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Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice

  • Authors:
    • Yuzhu Cheng
    • Zhanlun Ou
    • Qingguo Li
    • Juan Yang
    • Min Hu
    • Yubin Zhou
    • Xiaodong Zhuang
    • Zhenyu Jason Zhang
    • Shixia Guan
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, School of Materials Science and Engineering, College of Engineering, Nanyang Technological University, Singapore 639798, Republic of Singapore, Target Discovery Institute NDM Research Building, University of Oxford, Oxford OX3 7FZ, UK, School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 490-498
    |
    Published online on: November 23, 2018
       https://doi.org/10.3892/mmr.2018.9689
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Abstract

The present study investigated the feasibility of improving the tumor‑targeting efficacy and decreasing the toxicity of liposomal cabazitaxel (Cab) with aptamer modification. The process involved preparing aptamer (TLS1c)‑modified liposomes and studying the behavior of the liposomes in vitro and in vivo. TLS1c as an aptamer, which has high specificity for BNL 1ME A.7R.1 (MEAR) cells, was conjugated with Cab liposomes (Cab/lipo) to enhance MEAR tumor tissue targeting. Confocal laser scanning microscopy and flow cytometry analyses demonstrated that the fluorescence of the liposomes modified with the aptamer was notably stronger compared with that of the unmodified liposomes. Furthermore, the biodistribution data of the modified liposomes tested in tumor‑bearing mice revealed high specificity of biotinylated TLS1c‑modified Cab/lipo (BioTL‑Cab/lipo) for tumor tissues. Furthermore, the modified liposomes demonstrated decreased cytotoxicity and simultaneously retained potent inhibition against tumor growth. It is likely that the specific binding of the aptamer (TLS1c) to the targeted cells (MEAR) facilitates the binding of the liposomes to the targeted cells. Therefore, BioTL‑Cab/lipo may be considered as a promising delivery system to improve cell targeting and reduce drug toxicity in the treatment of cancer.
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1 

Force T and Kerkela R: Cardiotoxicity of the new cancer therapeutics-mechanisms of, and approaches to, the problem. Drug Discov Today. 13:778–784. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Tuerk C and Gold L: Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage t4 DNA polymerase. Science. 249:505–510. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Shangguan D, Li Y, Tang Z, Cao ZC, Chen HW, Mallikaratchy P, Sefah K, Yang CJ and Tan W: Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci USA. 103:11838–11843. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Taghdisi SM, Lavaee P, Ramezani M and Abnous K: Reversible Targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. Eur J Pharm Biopharm. 77:200–206. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Shigdar S, Macdonald J, O'Connor M, Wang T, Xiang D, Al Shamaileh H, Qiao L, Wei M, Zhou SF, Zhu Y, et al: Aptamers as theranostic agents: Modifications, serum stability and functionalisation. Sensors (Basel). 13:13624–13637. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Fang X and Tan W: Aptamers generated from cell-SELEX for molecular medicine: A chemical biology approach. Acc Chem Res. 43:48–57. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Alibolandi M, Ramezani M, Abnous K and Hadizadeh F: AS1411 aptamer-decorated biodegradable polyethylene glycol-poly(lactic-co-glycolic acid) nanopolymersomes for the targeted delivery of gemcitabine to non-small cell lung cancer in vitro. J Pharm Sci. 105:1741–1750. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Keefe AD, Pai S and Ellington A: Aptamers as therapeutics. Nat Rev Drug Discov. 9:537–550. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Sperlich C and Saad F: Optimal management of patients receiving cabazitaxel-based chemotherapy. Can Urol Assoc J. 7 (1-2 Suppl 1):S18–S24. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardona D, Witek RP, Liu C and Tan W: Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80:721–728. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Ishii M, Koyama A, Iseki H, Narumi H, Yokoyama N and Kojima N: Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j I as immunotherapy for Japanese cesar pollinosis in mice. Int Immunopharmacol. 10:1041–1046. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Banghan AD and Horne RW: Negative staining of phospholipids and their structural modification by-surface active agents as observed in electron microscope. J Mol Biol. 8:660–668. 1964. View Article : Google Scholar : PubMed/NCBI

13 

Szoka F Jr and Papahadjopoulos D: Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci USA. 75:4194–4198. 1978. View Article : Google Scholar : PubMed/NCBI

14 

He C, Hu Y, Yin L, Tang C and Yin C: Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 31:3657–3666. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Sethna SM and Shah NM: The chemistry of coumarins. Chem Rev. 36:1–62. 1945. View Article : Google Scholar

16 

Malhotra M, Dhingra R, Sharma T, Deep A, Narasimhan B, Phogat P and Sharma PC: Cabazitaxel: A novel drug for hormone-refractory prostate cancer. Mini Rev Med Chem. 13:915–920. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Medarova Z, Pham W, Farrar C, Petkova V and Moore A: In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 13:372–377. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Chen Z, Tai Z, Gu F, Hu C, Zhu Q and Gao S: Aptamer-mediated delivery of docetaxel to prostate cancer through polymeric nanoparticles for enhancement of antitumor efficacy. Eur J Pharm Biopharm. 107:130–141. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Brown DM and Todd AR: 13. Nucleotides. Part X. Some observations on the structure and chemical behaviour of the nucleic acids. J Chem Soc. 52–58. 1952. View Article : Google Scholar

20 

Beaucage SL and Caruthers MH: Deoxynucleoside phosphoramidites-A new class of key intermediates for deoxypolynucleotide synthesis. Tetrahedron Lett. 22:1859–1862. 1981. View Article : Google Scholar

21 

Reese CB: Oligo-and poly-nucleotides: 50 years of chemical synthesis. Org Biomol Chem. 3:3851–3868. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R and Langer R: Nanocarriers as an emerging platform for cancer therap. Nat Nanotechnol. 2:751–760. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Shrivastava G, Hyodo M, Yoshimura SH, Akita H and Harashima H: Identification of a nucleoporin358-specific RNA aptamer for use as a nucleus-targeting liposomal delivery system. Nucleic Acid Ther. 26:286–298. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Scaggiantie B, Dapas B, Farra R, Grassi M, Pozzato G, Giansante C, Fiotti N, Tamai E, Tonon F and Grassi G: Aptamers as targeting delivery devices or anti-cancer drugs for fighting tumors. Curr Drug Metab. 14:565–582. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Aravind A, Jeyamohan P, Nair R, Veeranarayanan S, Nagaoka Y, Yoshida Y, Maekawa T and Kumar DS: AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery. Biotechnol Bioeng. 109:2920–2931. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Li L, Hou J, Liu X, Guo Y, Wu Y, Zhang L and Yang Z: Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanoma. Biomaterials. 35:3840–3850. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Chu C, Xu P, Zhao H, Chen Q, Chen D, Hu H, Zhao X and Qiao M: Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes. Asian J Pharm Sci. 11:655–661. 2016. View Article : Google Scholar

28 

Batzei S and Korn ED: Interaction of phospholipid vesicles with cells. Endocytosis and fusion as alternate mechanisms for the uptake of lipid-soluble and water-soluble molecules. J Cell Biol. 66:621–634. 1975. View Article : Google Scholar : PubMed/NCBI

29 

Szymanowskia F, Hugoa AA, Alvesc P, Simõesc PN, Gómez-Zavagliaa A and Péreza PF: Endocytosis and intracellular traffic of cholesterol-PDMAEMA liposome complexes in human epithelial-like cells. Colloids Surf B Biointerfaces. 156:38–43. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Le UM and Cui Z: Biodistribution and tumor-accumulation of gadolinium (Gd) encapsulated in long-circulating liposomes in tumor-bearing mice for potential neutron capture therapy. Int J Pharm. 320:96–103. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Ou Z, Li Q, Yang J, Hu M, Zhou Y, Zhuang X, Zhang ZJ and Guan S: Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice. Mol Med Rep 19: 490-498, 2019.
APA
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y. ... Guan, S. (2019). Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice. Molecular Medicine Reports, 19, 490-498. https://doi.org/10.3892/mmr.2018.9689
MLA
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y., Zhuang, X., Zhang, Z. J., Guan, S."Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice". Molecular Medicine Reports 19.1 (2019): 490-498.
Chicago
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y., Zhuang, X., Zhang, Z. J., Guan, S."Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice". Molecular Medicine Reports 19, no. 1 (2019): 490-498. https://doi.org/10.3892/mmr.2018.9689
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Ou Z, Li Q, Yang J, Hu M, Zhou Y, Zhuang X, Zhang ZJ and Guan S: Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice. Mol Med Rep 19: 490-498, 2019.
APA
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y. ... Guan, S. (2019). Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice. Molecular Medicine Reports, 19, 490-498. https://doi.org/10.3892/mmr.2018.9689
MLA
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y., Zhuang, X., Zhang, Z. J., Guan, S."Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice". Molecular Medicine Reports 19.1 (2019): 490-498.
Chicago
Cheng, Y., Ou, Z., Li, Q., Yang, J., Hu, M., Zhou, Y., Zhuang, X., Zhang, Z. J., Guan, S."Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice". Molecular Medicine Reports 19, no. 1 (2019): 490-498. https://doi.org/10.3892/mmr.2018.9689
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