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Article Open Access

Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis

  • Authors:
    • Lei Zhao
    • Weiwei Chi
    • Huan Cao
    • Weina Cui
    • Wenxia Meng
    • Wei Guo
    • Baoshan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Otorhinolaryngology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Laboratory of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050019, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 143-154
    |
    Published online on: November 9, 2018
       https://doi.org/10.3892/mmr.2018.9639
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Abstract

In order to identify potential diagnostic and prognostic biomarkers, and treatment targets for head and neck squamous cell carcinoma (HNSCC), the present study obtained the gene expression profiles in HNSCC through public data mining, and core genes were identified using a series of bioinformatics analysis methods and databases. A total of nine hub genes (SPP1, ITGA6, TMPRSS11D, MMP1, LAMC2, FAT1, ACTA1, SERPINE1 and CEACAM1) were identified to be significantly correlated with HNSCC. Furthermore, overall survival analysis demonstrated that the expression values of hub genes were associated with overall survival in HNSCC. Furthermore, certain of the identified genes, including, TMPRSS11D, ACTA1 and CEACAM1, have not been thoroughly investigated in HNSCC previously. Taken together, the nine hub genes obtained by screening in the present study may serve as potential tumor markers and important prognostic indicators for HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Chi W, Cao H, Cui W, Meng W, Guo W and Wang B: Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Mol Med Rep 19: 143-154, 2019.
APA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., & Wang, B. (2019). Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Molecular Medicine Reports, 19, 143-154. https://doi.org/10.3892/mmr.2018.9639
MLA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19.1 (2019): 143-154.
Chicago
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19, no. 1 (2019): 143-154. https://doi.org/10.3892/mmr.2018.9639
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Chi W, Cao H, Cui W, Meng W, Guo W and Wang B: Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Mol Med Rep 19: 143-154, 2019.
APA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., & Wang, B. (2019). Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Molecular Medicine Reports, 19, 143-154. https://doi.org/10.3892/mmr.2018.9639
MLA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19.1 (2019): 143-154.
Chicago
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19, no. 1 (2019): 143-154. https://doi.org/10.3892/mmr.2018.9639
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