Open Access

Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo

  • Authors:
    • Guixiang Tian
    • Xiue Sun
    • Jingkun Bai
    • Jinhua Dong
    • Bo Zhang
    • Zhiqin Gao
    • Jingliang Wu
  • View Affiliations

  • Published online on: November 22, 2018     https://doi.org/10.3892/mmr.2018.9687
  • Pages: 133-142
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A novel GHH copolymer was synthesized using hyaluronic acid modified with glycyrrhetinic acid and L‑histidine (His), and doxorubicin‑loaded GHH nanoparticles (DOX/GHH) were prepared for liver‑targeted drug delivery and pH‑responsive drug release. In the present study, GHH nanoparticles were characterized, and their pH‑responsive behaviors were evaluated at different pH levels. The antitumor effect of the DOX/GHH nanoparticles was investigated in vitro and in vivo. Results showed that the DOX/GHH nanoparticles were spherical, and the particle sizes ranged from 238.1 to 156.7 nm with an increase in the degree of substitution of His. The GHH nanoparticles were obviously internalized into human hepatoblastoma cells. In vitro cytotoxicity assay results showed that the DOX/GHH nanoparticles exhibited a dose‑dependent antitumor effect. Compared with free DOX, the DOX/GHH nanoparticles displayed higher antitumor efficacy. These results indicate that GHH nanoparticles could be a promising nano‑delivery carrier of hydrophobic drugs for liver‑targeted therapy.
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January-2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Tian G, Sun X, Bai J, Dong J, Zhang B, Gao Z and Wu J: Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo. Mol Med Rep 19: 133-142, 2019
APA
Tian, G., Sun, X., Bai, J., Dong, J., Zhang, B., Gao, Z., & Wu, J. (2019). Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo. Molecular Medicine Reports, 19, 133-142. https://doi.org/10.3892/mmr.2018.9687
MLA
Tian, G., Sun, X., Bai, J., Dong, J., Zhang, B., Gao, Z., Wu, J."Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo". Molecular Medicine Reports 19.1 (2019): 133-142.
Chicago
Tian, G., Sun, X., Bai, J., Dong, J., Zhang, B., Gao, Z., Wu, J."Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo". Molecular Medicine Reports 19, no. 1 (2019): 133-142. https://doi.org/10.3892/mmr.2018.9687