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Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade

  • Authors:
    • Chuanjun Chen
    • Huiguo Shan
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    Affiliations: Oncology Department, Xinchang People's Hospital, Shaoxing, Zhejiang 312500, P.R. China, Oncology Department, The Affiliated Dongtai Hospital of Nantong University, Dongtai, Jiangsu 224200, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3477-3484
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    Published online on: March 18, 2019
       https://doi.org/10.3892/mmr.2019.10055
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Abstract

Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. This study aimed to study the mechanisms of ectopic keratin 6A (KRT6A) in NPC. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were performed to detect KRT6A levels in NPC cell lines (C666‑1, 5‑8F and SUNE‑1) and a nasopharyngeal epithelial cell line (NP69, as a control). After SUNE‑1 NPC cells had been silenced by KRT6A, cell viability, metastasis and invasion were determined using Cell Counting Kit‑8, wound healing and Transwell assays, respectively. KRT6A levels, metastasis‑associated factors and the Wnt/β‑catenin pathway were measured using RT‑qPCR and western blotting. It was demonstrated that KRT6A was upregulated in all detected NPC cells, among which KRT6A was the highest in SUNE‑1 cells. In SUNE‑1 cells, cell viability was inhibited at 24 and 48 h, and that cell metastasis and invasion were demonstrated to be suppressed by KRT6A silencing. Both the mRNA and protein levels of KRT6A, matrix metalloproteinase (MMP)‑2, MMP‑9, β‑catenin, lymphoid enhancer binding factor 1 and T‑cell specific factor 4 were reduced in the small interfering (si)KRT6A group. However, the results demonstrated that the levels of epithelial‑cadherin and tissue inhibitor of metalloproteinase‑2 (TIMP‑2) were promoted in the siKRT6A group. The activation of the Wnt/β‑catenin pathway by lithium chloride reversed the effect of si‑KRT6A by modulating the expression of MMP‑2/9 and TIMP2. It was observed that KRT6A silencing suppressed cell invasion and metastasis of NPC via the β‑catenin cascade. Together these results provide important insights into a novel approach for the diagnosis and treatment of NPC.
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View References

1 

Liu TF: Recent developments in diagnosis and treatment of nasopharyngeal carcinoma. Keio J Med. 40:59–62. 1991. View Article : Google Scholar : PubMed/NCBI

2 

Wyatt DE, Brooker DS, Connolly JH and Coyle PV: Prognostic value of Epstein-Barr virus serology in patients with nasopharyngeal carcinoma. J Infect. 26:171–175. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Wang Y, Shen C, Lu X and Hu C: The incidence and prognosis of nasopharyngeal carcinoma patients with family history. Oncotarget. 8:97323–97330. 2017.PubMed/NCBI

4 

Wei KR, Zheng RS, Zhang SW, Liang ZH, Li ZM and Chen WQ: Nasopharyngeal carcinoma incidence and mortality in China, 2013. Chin J Cancer. 36:902017. View Article : Google Scholar : PubMed/NCBI

5 

Lu TX: Advance in diagnosis and management of local recurrent nasopharyngeal carcinoma. Ai Zheng. 23:230–234. 2004.(In Chinese). PubMed/NCBI

6 

Xia L, Zhang W, Zhu L and Yu G: Abnormally expressed long non-coding RNAs in nasopharyngeal carcinoma: A meta-analysis. Clin Lab. 64:585–595. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Chan AT, Leung TW, Kwan WH, Mok TS, Yeo W, Lai M and Johnson PJ: Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma. Cancer Chemother Pharmacol. 42:247–249. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Li Y, Ou X, Shen C, Xu T, Li W and Hu C: Patterns of local failures and suggestions for reduction of clinical target volume for nasopharyngeal carcinoma patients without cervical lymph node metastasis. Onco Targets Ther. 11:2545–2555. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Qi XK, Han HQ, Zhang HJ, Xu M, Li L, Chen L, Xiang T, Feng QS, Kang T, Qian CN, et al: OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma. Theranostics. 8:2202–2216. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Ogasawara N, Kudo T, Sato M, Kawasaki Y, Yonezawa S, Takahashi S, Miyagi Y, Natori Y and Sugiyama A: Reduction of membrane protein CRIM1 decreases E-cadherin and increases claudin-1 and MMPs, enhancing the migration and invasion of renal carcinoma cells. Biol Pharm Bull. 41:604–611. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Tuo Z, Zhang J and Xue W: LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway. Biochem Biophys Res Commun. 499:875–881. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Shi B, Wang Y and Yin F: MALAT1/miR-124/Capn4 axis regulates proliferation, invasion and EMT in nasopharyngeal carcinoma cells. Cancer Biol Ther. 18:792–800. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Li S, Zhang X, Zhang R, Liang Z, Liao W, Du Z, Gao C, Liu F, Fan Y and Hong H: Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cells. Cell Cycle. 16:1601–1610. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Zuo LL, Zhang J, Liu LZ, Zhou Q, Du SJ, Xin SY, Ning ZP, Yang J, Yu HB, Yue WX, et al: Cadherin 6 is activated by Epstein-Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis. 6:4022017. View Article : Google Scholar : PubMed/NCBI

15 

Wu SL, Li YJ, Liao K, Shi L, Zhang N, Liu S, Hu YY, Li SL and Wang Y: 2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal. Oncol Rep. 37:793–802. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Hu Y, Qi MF, Xu QL, Kong XY, Cai R, Chen QQ, Tang HY and Jiang W: Candidate tumor suppressor ZNF154 suppresses invasion and metastasis in NPC by inhibiting the EMT via Wnt/β-catenin signalling. Oncotarget. 8:85749–85758. 2017.PubMed/NCBI

17 

Wang G, Zhang L, Zhou Y, Sun Q, Xu H, Cai F, Xiang P, Chen Z and Jiang H: KAI1/CD82 genetically engineered endothelial progenitor cells inhibit metastasis of human nasopharyngeal carcinoma in a mouse model. Med Sci Monit. 24:3146–3152. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Aouf S, Laribi A, Gabbouj S, Hassen E, Bouaouinaa N, Zakhama A and Harizi H: Contribution of Nitric oxide synthase 3 genetic variants to nasopharyngeal carcinoma risk and progression in a Tunisian population. Eur Arch Otorhinolaryngol. 13–Feb;2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

19 

Chua HH, Kameyama T, Mayeda A and Yeh TH: Cancer-specifically re-spliced TSG101 mRNA promotes invasion and metastasis of nasopharyngeal carcinoma. Int J Mol Sci. 20(pii): E7732019. View Article : Google Scholar : PubMed/NCBI

20 

Petersson F: EBV-associated non-keratinizing nasopharyngeal carcinoma with prominent spindled cell and whorling patterns: A previously unreported histological variant in a patient presenting with dermatomyositis. Head Neck Pathol. 13–Feb;2019.(Epub ahead of print). View Article : Google Scholar :

21 

Xiao H, Guo Y, Yi J, Xia H, Xu H, Yuan L, Hu P, Yang Z, He Z, Lu H and Deng H: Identification of a novel keratin 9 missense mutation in a chinese family with epidermolytic palmoplantar keratoderma. Cell Physiol Biochem. 46:1919–1929. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Jacob JT, Coulombe PA, Kwan R and Omary MB: Types I and II keratin intermediate filaments. Cold Spring Harb Perspect Biol. 10(pii): a0182752018. View Article : Google Scholar : PubMed/NCBI

23 

Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Kimura-Ono A, Takarada T, et al: Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Sci Rep. 8:26122018. View Article : Google Scholar : PubMed/NCBI

24 

Deo PN and Deshmukh R: Pathophysiology of keratinization. J Oral Maxillofac Pathol. 22:86–91. 2018.PubMed/NCBI

25 

Gu LH and Coulombe PA: Keratin function in skin epithelia: A broadening palette with surprising shades. Curr Opin Cell Biol. 19:13–23. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Chang HH, Dreyfuss JM and Ramoni MF: A transcriptional network signature characterizes lung cancer subtypes. Cancer. 117:353–360. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Forrest CE, Casey G, Mordaunt DA, Thompson EM and Gordon L: Pachyonychia congenita: A spectrum of KRT6a mutations in australian patients. Pediatr Dermatol. 33:337–342. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Cammarata-Scalisi F, Natsuga K, Toyonaga E, Nishie W, Shimizu H, Avendaño A, Araque D, Da Silva G, Bellacchio E and Callea M: Early severe pachyonychia congenita subtype PC-K6a with a novel mutation in the KRT6A gene. J Eur Acad Dermatol Venereol. 31:e94–e96. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chai AW, Cheung AK, Dai W, Ko JM, Ip JC, Chan KW, Kwong DL, Ng WT, Lee AW, Ngan RK, et al: Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma. Oncotarget. 7:78859–78871. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Zhang P, Zhang L, Liu H, Zhao L, Li Y, Shen JX, Liu Q, Liu MZ and Xi M: Clinicopathologic characteristics and prognosis of tongue squamous cell carcinoma in patients with and without a history of radiation for nasopharyngeal carcinoma: A matched case-control study. Cancer Res Treat. 49:695–705. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Clement-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, Estrera K, Warman ML, Baron R and Rawadi G: Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci USA. 102:17406–17411. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Wang P, Shen N, Liu D, Ning X, Wu D and Huang X: TRIM24 siRNA induced cell apoptosis and reduced cell viability in human nasopharyngeal carcinoma cells. Mol Med Rep. 18:369–376. 2018.PubMed/NCBI

34 

Setyaningsih WAW, Arfian N, Suryadi E, Romi MM, Tranggono U and Sari DCR: Hyperuricemia induces Wnt5a/Ror2 gene expression, epithelial-mesenchymal transition, and kidney tubular injury in mice. Iran J Med Sci. 43:164–173. 2018.PubMed/NCBI

35 

Yang F, Wei K, Qin Z, Liu W, Shao C, Wang C, Ma L, Xie M, Shu Y and Shen H: MiR-598 suppresses invasion and migration by negative regulation of derlin-1 and epithelial-mesenchymal transition in non-small cell lung cancer. Cell Physiol Biochem. 47:245–256. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Zheng P, Li H, Xu P, Wang X, Shi Z, Han Q and Li Z: High lncRNA HULC expression is associated with poor prognosis and promotes tumor progression by regulating epithelial-mesenchymal transition in prostate cancer. Arch Med Sci. 14:679–686. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Y, Zhao L, Wang L, Yang X, Zhou A and Wang J: Placental growth factor promotes epithelial-mesenchymal transition-like changes in ARPE-19 cells under hypoxia. Mol Vis. 24:340–352. 2018.PubMed/NCBI

38 

Chiu YJ, Hour MJ, Jin YA, Lu CC, Tsai FJ, Chen TL, Ma H, Juan YN and Yang JS: Disruption of IGF-1R signaling by a novel quinazoline derivative, HMJ-30, inhibits invasiveness and reverses epithelial-mesenchymal transition in osteosarcoma U-2 OS cells. Int J Oncol. 16–Mar;2018.(Epub ahead of print). View Article : Google Scholar

39 

Ciaramella V, Della Corte CM, Di Mauro C, Tomassi S, Di Maro S, Troiani T, Martinelli E, Bianco R, Cosconati S, Pierantoni R, et al: Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells. Oncotarget. 9:19273–19282. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Fu X, Zhu Y, Zheng B, Zou Y, Wang C, Wu P, Wang J, Chen H, Du P, Liang B and Fang L: KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma. Int J Oncol. 52:1912–1922. 2018.PubMed/NCBI

41 

Jiang Y, Jiao Y, Liu Y, Zhang M, Wang Z, Li Y, Li T, Zhao X and Wang D: Sinomenine hydrochloride inhibits the metastasis of human glioblastoma cells by suppressing the expression of matrix metalloproteinase-2/-9 and reversing the endogenous and exogenous epithelial-mesenchymal transition. Int J Mol Sci. 19(pii): E8442018. View Article : Google Scholar : PubMed/NCBI

42 

Kur-Piotrowska A, Bukowska J, Kopcewicz MM, Dietrich M, Nynca J, Slowinska M and Gawronska-Kozak B: Foxn1 expression in keratinocytes is stimulated by hypoxia: Further evidence of its role in skin wound healing. Sci Rep. 8:54252018. View Article : Google Scholar : PubMed/NCBI

43 

Bush BM, Brock AT, Deng JA, Nelson RA and Sumter TF: The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer. Cell Biochem Funct. 31:228–236. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Narasipura SD, Henderson LJ, Fu SW, Chen L, Kashanchi F and Al-Harthi L: Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes. J Virol. 86:1911–1921. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Yu XW, Xu Q, Xu Y, Gong YH and Yuan Y: Expression of the E-cadherin/β-catenin/tcf-4 pathway in gastric diseases with relation to Helicobacter pylori infection: Clinical and pathological implications. Asian Pac J Cancer Prev. 15:215–220. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Zhang J, Huang K, Shi Z, Zou J, Wang Y, Jia Z, Zhang A, Han L, Yue X, Liu N, et al: High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression. Neuro Oncol. 13:600–609. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Qian L, Zhang W, Zhang P, Lei B, Wang X, Wang M, Bai J and He A: The anti-apoptosis effect of MLAA-34 in leukemia and the β-catenin/T cell factor 4 protein pathway. Am J Transl Res. 7:2270–2278. 2015.PubMed/NCBI

48 

Sun J, Jia Z, Li B, Zhang A, Wang G, Pu P, Chen Z, Wang Z and Yang W: MiR-19 regulates the proliferation and invasion of glioma by RUNX3 via β-catenin/Tcf-4 signaling. Oncotarget. 8:110785–110796. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Wang K, Wang X, Zou J, Zhang A, Wan Y, Pu P, Song Z, Qian C, Chen Y, Yang S and Wang Y: miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. Neuro Oncol. 15:578–588. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Xie J, Xiang DB, Wang H, Zhao C, Chen J, Xiong F, Li TY and Wang XL: Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. PLoS One. 7:e456172012. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Chen C and Shan H: Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Mol Med Rep 19: 3477-3484, 2019.
APA
Chen, C., & Shan, H. (2019). Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Molecular Medicine Reports, 19, 3477-3484. https://doi.org/10.3892/mmr.2019.10055
MLA
Chen, C., Shan, H."Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade". Molecular Medicine Reports 19.5 (2019): 3477-3484.
Chicago
Chen, C., Shan, H."Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade". Molecular Medicine Reports 19, no. 5 (2019): 3477-3484. https://doi.org/10.3892/mmr.2019.10055
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C and Shan H: Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Mol Med Rep 19: 3477-3484, 2019.
APA
Chen, C., & Shan, H. (2019). Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Molecular Medicine Reports, 19, 3477-3484. https://doi.org/10.3892/mmr.2019.10055
MLA
Chen, C., Shan, H."Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade". Molecular Medicine Reports 19.5 (2019): 3477-3484.
Chicago
Chen, C., Shan, H."Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade". Molecular Medicine Reports 19, no. 5 (2019): 3477-3484. https://doi.org/10.3892/mmr.2019.10055
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