Open Access

Oral microbial flora of patients with Sicca syndrome

  • Authors:
    • Shuang Zhou
    • Ye Cai
    • Min Wang
    • Wei‑Dong Yang
    • Ning Duan
  • View Affiliations

  • Published online on: September 27, 2018     https://doi.org/10.3892/mmr.2018.9520
  • Pages: 4895-4903
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary sicca syndrome (pSS) is a systemic autoimmune disease. However, its exact etiology and pathogenesis remain elusive. Various infectious factors have been identified to be closely associated with the occurrence and development of PSS. The present study aimed to assess the composition of the oral microbial flora of patients with pSS in China in order to provide guidance for treatment. The microbial flora of nine patients with pSS and five healthy controls from East China was evaluated in saliva samples using high‑throughput sequencing. A high microbial diversity was detected in the pSS and control groups, with bacteroidetes, firmicutes and proteobacteria constituting the largest phyla in the two groups. Compared with the control group, bacteroidetes and actinobacteria were significantly more abundant in the pSS group, whereas proteobacteria were significantly less abundant. However, no significant differences in bacterial richness and diversity were observed between the two groups. According to a Kyoto Encyclopedia of Genes and Genomes linear discriminant analysis, genes regulating cell apoptosis and the immune and digestive systems were significantly upregulated in the pSS group compared with those in the control group. In conclusion, the present study provided basic data on the flora of the oral cavity in patients with pSS from East China and may serve as a reference for the treatment of this condition.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhou S, Cai Y, Wang M, Yang WD and Duan N: Oral microbial flora of patients with Sicca syndrome. Mol Med Rep 18: 4895-4903, 2018
APA
Zhou, S., Cai, Y., Wang, M., Yang, W., & Duan, N. (2018). Oral microbial flora of patients with Sicca syndrome. Molecular Medicine Reports, 18, 4895-4903. https://doi.org/10.3892/mmr.2018.9520
MLA
Zhou, S., Cai, Y., Wang, M., Yang, W., Duan, N."Oral microbial flora of patients with Sicca syndrome". Molecular Medicine Reports 18.6 (2018): 4895-4903.
Chicago
Zhou, S., Cai, Y., Wang, M., Yang, W., Duan, N."Oral microbial flora of patients with Sicca syndrome". Molecular Medicine Reports 18, no. 6 (2018): 4895-4903. https://doi.org/10.3892/mmr.2018.9520