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Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer

  • Authors:
    • Fengfeng Cai
    • Lu Cai
    • Zhuchao Zhou
    • Xin Pan
    • Minghong Wang
    • Su Chen
    • Manuel Antonio Falar Luis
    • Chunmei Cen
    • Ewelina Biskup
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of General Surgery, Huashan Hospital, Fudan University, School of Medicine, Shanghai 200041, P.R. China, Department of Central Laboratory, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Cardiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China, Department of Molecular and Cellular Biology, School of Forensic Sciences, Xi'an Jiao Tong University Health Science Center, Xi'an, Shanxi 710061, P.R. China, Department of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3685-3695
    |
    Published online on: March 14, 2019
       https://doi.org/10.3892/mmr.2019.10033
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Abstract

Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to investigate the association of Tif1γ with overall survival (OS). The results indicated that Tif1γ is an independent prognostic and predictive factor in breast cancer, and thus, a promising target protein for use in diagnostics and patient follow‑up. Plasma levels of Tif1γ were measured in samples obtained from 110 patients with operable breast cancer and in 110 healthy volunteers at the Breast Cancer Department of Yangpu Hospital between 2008 and 2016. The association between Tif1γ levels and clinicopathologic parameters, and the OS in a follow‑up period of 98 months was evaluated. The prognostic significance was assessed using the Kaplan‑Meier method. The levels of Tif1γ were significantly lower in patients with breast cancer compared with healthy controls. The average concentration of 18.40 ng/ml was used to discriminate between Tif1γ‑positive (52) and Tif1γ‑negative patients (58). Tif1γ‑positive patients had a significantly improved OS compared with Tif1γ‑negative patients. In the multivariate analysis, Tif1γ was an independent predictor of a favorable OS in a prospective follow‑up setting; thus, Tif1γ plasma levels are an independent prognostic factor for patients with breast cancer. These findings support the potential of using measurements of Tif1γ plasma levels to guide breast cancer therapy and monitoring. Further studies are required to validate Tif1γ as an easily detectable, non‑invasive prognostic biomarker for breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cai F, Cai L, Zhou Z, Pan X, Wang M, Chen S, Luis MA, Cen C and Biskup E: Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Mol Med Rep 19: 3685-3695, 2019.
APA
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S. ... Biskup, E. (2019). Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Molecular Medicine Reports, 19, 3685-3695. https://doi.org/10.3892/mmr.2019.10033
MLA
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S., Luis, M. A., Cen, C., Biskup, E."Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer". Molecular Medicine Reports 19.5 (2019): 3685-3695.
Chicago
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S., Luis, M. A., Cen, C., Biskup, E."Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer". Molecular Medicine Reports 19, no. 5 (2019): 3685-3695. https://doi.org/10.3892/mmr.2019.10033
Copy and paste a formatted citation
x
Spandidos Publications style
Cai F, Cai L, Zhou Z, Pan X, Wang M, Chen S, Luis MA, Cen C and Biskup E: Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Mol Med Rep 19: 3685-3695, 2019.
APA
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S. ... Biskup, E. (2019). Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer. Molecular Medicine Reports, 19, 3685-3695. https://doi.org/10.3892/mmr.2019.10033
MLA
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S., Luis, M. A., Cen, C., Biskup, E."Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer". Molecular Medicine Reports 19.5 (2019): 3685-3695.
Chicago
Cai, F., Cai, L., Zhou, Z., Pan, X., Wang, M., Chen, S., Luis, M. A., Cen, C., Biskup, E."Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer". Molecular Medicine Reports 19, no. 5 (2019): 3685-3695. https://doi.org/10.3892/mmr.2019.10033
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