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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2019 Volume 19 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mechanisms shaping the role of ERK1/2 in cellular senescence (Review)

Junrong Zou, Tingting Lei, Pei Guo, Jason Yu, Qichao Xu, Yunfei Luo, Rong Ke, Deqiang Huang
Pages: 759-770
Published online on: 29 November 2018

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Review Open Access

Pivotal prognostic and diagnostic role of the long non‑coding RNA colon cancer‑associated transcript 1 expression in human cancer (Review)

Ni Wang, Yang Yu, Boming Xu, Mingjiong Zhang, Quanpeng Li, Lin Miao
Pages: 771-782
Published online on: 04 December 2018

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Review Open Access

PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review)

Youbang Xie, Xuefeng Shi, Kuo Sheng, Guoxiong Han, Wenqian Li, Qiangqiang Zhao, Baili Jiang, Jianming Feng, Jianping Li, Yuhai Gu
Pages: 783-791
Published online on: 03 December 2018

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Article

Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats

Chin‑Yi Cheng, Shung‑Te Kao, Yu‑Chen Lee
Pages: 792-804
Published online on: 11 December 2018

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Article Open Access

miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro

Qi Wang, Hongmei Yu, Hong Yu, Meina Ma, Yali Ma, Rui Li
Pages: 805-812
Published online on: 11 December 2018

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Article Open Access

Effects of menstrual blood‑derived stem cells on endometrial injury repair

Jia Hu, Kuangyu Song, Jing Zhang, Yiqiong Zhang, Bu‑Zhen Tan
Pages: 813-820
Published online on: 12 December 2018

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Article Open Access

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro

Jun Li, Jianping Zheng
Pages: 821-830
Published online on: 12 December 2018

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Article Open Access

MicroRNA‑29a enhances cisplatin sensitivity in non‑small cell lung cancer through the regulation of REV3L

Xialin Chen, Hong Zhu, Wanli Ye, Yayun Cui, Ming Chen
Pages: 831-840
Published online on: 04 December 2018

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Article Open Access

α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy

Guangwei Liu, Jiangkai Liu, Linping Pian, Songlin Gui, Baoping Lu
Pages: 841-850
Published online on: 04 December 2018

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Article Open Access

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

Yingcheng Wu, Keren Jia, Huiqun Wu, Aimin Sang, Lei Wang, Lili Shi, Kui Jiang, Jiancheng Dong
Pages: 851-860
Published online on: 03 December 2018

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Article Open Access

Long noncoding RNA RUSC1‑AS‑N promotes cell proliferation and metastasis through Wnt/β‑catenin signaling in human breast cancer

Peng Zhou, Peng Liu, Jin Zhang
Pages: 861-868
Published online on: 14 December 2018

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Article Open Access

Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells

Xiaoyan Li, Shengbing Zang, Haili Cheng, Jiasi Li, Aimin Huang
Pages: 869-876
Published online on: 29 November 2018

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Article Open Access

High expression of ACTL8 is poor prognosis and accelerates cell progression in head and neck squamous cell carcinoma

Bo Li, Jie Zhu, Lei Meng
Pages: 877-884
Published online on: 03 December 2018

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Article Open Access

Inactivation of RUNX3 protein expression in tongue squamous cell carcinoma and its association with clinicopathological characteristics

Wei‑Na Zhou, Yi‑Fei Du, Yang Zheng, Wei Zhang, Yu‑Nong Wu, Xiao‑Meng Song, Jin Bai
Pages: 885-894
Published online on: 29 November 2018

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Article Open Access

Intranasal instillation of miR‑410 targeting IL‑4/IL‑13 attenuates airway inflammation in OVA‑induced asthmatic mice

Rong Jin, Sujuan Hu, Xiaomei Liu, Renzheng Guan, Ling Lu, Rongjun Lin
Pages: 895-900
Published online on: 28 November 2018

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Article Open Access

Cordycepin induces Bax‑dependent apoptosis in colorectal cancer cells

Shang‑Ze Li, Jian‑Wei Ren, Jing Fei, Xiao‑Dong Zhang, Run‑Lei Du
Pages: 901-908
Published online on: 03 December 2018

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Article Open Access

High expression of RAB38 promotes malignant progression of pancreatic cancer

Bao‑Yu Li, Li‑Jie He, Xiang‑Lian Zhang, Hui Liu, Bin Liu
Pages: 909-918
Published online on: 10 December 2018

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Article Open Access

In vitro analysis of the role of tumor necrosis factor‑stimulated gene‑6 in keloid

Xinyi Li, Zhao Chen, Xiaojing Li, Hui Wang
Pages: 919-926
Published online on: 14 December 2018

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Article Open Access

Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen‑induced retinopathy in mice Erratum in /10.3892/mmr.2020.11753

Shuai Wang, Li‑Yang Ji, Li Li, Jing‑Min Li
Pages: 927-934
Published online on: 13 December 2018

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Article Open Access

MicroRNA‑363‑3p inhibits hepatocarcinogenesis by targeting HMGA2 and is associated with liver cancer stage

Jing Wang, Huimin Liang, Haize Ge, Xinling Guo, Dongmei Gu, Yuhua Yuan
Pages: 935-942
Published online on: 29 November 2018

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Article Open Access

Concentrated growth factor exudate enhances the proliferation of human periodontal ligament cells in the presence of TNF‑α

Xiaoju Li, Huixiao Yang, Zijian Zhang, Zhonghai Yan, Huling Lv, Yan Zhang, Bin Wu
Pages: 943-950
Published online on: 03 December 2018

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Article Open Access

Exosomes derived from preadipocytes improve osteogenic differentiation, potentially via reduced miR‑223 expression

Wenhua Du, Lingkai Su, Ning Zhang, Huiming Wang
Pages: 951-958
Published online on: 13 December 2018

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Article Open Access

Investigation into the underlying molecular mechanisms of white adipose tissue through comparative transcriptome analysis of multiple tissues

Song Zhang, Li Wang, Linsen Zan
Pages: 959-966
Published online on: 11 December 2018

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Article Open Access

Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes

Yang Wang, Hua‑Jun Sun, Rong‑Gui Li, Xiao‑Mei Wang, Zhi‑Qiang Cheng, Nan Lou
Pages: 967-973
Published online on: 12 December 2018

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Article Open Access

Expression of miR‑542‑3p in osteosarcoma with miRNA microarray data, and its potential signaling pathways

Zhen Li, Jian‑Ni Yao, Wen‑Ting Huang, Rong‑Quan He, Jie Ma, Gang Chen, Qing‑Jun Wei
Pages: 974-983
Published online on: 13 December 2018

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Article Open Access

Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang‑Youel Park
Pages: 984-993
Published online on: 12 December 2018

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Article Open Access

Construction and analysis of the lncRNA‑miRNA‑mRNA network based on competitive endogenous RNA reveals functional genes in heart failure

Guohong Wang, Xianghui Zheng, Yang Zheng, Rui Cao, Maomao Zhang, Yong Sun, Jian Wu
Pages: 994-1003
Published online on: 10 December 2018

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Article Open Access

Identification of putative drugs for gastric adenocarcinoma utilizing differentially expressed genes and connectivity map

Zu‑Xuan Chen, Xiao‑Ping Zou, Huang‑Qun Yan, Rui Zhang, Jin‑Shu Pang, Xin‑Gan Qin, Rong‑Quan He, Jie Ma, Zhen‑Bo Feng, Gang Chen, Ting‑Qing Gan
Pages: 1004-1015
Published online on: 13 December 2018

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Article Open Access

Novel adeno‑associated virus‑based genetic vaccines encoding hepatitis C virus E2 glycoprotein elicit humoral immune responses in mice

Fengqin Zhu, Yibo Wang, Zhen Xu, Haiyang Qu, Hairong Zhang, Lingling Niu, Honglu Xue, Dehuai Jing, Heng He
Pages: 1016-1023
Published online on: 11 December 2018

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Article Open Access

Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway

Zhenlong Ran, Yueling Zhang, Xiaoying Wen, Jingxue Ma
Pages: 1024-1031
Published online on: 12 December 2018

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Article Open Access

Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats

Gholamreza Bagheri, Ramin Rezaee, Konstantinos Tsarouhas, Anca Oana Docea, Jafar Shahraki, Malihe Shahriari, Martin F. Wilks, Hosseinali Jahantigh, Kaveh Tabrizian, Alireza Abdollahi Moghadam, Somayeh Bagheri, Demetrios A. Spandidos, Aristidis Tsatsakis, Mahmoud Hashemzaei
Pages: 1032-1039
Published online on: 17 December 2018

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Article Open Access

A SIRT1 agonist reduces cognitive decline in type 2 diabetic rats through antioxidative and anti‑inflammatory mechanisms

Fei Wang, Yanchang Shang, Rong Zhang, Xiangyang Gao, Qiang Zeng
Pages: 1040-1048
Published online on: 27 November 2018

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Article Open Access

MicroRNA‑3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A

Taotao Shou, Huyin Yang, Jia Lv, Dai Liu, Xiaoyang Sun
Pages: 1049-1055
Published online on: 27 November 2018

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Article Open Access

An experimental study of amniotic lacrimal duct stents in the treatment of perimenopausal female rabbits with dry eye

Mingyang Ma, Qing Yuan, Lei Ye, Kangcheng Liu, Linhong Ye, You‑Lan Min, Nan Jiang, Qinghai Li, Wenqing Shi, Xiaowei Xu, Peiwen Zhu, Yi Shao
Pages: 1056-1064
Published online on: 10 December 2018

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Article Open Access

Identification of gene biomarkers in patients with postmenopausal osteoporosis

Chenggang Yang, Jing Ren, Bangling Li, Chuandi Jin, Cui Ma, Cheng Cheng, Yaolan Sun, Xiaofeng Shi
Pages: 1065-1073
Published online on: 12 December 2018

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Article Open Access

Irisin regulates the expression of BDNF and glycometabolism in diabetic rats

Lingning Huang, Sunjie Yan, Li Luo, Liyong Yang
Pages: 1074-1082
Published online on: 12 December 2018

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Article Open Access

Hypertonic saline maintains coagulofibrinolytic homeostasis following moderate‑to‑severe traumatic brain injury by regulating monocyte phenotype via expression of lncRNAs

Xiping Yang, Yisheng Chen, Jianxin Li, Lijun Chen, Hefei Ren, Yang Liu, Xinyu Zhang
Pages: 1083-1091
Published online on: 12 December 2018

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Article Open Access

MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5‑fluorouracil in MEK1 Q56P‑mutant colorectal cancer cells

Changwen Jing, Huizi Li, Yuanyuan Du, Haixia Cao, Siwen Liu, Zhuo Wang, Rong Ma, Jifeng Feng, Jianzhong Wu
Pages: 1092-1100
Published online on: 07 December 2018

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Article Open Access

Construction of a transcription factor‑long non‑coding RNA‑microRNA network for the identification of key regulators in lung adenocarcinoma and lung squamous cell carcinoma

Shuai Zhao, Hong Chen, Beichen Ding, Jianing Li, Fuzhen Lv, Kaiyu Han, Dan Zhou, Baiquan Yu, Yao Yu, Wei Zhang
Pages: 1101-1109
Published online on: 14 December 2018

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Article Open Access

miR‑15a‑3p affects the proliferation, migration and apoptosis of lens epithelial cells

Shu‑Jun Liu, Wen‑Ting Wang, Feng‑Lan Zhang, Yong‑Hong Yu, Hua‑Jun Yu, Yan Liang, Ning Li, Yuan‑Bin Li
Pages: 1110-1116
Published online on: 11 December 2018

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Article Open Access

Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo

Jiayu Liang, Zhihong Liu, Zijun Zou, Xiangxiu Wang, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Yiping Lu
Pages: 1117-1127
Published online on: 12 December 2018

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Article Open Access

A risk assessment model for the prognosis of osteosarcoma utilizing differentially expressed lncRNAs

Kai Sun, Jianmin Zhao
Pages: 1128-1138
Published online on: 14 December 2018

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Article Open Access

Intranasal erythropoietin ameliorates neurological function impairments and neural pathology in mice with chronic alcoholism by regulating autophagy‑related Nrf2 degradation

Xuedan Nie, Wenbo Wang, Qin Wang, Dan Zhu, Hongshan Song
Pages: 1139-1149
Published online on: 29 November 2018

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Article Open Access

Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia

Jiying Chen, Lijian Zhao, Dengchuan Wang, Yanbin Xu, Haijie Gao, Wenqing Tan, Chenhong Wang
Pages: 1150-1158
Published online on: 10 December 2018

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Article Open Access

Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells

Shuang Liu, Huan Hou, Panpan Zhang, Yifan Wu, Xuanhong He, Hua Li, Nianlong Yan
Pages: 1159-1167
Published online on: 04 December 2018

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Article Open Access

Expression and potential molecular mechanisms of miR‑204‑5p in breast cancer, based on bioinformatics and a meta‑analysis of 2,306 cases

Kai‑Teng Cai, An‑Gui Liu, Ze‑Feng Wang, Hang‑Wei Jiang, Jing‑Jing Zeng, Rong‑Quan He, Jie Ma, Gang Chen, Jin‑Cai Zhong
Pages: 1168-1184
Published online on: 14 December 2018

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Article Open Access

Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats

Yunzhou Li, Han Yu, Zongying Xu, Shaohua Shi, Dingnan Wang, Xinghua Shi, Yuchen Wang, Baihui Zeng, Huifang Deng, Xiulan Deng, Xianggen Zhong
Pages: 1185-1193
Published online on: 12 December 2018

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Article Open Access

Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity

Shaoxue Ding, Chunyan Liu, Yang Li, Hui Liu, Zhaoyun Liu, Tong Chen, Tian Zhang, Zonghong Shao, Rong Fu
Pages: 1194-1202
Published online on: 12 December 2018

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Article Open Access

Metformin attenuates cells stemness and epithelial‑mesenchymal transition in colorectal cancer cells by inhibiting the Wnt3a/β‑catenin pathway

Chu Zhang, Yuchen Wang
Pages: 1203-1209
Published online on: 14 December 2018

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Article

Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression

Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Xin Liu, Jianfeng Zhao, Wen Shang, Xiang Zhao
Pages: 1210-1221
Published online on: 28 November 2018

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Article

Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression

Chi Zhang, Weizhong Yu, Chongbo Huang, Qinghe Ding, Chizhang Liang, Le Wang, Zhiqi Hou, Zhiyong Zhang
Pages: 1222-1229
Published online on: 04 December 2018

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Article

Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway

Haijuan Li, Lianzhi Yu, Changsheng Zhao
Pages: 1230-1237
Published online on: 27 November 2018

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Article

Characterization of estrogenic active ingredients in Cuscuta chinensis Lam. based on spectral characteristics and high‑performance liquid chromatography/quadrupole time‑of‑flight mass spectrometry

Jing‑Xin Ding, Wen‑Lan Li, Yang Hu, Hui Song, Xiang‑Ming Sun, Yu‑Bin Ji
Pages: 1238-1247
Published online on: 12 December 2018

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Article

Long non‑coding RNA DLX6‑AS1 promotes proliferation by acting as a ceRNA targeting miR‑199a in cervical cancer

Xiaobo Wang, Yiqin Lin, Jiangang Liu
Pages: 1248-1255
Published online on: 07 December 2018

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Article

Role of mitochondrial damage in Cr(VI)‑induced endoplasmic reticulum stress in L‑02 hepatocytes

Qi Liang, Yujing Zhang, Manfeng Huang, Yuanyuan Xiao, Fang Xiao
Pages: 1256-1265
Published online on: 29 November 2018

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Article

Upregulated IGF‑1 in the lungs of asthmatic mice originates from alveolar macrophages

Jing He, Mimi Mu, Helong Wang, Hua Ma, Xu Tang, Qiang Fang, Shujun Guo, Chuanwang Song
Pages: 1266-1271
Published online on: 05 December 2018

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Article

Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways

Min Wang, Guang‑Hua Luo, Hong Liu, You‑Pu Zhang, Bin Wang, Dong‑Mei Di, Xiang‑Hong Zhan, Yang Yu, Shuang Yao, Xiao‑Ying Zhang, Ning Xu
Pages: 1272-1283
Published online on: 12 December 2018

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Article

Role of the mTOR‑FOXO1 pathway in obesity‑associated renal tubulointerstitial inflammation

Hong Sun, Xinyu Shao, Jiajia He, Michal Golos, Bimin Shi
Pages: 1284-1293
Published online on: 05 December 2018

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Article

A novel four‑snoRNA signature for predicting the survival of patients with uveal melanoma

Qiong Yi, Wen‑Jin Zou
Pages: 1294-1301
Published online on: 14 December 2018

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Article

Evaluation of a DNA vaccine encoding Brucella BvrR in BALB/c mice

Bo Chen, Baoshan Liu, Zhina Zhao, Guizhen Wang
Pages: 1302-1308
Published online on: 11 December 2018

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Article Open Access

Salvianolic acid B, an antioxidant derived from Salvia militarize, protects mice against γ‑radiation‑induced damage through Nrf2/Bach1

Ruifang Zhou, Haishan Long, Bei Zhang, Zhizhao Lao, Quanyu Zheng, Tiancheng Wang, Yongxin Zhang, Qingguang Wu, Xiaoping Lai, Geng Li, Lizhu Lin
Pages: 1309-1317
Published online on: 03 December 2018

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Article

Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function

Jian Li, Nan Li, Shuangtong Yan, Yanhui Lu, Xinyu Miao, Zhaoyan Gu, Yinghong Shao
Pages: 1318-1330
Published online on: 29 November 2018

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MicroRNA‑506‑3p reverses gefitinib resistance in non‑small cell lung cancer by targeting Yes‑associated protein 1

Junfei Zhu, Lianqin Tao, Litong Jin
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Early diagnosis of trisomy 21, trisomy 18 and trisomy 13 using nuchal translucency thickness and ductus venosus blood flow waveform in West China

Ying Tang, Hong Luo, Dezhi Mu, Taizhu Yang, Qi Zhu, Fan Yang, Guanjian Liu
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Bioinformatics analysis of the interactions among lncRNA, miRNA and mRNA expression, genetic mutations and epigenetic modifications in hepatocellular carcinoma

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A GLP‑1 receptor agonist attenuates human islet amyloid polypeptide‑induced autophagy and apoptosis in MIN6 cells

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Costunolide isolated from Vladimiria souliei inhibits the proliferation and induces the apoptosis of HepG2 cells

Jingxin Mao, Man Yi, Yunyi Tao, Yuanshe Huang, Min Chen
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MicroRNA‑766 inhibits the malignant biological behaviours of pancreatic ductal adenocarcinoma by directly targeting ETS1

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MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori

Na Li, Jianlong Wang, Wenqian Yu, Kai Dong, Feng You, Biao Si, Bin Tang, Yan Zhang, Tongjian Wang, Bin Qiao
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Gambogic acid prevents angiotensin II‑induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF‑κB signaling pathways

Qiang Liu, Peng Shan, Haibin Li
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MicroRNA‑509 targets PAX6 to inhibit cell proliferation and invasion in papillary thyroid carcinoma Retraction in /10.3892/mmr.2022.12910

Shuilong Zhang, Qiang Wang, Dewei Li, Bo Huang, Xia Hou, Dongliang Wang
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Different types of viral‑host junction found in HBV integration breakpoints in HBV‑infected patients

Peng Ruan, Xiufang Dai, Jun Sun, Chunping He, Chao Huang, Rui Zhou, Zhuo Cao, Lan Ye
Pages: 1410-1416
Published online on: 29 November 2018

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Article Number: 51
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Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
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Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
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Published online on: 10 November 2025

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Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Published online on: 31 October 2025

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Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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