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Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway

  • Authors:
    • Jin Yi
    • Ruohui Tang
    • Jing Yang
    • Yueqi Chen
    • Jun Fei
  • View Affiliations / Copyright

    Affiliations: Centre of Trauma of PLA, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China, Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 414-422
    |
    Published online on: November 15, 2018
       https://doi.org/10.3892/mmr.2018.9662
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Abstract

Streptococcus pyogenes (GAS) is a clinically significant bacterial strain that causes bacterial arthritis, osteomyelitis and implant infections. Infection complications can lead to serious bone destruction. Osteoclasts, the only type of cell with bone resorption function, participate in this process. Streptolysin O (SLO) is produced by almost all clinical Streptococcus pyogenes isolates. However, the role of SLO in bone infection caused by GAS had not been previously examined. The current study was performed to define the effects of SLO on receptor activator of NF‑κB ligand‑stimulated osteoclast differentiation in vitro. Results demonstrated that SLO decreased the phosphorylation of p65 and NF‑κB inhibitor α, suppressed c‑FOS and nuclear factor of activated T‑cells cytoplasmic 1, and downregulated the expression of osteoclast marker genes. SLO also induced apoptosis of mature osteoclasts. The results suggested that SLO blocked osteoclast activation during GAS infection. These findings may prove useful in the development of novel strategies for treating GAS‑associated bone infectious diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Yi J, Tang R, Yang J, Chen Y and Fei J: Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway. Mol Med Rep 19: 414-422, 2019.
APA
Yi, J., Tang, R., Yang, J., Chen, Y., & Fei, J. (2019). Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway. Molecular Medicine Reports, 19, 414-422. https://doi.org/10.3892/mmr.2018.9662
MLA
Yi, J., Tang, R., Yang, J., Chen, Y., Fei, J."Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway". Molecular Medicine Reports 19.1 (2019): 414-422.
Chicago
Yi, J., Tang, R., Yang, J., Chen, Y., Fei, J."Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway". Molecular Medicine Reports 19, no. 1 (2019): 414-422. https://doi.org/10.3892/mmr.2018.9662
Copy and paste a formatted citation
x
Spandidos Publications style
Yi J, Tang R, Yang J, Chen Y and Fei J: Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway. Mol Med Rep 19: 414-422, 2019.
APA
Yi, J., Tang, R., Yang, J., Chen, Y., & Fei, J. (2019). Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway. Molecular Medicine Reports, 19, 414-422. https://doi.org/10.3892/mmr.2018.9662
MLA
Yi, J., Tang, R., Yang, J., Chen, Y., Fei, J."Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway". Molecular Medicine Reports 19.1 (2019): 414-422.
Chicago
Yi, J., Tang, R., Yang, J., Chen, Y., Fei, J."Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway". Molecular Medicine Reports 19, no. 1 (2019): 414-422. https://doi.org/10.3892/mmr.2018.9662
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