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Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis

  • Authors:
    • Wendong Wang
    • Zhiwei Xu
    • Xiaobo Zhu
    • Xiaotong Chang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, College of Laboratory Medicine, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5069-5075
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    Published online on: October 10, 2018
       https://doi.org/10.3892/mmr.2018.9551
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Abstract

The present study aimed to mine therapeutic molecular targets that play an important part in the progression of coronary artery disease (CAD). The gene expression profile GSE28829 dataset and the microRNA (miRNA) expression profile GSE59421 dataset were downloaded from the Gene Expression Omnibus (GEO) database. The GEO2R online analytical tool was used to identify differentially expressed genes (DEGs) and miRNAs (DEMs). The target genes of DEMs were identified using the miRWalk2.0 web‑based tool and 2 miRNA‑gene regulatory networks were constructed using Cytoscape software. Subsequently, enriched Gene Ontology (GO) terms of miRNA‑target DEGs were obtained using the Database for Visualization, Annotation and Integrated Analysis, and locations of these genes in the chromosomes were determined by Map Viewer. In the present study, 350 DEGs and 66 DEMs were screened. A total of 3,588 target genes were identified from the DEMs, and 57 of these target genes and established DEGs were identified to overlap. GO terms associated with 5 processes, and 4 types of composition were identified to be enriched in the miRNA‑target DEGs. Furthermore, 26 miRNA‑gene regulatory pairs were obtained between the 57 target genes and DEMs. The 26 miRNA‑target DEGs were unevenly distributed, and no genes were located on the sex chromosomes. As a result of the present study, potential therapeutic targets for CAD were identified through bioinformatics analysis.
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View References

1 

Mendis S, Puska P and Norrving B: Global: Atlas on cardiovascular disease prevention and control. Geneva: World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization. 3–18. 2011.

2 

Ding D, Wang M, Su D, Hong C, Li X, Yang Y, Zhang Y, Hu G and Ling W: Body mass index, high-sensitivity C-reactive protein and mortality in Chinese with coronary artery disease. PLoS One. 10:e01357132015. View Article : Google Scholar : PubMed/NCBI

3 

Centers for Disease Control and Prevention (CDC): Prevalence of coronary heart disease-United States, 2006–2006. MMWR Morb Mortal Wkly Rep. 60:1377–1381. 2011.PubMed/NCBI

4 

GBD 2015 Disease and Injury Incidence and Prevalence Collaborators: Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–1990: A systematic analysis for the global burden of disease study 2015. Lancet. 388:1545–1602. 2016.PubMed/NCBI

5 

Kontos MC, Diercks DB and Kirk JD: Emergency department and office-based evaluation of patients with chest pain. Mayo Clin Proc. 85:284–299. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Dai X, Wiernek S, Evans JP and Runge MS: Genetics of coronary artery disease and myocardial infarction. World J Cardiol. 8:1–23. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Zimmerman AL and Wu S: MicroRNAs, cancer and cancer stem cells. Cancer Lett. 300:10–19. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Doring Y, Manthey HD, Drechsler M, Lievens D, Megens RT, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, et al: Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation. 125:1673–1683. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kok MG, Halliani A, Moerland PD, Meijers JC, Creemers EE and Pinto-Sietsma SJ: Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR. FASEB J. 29:3853–3862. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Dweep H, Sticht C, Pandey P and Gretz N: miRWalk-database: Prediction of possible miRNA binding sites by ‘walking’ the genes of 3 genomes. J Biomed Inform. 44:839–837. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Dweep H and Gretz N: miRWalk2.0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:697. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

15 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Hulsegge I, Kommadath A and Smits MA: Globaltest and GOEAST: Two different approaches for Gene Ontology analysis. BMC Proc. 3 Suppl 4:S102009. View Article : Google Scholar : PubMed/NCBI

17 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Wolfsberg TG: Using the NCBI Map Viewer to browse genomic sequence data. Curr Protoc Hum Genet Chapter. 18:Unit 18.5. 2011.

19 

Peterson KJ, Dietrich MR and McPeek MA: MicroRNAs and metazoan macroevolution: Insights into canalization, complexity, and the Cambrian explosion. Bioessays. 31:736–747. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM and Wang DZ: Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 42:1137–1141. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Insull W Jr: The pathology of atherosclerosis: Plaque development and plaque responses to medical treatment. Am J Med. 122 1 Suppl:S3–S14. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Phillips MC: Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB Life. 66:616–623. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE and Stroehla BC: Apolipoprotein E polymorphism and cardiovascular disease: A HuGE review. Am J Epidemiol. 155:487–495. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Mahley RW, Weisgraber KH and Huang Y: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA. 103:5644–5651. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Chang IW, Wu WJ, Wang YH, Wu TF, Liang PI, He HL, Yeh BW and Li CF: BCAT1 overexpression is an indicator of poor prognosis in patients with urothelial carcinomas of the upper urinary tract and urinary bladder. Histopathology. 68:520–532. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam MM and Hutson SM: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. J Biol Chem. 280:37246–37256. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Ashkenas J, Penman M, Vasile E, Acton S, Freeman M and Krieger M: Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J Lipid Res. 34:983–1000. 1993.PubMed/NCBI

28 

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS and Sabatini DM: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 137:873–886. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Mitrasinovic OM, Grattan A, Robinson CC, Lapustea NB, Poon C, Ryan H, Phong C and Murphy GM Jr: Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. J Neurosci. 25:4442–4451. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, et al: Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes. 62:56–64. 2013. View Article : Google Scholar : PubMed/NCBI

31 

King K, Moody A, Fisher SA, Mirza MM, Cuthbert AP, Hampe J, Sutherland-Craggs A, Sanderson J, MacPherson AJ, Forbes A, et al: Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. Eur J Immunogenet. 30:187–190. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Ahn KJ, Kim J, Yun M, Park JH and Lee JD: Enzymatic properties of the N- and C-terminal halves of human hexokinase II. BMB Rep. 42:350–355. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A and Huebner K: Assignment of DAP1 and DAPK-genes that positively mediate programmed cell death triggered by IFN-gamma-to chromosome regions 5p12.2 and 9q34.1, respectively. Genomics. 29:305–307. 1995. View Article : Google Scholar : PubMed/NCBI

34 

van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM and Schuuring E: Comparative genome analysis of cortactin and HS1: The significance of the F-actin binding repeat domain. BMC Genomics. 6:152005. View Article : Google Scholar : PubMed/NCBI

35 

Mohler ER III, Ballantyne CM, Davidson MH, Hanefeld M, Ruilope LM, Johnson JL and Zalewski A: Darapladib Investigators: The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: The results of a multicenter, randomized, double-blind, placebo-controlled study. J Am Coll Cardiol. 51:1632–1641. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Ninio E, Tregouet D, Carrier JL, Stengel D, Bickel C, Perret C, Rupprecht HJ, Cambien F, Blankenberg S and Tiret L: Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. Hum Mol Genet. 13:1341–1351. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Cawthon RM, O'Connell P, Buchberg AM, Viskochil D, Weiss RB, Culver M, Stevens J, Jenkins NA, Copeland NG and White R: Identification and characterization of transcripts from the neurofibromatosis 1 region: The sequence and genomic structure of EVI2 and mapping of other transcripts. Genomics. 7:555–565. 1990. View Article : Google Scholar : PubMed/NCBI

38 

Janciauskiene SM, Bals R, Koczulla R, Vogelmeier C, Köhnlein T and Welte T: The discovery of α1-antitrypsin and its role in health and disease. Respir Med. 105:1129–1139. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, et al: The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol. 172:6362–6372. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Addobbati C, Brandão LA, Guimarães RL, Pancotto JA, Donadi EA, Crovella S, Segat L and Sandrin-Garcia P: FYB gene polymorphisms are associated with susceptibility for systemic lupus erythemathosus (SLE). Hum Immunol. 74:1009–1014. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Zimmer A, Bouley J, Le Mignon M, Pliquet E, Horiot S, Turfkruyer M, Baron-Bodo V, Horak F, Nony E, Louise A, et al: A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy. J Allergy Clin Immunol. 129:1020–1030. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Asanoma K, Kato H, Inoue T, Matsuda T and Wake N: Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. J Reprod Med. 49:617–626. 2004.PubMed/NCBI

43 

Heufler C, Ortner D and Hofer S: Cybr, CYTIP or CASP: An attempt to pinpoint a molecule's functions and names. Immunobiology. 213:729–732. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Zjablovskaja P, Kardosova M, Danek P, Angelisova P, Benoukraf T, Wurm AA, Kalina T, Sian S, Balastik M, Delwel R, et al: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. Cell Death Differ. 24:705–716. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Prieto D and Zolessi FR: Functional diversification of the four MARCKS family members in zebrafish neural development. J Exp Zool B Mol Dev Evol. 328:119–138. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Yang Q, Yin RX, Zhou YJ, Cao XL, Guo T and Chen WX: Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: A case-control study. Lipids Health Dis. 14:792015. View Article : Google Scholar : PubMed/NCBI

47 

Dwyer J, Li H, Xu D and Liu JP: Transcriptional regulation of telomerase activity: Roles of the Ets transcription factor family. Ann N Y Acad Sci. 1114:36–47. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Kerber RA, OBrien E and Cawthon RM: Gene expression profiles associated with aging and mortality in humans. Aging Cell. 8:239–250. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Xu Z, Gakhar L, Bain FE, Spies M and Fuentes EJ: The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. J Biol Chem. 292:17777–17793. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Ren XR, Hong Y, Feng Z, Yang HM, Mei L and Xiong WC: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. Neurosignals. 16:235–345. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Jean E, Ebbo M, Valleix S, Benarous L, Heyries L, Grados A, Bernit E, Grateau G, Papo T, Granel B, et al: A new family with hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease as prevailing symptoms. BMC Gastroenterol. 14:1592014. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wang W, Xu Z, Zhu X and Chang X: Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis. Mol Med Rep 18: 5069-5075, 2018.
APA
Wang, W., Xu, Z., Zhu, X., & Chang, X. (2018). Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis. Molecular Medicine Reports, 18, 5069-5075. https://doi.org/10.3892/mmr.2018.9551
MLA
Wang, W., Xu, Z., Zhu, X., Chang, X."Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis". Molecular Medicine Reports 18.6 (2018): 5069-5075.
Chicago
Wang, W., Xu, Z., Zhu, X., Chang, X."Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis". Molecular Medicine Reports 18, no. 6 (2018): 5069-5075. https://doi.org/10.3892/mmr.2018.9551
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Xu Z, Zhu X and Chang X: Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis. Mol Med Rep 18: 5069-5075, 2018.
APA
Wang, W., Xu, Z., Zhu, X., & Chang, X. (2018). Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis. Molecular Medicine Reports, 18, 5069-5075. https://doi.org/10.3892/mmr.2018.9551
MLA
Wang, W., Xu, Z., Zhu, X., Chang, X."Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis". Molecular Medicine Reports 18.6 (2018): 5069-5075.
Chicago
Wang, W., Xu, Z., Zhu, X., Chang, X."Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis". Molecular Medicine Reports 18, no. 6 (2018): 5069-5075. https://doi.org/10.3892/mmr.2018.9551
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