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High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer

  • Authors:
    • Yao He
    • Hui Wang
    • Meina Yan
    • Xinxin Yang
    • Rong Shen
    • Xiaoge Ni
    • Xiaokun Chen
    • Peifang Yang
    • Miao Chen
    • Xiaodong Lu
    • Genbao Shao
    • Xiaoming Zhou
    • Qixiang Shao
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Gynecology and Obstetrics, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Department of Gynecology and Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5327-5336
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    Published online on: October 16, 2018
       https://doi.org/10.3892/mmr.2018.9562
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Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA‑binding protein, which serves a fundamental role in cell development and pluripotency. Polo‑like kinase 4 (PLK4) is a member of the polo‑like kinase family, which primarily takes part in the mitotic regulation. Overexpression of LIN28A has been demonstrated in ovarian cancer; however, the expression of PLK4 and the correlation between the expression of LIN28A and PLK4 in EOC has not been discussed. In the present study, the mRNA and protein levels of LIN28A and PLK4 were evaluated by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry in ovarian tissues of patients. Results demonstrated significantly increased expression in EOC compared with benign epithelial ovarian tumors. High expression of LIN28A and PLK4 was detected at the advanced pathological stage. Furthermore, PLK4 expression was positively correlated with LIN28A (r=0.555; P=0.039). The median survival analysis of patients with EOC with LIN28A and PLK4 double positive expression was 14 months, compared with 30 months in single positive and 60 months in double negative patients by Kaplan‑Meier analysis (P<0.05). The expressions of LIN28A and PLK4 was elevated in different EOC cell lines compared to with a normal ovarian cell line. The 293T cells transfected with LIN28A plus a PLK4 plasmid were the fastest‑growing group. These results suggest that co‑expression of LIN28A and PLK4 may be associated with poor prognosis of EOC and could serve as promising prognostic biomarkers and therapeutic targets in EOC. LIN28A and PLK4 may be used along with traditional morphological and clinical characteristics for predicting prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
He Y, Wang H, Yan M, Yang X, Shen R, Ni X, Chen X, Yang P, Chen M, Lu X, Lu X, et al: High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer. Mol Med Rep 18: 5327-5336, 2018.
APA
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X. ... Shao, Q. (2018). High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer. Molecular Medicine Reports, 18, 5327-5336. https://doi.org/10.3892/mmr.2018.9562
MLA
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X., Chen, X., Yang, P., Chen, M., Lu, X., Shao, G., Zhou, X., Shao, Q."High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer". Molecular Medicine Reports 18.6 (2018): 5327-5336.
Chicago
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X., Chen, X., Yang, P., Chen, M., Lu, X., Shao, G., Zhou, X., Shao, Q."High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer". Molecular Medicine Reports 18, no. 6 (2018): 5327-5336. https://doi.org/10.3892/mmr.2018.9562
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Wang H, Yan M, Yang X, Shen R, Ni X, Chen X, Yang P, Chen M, Lu X, Lu X, et al: High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer. Mol Med Rep 18: 5327-5336, 2018.
APA
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X. ... Shao, Q. (2018). High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer. Molecular Medicine Reports, 18, 5327-5336. https://doi.org/10.3892/mmr.2018.9562
MLA
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X., Chen, X., Yang, P., Chen, M., Lu, X., Shao, G., Zhou, X., Shao, Q."High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer". Molecular Medicine Reports 18.6 (2018): 5327-5336.
Chicago
He, Y., Wang, H., Yan, M., Yang, X., Shen, R., Ni, X., Chen, X., Yang, P., Chen, M., Lu, X., Shao, G., Zhou, X., Shao, Q."High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer". Molecular Medicine Reports 18, no. 6 (2018): 5327-5336. https://doi.org/10.3892/mmr.2018.9562
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