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Article Open Access

Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation

  • Authors:
    • Fengying Sun
    • Changhui Yu
    • Ximing Liu
    • Dan Wang
    • Na Liu
    • Jiaxin Liu
    • Lesheng Teng
    • Youxin Li
  • View Affiliations / Copyright

    Affiliations: The Center for Pharmaceutical Research, School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1595-1602
    |
    Published online on: December 24, 2018
       https://doi.org/10.3892/mmr.2018.9797
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Abstract

The present study aimed to investigate the effects of butyl stearate on t‑butoxyl paliperidone derivative (isoperidone)‑loaded poly(lactide‑co‑glycolide) (PLGA) microspheres. The mechanism of drug release rate delay by butyl stearate was examined by accelerated testing, morphological observation, thermal and fluorescence analyses. In vivo pharmacokinetic study was conducted on female beagle dogs. Spherical microspheres with smooth surfaces, small internal pores and shell structures were initially prepared. It was found that 3% (w/w) butyl stearate prolonged the in vitro drug release period from 46 to 82 days, and in vivo release period from 20 to 27 days. Furthermore, the results demonstrated that the green fluorescence imaging of isoperidone approaching the cores of microspheres with 3% butyl stearate was brighter than in microspheres without additives. In conclusion, it was shown that butyl stearate affected the microsphere structure, isoperidone microsphere distribution and isoperidone crystallinity. The results of the present study thus provide a potential method to develop sustained‑release preparations.
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Copy and paste a formatted citation
Spandidos Publications style
Sun F, Yu C, Liu X, Wang D, Liu N, Liu J, Teng L and Li Y: Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Mol Med Rep 19: 1595-1602, 2019.
APA
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J. ... Li, Y. (2019). Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Molecular Medicine Reports, 19, 1595-1602. https://doi.org/10.3892/mmr.2018.9797
MLA
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J., Teng, L., Li, Y."Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation". Molecular Medicine Reports 19.3 (2019): 1595-1602.
Chicago
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J., Teng, L., Li, Y."Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation". Molecular Medicine Reports 19, no. 3 (2019): 1595-1602. https://doi.org/10.3892/mmr.2018.9797
Copy and paste a formatted citation
x
Spandidos Publications style
Sun F, Yu C, Liu X, Wang D, Liu N, Liu J, Teng L and Li Y: Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Mol Med Rep 19: 1595-1602, 2019.
APA
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J. ... Li, Y. (2019). Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Molecular Medicine Reports, 19, 1595-1602. https://doi.org/10.3892/mmr.2018.9797
MLA
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J., Teng, L., Li, Y."Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation". Molecular Medicine Reports 19.3 (2019): 1595-1602.
Chicago
Sun, F., Yu, C., Liu, X., Wang, D., Liu, N., Liu, J., Teng, L., Li, Y."Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation". Molecular Medicine Reports 19, no. 3 (2019): 1595-1602. https://doi.org/10.3892/mmr.2018.9797
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