Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2019 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway

  • Authors:
    • Xiuzhen Hao
    • Jie Yuan
    • Huixiao Dong
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jining No. 1 People's Hospital, Jining, Shandong 272000, P.R. China, Institute of Mental Health, North China University of Science and Technology, Tangshan, Hebei 063009, P.R. China
  • Pages: 678-684
    |
    Published online on: November 2, 2018
       https://doi.org/10.3892/mmr.2018.9621
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In previous years, it has been found that Rhodiola has a wide range of pharmacological effects in diseases of the cardiovascular system, as it can remove superoxide anions and hydroxyl radicals in chemical reactions. Behavioral assessment was used to measure cognitive impairment. Inflammation, oxidative stress and caspase‑3 activity were measured using commercial kits. Western blot analysis was used to measure Rho/Rho‑associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)‑κB protein expression. The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes‑induced cognitive impairment. The results of the study demonstrated that salidroside prevented cognitive impairment, decreased serum blood glucose levels and increased body weight, reduced fasting blood glucose levels and blood lipid levels, and inhibited oxidative stress, inflammation and nerve cell apoptosis in the diabetic rat model. Salidroside suppressed ROCK/ SIRT1 NF‑κB pathway and protein expression in the diabetic rats. These data showed that salidroside prevented diabetes‑induced cognitive impairment by regulating the Rho/ROCK/SIRT1/NF‑κB pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Forouhi NG, Menon RK, Sharp SJ, Mannan N, Timms PM, Martineau AR, Rickard AP, Boucher BJ, Chowdhury TA, Griffiths CJ, et al: Effects of vitamin D2 or D3 supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: Results of a randomized double-blind placebo-controlled trial. Diabetes Obes Metab. 18:392–400. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Karashima S, Yoneda T, Kometani M, Ohe M, Mori S, Sawamura T, Furukawa K, Yamagishi M and Takeda Y: Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus. Clin Exp Hypertens. 38:565–570. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Li D, Xu X, Zhang Y, Zhu J, Ye L, Lee KO and Ma J: Liraglutide treatment causes upregulation of adiponectin and downregulation of resistin in Chinese type 2 diabetes. Diabetes Res Clin Pract. 110:224–228. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Fiocco AJ, Scarcello S, Marzolini S, Chan A, Oh P, Proulx G and Greenwood C: The effects of an exercise and lifestyle intervention program on cardiovascular, metabolic factors and cognitive performance in middle-aged adults with type II diabetes: A pilot study. Can J Diabetes. 37:214–219. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Watson NA, Dyer KA, Buckley JD, Brinkworth GD, Coates AM, Parfitt G, Howe PRC, Noakes M, Dye L, Chadwick H and Murphy KJ: A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: Study protocol. Contemp Clin Trials. 45:217–225. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Ma LY, Zhang DM, Tang Y, Lu Y, Zhang Y, Gao Y, Xia L, Zhao KX, Chai LY and Xiao Q: Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats. Alzheimer Dis Assoc Disord. 25:352–363. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J, Brodaty H, Wen W, Singh N, Baune BT, Suo C, et al: The study of mental and resistance training (SMART) study-resistance training and/or cognitive training in mild cognitive impairment: A randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc. 15:873–880. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Tian X, Liu Y, Ren G, Yin L, Liang X, Geng T, Dang H and An R: Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. Brain Res. 1650:1–9. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Leguina-Ruzzi A, Pereira J, Pereira-Flores K, Valderas JP, Mezzano D, Velarde V and Sáez CG: Increased RhoA/Rho-kinase activity and markers of endothelial dysfunction in Young adult subjects with metabolic syndrome. Metab Syndr Relat Disord. 13:373–380. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Sun Z, Wu X, Li W, Peng H, Shen X, Ma L, Liu H and Li H: RhoA/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vessels. BMC Cardiovasc Disord. 16:1932016. View Article : Google Scholar : PubMed/NCBI

11 

Luo F, Liu J, Yan T and Miao M: Salidroside alleviates cigarette smoke-induced COPD in mice. Biomed Pharmacother. 86:155–161. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Sun P, Song SZ, Jiang S, Li X, Yao YL, Wu YL, Lian LH and Nan JX: Salidroside regulates inflammatory response in raw 264.7 macrophages via TLR4/TAK1 and ameliorates inflammation in alcohol binge drinking-induced liver injury. Molecules. 21(pii): E14902016. View Article : Google Scholar : PubMed/NCBI

13 

Li H, Ying H, Hu A, Li D and Hu Y: Salidroside modulates insulin signaling in a rat model of nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2017:96513712017.PubMed/NCBI

14 

Inouye J, Li D, Davis J and Arakaki R: Psychosocial and clinical outcomes of a cognitive behavioral therapy for asians and pacific islanders with type 2 diabetes: A randomized clinical trial. Hawaii J Med Public Health. 74:360–368. 2015.PubMed/NCBI

15 

Luchsinger JA, Perez T, Chang H, Mehta P, Steffener J, Pradabhan G, Ichise M, Manly J, Devanand DP and Bagiella E: Metformin in amnestic mild cognitive impairment: Results of a pilot randomized placebo controlled clinical trial. J Alzheimers Dis. 51:501–514. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Jacob L, Bohlken J and Kostev K: Risk factors for mild cognitive impairment in german primary care practices. J Alzheimers Dis. 56:379–384. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Watzlawick R, Sena ES, Dirnagl U, Brommer B, Kopp MA, Macleod MR, Howells DW and Schwab JM: Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: A systematic review and meta-analysis. JAMA Neurol. 71:91–99. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ma Z, Chu L, Liu H, Li J, Zhang Y, Liu W, Dai J, Yi J and Gao Y: Paeoniflorin alleviates non-alcoholic steatohepatitis in rats: Involvement with the ROCK/NF-κB pathway. Int Immunopharmacol. 38:377–384. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Golokhvast K, Sergievich A and Grigoriev N: Geophagy (rock eating), experimental stress and cognitive idiosyncrasy. Asian Pac J Trop Biomed. 4:362–366. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhu L, Chen T, Chang X, Zhou R, Luo F, Liu J, Zhang K, Wang Y, Yang Y, Long H, et al: Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway. Neuropharmacology. 103:134–142. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Xu J, Li N, Wang J, Zhang C, Ding S, Jiao Y and Zhang J: Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 38:882–887. 2013.(In Chinese). PubMed/NCBI

22 

Cheng L, Li B, Chen X, Su J, Wang H, Yu S and Zheng Q: CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation. Biochem Biophys Res Commun. 477:685–691. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Yin Z, Yu H, Chen S, Ma C, Ma X, Xu L, Ma Z, Qu R and Ma S: Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway. Behav Brain Res. 292:288–299. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Murdock KW, LeRoy AS, Lacourt TE, Duke DC, Heijnen CJ and Fagundes CP: Executive functioning and diabetes: The role of anxious arousal and inflammation. Psychoneuroendocrinology. 71:102–109. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, Ghasemi Z and Roghani M: S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. Eur J Pharmacol. 794:69–76. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Du LL, Xie JZ, Cheng XS, Li XH, Kong FL, Jiang X, Ma ZW, Wang JZ, Chen C and Zhou XW: Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 36:613–623. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Wang J, Li JZ, Lu AX, Zhang KF and Li BJ: Anticancer effect of salidroside on A549 lung cancer cells through inhibition of oxidative stress and phospho-p38 expression. Oncol Lett. 7:1159–1164. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Khare P, Datusalia AK and Sharma SS: Parthenolide, an NF-κB inhibitor ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model. Neuromolecular Med. 19:101–112. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Zhao Z, Huang G, Wang B and Zhong Y: Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats. Behav Brain Res. 238:44–47. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Kuhad A, Bishnoi M, Tiwari V and Chopra K: Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol Biochem Behav. 92:251–259. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Gao J, Zhou R, You X, Luo F, He H, Chang X, Zhu L, Ding X and Yan T: Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway. Metab Brain Dis. 31:771–778. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hao X, Yuan J and Dong H: Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway. Mol Med Rep 19: 678-684, 2019.
APA
Hao, X., Yuan, J., & Dong, H. (2019). Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway. Molecular Medicine Reports, 19, 678-684. https://doi.org/10.3892/mmr.2018.9621
MLA
Hao, X., Yuan, J., Dong, H."Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway". Molecular Medicine Reports 19.1 (2019): 678-684.
Chicago
Hao, X., Yuan, J., Dong, H."Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway". Molecular Medicine Reports 19, no. 1 (2019): 678-684. https://doi.org/10.3892/mmr.2018.9621
Copy and paste a formatted citation
x
Spandidos Publications style
Hao X, Yuan J and Dong H: Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway. Mol Med Rep 19: 678-684, 2019.
APA
Hao, X., Yuan, J., & Dong, H. (2019). Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway. Molecular Medicine Reports, 19, 678-684. https://doi.org/10.3892/mmr.2018.9621
MLA
Hao, X., Yuan, J., Dong, H."Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway". Molecular Medicine Reports 19.1 (2019): 678-684.
Chicago
Hao, X., Yuan, J., Dong, H."Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway". Molecular Medicine Reports 19, no. 1 (2019): 678-684. https://doi.org/10.3892/mmr.2018.9621
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team