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Article Open Access

Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Retraction in: /10.3892/mmr.2025.13725
  • Authors:
    • Hui Liu
    • Manman Zou
    • Pei Li
    • Haifeng Wang
    • Xijun Lin
    • Jin Ye
  • View Affiliations / Copyright

    Affiliations: Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 501630, P.R. China, Department of Otolaryngology‑Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 501630, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4081-4090
    |
    Published online on: March 20, 2019
       https://doi.org/10.3892/mmr.2019.10064
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Abstract

The dendritic cell (DC)‑regulatory T (Treg) system serves a leading role in the immunosuppression of the tumor microenvironment, which is not conducive to radiotherapy and chemotherapy treatment for lung cancer. The present study aimed to investigate the effect of oxymatrine (OMT) on the DC‑Treg system in the tumor microenvironment in vitro and to examine its mechanism. The expressions of CD83 antigen, T‑lymphocyte activation antigen CD86, CD11 antigen‑like family member C and major histocompatibility complex II in DCs were increased upon treatment with 1 mg/ml OMT, as detected by flow cytometry. Following pretreatment with OMT, the DCs mediated the forkhead box protein P3 overexpression in primitive cluster of differentiation 4+ T cells at the protein and mRNA expression levels. The expression levels of anti‑inflammatory factors, including interleukin (IL)‑10, tumor growth factor‑β, IL‑35, and pro‑inflammatory cytokines, including interferon‑γ, IL‑12 and IL‑2, in the co‑culture supernatant were increased as measured by ELISA. When DCs and DC‑Tregs were co‑cultured with cisplatin‑resistant A549 cells, the proportion of apoptosis in the co‑culture groups was increased under treatment with cisplatin, which was detected by Annexin V/propidium Iodide staining and western blotting. The present results suggested that OMT may promote the maturation of DCs, mediate the differentiation of T cells into Treg cells, and reverse the resistance of tumor cells to cisplatin in vitro. It was suggested that OMT is an important adjunct to chemotherapy through the regulation of antitumor responses.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Zou M, Li P, Wang H, Lin X and Ye J: Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725. Mol Med Rep 19: 4081-4090, 2019.
APA
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., & Ye, J. (2019). Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725. Molecular Medicine Reports, 19, 4081-4090. https://doi.org/10.3892/mmr.2019.10064
MLA
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., Ye, J."Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725". Molecular Medicine Reports 19.5 (2019): 4081-4090.
Chicago
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., Ye, J."Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725". Molecular Medicine Reports 19, no. 5 (2019): 4081-4090. https://doi.org/10.3892/mmr.2019.10064
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Zou M, Li P, Wang H, Lin X and Ye J: Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725. Mol Med Rep 19: 4081-4090, 2019.
APA
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., & Ye, J. (2019). Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725. Molecular Medicine Reports, 19, 4081-4090. https://doi.org/10.3892/mmr.2019.10064
MLA
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., Ye, J."Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725". Molecular Medicine Reports 19.5 (2019): 4081-4090.
Chicago
Liu, H., Zou, M., Li, P., Wang, H., Lin, X., Ye, J."Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells Retraction in /10.3892/mmr.2025.13725". Molecular Medicine Reports 19, no. 5 (2019): 4081-4090. https://doi.org/10.3892/mmr.2019.10064
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