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Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways

  • Authors:
    • Simeng Wu
    • Yajun Wang
    • Zhe Yuan
    • Siliang Wang
    • Hongmei Du
    • Xue Liu
    • Qiushi Wang
    • Xike Zhu
  • View Affiliations / Copyright

    Affiliations: Research Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Cord Blood Bank, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Medical Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Blood Transfusion, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 177-186
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/mmr.2018.9664
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Abstract

The influence and underlying mechanisms of human adipose‑derived stem cells (Hu‑ADSCs) on breast cancer cells in the tumor microenvironment remain unclear. Understanding the association between Hu‑ADSCs and cancer cells may provide targets for breast cancer treatment and reference for the clinical application of stem cells. Therefore, a Hu‑ADSC and breast cancer MCF7 cell coculture system was established to investigate the paracrine effects of Hu‑ADSCs on MCF7 cell migration and invasion, in addition to the potential mechanism of action by reverse transcription‑quantitative polymerase chain reaction and western blotting. Hu‑ADSCs enhanced MCF7 cell migration and invasion by decreasing the expression of epithelial marker E‑cadherin, and increasing the expression of interstitial marker N‑cadherin and epithelial‑mesenchymal transition (EMT) transcription factors in vitro. The EMT effect of cocultured MCF7 cells was inhibited with the addition of anti‑transforming growth factor (TGF)‑β1 or phosphoinositide 3‑kinase (PI3K) inhibitor LY294002, accompanied by a significant decrease in phosphorylated (p)‑mothers against decapentaplegic homolog (Smad) and p‑protein kinase B (AKT) expression. The data suggested that the paracrine effect of Hu‑ADSCs in the tumor microenvironment promoted the EMT of MCF7 cells by cross interacting with the TGF‑β/Smad and PI3K/AKT pathways.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Zare M, Bastami M, Solali S and Alivand MR: Aberrant miRNA promoter methylation and EMT-involving miRNAs in breast cancer metastasis: Diagnosis and therapeutic implications. J Cell Physiol. 233:3729–3744. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Iser IC, Ceschini SM, Onzi GR, Bertoni AP, Lenz G and Wink MR: Conditioned medium from adipose-derived stem cells (ADSCs) promotes epithelial-to-mesenchymal-like transition (EMT-Like) in glioma cells in vitro. Mol Neurobiol. 53:7184–7199. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Grzegrzolka J, Biala M, Wojtyra P, Kobierzycki C, Olbromski M, Gomulkiewicz A, Piotrowska A, Rys J, Podhorska-Okolow M and Dziegiel P: Expression of EMT Markers SLUG and TWIST in breast cancer. Anticancer Res. 35:3961–3968. 2015.PubMed/NCBI

6 

Bissell MJ and Hines WC: Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 17:320–329. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A and Ozawa K: NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. Cancer Res. 73:364–372. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Melzer C, Yang Y and Hass R: Interaction of MSC with tumor cells. Cell Commun Signal. 14:202016. View Article : Google Scholar : PubMed/NCBI

9 

Xu X, Zheng L, Yuan Q, Zhen G, Crane JL, Zhou X and Cao X: Transforming growth factor-β in stem cells and tissue homeostasis. Bone Res. 6:22018. View Article : Google Scholar : PubMed/NCBI

10 

Xie F, Ling L, van Dam H, Zhou F and Zhang L: TGF-β signaling in cancer metastasis. Acta Biochim Biophys Sin (Shanghai). 50:121–132. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Smith AL, Iwanaga R, Drasin DJ, Micalizzi DS, Vartuli RL, Tan AC and Ford HL: The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene. 31:5162–5171. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Lamouille S and Derynck R: Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 178:437–451. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Schrantz N, Bourgeade MF, Mouhamad S, Leca G, Sharma S and Vazquez A: p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFbeta-induced apoptosis in human Burkitt lymphoma B cells BL41. Mol Biol Cell. 12:3139–3151. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Lamouille S and Derynck R: Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. Cells Tissues Organs. 193:8–22. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Song K, Wang H, Krebs TL and Danielpour D: Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J. 25:58–69. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Xu Q, Wang L, Li H, Han Q, Li J, Qu X, Huang S and Zhao RC: Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β. Int J Oncol. 41:959–968. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wang Z, Li H, Zhang D, Liu X, Zhao F, Pang X and Wang Q: Effect of advanced glycosylation end products on apoptosis in human adipose tissue-derived stem cells in vitro. Cell Biosci. 5:32015. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Chu Y, Yue B, Ma X, Zhang G, Xiang H, Liu Y, Wang T, Wu X and Chen B: Adipose-derived mesenchymal stem cells promote osteosarcoma proliferation and metastasis by activating the STAT3 pathway. Oncotarget. 8:23803–23816. 2017.PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Shamir ER and Ewald AJ: Adhesion in mammary development: Novel roles for E-cadherin in individual and collective cell migration. Curr Top Dev Biol. 112:353–382. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Davies LC, Heldring N, Kadri N and Le Blanc K: Mesenchymal stromal cell secretion of programmed death-1 ligands regulates T cell mediated immunosuppression. Stem Cells. 35:766–776. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, et al: Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res. 65:3307–3318. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Kariminekoo S, Movassaghpour A, Rahimzadeh A, Talebi M, Shamsasenjan K and Akbarzadeh A: Implications of mesenchymal stem cells in regenerative medicine. Artif Cells Nanomed Biotechnol. 44:749–757. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Hong IS, Lee HY and Kang KS: Mesenchymal stem cells and cancer: Friends or enemies? Mutat Res. 768:98–106. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Yagi H and Kitagawa Y: The role of mesenchymal stem cells in cancer development. Front Genet. 4:2612013. View Article : Google Scholar : PubMed/NCBI

26 

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj and Horwitz E: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 8:315–317. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Bajetto A, Pattarozzi A, Corsaro A, Barbieri F, Daga A, Bosio A, Gatti M, Pisaturo V, Sirito R and Florio T: Different effects of human umbilical cord mesenchymal stem cells on glioblastoma stem cells by direct cell interaction or via released soluble factors. Front Cell Neurosci. 11:3122017. View Article : Google Scholar : PubMed/NCBI

28 

Takahara K, Ii M, Inamoto T, Komura K, Ibuki N, Minami K, Uehara H, Hirano H, Nomi H, Kiyama S, et al: Adipose-derived stromal cells inhibit prostate cancer cell proliferation inducing apoptosis. Biochem Biophys Res Commun. 446:1102–1107. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Kabashima-Niibe A, Higuchi H, Takaishi H, Masugi Y, Matsuzaki Y, Mabuchi Y, Funakoshi S, Adachi M, Hamamoto Y, Kawachi S, et al: Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells. Cancer Sci. 104:157–164. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Prantl L, Muehlberg F, Navone NM, Song YH, Vykoukal J, Logothetis CJ and Alt EU: Adipose tissue-derived stem cells promote prostate tumor growth. Prostate. 70:1709–1715. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Li X, Luo Q, Sun J and Song G: Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling. Biotechnol Lett. 37:511–521. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Freese KE, Kokai L, Edwards RP, Philips BJ, Sheikh MA, Kelley J, Comerci J, Marra KG, Rubin JP and Linkov F: adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: A systematic review. Cancer Res. 75:1161–1168. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Nieman KM, Romero IL, Van Houten B and Lengyel E: Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 1831:1533–1541. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Schweizer R, Tsuji W, Gorantla VS, Marra KG, Rubin JP and Plock JA: The role of adipose-derived stem cells in breast cancer progression and metastasis. Stem Cells Int. 2015:1209492015. View Article : Google Scholar : PubMed/NCBI

35 

Park YM, Yoo SH and Kim SH: Adipose-derived stem cells induced EMT-like changes in H358 lung cancer cells. Anticancer Res. 33:4421–4430. 2013.PubMed/NCBI

36 

Chou YS and Yang MH: Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy. J Chin Med Assoc. 78:438–445. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Yan XL, Fu CJ, Chen L, Qin JH, Zeng Q, Yuan HF, Nan X, Chen HX, Zhou JN, Lin YL, et al: Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway. Breast Cancer Res Treat. 132:153–164. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y and Johnson KR: Cadherin switching. J Cell Sci. 121:727–735. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Brzozowa M, Michalski M, Wyrobiec G, Piecuch A, Dittfeld A, Harabin-Slowinska M, Boron D and Wojnicz R: The role of Snail1 transcription factor in colorectal cancer progression and metastasis. Contemp Oncol (Pozn). 19:265–270. 2015.PubMed/NCBI

40 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Trivanovic D, Jaukovic A, Krstic J, Nikolić S, Okić Djordjević I, Kukolj T, Obradović H, Mojsilović S, Ilić V, Santibanez JF and Bugarski D: Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1. IUBMB Life. 68:190–200. 2016. View Article : Google Scholar : PubMed/NCBI

42 

McAndrews KM, McGrail DJ, Ravikumar N and Dawson MR: Mesenchymal stem cells induce directional migration of invasive breast cancer cells through TGF-β. Sci Rep. 5:169412015. View Article : Google Scholar : PubMed/NCBI

43 

Diaz VM, Vinas-Castells R and Garcia de Herreros A: Regulation of the protein stability of EMT transcription factors. Cell Adh Migr. 8:418–428. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Zhang YE: Non-Smad pathways in TGF-beta signaling. Cell Res. 19:128–139. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Wang Y, Yuan Z, Wang S, Du H, Liu X, Wang Q and Zhu X: Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. Mol Med Rep 19: 177-186, 2019.
APA
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X. ... Zhu, X. (2019). Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. Molecular Medicine Reports, 19, 177-186. https://doi.org/10.3892/mmr.2018.9664
MLA
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X., Wang, Q., Zhu, X."Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways". Molecular Medicine Reports 19.1 (2019): 177-186.
Chicago
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X., Wang, Q., Zhu, X."Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways". Molecular Medicine Reports 19, no. 1 (2019): 177-186. https://doi.org/10.3892/mmr.2018.9664
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Wang Y, Yuan Z, Wang S, Du H, Liu X, Wang Q and Zhu X: Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. Mol Med Rep 19: 177-186, 2019.
APA
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X. ... Zhu, X. (2019). Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. Molecular Medicine Reports, 19, 177-186. https://doi.org/10.3892/mmr.2018.9664
MLA
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X., Wang, Q., Zhu, X."Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways". Molecular Medicine Reports 19.1 (2019): 177-186.
Chicago
Wu, S., Wang, Y., Yuan, Z., Wang, S., Du, H., Liu, X., Wang, Q., Zhu, X."Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways". Molecular Medicine Reports 19, no. 1 (2019): 177-186. https://doi.org/10.3892/mmr.2018.9664
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