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Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

  • Authors:
    • Hua Li
    • Zijie Cheng
    • Yuanyuan Tang
    • Mengwen Feng
    • Anwen Yin
    • Hao Zhang
    • Jia Xu
    • Qijun Zhang
    • Jinsong Zhang
    • Lingmei Qian
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Departmant of General Medicine, Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, Jiangsu 210004, P.R. China, Department of Cardiology, YinZhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, Zhejiang 315040, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 302-308
    |
    Published online on: November 13, 2018
       https://doi.org/10.3892/mmr.2018.9658
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Abstract

Acute myocardial infarction (AMI) is a life‑threatening disease and seriously influences patient quality of life. Long non‑coding RNAs (lncRNAs), an emerging class of non‑coding genes, have attracted attention in research, however, whether lncRNAs serve a function in acute ischemic hypoxia remains to be elucidated. In the present study, an lncRNA microarray was used to analyze differential lncRNA expression in acute ischemic hypoxia. A total of 323 lncRNAs were identified, 168 of which were upregulated and 155 of which were downregulated. Gene Ontology and Pathway analyses were also used to identify the potential functions of dysregulated lncRNAs; it was predicted that these dysregulated lncRNAs may contribute to the initiation of AMI. It was demonstrated that an lncRNA termed sloyfley may influence acute ischemic hypoxia through its neighboring gene Peg3, which has been linked to brain ischemia hypoxia. In summary, the present study identified numerous lncRNAs, which may provide further opportunities for the development of novel therapeutic strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Cheng Z, Tang Y, Feng M, Yin A, Zhang H, Xu J, Zhang Q, Zhang J, Qian L, Qian L, et al: Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia. Mol Med Rep 19: 302-308, 2019.
APA
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H. ... Qian, L. (2019). Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia. Molecular Medicine Reports, 19, 302-308. https://doi.org/10.3892/mmr.2018.9658
MLA
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H., Xu, J., Zhang, Q., Zhang, J., Qian, L."Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia". Molecular Medicine Reports 19.1 (2019): 302-308.
Chicago
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H., Xu, J., Zhang, Q., Zhang, J., Qian, L."Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia". Molecular Medicine Reports 19, no. 1 (2019): 302-308. https://doi.org/10.3892/mmr.2018.9658
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Cheng Z, Tang Y, Feng M, Yin A, Zhang H, Xu J, Zhang Q, Zhang J, Qian L, Qian L, et al: Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia. Mol Med Rep 19: 302-308, 2019.
APA
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H. ... Qian, L. (2019). Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia. Molecular Medicine Reports, 19, 302-308. https://doi.org/10.3892/mmr.2018.9658
MLA
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H., Xu, J., Zhang, Q., Zhang, J., Qian, L."Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia". Molecular Medicine Reports 19.1 (2019): 302-308.
Chicago
Li, H., Cheng, Z., Tang, Y., Feng, M., Yin, A., Zhang, H., Xu, J., Zhang, Q., Zhang, J., Qian, L."Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia". Molecular Medicine Reports 19, no. 1 (2019): 302-308. https://doi.org/10.3892/mmr.2018.9658
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