Open Access

Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis

  • Authors:
    • Lei Zhao
    • Weiwei Chi
    • Huan Cao
    • Weina Cui
    • Wenxia Meng
    • Wei Guo
    • Baoshan Wang
  • View Affiliations

  • Published online on: November 9, 2018     https://doi.org/10.3892/mmr.2018.9639
  • Pages: 143-154
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In order to identify potential diagnostic and prognostic biomarkers, and treatment targets for head and neck squamous cell carcinoma (HNSCC), the present study obtained the gene expression profiles in HNSCC through public data mining, and core genes were identified using a series of bioinformatics analysis methods and databases. A total of nine hub genes (SPP1, ITGA6, TMPRSS11D, MMP1, LAMC2, FAT1, ACTA1, SERPINE1 and CEACAM1) were identified to be significantly correlated with HNSCC. Furthermore, overall survival analysis demonstrated that the expression values of hub genes were associated with overall survival in HNSCC. Furthermore, certain of the identified genes, including, TMPRSS11D, ACTA1 and CEACAM1, have not been thoroughly investigated in HNSCC previously. Taken together, the nine hub genes obtained by screening in the present study may serve as potential tumor markers and important prognostic indicators for HNSCC.
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January-2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhao L, Chi W, Cao H, Cui W, Meng W, Guo W and Wang B: Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Mol Med Rep 19: 143-154, 2019
APA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., & Wang, B. (2019). Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis. Molecular Medicine Reports, 19, 143-154. https://doi.org/10.3892/mmr.2018.9639
MLA
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19.1 (2019): 143-154.
Chicago
Zhao, L., Chi, W., Cao, H., Cui, W., Meng, W., Guo, W., Wang, B."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis". Molecular Medicine Reports 19, no. 1 (2019): 143-154. https://doi.org/10.3892/mmr.2018.9639