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Article

Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage

  • Authors:
    • Ya‑Wen Cheng
    • Wen‑Juan Li
    • Xiang‑Jun Dou
    • Rui Jia
    • Hua Yang
    • Xin‑Guang Liu
    • Cang‑Bao Xu
    • Jing Liu
    • Yong‑Xiao Cao
    • Guo‑Gang Luo
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, First Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China, Department of Neurology, Second Affiliated Hospital, Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Department of Neurology, Xi'an Children's Hospital, Xi'an, Shaanxi 710002, P.R. China, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China, Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 5229-5236
    |
    Published online on: September 27, 2018
       https://doi.org/10.3892/mmr.2018.9513
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Abstract

Cerebral vasospasm (CVS) is a severe complication of subarachnoid hemorrhage (SAH), and endothelin‑1 (ET‑1) may be involved in its pathogenesis. The present study aimed to investigate the expression of ET‑1 in cerebrospinal fluid (CSF) in patients with SAH and to analyze rat arterial contractility and the expression levels of ET‑1 receptors in vitro. CSF samples were collected from 28 patients and the expression levels of ET‑1 were measured. Rat cerebral basilar arteries were isolated and incubated with hemorrhagic or clear CSF. Contractility, as well as ETA and ETB mRNA expression were measured. ET‑1 levels in CSF increased and reached a peak within the initial 5 days after SAH onset and then gradually subsided. After 12 or 24 h, the contraction of arteries incubated in hemorrhagic CSF was substantially stronger than those in clear CSF. The mRNA expression levels of endothelin receptor type A and B in arteries incubated in hemorrhagic CSF were significantly higher than those in clear CSF. ET‑1 and its receptors may be involved in the pathogenic mechanism of CVS following SAH. ET‑1 expression in CSF may be used as a marker in CVS and its receptors may provide novel therapeutic targets in CVS.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng YW, Li WJ, Dou XJ, Jia R, Yang H, Liu XG, Xu CB, Liu J, Cao YX, Luo GG, Luo GG, et al: Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Mol Med Rep 18: 5229-5236, 2018.
APA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X. ... Luo, G. (2018). Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Molecular Medicine Reports, 18, 5229-5236. https://doi.org/10.3892/mmr.2018.9513
MLA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18.6 (2018): 5229-5236.
Chicago
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18, no. 6 (2018): 5229-5236. https://doi.org/10.3892/mmr.2018.9513
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng YW, Li WJ, Dou XJ, Jia R, Yang H, Liu XG, Xu CB, Liu J, Cao YX, Luo GG, Luo GG, et al: Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Mol Med Rep 18: 5229-5236, 2018.
APA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X. ... Luo, G. (2018). Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Molecular Medicine Reports, 18, 5229-5236. https://doi.org/10.3892/mmr.2018.9513
MLA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18.6 (2018): 5229-5236.
Chicago
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18, no. 6 (2018): 5229-5236. https://doi.org/10.3892/mmr.2018.9513
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