1
|
Kobayashi A, Ohta T and Yamamoto M: Unique
function of the Nrf2-Keap1 pathway in the inducible expression of
antioxidant and detoxifying enzymes. Methods Enzymol. 378:273–286.
2004. View Article : Google Scholar : PubMed/NCBI
|
2
|
Wakabayashi N, Itoh K, Wakabayashi J,
Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F,
Roop DR, et al: Keap1-null mutation leads to postnatal lethality
due to constitutive Nrf2 activation. Nat Genet. 35:238–245. 2003.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Heiss EH, Schachner D, Werner ER and
Dirsch VM: Active NF-E2-related factor (Nrf2) contributes to keep
endothelial NO synthase (eNOS) in the coupled state: Role of
reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1)
levels. J Biol Chem. 284:31579–31586. 2009. View Article : Google Scholar : PubMed/NCBI
|
4
|
Kobayashi A, Kang MI, Okawa H, Ohtsuji M,
Zenke Y, Chiba T, Igarashi K and Yamamoto M: Oxidative stress
sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to
regulate proteasomal degradation of Nrf2. Mol Cell Biol.
24:7130–7139. 2004. View Article : Google Scholar : PubMed/NCBI
|
5
|
Wang P, Li CG, Qi Z, Cui D and Ding S:
Acute exercise stress promotes Ref1/Nrf2 signalling and increases
mitochondrial antioxidant activity in skeletal muscle. Exp Physiol.
101:410–420. 2016. View
Article : Google Scholar : PubMed/NCBI
|
6
|
Tsou YH, Shih CT, Ching CH, Huang JY, Jen
CJ, Yu L, Kuo YM, Wu FS and Chuang JI: Treadmill exercise activates
Nrf2 antioxidant system to protect the nigrostriatal dopaminergic
neurons from MPP+ toxicity. Exp Neurol. 263:50–62. 2015. View Article : Google Scholar : PubMed/NCBI
|
7
|
Merry TL and Ristow M: Nuclear factor
erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced
mitochondrial biogenesis and the anti-oxidant response in mice. J
Physiol. 594:5195–5207. 2016. View
Article : Google Scholar : PubMed/NCBI
|
8
|
Kumar RR, Narasimhan M, Shanmugam G, Hong
J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM,
Hoidal JR and Rajasekaran NS: Abrogation of Nrf2 impairs
antioxidant signaling and promotes atrial hypertrophy in response
to high-intensity exercise stress. J Transl Med. 14:862016.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Done AJ and Traustadottir T: Nrf2 mediates
redox adaptations to exercise. Redox Biol. 10:191–199. 2016.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Ying SY, Chang DC and Lin SL: The microRNA
(miRNA): Overview of the RNA genes that modulate gene function. Mol
Biotechnol. 38:257–268. 2008. View Article : Google Scholar : PubMed/NCBI
|
11
|
Alvarez-Garcia I and Miska EA: MicroRNA
functions in animal development and human disease. Development.
132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI
|
12
|
Bushati N and Cohen SM: microRNA
functions. Annu Rev Cell Dev Biol. 23:175–205. 2007. View Article : Google Scholar : PubMed/NCBI
|
13
|
Bartel DP: MicroRNAs: Target recognition
and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI
|
14
|
Yang M, Yao Y, Eades G, Zhang Y and Zhou
Q: miR-28 regulates Nrf2 expression through a Keap1-independent
mechanism. Breast Cancer Res Treat. 129:983–991. 2011. View Article : Google Scholar : PubMed/NCBI
|
15
|
Zhou S, Ye W, Zhang Y, Yu D, Shao Q, Liang
J and Zhang M: miR-144 reverses chemoresistance of hepatocellular
carcinoma cell lines by targeting Nrf2-dependent antioxidant
pathway. Am J Transl Res. 8:2992–3002. 2016.PubMed/NCBI
|
16
|
Narasimhan M, Patel D, Vedpathak D,
Rathinam M, Henderson G and Mahimainathan L: Identification of
novel microRNAs in post-transcriptional control of Nrf2 expression
and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One.
7:e511112012. View Article : Google Scholar : PubMed/NCBI
|
17
|
Khan AUH, Rathore MG, Allende-Vega N, Vo
DN, Belkhala S, Orecchioni S, Talarico G, Bertolini F, Cartron G,
Lecellier CH and Villalba M: Human leukemic cells performing
oxidative phosphorylation (OXPHOS) generate an antioxidant response
independently of reactive oxygen species (ROS) production.
EBioMedicine. 3:43–53. 2015. View Article : Google Scholar : PubMed/NCBI
|
18
|
van Jaarsveld MT, Helleman J, Boersma AW,
van Kuijk PF, van Ijcken WF, Despierre E, Vergote I, Mathijssen RH,
Berns EM, Verweij J, et al: miR-141 regulates KEAP1 and modulates
cisplatin sensitivity in ovarian cancer cells. Oncogene.
32:4284–4293. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Shi L, Wu L, Chen Z, Yang J, Chen X, Yu F,
Zheng F and Lin X: miR-141 activates Nrf2-dependent antioxidant
pathway via down-regulating the expression of keap1 conferring the
resistance of hepatocellular carcinoma cells to 5-fluorouracil.
Cell Physiol Biochem. 35:2333–2348. 2015. View Article : Google Scholar : PubMed/NCBI
|
20
|
Aguiar AS Jr, Duzzioni M, Remor AP,
Tristão FS, Matheus FC, Raisman-Vozari R, Latini A and Prediger RD:
Moderate-intensity physical exercise protects against experimental
6-hydroxydopamine-induced hemiparkinsonism through Nrf2-antioxidant
response element pathway. Neurochem Res. 41:64–72. 2016. View Article : Google Scholar : PubMed/NCBI
|
21
|
Wan C, Han R, Liu L, Zhang F, Li F, Xiang
M and Ding W: Role of miR-155 in fluorooctane sulfonate-induced
oxidative hepatic damage via the Nrf2-dependent pathway. Toxicol
Appl Pharmacol. 295:85–93. 2016. View Article : Google Scholar : PubMed/NCBI
|
22
|
Safdar A, Abadi A, Akhtar M, Hettinga BP
and Tarnopolsky MA: miRNA in the regulation of skeletal muscle
adaptation to acute endurance exercise in C57Bl/6J male mice. PLoS
One. 4:e56102009. View Article : Google Scholar : PubMed/NCBI
|
23
|
Aoi W, Ichikawa H, Mune K, Tanimura Y,
Mizushima K, Naito Y and Yoshikawa T: Muscle-enriched microRNA
miR-486 decreases in circulation in response to exercise in young
men. Front Physiol. 4:802013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Gong H, Xie J, Zhang N, Yao L and Zhang Y:
MEF2A binding to the Glut4 promoter occurs via an AMPKα2-dependent
mechanism. Med Sci Sports Exerc. 43:1441–1450. 2011. View Article : Google Scholar : PubMed/NCBI
|
25
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
26
|
Agarwal V, Bell GW, Nam JW and Bartel DP:
Predicting effective microRNA target sites in mammalian mRNAs.
ELife. 4:2015. View Article : Google Scholar
|
27
|
Lewis BP, Burge CB and Bartel DP:
Conserved seed pairing, often flanked by adenosines, indicates that
thousands of human genes are microRNA targets. Cell. 120:15–20.
2005. View Article : Google Scholar : PubMed/NCBI
|
28
|
Friedman RC, Farh KK, Burge CB and Bartel
DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome
Res. 19:92–105. 2009. View Article : Google Scholar : PubMed/NCBI
|
29
|
Betel D, Wilson M, Gabow A, Marks DS and
Sander C: The microRNA.org resource: Targets and expression.
Nucleic Acids Res. 36:(Database Issue). D149–D153. 2008. View Article : Google Scholar : PubMed/NCBI
|
30
|
Enright AJ, John B, Gaul U, Tuschl T,
Sander C and Marks DS: MicroRNA targets in drosophila. Genome Biol.
5:R12003. View Article : Google Scholar : PubMed/NCBI
|
31
|
Paraskevopoulou MD, Georgakilas G,
Kostoulas N, Vlachos IS, Vergoulis T, Reczko M, Filippidis C,
Dalamagas T and Hatzigeorgiou AG: DIANA-microT web server v5.0:
Service integration into miRNA functional analysis workflows.
Nucleic Acids Res. 41:(Web Server Issue). W169–W173. 2013.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Reczko M, Maragkakis M, Alexiou P, Grosse
I and Hatzigeorgiou AG: Functional microRNA targets in protein
coding sequences. Bioinformatics. 28:771–776. 2012. View Article : Google Scholar : PubMed/NCBI
|
33
|
Wang Z: The guideline of the design and
validation of miRNA mimics. Methods Mol Biol. 676:211–223. 2011.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Betel D, Koppal A, Agius P, Sander C and
Leslie C: Comprehensive modeling of microRNA targets predicts
functional non-conserved and non-canonical sites. Genome Biol.
11:R902010. View Article : Google Scholar : PubMed/NCBI
|
35
|
Tang L, Chen HY, Hao NB, Tang B, Guo H,
Yong X, Dong H and Yang SM: microRNA inhibitors: Natural and
artificial sequestration of microRNA. Cancer Lett. 407:139–147.
2017. View Article : Google Scholar : PubMed/NCBI
|
36
|
Jiang HK, Miao Y, Wang YH, Zhao M, Feng
ZH, Yu XJ, Liu JK and Zang WJ: Aerobic interval training protects
against myocardial infarction-induced oxidative injury by enhancing
antioxidase system and mitochondrial biosynthesis. Clin Exp
Pharmacol Physiol. 41:192–201. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Tutakhail A, Nazary QA, Lebsir D,
Kerdine-Romer S and Coudore F: Induction of brain Nrf2-HO-1 pathway
and antinociception after different physical training paradigms in
mice. Life Sci. 209:149–156. 2018. View Article : Google Scholar : PubMed/NCBI
|
38
|
Done AJ, Newell MJ and Traustadottir T:
Effect of exercise intensity on Nrf2 signalling in young men. Free
Radic Res. 51:646–655. 2017. View Article : Google Scholar : PubMed/NCBI
|
39
|
Filipowicz W, Bhattacharyya SN and
Sonenberg N: Mechanisms of post-transcriptional regulation by
microRNAs: Are the answers in sight? Nat Rev Genet. 9:102–114.
2008. View Article : Google Scholar : PubMed/NCBI
|
40
|
Bartel DP: MicroRNAs: Genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Furukawa M and Xiong Y: BTB protein Keap1
targets antioxidant transcription factor Nrf2 for ubiquitination by
the Cullin 3-Roc1 ligase. Mol Cell Biol. 25:162–171. 2005.
View Article : Google Scholar : PubMed/NCBI
|
42
|
Kim JH, Lee KS, Lee DK, Kim J, Kwak SN, Ha
KS, Choe J, Won MH, Cho BR, Jeoung D, et al: Hypoxia-responsive
microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular
endothelial growth factor axis by targeting cullin 3. Antioxid
Redox Signal. 21:2469–2482. 2014. View Article : Google Scholar : PubMed/NCBI
|
43
|
Sihvola V and Levonen AL: Keap1 as the
redox sensor of the antioxidant response. Arch Biochem Biophys.
617:94–100. 2017. View Article : Google Scholar : PubMed/NCBI
|
44
|
Villeneuve NF, Lau A and Zhang DD:
Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin
proteasome system: An insight into cullin-ring ubiquitin ligases.
Antioxid Redox Signal. 13:1699–1712. 2010. View Article : Google Scholar : PubMed/NCBI
|
45
|
Li W, Yu S, Liu T, Kim JH, Blank V, Li H
and Kong AN: Heterodimerization with small Maf proteins enhances
nuclear retention of Nrf2 via masking the NESzip motif. Biochim
Biophys Acta. 1783:1847–1856. 2008. View Article : Google Scholar : PubMed/NCBI
|