Open Access

Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

  • Authors:
    • Guozong Wang
    • Zhentao Man
    • Nianping Zhang
    • Hua Xin
    • Yi Li
    • Tiantong Sun
    • Shui Sun
  • View Affiliations

  • Published online on: November 5, 2018     https://doi.org/10.3892/mmr.2018.9626
  • Pages: 407-413
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteonecrosis of the femoral head (ONFH) is a refractory disease present worldwide. In the development of therapies for this disease, mesenchymal stem cells (MSC) are a promising candidate cell source in tissue engineering (TE) and regenerative medicine. MSCs harvested from bone marrow (BM) are the gold standard. A significant barrier for BMMSC‑based therapies is the inability and decreased number of BMMSCs in the tissues of interest. The ability to recruit BMMSCs efficiently to defective or injured sites in tissues or organs, for example the necrotic area of the femoral head in vivo, has been a major concern. In the present study, a peptide sequence (CDNVAQSVC), termed D7, was identified through phage display technology using C57BL/6 mouse BMMSCs. Subsequent analysis suggested that the identified loop‑constrained heptapeptide exhibited a high specific affinity for mouse BMMSCs. Due to this specific affinity for BMMSCs, the present study provides a selective method to improve MSC‑based TE strategies for the treatment of ONFH.
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January-2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang G, Man Z, Zhang N, Xin H, Li Y, Sun T and Sun S: Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides. Mol Med Rep 19: 407-413, 2019
APA
Wang, G., Man, Z., Zhang, N., Xin, H., Li, Y., Sun, T., & Sun, S. (2019). Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides. Molecular Medicine Reports, 19, 407-413. https://doi.org/10.3892/mmr.2018.9626
MLA
Wang, G., Man, Z., Zhang, N., Xin, H., Li, Y., Sun, T., Sun, S."Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides". Molecular Medicine Reports 19.1 (2019): 407-413.
Chicago
Wang, G., Man, Z., Zhang, N., Xin, H., Li, Y., Sun, T., Sun, S."Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides". Molecular Medicine Reports 19, no. 1 (2019): 407-413. https://doi.org/10.3892/mmr.2018.9626