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Article

Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

  • Authors:
    • Qing Luo
    • Xue Li
    • Lu Zhang
    • Fangyi Yao
    • Zhen Deng
    • Cheng Qing
    • Rigu Su
    • Jianqing Xu
    • Yang Guo
    • Zikun Huang
    • Junming Li
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Clinical Laboratory Department, Jiangxi Province Blood Center, Nanchang, Jiangxi 330006, P.R. China, Intensive Care Unit, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 589-594
    |
    Published online on: November 8, 2018
       https://doi.org/10.3892/mmr.2018.9632
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Abstract

Peptidoglycan recognition protein‑1 (PGLYRP‑1) is a part of the innate immune system. It is well‑known that dysregulation of innate immune responses is present in patients with rheumatoid arthritis (RA). However, the role of Pglyrp1/PGLYPR‑1 in RA is poorly understood. Reverse transcription‑quantitative polymerase chain reaction was used to detect the level of Pglyrp1 in peripheral blood mononuclear cells. An ELISA was used to measure the level of PGLYPR‑1 in the serum, and correlation analysis was performed to analyze the association between the level of PGLYPR‑1 in the serum and clinical characteristics. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of PGLYPR‑1 in serum. The expression of PGLYPR‑1 in the serum of healthy controls compared with PGLYPR‑1 in the serum from patients with RA was significantly increased compared with patients with systemic lupus erythematosus (SLE). The level of PGLYPR‑1 in serum was correlated with rheumatoid factor and anti‑cyclic citrullinated peptide. ROC curve analysis suggested that PGLYPR‑1 in the serum may have significant value for RA diagnosis. In addition, the risk score based on PGLYPR‑1 in the serum also significantly discriminated the patients with RA from the disease controls (SLE). The present study suggested that increased expression of PGLYPR‑1 in the serum from patients with RA may serve as a potential biomarker for RA diagnosis.
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1 

Schett G and Gravallese E: Bone erosion in rheumatoid arthritis: Mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 8:656–664. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Crotti TN, Dharmapatni AA, Alias E, Zannettino AC, Smith MD and Haynes DR: The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Res Ther. 14:R2452012. View Article : Google Scholar : PubMed/NCBI

3 

Wong JB, Ramey DR and Singh G: Long-term morbidity, mortality, and economics of rheumatoid arthritis. Arthritis Rheum. 44:2746–2749. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Lajas C, Abasolo L, Bellajdel B, Hernández-García C, Carmona L, Vargas E, Lázaro P and Jover JA: Costs and predictors of costs in rheumatoid arthritis: A prevalence-based study. Arthritis Rheum. 49:64–70. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP and Yang M: Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from rheumatoid arthritis patients. Cell Physiol Biochem. 42:651–659. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Guan R and Mariuzza RA: Peptidoglycan recognition proteins of the innate immune system. Trends Microbiol. 15:127–134. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Royet J and Dziarski R: Peptidoglycan recognition proteins: Pleiotropic sensors and effectors of antimicrobial defences. Nat Rev Microbiol. 5:264–277. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Dziarski R and Gupta D: Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity. Innate Immun. 16:168–174. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Luo Q, Zeng L, Mei H, Huang Z, Luo X, Ye J, Li X, Guo Y and Li J: PD-L1-expressing neutrophils as a novel indicator to assess disease activity of rheumatoid arthritis. Int J Clin Exp Med. 10:7716–7724. 2017.

10 

Villanueva-Romero R, Gutiérrez-Cañas I, Carrión M, Pérez-García S, Seoane IV, Martínez C, Gomariz RP and Juarranz Y: The anti-inflammatory mediator, vasoactive intestinal peptide, modulates the differentiation and function of th subsets in rheumatoid arthritis. J Immunol Res. 2018:60437102018. View Article : Google Scholar : PubMed/NCBI

11 

Calabresi E, Petrelli F, Bonifacio AF, Puxeddu I and Alunno A: One year in review 2018: Pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 36:175–184. 2018.PubMed/NCBI

12 

Fodil M, Teixeira VH, Chaudru V, Hilliquin P, Bombardieri S, Balsa A, Westhovens R, Barrera P, Alves H, Migliorin P, et al: Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis. Scand J Rheumatol. 44:2–7. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315–324. 1988. View Article : Google Scholar : PubMed/NCBI

14 

Wang J, Shan Y, Jiang Z, Feng J, Li C, Ma L and Jiang Y: High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis. Clin Exp Immunol. 174:212–220. 2013.PubMed/NCBI

15 

Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB and van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38:44–48. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Hochberg MC: Updating the American College of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40:17251997. View Article : Google Scholar : PubMed/NCBI

17 

Luo Q, Zhang L, Li X, Fu B, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z and Li J: Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis. Clin Exp Immunol. 194:118–124. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Zhang F, Wu L, Qian J, Qu B, Xia S, La T, Wu Y, Ma J, Zeng J, Guo Q, et al: Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus. J Autoimmun. 75:96–104. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Park HJ, Noh JH, Eun JW, Koh YS, Seo SM, Park WS, Lee JY, Chang K, Seung KB, Kim PJ and Nam SW: Assessment and diagnostic relevance of novel serum biomarkers for early decision of ST-elevation myocardial infarction. Oncotarget. 6:12970–12983. 2015.PubMed/NCBI

20 

Alemao E, Guo Z, Frits ML, Iannaccone CK, Shadick NA and Weinblatt ME: Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study. Semin Arthritis Rheum. 47:630–638. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Haschka J, Englbrecht M, Hueber AJ, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Feuchtenberger M, et al: Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping anti-rheumatic therapy: Interim results from the prospective randomized controlled RETRO study. Ann Rheum Dis. 75:45–51. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Tydell CC, Yuan J, Tran P and Selsted ME: Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. J Immunol. 176:1154–1162. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Kedar MP, Acharya RV and Prakashini K: Performance of the 2010 American College of Rheumatology/European League against Rheumatism (ACR/EULAR) criteria for classification of rheumatoid arthritis in an Indian population: An observational study in a single centre. Indian J Med Res. 144:288–292. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Falkenburg WJJ, Kempers AC, Dekkers G, Ooijevaar-de Heer P, Bentlage AEH, Vidarsson G, van Schaardenburg D, Toes REM, Scherer HU and Rispens T: Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation. Rheumatology (Oxford). 56:2025–2030. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Schett G: The role of ACPAs in at-risk individuals: Early targeting of the bone and joints. Best Pract Res Clin Rheumatol. 31:53–58. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo Q, Li X, Zhang L, Yao F, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z, Huang Z, et al: Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Mol Med Rep 19: 589-594, 2019.
APA
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C. ... Li, J. (2019). Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Molecular Medicine Reports, 19, 589-594. https://doi.org/10.3892/mmr.2018.9632
MLA
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C., Su, R., Xu, J., Guo, Y., Huang, Z., Li, J."Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis". Molecular Medicine Reports 19.1 (2019): 589-594.
Chicago
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C., Su, R., Xu, J., Guo, Y., Huang, Z., Li, J."Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis". Molecular Medicine Reports 19, no. 1 (2019): 589-594. https://doi.org/10.3892/mmr.2018.9632
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Q, Li X, Zhang L, Yao F, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z, Huang Z, et al: Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Mol Med Rep 19: 589-594, 2019.
APA
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C. ... Li, J. (2019). Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Molecular Medicine Reports, 19, 589-594. https://doi.org/10.3892/mmr.2018.9632
MLA
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C., Su, R., Xu, J., Guo, Y., Huang, Z., Li, J."Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis". Molecular Medicine Reports 19.1 (2019): 589-594.
Chicago
Luo, Q., Li, X., Zhang, L., Yao, F., Deng, Z., Qing, C., Su, R., Xu, J., Guo, Y., Huang, Z., Li, J."Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis". Molecular Medicine Reports 19, no. 1 (2019): 589-594. https://doi.org/10.3892/mmr.2018.9632
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