Open Access

Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)

  • Authors:
    • Lingjuan Wu
    • Liqun Chen
  • View Affiliations

  • Published online on: September 27, 2018     https://doi.org/10.3892/mmr.2018.9515
  • Pages: 4793-4801
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear receptor subfamily 4 group A member 1 (NR4A1; also termed Nur77/TR3/NGFIB), a member of the nuclear receptor superfamily, is expressed as an early response gene to regulate the expression of multiple target genes. Nur77 has the typical structure of a nuclear receptor, including an N‑terminal domain, a DNA binding domain, and a ligand‑binding domain. The expression and localization of Nur77 are closely associated with its roles in cell proliferation and apoptosis. Nur77 was first identified as an orphan receptor, the endogenous ligand of which has not yet been identified; however, an increasing number of compounds targeting Nur77 have been reported to have beneficial effects in the treatment of cancer and other diseases. This review provides a brief overview of the identification, structure, expression and localization, transcriptional role and non‑genomic function of Nur77, and summarizes the ligands that have been shown to interact with Nur77, including cytosporone B, cisplatin, TMPA, PDNPA, CCE9, THPN, Z‑ligustilide, celastrol and bisindole methane compounds, which may potentially be used to treat cancer in humans.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wu L and Wu L: Characteristics of Nur77 and its ligands as potential anticancer compounds (Review). Mol Med Rep 18: 4793-4801, 2018
APA
Wu, L., & Wu, L. (2018). Characteristics of Nur77 and its ligands as potential anticancer compounds (Review). Molecular Medicine Reports, 18, 4793-4801. https://doi.org/10.3892/mmr.2018.9515
MLA
Wu, L., Chen, L."Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)". Molecular Medicine Reports 18.6 (2018): 4793-4801.
Chicago
Wu, L., Chen, L."Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)". Molecular Medicine Reports 18, no. 6 (2018): 4793-4801. https://doi.org/10.3892/mmr.2018.9515