Open Access

miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3

  • Authors:
    • Minhui Hua
    • Yongwei Qin
    • Meihong Sheng
    • Xiaopeng Cui
    • Weiguan Chen
    • Jianxin Zhong
    • Junming Yan
    • Yan Chen
  • View Affiliations

  • Published online on: March 5, 2019     https://doi.org/10.3892/mmr.2019.10004
  • Pages: 3575-3583
  • Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNA/miRs) have been demonstrated to be critical post‑transcriptional modulators of gene expression during tumorigenesis. Numerous miRNAs have been revealed to be downregulated in human epithelial ovarian cancer (EOC). In the present study, it was observed that the expression of miR‑145 was decreased in EOC tissues and cell lines. Overexpression of miR‑145 inhibited the proliferation, migration and invasion of EOC cells. The D‑type cyclin 2, cyclin D2 (CCND2), and E2F transcription factor 3 (E2F3) were confirmed to be targets of miR‑145. In addition, restoration of these 2 genes significantly reversed the tumor suppressive effects of miR‑145. Collectively, the results indicated that miR‑145 serves a critical role in suppressing the biological behavior of EOC cells by targeting CCND2 and E2F3. Therefore, miR‑145 was suggested to be a potential miRNA‑based therapeutic target in ovarian cancer.
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May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Hua M, Qin Y, Sheng M, Cui X, Chen W, Zhong J, Yan J and Chen Y: miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3. Mol Med Rep 19: 3575-3583, 2019
APA
Hua, M., Qin, Y., Sheng, M., Cui, X., Chen, W., Zhong, J. ... Chen, Y. (2019). miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3. Molecular Medicine Reports, 19, 3575-3583. https://doi.org/10.3892/mmr.2019.10004
MLA
Hua, M., Qin, Y., Sheng, M., Cui, X., Chen, W., Zhong, J., Yan, J., Chen, Y."miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3". Molecular Medicine Reports 19.5 (2019): 3575-3583.
Chicago
Hua, M., Qin, Y., Sheng, M., Cui, X., Chen, W., Zhong, J., Yan, J., Chen, Y."miR‑145 suppresses ovarian cancer progression via modulation of cell growth and invasion by targeting CCND2 and E2F3". Molecular Medicine Reports 19, no. 5 (2019): 3575-3583. https://doi.org/10.3892/mmr.2019.10004