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Article

miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer

  • Authors:
    • Jianyu Fan
    • Wenjing Zhang
    • Yanting Wu
    • Ping Wan
    • Qiang Guo
    • Yu Zhang
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650000, P.R. China, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China
  • Pages: 5270-5278
    |
    Published online on: September 27, 2018
       https://doi.org/10.3892/mmr.2018.9518
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Abstract

MicroRNA (miRNA/miR)-124 is a miRNA, which exerts tumor suppressive effects but is frequently absent in tumors. Although it has been validated to target oncogenic genes such as signal transducer and activator of transcription 3, forkhead box Q1, and Slug, the mechanistic link between miR‑124 and potential target genes that contribute to tumor progression, is yet to be investigated. IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein that participates in protein‑protein interactions and integrating diverse signaling pathways. Previous studies suggest that overexpression of IQGAP1 enhances activity of mitogen activated protein kinase 1 and β‑catenin signaling cascades to facilitate tumor progression. The present study aimed to identify the regulative link between miR‑124 and IQGAP1 in colorectal cancer (CRC). It was demonstrated that IQGAP1 was aberrantly overexpressed in CRC tissues and cell lines. Knockdown of IQGPA1 by introducing short hairpin‑IQGAP1 lentivirus inhibited CRC cell growth and colony formation ability, and simultaneously suppressed phosphorylation of extracellular signal‑regulated kinase (ERK)1/2 and β‑catenin expression. Furthermore, it was demonstrated that miR‑124 was silenced in CRC. Restoration of miR‑124 in CRC cells impeded cell growth and colony formation ability. The direct binding of miR‑124 to the 3'untranslated region of IQGAP1 mRNA was confirmed using a luciferase reporter gene assay. Importantly, downregulation of IQGAP1 expression was observed in miR‑124‑restoration cells with simultaneous reduction of phosphorylated‑ERK1/2 and β‑catenin. In conclusion, the present study describes a potential mechanism underlying the miR‑124/IQGAP1 link in CRC progression. Silencing of miR‑124 may depress IQGAP1 expression, leading to increased activity of ERK1/2 and β‑catenin signaling.
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View References

1 

Esquela-Kerschera A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I and Inazawa J: miR-124 and miR-203 are epigenetically silenced tumor suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis. 31:766–776. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR and Zhao Q: MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34:713–722. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Wan HY, Li QQ, Zhang Y, Tian W, Li YN, Liu M, Li X and Tang H: MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells. Cancer Lett. 355:148–158. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Peng XH, Huang HR, Lu J, Liu X, Zhao FP, Zhang B, Lin SX, Wang L, Chen HH, Xu X, et al: MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma. Mol Cancer. 13:1862014. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Li H, Han J and Zhang Y: Down-regulation of microRNA-124 is correlated with tumor metastasis and poor prognosis in patients with lung cancer. Int J Clin Exp Pathol. 8:1967–1972. 2015.PubMed/NCBI

7 

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT and Casero RA: Epigenetic silencing of miR-124 prevents spermine oxidase regulation: Implications for Helicobacter pylori-induced gastric cancer. Oncogene. 35:5480–5488. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Pronina IV, Loginov VI, Burdennyy AM, Fridman MV, Senchenko VN, Kazubskaya TP, Kushlinskii NE, Dmitriev AA and Braga EA: DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. Gene. 604:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wang H, Zhang TT, Jin S, Liu H, Zhang X, Ruan CG, Wu DP, Han Y and Wang XQ: Pyrosequencing quantified methylation level of miR-124 predicts shorter survival for patients with myelodysplastic syndrome. Clin Epigenetics. 9:912017. View Article : Google Scholar : PubMed/NCBI

10 

Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, et al: The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut. 61:278–289. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Cheng Y, Li Y, Nian Y, Liu D, Dai F and Zhang J: STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells. BMC Cancer. 15:3062015. View Article : Google Scholar : PubMed/NCBI

12 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Wang MJ, Li Y, Wang R, Wang C, Yu YY, Yang L, Zhang Y, Zhou B, Zhou ZG and Sun XF: Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. Int J Colorectal Dis. 28:183–189. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Jinushi T, Shibayama Y, Kinoshita I, Oizumi S, Jinushi M, Aota T, Takahashi T, Horita S, Dosaka-Akita H and Iseki K: Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4. Cancer Med. 3:1544–1552. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, Ito Y, Otsuki Y, Uno B, Uchiyama K and Akao Y: MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade incolorectal cancer. Cancer Lett. 363:17–27. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Chen Z, Liu S, Tian L, Wu M, Ai F, Tang W, Zhao L, Ding J, Zhang L and Tang A: miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. Oncotarget. 6:38139–38150. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhou L, Xu Z, Ren X, Chen K and Xin S: MicroRNA-124 (MiR-124) inhibits cell proliferation, metastasis and invasion in colorectal cancerby downregulating rho-associated protein kinase 1(ROCK1). Cell Physiol Biochem. 38:1785–1795. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y, Zheng L, Huang J, Gao F, Lin X, He L, Li D, Li Z, Ding Y and Chen L: MiR-124 Radiosensitizes human colorectal cancer cells by targeting PRRX1. PLoS One. 9:e939172014. View Article : Google Scholar : PubMed/NCBI

19 

Bai J, Li Y, Shao T, Zhao Z, Wang Y, Wu A, Chen H, Li S, Jiang C, Xu J and Li X: Integrating analysis reveals microRNA-mediated pathway crosstalk among Crohn's disease, ulcerative colitis and colorectal cancer. Mol Biosyst. 10:2317–2328. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Roy M, Li Z and Sacks DB: IQGAP1 is a scaffold for mitogen-activated protein kinase signalling. Mol Cell Biol. 25:7940–7952. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Roy M, Li Z and Sacks DB: IQGAP1 binds ERK2 and modulates its activity. J Biol Chem. 279:17329–17337. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Bourguignon LY, Gilad E, Rothman K and Peyrollier K: Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/Estrogen Receptor transcriptional activation, and ovarian cancer progression. J Biol Chem. 280:11961–11972. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Briggs MW, Li Z and Sacks DB: IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem. 277:7453–7465. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Wang A, Wang F, Wang M, Zhu M, Ma Y and Wu R: IQGAP1 activates Tcf signal independent of Rac1 and Cdc42 in injury and repair of bronchial epithelial cells. Exp Mol Pathol. 85:122–128. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Schmidt VA, Chiariello CS, Capilla E, Miller F and Bahou WF: Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol Cell Biol. 28:1489–1502. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Nabeshima K, Shimao Y, Inoue T and Koono M: Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: Its overexpression in carcinomas and association with invasion fronts. Cancer Lett. 176:101–109. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Hayashi H, Nabeshima K, Aoki M, Hamasaki M, Enatsu S, Yamauchi Y, Yamashita Y and Iwasaki H: Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion. Int J Cancer. 126:2563–2574. 2010.PubMed/NCBI

28 

Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, Pachlewski J, Oledzki J and Ostrowski J: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One. 5:e130912010. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression using real time PCR and the 2 (-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS and Malarkannan S: IQGAP1: Insights into the function of a molecular puppeteer. Mol Immunol. 65:336–349. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Dong P, Nabeshima K, Nishimura N, Kawakami T, Hachisuga T, Kawarabayashi T and Iwasaki H: Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett. 243:120–127. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Chen F, Zhu HH, Zhou LF, Wu SS, Wang J and Chen Z: IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation. Exp Mol Med. 42:477–483. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Wang XX, Li XZ, Zhai LQ, Liu ZR, Chen XJ and Pei Y: Overexpression of IQGAP1 in human pancreatic cancer. Hepatobiliary Pancreat Dis Int. 12:540–545. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Smith JM, Hedman AC and Sacks DB: IQGAPs choreograph cellular signaling from the membrane to the nucleus. Trends Cell Biol. 25:171–184. 2015. View Article : Google Scholar : PubMed/NCBI

35 

White CD, Brown MD and Sacks DB: IQGAPs in Cancer: A family of scaffold proteins underlying tumorigenesis. FEBS Lett. 583:1817–1824. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Jameson KL, Mazur PK, Zehnder AM, Zhang J, Zarnegar B, Sage J and Khavari PA: IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors. Nat Med. 19:626–630. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Pi F, Binzel DW, Lee TJ, Li Z, Sun M, Rychahou P, Li H, Haque F, Wang S, Croce CM, et al: Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression. Nat Nanotechnol. 13:82–89. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Zhao CY, Cheng R, Yang Z and Tian ZM: Nanotechnology for cancer therapy based on chemotherapy. Molecules. 23:E8262018. View Article : Google Scholar : PubMed/NCBI

39 

Awasthi R, Roseblade A, Hansbro PM, Rathbone MJ, Dua K and Bebawy M: Nanoparticles in cancer treatment: Opportunities and obstacles. Curr Drug Targets. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Rychahou P, Bae Y, Reichel D, Zaytseva YY, Lee EY, Napier D, Weiss HL, Roller N, Frohman H, Le AT and Mark Evers B: Colorectal cancer lung metastasis treatment with polymer-drug nanoparticles. J Control Release. 275:85–91. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Marquez J, Fernandez-Piñeiro I, Araúzo-Bravo MJ, Poschmann G, Stühler K, Khatib AM, Sanchez A, Unda F, Ibarretxe G, Bernales I and Badiola I: Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine coloncancer metastasis to the liver. Int J Cancer. 143:709–719. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Li Y, Duo Y, Bi J, Zeng X, Mei L, Bao S, He L, Shan A, Zhang Y and Yu X: Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy. Int J Nanomedicine. 13:1241–1256. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fan J, Zhang W, Wu Y, Wan P, Guo Q and Zhang Y: miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. Mol Med Rep 18: 5270-5278, 2018.
APA
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., & Zhang, Y. (2018). miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. Molecular Medicine Reports, 18, 5270-5278. https://doi.org/10.3892/mmr.2018.9518
MLA
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., Zhang, Y."miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer". Molecular Medicine Reports 18.6 (2018): 5270-5278.
Chicago
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., Zhang, Y."miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer". Molecular Medicine Reports 18, no. 6 (2018): 5270-5278. https://doi.org/10.3892/mmr.2018.9518
Copy and paste a formatted citation
x
Spandidos Publications style
Fan J, Zhang W, Wu Y, Wan P, Guo Q and Zhang Y: miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. Mol Med Rep 18: 5270-5278, 2018.
APA
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., & Zhang, Y. (2018). miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. Molecular Medicine Reports, 18, 5270-5278. https://doi.org/10.3892/mmr.2018.9518
MLA
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., Zhang, Y."miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer". Molecular Medicine Reports 18.6 (2018): 5270-5278.
Chicago
Fan, J., Zhang, W., Wu, Y., Wan, P., Guo, Q., Zhang, Y."miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer". Molecular Medicine Reports 18, no. 6 (2018): 5270-5278. https://doi.org/10.3892/mmr.2018.9518
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