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Article Open Access

Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression

  • Authors:
    • Yan Lang
    • Jingchao Zhang
    • Zheng Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Lang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3411-3420
    |
    Published online on: March 5, 2019
       https://doi.org/10.3892/mmr.2019.10009
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Abstract

The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease. In the present study, ceRNA networks for depression and the corresponding normal physiological states were constructed. Further analysis of the ceRNA networks revealed that ceRNA regulation may be important for depression. Hub ceRNAs including high mobility group nucleosomal binding domain 3, peroxisome proliferator‑activated receptor‑γ coactivator 1β and leukemia inhibitory factor receptor‑α were associated with depression. A common core ceRNA network was identified by comparison analysis. Functional analysis suggested that these ceRNAs may be implicated in depression. Differential expression analysis revealed that ceRNAs in the obtained ceRNA interaction networks were significantly enriched with significantly differentially expressed genes. A total of 8 key functional modules for depression were identified, and small target molecules were screened. ceRNA protocadherin‑α subfamily C2 in module 1 and ceRNA Cyclin‑dependent kinase 6 in module 3 were reported to be implicated in the occurrence and development of depressive disorders. Thus, the present analysis may provide insight into the pathogenesis of depression and improve its treatment.
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1 

Sullivan PF, Neale MC and Kendler KS: Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry. 157:1552–1562. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Kohen R, Dobra A, Tracy JH and Haugen E: Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness. Transl Psychiatry. 4:e3662014. View Article : Google Scholar : PubMed/NCBI

3 

Lacerda-Pinheiro SF, Pinheiro Junior RF, Pereira de Lima MA, Lima da Silva CG, Vieira dos Santos Mdo S, Teixeira Júnior AG, Lima de Oliveira PN, Ribeiro KD, Rolim-Neto ML and Bianco BA: Are there depression and anxiety genetic markers and mutations? A systematic review. J Affect Disord. 168:387–398. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Heiman GA, Kamberakis K, Gill R, Kalachikov S, Pedley TA, Hauser WA and Ottman R: Evaluation of depression risk in LGI1 mutation carriers. Epilepsia. 51:1685–1690. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ergun S and Oztuzcu S: Oncocers: ceRNA-mediated cross-talk by sponging miRNAs in oncogenic pathways. Tumour Biol. 36:3129–3136. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y and Guo J: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep. 4:60882014. View Article : Google Scholar : PubMed/NCBI

8 

Sumazin P, Yang X, Chiu HS, Chung WJ, Iyer A, Llobet-Navas D, Rajbhandari P, Bansal M, Guarnieri P, Silva J and Califano A: An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell. 147:370–381. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, et al: In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 147:382–395. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, et al: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 147:344–357. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan Z and Ai K: H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT. Tumour Biol. 35:9163–9169. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Cao C, Zhang T, Zhang D, Xie L, Zou X, Lei L, Wu D and Liu L: The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma. Oncogene. 36:1112–1122. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zhou X, Liu J and Wang W: Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data. IET Syst Biol. 8:96–103. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW and Liu XS: Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 7:109822016. View Article : Google Scholar : PubMed/NCBI

15 

Jiang H, Ma R, Zou S, Wang Y, Li Z and Li W: Reconstruction and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis. Mol Biosyst. 13:1182–1192. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Lai Y, He S, Ma L, Lin H, Ren B, Ma J, Zhu X and Zhuang S: HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy. Mol Cell Biochem. 432:179–187. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Lin R and Turecki G: Noncoding RNAs in depression. Adv Exp Med Biol. 978:197–210. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42:D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

21 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

24 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, et al: The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease. Science. 313:1929–1935. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Cai N, Li Y, Chang S, Liang J, Lin C, Zhang X, Liang L, Hu J, Chan W, Kendler KS, et al: Genetic control over mtDNA and Its relationship to major depressive disorder. Curr Biol. 25:3170–3177. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, et al: Profiling trait anxiety: Transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS One. 6:e236042011. View Article : Google Scholar : PubMed/NCBI

28 

Kripke DF, Nievergelt CM, Joo E, Shekhtman T and Kelsoe JR: Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 7:22009. View Article : Google Scholar : PubMed/NCBI

29 

Kripke DF, Nievergelt CM, Tranah GJ, Murray SS, Rex KM, Grizas AP, Hahn EK, Lee HJ, Kelsoe JR and Kline LE: FMR1, circadian genes and depression: Suggestive associations or false discovery? J Circadian Rhythms. 11:32013. View Article : Google Scholar : PubMed/NCBI

30 

Maes M, Ombelet W, Verkerk R, Bosmans E and Scharpé S: Effects of pregnancy and delivery on the availability of plasma tryptophan to the brain: Relationships to delivery-induced immune activation and early post-partum anxiety and depression. Psychol Med. 31:847–858. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Murray JM, Sletten TL, Magee M, Gordon C, Lovato N, Bartlett DJ, Kennaway DJ, Lack LC, Grunstein RR, Lockley SW, et al: Prevalence of circadian misalignment and its association with depressive symptoms in delayed sleep phase disorder. Sleep. 402017.doi: 10.1093/sleep/zsw002.

32 

Takaesu Y, Inoue Y, Ono K, Murakoshi A, Futenma K, Komada Y and Inoue T: Circadian rhythm sleep-wake disorders as predictors for bipolar disorder in patients with remitted mood disorders. J Affect Disord. 220:57–61. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Lee JH, Park SK, Ryoo JH, Oh CM, Mansur RB, Alfonsi JE, Cha DS, Lee Y, McIntyre RS and Jung JY: The association between insulin resistance and depression in the Korean general population. J Affect Disord. 208:553–559. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q and Maniatis T: Pcdhalphac2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science. 356:406–411. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Bai M, Zhu X, Zhang Y, Zhang S, Zhang L, Xue L, Yi J, Yao S and Zhang X: Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life. PLoS One. 7:e469212012. View Article : Google Scholar : PubMed/NCBI

36 

Baudry A, Mouillet-Richard S, Schneider B, Launay JM and Kellermann O: miR-16 targets the serotonin transporter: A new facet for adaptive responses to antidepressants. Science. 329:1537–1541. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Shao QY, You F, Zhang YH, Hu LL, Liu WJ, Liu Y, Li J, Wang SD and Song MF: CSF miR-16 expression and its association with miR-16 and serotonin transporter in the raphe of a rat model of depression. J Affect Disord. 238:609–614. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Gheysarzadeh A, Sadeghifard N, Afraidooni L, Pooyan F, Mofid MR, Valadbeigi H, Bakhtiari H and Keikhavani S: Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202. J Res Med Sci. 23:692018. View Article : Google Scholar : PubMed/NCBI

39 

Mihailova S, Ivanova-Genova E, Lukanov T, Stoyanova V, Milanova V and Naumova E: A study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ gene polymorphisms in patients with depression. J Neuroimmunol. 293:123–128. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P and Perlis RH: Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord. 16:199–203. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lang Y, Zhang J and Yuan Z: Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression. Mol Med Rep 19: 3411-3420, 2019.
APA
Lang, Y., Zhang, J., & Yuan, Z. (2019). Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression. Molecular Medicine Reports, 19, 3411-3420. https://doi.org/10.3892/mmr.2019.10009
MLA
Lang, Y., Zhang, J., Yuan, Z."Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression". Molecular Medicine Reports 19.5 (2019): 3411-3420.
Chicago
Lang, Y., Zhang, J., Yuan, Z."Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression". Molecular Medicine Reports 19, no. 5 (2019): 3411-3420. https://doi.org/10.3892/mmr.2019.10009
Copy and paste a formatted citation
x
Spandidos Publications style
Lang Y, Zhang J and Yuan Z: Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression. Mol Med Rep 19: 3411-3420, 2019.
APA
Lang, Y., Zhang, J., & Yuan, Z. (2019). Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression. Molecular Medicine Reports, 19, 3411-3420. https://doi.org/10.3892/mmr.2019.10009
MLA
Lang, Y., Zhang, J., Yuan, Z."Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression". Molecular Medicine Reports 19.5 (2019): 3411-3420.
Chicago
Lang, Y., Zhang, J., Yuan, Z."Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression". Molecular Medicine Reports 19, no. 5 (2019): 3411-3420. https://doi.org/10.3892/mmr.2019.10009
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