461-5472
Published online on: 26 October 2018

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Overexpression of klotho in adipose-derived stem cells protects against UVB-induced photoaging in co-cultured human fibroblasts

Furong Fan, Yufei Li, Yi Liu, Li Shao, Juehua Yu, Ziwei Li
Pages: 5473-5480
Published online on: 25 October 2018

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Overexpression of miR‑146a blocks the effect of LPS on RANKL‑induced osteoclast differentiation

Yingjian Gao, Bo Wang, Conghuan Shen, Weiwei Xin
Pages: 5481-5488
Published online on: 30 October 2018

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miR‑371b‑5p inhibits endothelial cell apoptosis in monocrotaline‑induced pulmonary arterial hypertension via PTEN/PI3K/Akt signaling pathways

Guangfa Zhu, Wenmei Zhang, Yan Liu, Shenghao Wang
Pages: 5489-5501
Published online on: 31 October 2018

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miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment

Feng Chen, Ren‑Jie Wang, Guang‑Zong Li, Yi Zhang, Shuo Yu, Ying‑Fu Liu, Xiao‑Yi Chen, Shi‑Ke Hou
Pages: 5502-5510
Published online on: 22 October 2018

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Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes

Liping Zhai, Xu Wang
Pages: 5511-5519
Published online on: 23 October 2018

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In vitro study of the effects of reprogramming neonatal rat fibroblasts transfected with TBX18 on spontaneous beating in neonatal rat cardiomyocytes

Dajun Quan, He Huang
Pages: 5520-5526
Published online on: 22 October 2018

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Effects of mimicked acetylated HMGB1 on macrophages and dendritic cells

Xiaohong Chen, Yong Xu, Ping Xiong, Zheng Tan, Feili Gong, Xiaohua Hou, Fang Zheng
Pages: 5527-5535
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Long noncoding RNA TSLNC8 suppresses cell proliferation and metastasis and promotes cell apoptosis in human glioma

Dong Chen, Xin Yu
Pages: 5536-5544
Published online on: 30 October 2018

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Lentiviral‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury

Yantao Liu, Yan Zhang, Ruirui Pan, Mo Chen, Xiaoqiang Wang, Erliang Kong, Weifeng Yu, Yuming Sun, Feixiang Wu
Pages: 5545-5551
Published online on: 16 October 2018

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UBA2 promotes proliferation of colorectal cancer

Ping He, Xun Sun, Hong‑Jing Cheng, Ya‑Bin Zou, Quan Wang, Chang‑Li Zhou, Wan‑Qi Liu, Yue‑Ming Hao, Xiang‑Wei Meng
Pages: 5552-5562
Published online on: 30 October 2018

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Therapeutic effects of a mesenchymal stem cell‑based insulin‑like growth factor‑1/enhanced green fluorescent protein dual gene sorting system in a myocardial infarction rat model

Subin Jung, Jung‑Hyun Kim, Changwhi Yim, Minhyung Lee, Hyo Jin Kang, Donghoon Choi
Pages: 5563-5571
Published online on: 16 October 2018

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Zeylenone represses the progress of human prostate cancer by downregulating the Wnt/β‑catenin pathway

Shaohua Zeng, Baoyi Zhu, Jun Zeng, Wenqi Wu, Chonghe Jiang
Pages: 5572-5578
Published online on: 17 October 2018

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LASSO‑based Cox‑PH model identifies an 11‑lncRNA signature for prognosis prediction in gastric cancer

Yonghong Zhang, Huamin Li, Wenyong Zhang, Ya Che, Weibing Bai, Guanglin Huang
Pages: 5579-5593
Published online on: 22 October 2018

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Bioinformatics analysis to identify key genes and pathways influencing synovial inflammation in osteoarthritis

Jie Lin, Guangwen Wu, Zhongsheng Zhao, Yanfeng Huang, Jun Chen, Changlong Fu, Jinxia Ye, Xianxiang Liu
Pages: 5594-5602
Published online on: 23 October 2018

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MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4 Retraction in /10.3892/mmr.2022.12673

Yifu Tian, Xiaodan Fu, Qingling Li, Ying Wang, Dan Fan, Qin Zhou, Weilu Kuang, Liangfang Shen
Pages: 5603-5613
Published online on: 22 October 2018

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lncRNA FEZF1‑AS1 contributes to cell proliferation, migration and invasion by sponging miR‑4443 in hepatocellular carcinoma

Jianhua Gong, Junyi Wang, Tianpin Liu, Jun Hu, Jun Zheng
Pages: 5614-5620
Published online on: 24 October 2018

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Examination of the expression and prognostic significance of DLGAPs in gastric cancer using the TCGA database and bioinformatic analysis

Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Tuotuo Gong, Demao Yao
Pages: 5621-5629
Published online on: 23 October 2018

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Exploration of the diagnostic value and molecular mechanism of miR‑1 in prostate cancer: A study based on meta‑analyses and bioinformatics

Zu‑Cheng Xie, Jia‑Cheng Huang, Li‑Jie Zhang, Bin‑Liang Gan, Dong‑Yue Wen, Gang Chen, Sheng‑Hua Li, Hai‑Biao Yan
Pages: 5630-5646
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Expression of claudin‑11 in a rat model of varicocele and its effects on the blood‑testis barrier

Jiangang Pan, Zhirong Zhu, Gang Xu, Lili Niu, Lihang Yu, Zhengang Luo, Jiajun Yan
Pages: 5647-5651
Published online on: 26 October 2018

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Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice

Huan Zhou, Hui‑Jing Zhang, Lin Guan, Yi‑Ning Zhang, Yue Li, Ming‑Jun Sun
Pages: 5652-5662
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Article

Parkin deficiency elevates hepatic ischemia/reperfusion injury accompanying decreased mitochondrial autophagy, increased apoptosis, impaired DNA damage repair and altered cell cycle distribution

Xiao‑Jie Ning, Xiong Yan, Yan‑Feng Wang, Ren Wang, Xiao‑Li Fan, Zi‑Biao Zhong, Qi‑Fa Ye
Pages: 5663-5668
Published online on: 29 October 2018

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High‑throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars

Min Li, Jian Wang, Dewu Liu, Heping Huang
Pages: 5669-5682
Published online on: 15 October 2018

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Article

miR‑23b‑3p promotes the apoptosis and inhibits the proliferation and invasion of osteosarcoma cells by targeting SIX1

Hua Liu, Wei Wei, Xiaojian Wang, Xiaojun Guan, Qingqing Chen, Zhongjin Pu, Xudong Xu, Aichun Wei
Pages: 5683-5692
Published online on: 30 October 2018

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Article

Inhibitory effect of tranilast on the myofibroblast differentiation of rat mesenchymal stem cells induced by transforming growth factor‑β1 in vitro

Wenxian Tang, Yuejuan Zhang, Lin Tang, Jun Zhang, Lei Xiong, Baohe Wang
Pages: 5693-5700
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Article

Identification of the inhibitory activity of walnut extract on the E3 ligase Syvn1

Hidetoshi Fujita, Satoko Aratani, Naoko Yagishita, Kusuki Nishioka, Toshihiro Nakajima
Pages: 5701-5708
Published online on: 23 October 2018

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Article

Comparison of human lumbar disc pressure characteristics during simulated spinal manipulation vs. spinal mobilization

Fei Wang, Jun Zhang, Wei Feng, Qiang Liu, Xianwen Yang, Hui Zhang, Lei Han, Yaqing Min, Ping Zhao
Pages: 5709-5716
Published online on: 25 October 2018

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Article

Differentiation of human amniotic epithelial cells into osteoblasts is induced by mechanical stretch via the Wnt/β‑catenin signalling pathway

Fujun Luan, Kunlong Ma, Jia Mao, Fan Yang, Minghua Zhang, Hexu Luan
Pages: 5717-5725
Published online on: 22 October 2018

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Article

Hepatitis B core antigen regulates dendritic cell proliferation and apoptosis through regulation of PKC/NF‑κB signaling pathway Retraction in /10.3892/mmr.2025.13651

Lan Liu, Yanxin Huang, Kaili Zhang, Shupeng Song, Shuangxing Li, Yongguo Li, Yinghua Lan
Pages: 5726-5732
Published online on: 26 October 2018

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Article

Helicobacter pylori infection enhances heparanase leading to cell proliferation via mitogen‑activated protein kinase signalling in human gastric cancer cells

Liping Liu, Yongxun Zhao, Guangrui Fan, Tiankui Shuai, Bin Li, Yumin Li
Pages: 5733-5741
Published online on: 15 October 2018

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Article

Downregulation of growth arrest‑specific transcript 5 alleviates palmitic acid‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis

Qingxiong Yue, Cuiting Zhao, Yonghuai Wang, Lanting Zhao, Qing Zhu, Guangyuan Li, Nan Wu, Dalin Jia, Chunyan Ma
Pages: 5742-5750
Published online on: 25 October 2018

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Article

Isolation and characterization of stem cells from differentially degenerated human lumbar zygapophyseal articular cartilage

Liang Xiao, Shujuan Xu, Xiao Wang, Zhongxing Jin, Jing Wang, Bijing Yang, Hongguang Xu
Pages: 5751-5759
Published online on: 25 October 2018

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Case Report

Two novel pathogenic variants of L1CAM gene in two fetuses with isolated X‑linked hydrocephaly: A case report

Bobo Xie, Jingsi Luo, Yaqin Lei, Qi Yang, Mengting Li, Shang Yi, Shiyu Luo, Jin Wang, Zailong Qin, Zuojian Yang, Hongwei Wei, Xin Fan
Pages: 5760-5764
Published online on: 24 October 2018

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Article

Activator protein‑1 is a novel regulator of mesencephalic astrocyte‑derived neurotrophic factor transcription

Chang‑Hui Wang, Tong‑Cui Jiang, Wei‑Min Qiang, Li Zhang, Li‑Jie Feng, Yu‑Jun Shen, Yu‑Xian Shen
Pages: 5765-5774
Published online on: 26 October 2018

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Article

Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis

Weiping Huang, Linqiang Huang, Miaoyun Wen, Ming Fang, Yiyu Deng, Hongke Zeng
Pages: 5775-5783
Published online on: 16 October 2018

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Article

Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

Meng Li, Huijuan Fang, Jian Hu
Pages: 5784-5790
Published online on: 29 October 2018

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Article

Long noncoding RNA TUG1 promotes renal cell carcinoma cell proliferation, migration and invasion by downregulating microRNA‑196a

Yang Yang, De‑Ming Sun, Jun‑Feng Yu, Man Zhang, Cheng Yi, Rui Yang, Bao‑Hua Dan, Ai‑Jun Li
Pages: 5791-5798
Published online on: 29 October 2018

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Article

Downregulation of microRNA‑30a in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis patients

Bao Liu, Tingshu Jiang, Xingang Hu, Zhida Liu, Liming Zhao, Hongmei Liu, Zhaihua Liu, Lijun Ma
Pages: 5799-5806
Published online on: 18 October 2018

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Article

MicroRNA‑93‑5p promotes the progression of human retinoblastoma by regulating the PTEN/PI3K/AKT signaling pathway

Yongliang Cao, Fei Xia, Ping Wang, Meng Gao
Pages: 5807-5814
Published online on: 23 October 2018

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Article

Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cells

Zhicheng Peng, Xiaobing Li, Dongmei Xing, Xiliang Du, Zhe Wang, Guowen Liu, Xinwei Li
Pages: 5815-5822
Published online on: 31 October 2018

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Article

A multiplex ligation‑dependent probe amplification‑based next‑generation sequencing approach for the detection of copy number variations in the human genome

Yongchen Yang, Chaoran Xia, Zaiwei Zhou, Dongkai Wei, Kangping Xu, Jia Jia, Wuhen Xu, Hong Zhang
Pages: 5823-5833
Published online on: 24 October 2018

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Article

Long term exposure to γ‑rays induces radioresistance and enhances the migration ability of bladder cancer cells

Guangmin Mao, Ye Yao, Zhaolu Kong
Pages: 5834-5840
Published online on: 26 October 2018

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Impact Factor: 3.5

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CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Article Open Access

Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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Article Open Access

High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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Correction Open Access

[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Article Open Access

Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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Retraction Open Access

[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Article Open Access

Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Review Open Access

Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Review Open Access

Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Review Open Access

Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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Article Open Access

MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Review Open Access

Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Article Open Access

Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Review Open Access

Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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Review Open Access

From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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Correction Open Access

[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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Retraction Open Access

[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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