Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2019 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 19 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

  • Authors:
    • Jin Ju Park
    • Ji Eun Kim
    • Woo Bin Yun
    • Mi Rim Lee
    • Jun Young Choi
    • Bo Ram Song
    • Hong Joo Son
    • Yong Lim
    • Hyun‑Gu Kang
    • Beum Soo An
    • Seung Yun Yang
    • Sung Baek Seo
    • Dae Youn Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Gyeongsangnam‑do 50463, Republic of Korea, Department of Clinical Laboratory Science, College of Nursing and Healthcare Science, Dong‑Eui University, Busan 47340, Republic of Korea, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, North Chungcheong 28644, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 452-460
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/mmr.2018.9668
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cellulose in different forms has extensively been applied in biomedical treatments, including scaffolding, tissue engineering and tissue formation. To evaluate the therapeutic effects of a liquid bandage (LB) prepared with cellulose powders from Styela clava tunics (SCT) and Broussonetia kazinoki bark (BSLB) for healing cutaneous wounds, the remedial effects of a low concentration (LoBSLB) and a high concentration (HiBSLB) of BSLB on skin regeneration and toxicity in Sprague Dawley rats. Results indicated that the total area of skin involved in the surgical wound was lower in the BSLB‑treated group compared with the Vehicle‑treated group at days 4‑12, although some variations were observed in the HiBSLB‑treated group. In addition, the BSLB‑treated group showed significantly enhanced width of the re‑epithelialization region and epidermal thickness when compared with the Vehicle‑treated group. Furthermore, significant stimulation in the expression level of collagen‑1 and the signaling pathway of VEGF after topical application of BSLB was indicated. No liver or kidney toxicities were detected for either doses of BSLB. Overall, the results of the present study suggest that BSLB accelerates the process of wound healing in surgical skin wounds of Sprague Dawley rats through stimulation of re‑epithelialization and connective tissue formation, without any accompanying significant toxicity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Crépy L, Monchau F, Chai F, Raoul G, Hivart P, Hildebrand HF, Martin P and Joly N: Evaluation of a bio-based hydrophobic cellulose laurate film as biomaterial-study on biodegradation and cytocompatibility. J Biomed Mater Res B Appl Biomater. 100:1000–1008. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Lavoine N, Desloges I, Dufresne A and Bras J: Microfibrillated cellulose-its barrier properties and applications in cellulosic materials: A review. Carbohydr Polym. 90:735–764. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Spencer PC, Schmidt B, Samtleben W, Bosch T and Gurland HJ: Ex vivo model of hemodialysis membrane biocompatibility. Trans Am Soc Artif Intern Organs. 31:495–498. 1985.PubMed/NCBI

4 

Gissinger D and Stamm A: A comparative study of cross-linked carboxymethylcellulose as tablet disintegrant. Pharm Ind. 42:189–192. 1980.

5 

Franz G: Polysaccharides in pharmacy. Adv Polymer Sci. 76:1–30. 1986. View Article : Google Scholar

6 

Ito H, Shibata T, Miyamoto T, Noishiki Y and Inagaki H: Formation of polyelectrolyte complexes between cellulose derivatives and their blood compatibility. J Appl Polym Sci. 31:2491–2500. 1986. View Article : Google Scholar

7 

Matasuzaki K, Yamamoto I, Sato T and Oshima R: Synthesis of water-soluble branched polysaccharides and their antitumor activity, 1. Branched polysaccharides from cellulose acetate. Macromol Chem Phys. 186:449–456. 1985. View Article : Google Scholar

8 

Lee CG, Da Silva CA, Lee JY, Hartl D and Elias JA: Chitin regulation of immune responses: An old molecule with new roles. Curr Opin Immunol. 20:684–689. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Hirano S: Chitin biotechnology applications. Biotechnol Annu Rev. 2:237–258. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Mu X, Yu H, Zhang C, Chen X, Cheng Z, Bai R, Wu X, Yu Q, Wu C and Diao Y: Nano-porous nitrocellulose liquid bandage modulates cell and cytokine response and accelerates cutaneous wound healing in a mouse model. Carbohydr Polym. 136:618–629. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Fricain JC, Granja PL, Barbosa MA, de Jéso B, Barthe N and Baquey C: Cellulose phosphates as biomaterials. In vivo biocompatibility studies. Biomaterials. 23:971–980. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Martson M, Viljanto J, Hurme T, Laippala P and Saukko P: Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat. Biomaterials. 20:1989–1995. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Petkewich R: Liquid bandages. Chem Eng News. 86:612008. View Article : Google Scholar

14 

Choi SJ, Lee JH, Lee YH, Hwang DY and Kim HD: Synthesis and properties of polyurethane-urea-based liquid bandage materials. J Appl Polym Sci. 121:3516–3524. 2011. View Article : Google Scholar

15 

Shepler TR and Seiff SR: Use of isobutyl cyanoacrylate tissue adhesive to stabilize external eyelid weights in temporary treatment of facial palsies. Ophthalmic Plast Reconstr Surg. 17:169–173. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Taravella MJ and Chang CD: 2-Octyl cyanoacrylate medical adhesive in treatment of a corneal perforation. Cornea. 20:220–221. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Suhr MA, Günther M and Springer IN: Ptosis relief after botox injection using dermabond. Plast Reconstr Surg. 114:262–263. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Osaki TH, Osaki MH, Belfort R Jr, Osaki T, Sant'anna AE and Haraguchi DK: Management of progressive myopathic blepharoptosis with daily application of octyl-2-cyanoacrylate liquid bandage. Ophthalmic Plast Reconstr Surg. 25:264–266. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Osaki TH, Osaki MH and Osaki TH: Temporary management of involutional entropion with octyl-2-cyanoacrylate liquid bandage application. Arq Bras Oftalmol. 73:120–124. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Song SH, Kim JE, Lee YJ, Kwak MH, Sung GY, Kwon SH, Son HJ, Lee HS, Jung YJ and Hwang DY: Cellulose film regenerated from Styela clava tunics have biodegradability, toxicity and biocompatibility in the skin of SD rats. J Mater Sci Mater Med. 25:1519–1530. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Hwang DY, Chae KR, Kang TS, Hwang JH, Lim CH, Kang HK, Goo JS, Lee MR, Lim HJ, Min SH, et al: Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 16:805–813. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Eaglstein WH: Moist wound healing with occlusive dressings: A clinical focus. Dermatol Surg. 27:175–181. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Nissen NN and DiPietro LA: Angiogenic mediators in healing wounds. angiogenesis in Health and Disease. Gabor MR: Marcel Dekker Inc.; New York: pp. 417–427. 2000

24 

Ferrara N: Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res. 55:15–36. 2000.PubMed/NCBI

25 

Ferrara N: Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 208:C1358–C1366. 2001. View Article : Google Scholar

26 

Taub PJ, Silver L and Weinberg H: Plastic surgical perspectives on vascular endothelial growth factor as gene therapy for angiogenesis. Plast Reconstr Surg. 105:1034–1042. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V and Ferrara N: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem. 273:30336–30343. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K and Aird WC: Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 24:294–300. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Zheng J, Wen Y, Song Y, Wang K, Chen DB and Magness RR: Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod. 78:143–150. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Frank S, Hübner G, Breier G, Longaker MT, Greenhalgh DG and Werner S: Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem. 270:12607–12613. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Kant V, Gopal A and Kumar D, Bag S, Kurade NP, Kumar A, Tandan SK and Kumar D: Topically applied substance P enhanced healing of open excision wound in rats. Eur J Pharmacol. 715:345–353. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Sun X, Cheng L, Zhu W, Hu C, Jin R, Sun B, Shi Y, Zhang Y and Cui W: Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin. Colloids Surf B Biointerfaces. 115:61–70. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Mian M, Beghè F and Mian E: Collagen as a pharmacological approach in wound healing. Int J Tissue React. 14 Suppl:S1–S9. 1992.

34 

Kwak MH, Go J, Kim JE, Lee YJ, Lee SH, Lee HS, Son HJ, Jung YJ and Hwang DY: Property and efficacy analysis of hydrocolloid membrane containing Styela clava tunic on the wound repair of skin in SD rats. Biomat Res. 17:91–101. 2013.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Park JJ, Kim JE, Yun WB, Lee MR, Choi JY, Song BR, Son HJ, Lim Y, Kang HG, An BS, An BS, et al: Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats. Mol Med Rep 19: 452-460, 2019.
APA
Park, J.J., Kim, J.E., Yun, W.B., Lee, M.R., Choi, J.Y., Song, B.R. ... Hwang, D.Y. (2019). Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats. Molecular Medicine Reports, 19, 452-460. https://doi.org/10.3892/mmr.2018.9668
MLA
Park, J. J., Kim, J. E., Yun, W. B., Lee, M. R., Choi, J. Y., Song, B. R., Son, H. J., Lim, Y., Kang, H., An, B. S., Yang, S. Y., Seo, S. B., Hwang, D. Y."Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats". Molecular Medicine Reports 19.1 (2019): 452-460.
Chicago
Park, J. J., Kim, J. E., Yun, W. B., Lee, M. R., Choi, J. Y., Song, B. R., Son, H. J., Lim, Y., Kang, H., An, B. S., Yang, S. Y., Seo, S. B., Hwang, D. Y."Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats". Molecular Medicine Reports 19, no. 1 (2019): 452-460. https://doi.org/10.3892/mmr.2018.9668
Copy and paste a formatted citation
x
Spandidos Publications style
Park JJ, Kim JE, Yun WB, Lee MR, Choi JY, Song BR, Son HJ, Lim Y, Kang HG, An BS, An BS, et al: Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats. Mol Med Rep 19: 452-460, 2019.
APA
Park, J.J., Kim, J.E., Yun, W.B., Lee, M.R., Choi, J.Y., Song, B.R. ... Hwang, D.Y. (2019). Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats. Molecular Medicine Reports, 19, 452-460. https://doi.org/10.3892/mmr.2018.9668
MLA
Park, J. J., Kim, J. E., Yun, W. B., Lee, M. R., Choi, J. Y., Song, B. R., Son, H. J., Lim, Y., Kang, H., An, B. S., Yang, S. Y., Seo, S. B., Hwang, D. Y."Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats". Molecular Medicine Reports 19.1 (2019): 452-460.
Chicago
Park, J. J., Kim, J. E., Yun, W. B., Lee, M. R., Choi, J. Y., Song, B. R., Son, H. J., Lim, Y., Kang, H., An, B. S., Yang, S. Y., Seo, S. B., Hwang, D. Y."Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats". Molecular Medicine Reports 19, no. 1 (2019): 452-460. https://doi.org/10.3892/mmr.2018.9668
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team