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Article

Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family

  • Authors:
    • Yong Cui
    • Duan‑Jun He
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The PLA 254 Hospital, Tianjin 300142, P.R. China
  • Pages: 5159-5165
    |
    Published online on: September 27, 2018
       https://doi.org/10.3892/mmr.2018.9519
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Abstract

Mutations in the mitochondrial genome have been identified to be associated with hearing loss. The aim of the present study was to investigate the role of mitochondrial DNA (mtDNA) variants in a Chinese family with hearing loss. Polymerase chain reaction (PCR)‑Sanger sequencing was used to screen the mtDNA variants and nuclear genes [gap junction protein β2 (GJB2) and transfer (t)RNA 5‑methylaminomethyle‑2‑thiouridylate methyltransferase (TRMU)]; in addition, the mtDNA copy number was determined by quantitative PCR. The present study characterized the molecular features of a Chinese family with maternally‑inherited hearing loss and identified mtDNA A1555G and tRNAIle A4317G mutations. The A4317G mutation was localized at the TΨC arm of tRNAIle (position 59) and created a novel base‑pairing (G59‑C54), which may alter the secondary structure of the tRNA. In addition, patients carrying the A4317G mutation exhibited a lower mtDNA copy number compared with the controls, suggesting that this mutation may cause mitochondrial dysfunction that is responsible for the deafness. However, no functional variants in the GJB2 and TRMU genes were detected. mtDNA A1555G and A4317G mutations may contribute to the clinical manifestation of hearing loss in this family.
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1 

Lin X, Teng Y, Lan J, He B, Sun H and Xu F: GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss. Mol Med Rep. 13:2857–2863. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Nikopoulos K, Farinelli P, Giangreco B, Tsika C, Royer-Bertrand B, Mbefo MK, Bedoni N, Kjellström U, El Zaoui I, Di Gioia SA, et al: Mutations in CEP78 cause cone-rod dystrophy and hearing loss associated with primary-cilia defects. Am J Hum Genet. 99:770–776. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Namburi P, Ratnapriya R, Khateb S, Lazar CH, Kinarty Y, Obolensky A, Erdinest I, Marks-Ohana D, Pras E, Ben-Yosef T, et al: Bi-allelic truncating mutations in CEP78, encoding centrosomal protein 78, cause cone-rod degeneration with sensorineural hearing loss. Am J Hum Genet. 99:777–784. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Franzè A, Esposito G, Di Domenico C, Iossa S, Sauchelli G, Fioretti T, Cavaliere M, Auletta G, Corvino V, Laria C, et al: SLC26A4 genotypes associated with enlarged vestibular aqueduct malformation in south Italian children with sensorineural hearing loss. Clin Chem Lab Med. 54:e259–e263. 2016.PubMed/NCBI

5 

Bakhchane A, Bousfiha A, Charoute H, Salime S, Detsouli M, Snoussi K, Nadifi S, Kabine M, Rouba H, Dehbi H, et al: Update of the spectrum of GJB2 gene mutations in 152 Moroccan families with autosomal recessive nonsyndromic hearing loss. Eur J Med Genet. 59:325–329. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kim SJ, Lee S, Park HJ, Kang TH, Sagong B, Baek JI, Oh SK, Choi JY, Lee KY and Kim UK: Genetic association of MYH genes with hereditary hearing loss in Korea. Gene. 591:177–182. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Guan J, Wang D, Cao W, Zhao Y, Du R, Yuan H, Liu Q, Lan L, Zong L, Yang J, et al: SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans. J Hum Genet. 61:917–922. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhu GJ, Shi LS, Zhou H, Yang Y, Chen J and Gao X: A novel compound heterozygous mutation of SLC26A4 in two Chinese families with nonsyndromic hearing loss and enlarged vestibular aqueducts. Mol Med Rep. 16:9011–9016. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wong SH, Wang WH, Chen PH, Li SY and Yang JJ: Functional analysis of a nonsyndromic hearing loss-associated mutation in the transmembrane II domain of the GJC3 gene. Int J Med Sci. 14:246–256. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, Jin K, Huang J, Jiang N, Wang X, et al: New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss. Hum Mutat. 38:1421–1431. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Lee KY, Choi SY, Bae JW, Kim S, Chung KW, Drayna D, Kim UK and Lee SH: Molecular analysis of the GJB2, GJB6 and SLC26A4 genes in Korean deafness patients. Int J Pediatr Otorhinolaryngol. 72:1301–1309. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Zhou XL, He LX, Yu LJ, Wang Y, Wang XJ, Wang ED and Yang T: Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism. Hum Mutat. 38:1740–1750. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Cai XZ, Li Y, Xia L, Peng Y, He CF, Jiang L, Feng Y, Xia K, Liu XZ, Mei LY and Hu ZM: Exome sequencing identifies POU4F3 as the causative gene for a large chinese family with non-syndromic hearing loss. J Hum Genet. 62:317–320. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Palombo F, Al-Wardy N, Ruscone GA, Oppo M, Kindi MN, Angius A, Al Lamki K, Girotto G, Giangregorio T, Benelli M, et al: A novel founder MYO15a frameshift duplication is the major cause of genetic hearing loss in oman. J Hum Genet. 62:259–264. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ryu N, Lee S, Park HJ, Lee B, Kwon TJ, Bok J, Park CI, Lee KY, Baek JI and Kim UK: Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing. Gene. 627:233–238. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Li D, Sun J, Zhao L, Guo W, Sun W and Yang S: Aminoglycoside increases permeability of osseous spiral laminae of cochlea by interrupting MMP-2 and MMP-9 balance. Neurotox Res. 31:348–357. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Sagwa EL, Souverein PC, Ribeiro I, Leufkens HG and Mantel-Teeuwisse AK: Differences in VigiBase® reporting of aminoglycoside and capreomycin-suspected ototoxicity during tuberculosis treatment. Pharmacoepidemiol Drug Saf. 26:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Ding Y, Leng J, Fan F, Xia B and Xu P: The role of mitochondrial DNA mutations in hearing loss. Biochem Genet. 51:588–602. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Li Z, Li R, Chen J, Liao Z, Zhu Y, Qian Y, Xiong S, Heman-Ackah S, Wu J, Choo DI and Guan MX: Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss. Hum Genet. 117:9–15. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Zheng J, Ji Y and Guan MX: Mitochondrial tRNA mutations associated with deafness. Mitochondrion. 12:406–413. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Guan MX, Fischel-Ghodsian N and Attardi G: A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity. Hum Mol Genet. 9:1787–1793. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Guan MX, Fischel-Ghodsian N and Attardi G: Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation. Hum Mol Genet. 5:963–971. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Lu J, Qian Y, Li Z, Yang A, Zhu Y, Li R, Yang L, Tang X, Chen B, Ding Y, et al: Mitochondrial haplotypes may modulate the phenotypic manifestation of the deafness-associated 12S rRNA 1555A>G mutation. Mitochondrion. 10:69–81. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Rieder MJ, Taylor SL, Tobe VO and Nickerson DA: Automating the identification of DNA variations using quality-based fluorescence re-sequencing: Analysis of the human mitochondrial genome. Nucleic Acids Res. 26:967–973. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM and Howell N: Reanalysis and revision of the cambridge reference sequence for human mitochondrial DNA. Nat Genet. 23:1471999. View Article : Google Scholar : PubMed/NCBI

26 

Ding Y, Xia BH, Liu Q, Li MY, Huang SX and Zhuo GC: Allele-specific PCR for detecting the deafness-associated mitochondrial 12S rRNA mutations. Gene. 591:148–152. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Guan MX, Yan Q, Li X, Bykhovskaya Y, Gallo-Teran J, Hajek P, Umeda N, Zhao H, Garrido G, Mengesha, et al: Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet. 79:291–302. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ and Reed MW: Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods. Anal Biochem. 285:194–204. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Bibb MJ, Van Etten RA, Wright CT, Walberg MW and Clayton DA: Sequence and gene organization of mouse mitochondrial DNA. Cell. 26:167–180. 1981. View Article : Google Scholar : PubMed/NCBI

30 

Gadaleta G, Pepe G, De Candia G, Quagliariello C, Sbisà E and Saccone C: The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: Cryptic signals revealed by comparative analysis between vertebrates. J Mol Evol. 28:497–516. 1989. View Article : Google Scholar : PubMed/NCBI

31 

Roe BA, Ma DP, Wilson R and Wong JF: The complete nucleotide sequence of the xenopus laevis mitochondrial genome. J Biol Chem. 260:9759–9774. 1985.PubMed/NCBI

32 

Dai ZY, Sun BC, Huang SS, Yuan YY, Zhu YH, Su Y and Dai P: Correlation analysis of phenotype and genotype of GJB2 in patients with non-syndromic hearing loss in china. Gene. 570:272–276. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Kong QP, Bandelt HJ, Sun C, Yao YG, Salas A, Achilli A, Wang CY, Zhong L, Zhu CL, Wu SF, et al: Updating the East Asian mtDNA phylogeny: A prerequisite for the identification of pathogenic mutations. Hum Mol Genet. 15:2076–2086. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L and Rotter JI: Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet. 4:289–294. 1993. View Article : Google Scholar : PubMed/NCBI

35 

el-Schahawi M, de Munain López A, Sarrazin AM, Shanske AL, Basirico M, Shanske S and DiMauro S: Two large Spanish pedigrees with nonsyndromic sensorineural deafness and the mtDNA mutation at nt 1555 in the 12s rRNA gene: Evidence of heteroplasmy. Neurology. 48:453–456. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Yuan EF, Xia W, Huang JT, Hu L, Liao X, Dai X and Liu SM: A sensitive and convenient method for clinical detection of non-syndromic hearing loss-associated common mutations. Gene. 628:322–328. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Lu J, Li Z, Zhu Y, Yang A, Li R, Zheng J, Cai Q, Peng G, Zheng W, Tang X, et al: Mitochondrial 12S rRNA variants in 1642 han chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss. Mitochondrion. 10:380–390. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Suzuki T and Nagao A: Human mitochondrial tRNAs: Biogenesis, function, structural aspects, and diseases. Annu Rev Genet. 45:299–329. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Pütz J, Giegé R and Florentz C: Diversity and similarity in the tRNA world: Overall view and case study on malaria-related tRNAs. FEBS Lett. 584:350–358. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Tanaka M, Ino H, Ohno K, Hattori K, Sato W, Ozawa T, Tanaka T and Itoyama S: Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet. 336:14521990. View Article : Google Scholar : PubMed/NCBI

41 

Lechowicz U, Pollak A, Frączak A, Rydzanicz M, Stawiński P, Lorens A, Skarżyński PH, Skarżyński H, Płoski R and Ołdak M: Application of next-generation sequencing to identify mitochondrial mutations: Study on m.7511T>C in patients with hearing loss. Mol Med Rep. 17:1782–1790. 2018.PubMed/NCBI

42 

Zhu HY, Wang SW, Liu L, Chen R, Wang L, Gong XL and Zhang ML: Genetic variants in mitochondrial tRNA genes are associated with essential hypertension in a chinese Han population. Clin Chim Acta. 410:64–69. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Degoul F, Brule H, Cepanec C, Helm M, Marsac C, Leroux J, Giegé R and Florentz C: Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene. Hum Mol Genet. 7:347–354. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Ding Y, Zhuo G and Zhang C: The mitochondrial tRNALeu(UUR) A3302G mutation may be associated with insulin resistance in woman with polycystic ovary syndrome. Reprod Sci. 23:228–233. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Jeng JY, Yeh TS, Lee JW, Lin SH, Fong TH and Hsieh RH: Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth. J Cell Biochem. 103:347–357. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR and Smith RJH: RNA interference prevents autosomal-dominant hearing loss. Am J Hum Genet. 98:1101–1113. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cui Y and He DJ: Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family. Mol Med Rep 18: 5159-5165, 2018.
APA
Cui, Y., & He, D. (2018). Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family. Molecular Medicine Reports, 18, 5159-5165. https://doi.org/10.3892/mmr.2018.9519
MLA
Cui, Y., He, D."Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family". Molecular Medicine Reports 18.6 (2018): 5159-5165.
Chicago
Cui, Y., He, D."Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family". Molecular Medicine Reports 18, no. 6 (2018): 5159-5165. https://doi.org/10.3892/mmr.2018.9519
Copy and paste a formatted citation
x
Spandidos Publications style
Cui Y and He DJ: Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family. Mol Med Rep 18: 5159-5165, 2018.
APA
Cui, Y., & He, D. (2018). Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family. Molecular Medicine Reports, 18, 5159-5165. https://doi.org/10.3892/mmr.2018.9519
MLA
Cui, Y., He, D."Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family". Molecular Medicine Reports 18.6 (2018): 5159-5165.
Chicago
Cui, Y., He, D."Mitochondrial tRNAIle A4317G mutation may be associated with hearing impairment in a Han Chinese family". Molecular Medicine Reports 18, no. 6 (2018): 5159-5165. https://doi.org/10.3892/mmr.2018.9519
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