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Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway

  • Authors:
    • Bo Yang
    • Zhenyu Cai
    • Weilin Zhang
    • Dali Yin
    • Wei Zhao
    • Maowei Yang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Orthopedics, The Fourth Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4091-4100
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    Published online on: March 21, 2019
       https://doi.org/10.3892/mmr.2019.10069
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Abstract

Alzheimer's disease (AD) and osteoporosis (OP) are 2 common progressive age‑associated diseases, primarily affecting the elderly worldwide. Accumulating evidence has demonstrated that patients with AD are more likely to suffer from bone mass loss and even OP, but whether it is a pathological feature of AD or secondary to motor dysfunction remains poorly understood. The present study aimed to investigate whether amyloid‑β1‑42 (Aβ1‑42), the typical pathological product of AD, exhibited a negative effect on the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the role of autophagy. The proliferation of BMSCs was measured using a Cell Counting Kit‑8 assay, cell cycle analysis and 5‑ethynyl‑2'‑deoxyuridine (EdU) staining. The autophagy‑associated proteins microtubule‑associated proteins 1A/1B light chain 3B and sequestosome 1 (p62) were evaluated by western blot analysis and autophagosomes were detected by transmission electron microscopy and immunofluorescence. The activity of the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway was measured using western blot analysis, and the autophagy inducer rapamycin (RAPA), inhibitor 3‑methyladenine (3‑MA) and the AKT activator SC79 were also used to investigate the role of AKT/mTOR signaling pathway and autophagy in the proliferation of BMSCs. The results suggested that the proliferation of BMSCs treated with Aβ1‑42 was inhibited, with the autophagy level increasing following treatment with Aβ1‑42 in a dose‑dependent manner, while the AKT/mTOR signaling pathway participated in the regulation of the autophagy level. Activation of autophagy using RAPA inhibited the decrease in proliferation of BMSCs, while suppression of autophagy by 3‑MA and activation of the AKT/mTOR signaling pathway increased the decrease in proliferation of BMSCs caused by Aβ1‑42. It was concluded that Aβ1‑42, as an external stimulus, suppressed the proliferation of BMSCs directly and that the AKT/mTOR signaling pathway participated in the regulation of the level of autophagy. Concomitantly, autophagy may serve as a resistance mechanism in inhibiting the decreased proliferation of BMSCs treated with Aβ1‑42.
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1 

Roos PM: Osteoporosis in neurodegeneration. J Trace Elem Med Biol. 28:418–421. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Zhou R, Deng J, Zhang M, Zhou HD and Wang YJ: Association between bone mineral density and the risk of Alzheimer's disease. J Alzheimers Dis. 24:101–108. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Zha Y, Shen L and Ji HF: Osteoporosis risk and bone mineral density levels in patients with Parkinson's disease: A meta-analysis. Bone. 52:498–505. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Sato Y, Honda Y, Asoh T, Kikuyama M and Oizumi K: Hypovitaminosis D and decreased bone mineral density in amyotrophic lateral sclerosis. Eur Neurol. 37:225–229. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Weinstockguttman B, Gallaghe E, Baier M, Green L, Feichter J, Patrick K, Miller C, Wrest K and Ramanathan M: Risk of bone loss in men with multiple sclerosis. Mult Scler. 10:170–175. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Tysiewicz-Dudek M, Pietraszkiewicz F and Drozdzowska B: Alzheimer's disease and osteoporosis: Common risk factors or one condition predisposing to the other? Ortop Traumatol Rehabili. 10:315–323. 2008.(In English, Polish).

7 

Peters R, Peters J, Warner J, Beckett N and Bulpitt C: Alcohol, dementia and cognitive decline in the elderly: A systematic review. Age Ageing. 37:505–512. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Cataldo JK, Prochaska JJ and Glantz SA: Cigarette smoking is a risk factor for Alzheimer's Disease: An analysis controlling for tobacco industry affiliation. J Alzheimers Dis. 19:465–480. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Yang MW, Wang TH, Yan PP, Chu LW, Yu J, Gao ZD, Li YZ and Guo BL: Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine. 18:205–213. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Li S, Liu B, Zhang L and Rong L: Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function. Bone. 61:164–175. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, et al: Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J. 29:3408–3420. 2014. View Article : Google Scholar

12 

Song C, Song C and Tong F: Autophagy induction is a survival response against oxidative stress in bone marrow-derived mesenchymal stromal cells. Cytotherapy. 16:1361–1370. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Wan Y, Zhuo N, Li Y, Zhao W and Jiang D: Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae. Biochem Biophys Res Commun. 488:46–52. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Barbero-Camps E, Roca-Agujetas V, Bartolessis I, de Dios C, Fernandez-Checa JC, Mari M, Morales A, Hartmann T and Colell A: Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 14:1129–1154. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Schmelzle T and Hall MN: TOR, a central controller of cell growth. Cell. 103:253–262. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Hu B, Zhang Y, Jia L, Wu H, Fan C, Sun Y, Ye C, Liao M and Zhou J: Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway. Autophagy. 11:503–515. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Lee EO, Kang JL and Chong YH: The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells. J Biol Chem. 280:7845–7853. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Squitti R: Metals in Alzheimer's disease: A systemic perspective. Front Biosci. 17:451–472. 2012. View Article : Google Scholar

19 

Brewer GJ: Alzheimer's disease causation by copper toxicity and treatment with zinc. Front Aging Neurosci. 6:922014. View Article : Google Scholar : PubMed/NCBI

20 

Dusek P, Roos PM, Litwin T, Schneider SA, Flaten TP and Aaseth J: The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases. J Trace Elem Med Biol. 31:193–203. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Roos PM, Vesterberg O, Syversen T, Flaten TP and Nordberg M: Metal concentrations in cerebrospinal fluid and blood plasma from patients with amyotrophic lateral sclerosis. Biol Trace Elem Res. 151:159–170. 2013. View Article : Google Scholar : PubMed/NCBI

22 

LeVine SM, Bilgen M and Lynch SG: Iron accumulation in multiple sclerosis: An early pathogenic event. Expert Rev Neurother. 13:247–250. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Zhu G, Wang H, Shi Y, Weng S, Jin T, Kong Q and Nordberg GF: Environmental cadmium exposure and forearm bone density. Biometals. 17:499–503. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S and Vahter M: Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect. 114:830–834. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Wang HK, Hung CM, Lin SH, Tai YC, Lu K, Liliang PC, Lin CW, Lee YC, Fang PH and Chang LC: Increased risk of hip fractures in patients with dementia: A nationwide population-based study. Bmc Neurol. 14:1752014. View Article : Google Scholar : PubMed/NCBI

26 

Zhao Y, Shen L and Ji HF: Alzheimer's disease and risk of hip fracture: A meta-analysis study. ScientificWorldJournal. 2012:8721732012. View Article : Google Scholar : PubMed/NCBI

27 

Zhao L, Liu S, Wang Y, Zhang Q, Zhao W, Wang Z and Yin M: Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice. PLoS One. 10:e01332892015. View Article : Google Scholar : PubMed/NCBI

28 

Xia WF, Jung JU, Cui S, Xiong S, Xiong L, Shi XM, Mei L and Xiong WC: Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. J Bone Miner Res. 28:2122–2135. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhou Z, Immel D, Xi CX, Bierhaus A, Feng X, Mei L, Nawroth P, Stern DM and Xiong WC: Regulation of osteoclast function and bone mass by RAGE. J Exp Med. 203:1067–1080. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Cui S, Xiong F, Hong Y, Jung JU, Li XS, Liu JZ, Yan R, Mei L, Feng X and Xiong WC: APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner. J Bone Miner Res. 26:1084–1098. 2011. View Article : Google Scholar : PubMed/NCBI

31 

L S, Yang B, Teguh D, Zhou L, Xu J and Rong L: Amyloid β peptide enhances RANKL-induced osteoclast activation through NF-κB, ERK, and calcium oscillation signaling. International J Mol Sci. 17:16832016. View Article : Google Scholar

32 

Hardy J: Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal. J Alzheimers Dis. 9 (3 Suppl):S151–S153. 2006. View Article : Google Scholar

33 

Haass C and Selkoe DJ: Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 8:101–112. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lee IS, Jung K, Kim IS and Park KI: Amyloid-β oligomers regulate the properties of human neural stem cells through GSK-3β signaling. Exp Mol Med. 45:e602013. View Article : Google Scholar : PubMed/NCBI

35 

Levine B: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:10692008. View Article : Google Scholar : PubMed/NCBI

37 

Rubinsztein DC, Codogno P and Levin B: Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Dis. 11:709–730. 2012. View Article : Google Scholar

38 

Kim I and Lemasters JJ: Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol. 300:C3082011. View Article : Google Scholar : PubMed/NCBI

39 

Lee J: Neuronal Autophagy: A housekeeper or a fighter in neuronal cell survival? Exp Neurobiol. 21:1–8. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Shenab HM: Autophagy is a survival force via suppression of necrotic cell death. Exp Cell Res. 318:1304–1308. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Loos B, Engelbrecht AM, Lockshin RA, Klionsky DJ and Zakeri Z: The variability of autophagy and cell death susceptibility. Autophagy. 9:1270–1285. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al: Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd). Autophagy. 12:1–222. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Pajak B, Songin M, Strosznajder JB, Orzechowski A and Gajkowska B: Ultrastructural evidence of amyloid β-induced autophagy in PC12 cells. Folia Neuropathol. 47:252–258. 2009.PubMed/NCBI

44 

Neill CO: PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease. Exp Gerontol. 48:647–653. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R and O'Neill C: Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem. 93:105–117. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Levine B and Yuan J: Autophagy in cell death. An innocent convict J Clin Invest. 115:2679–2688. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Alva AS, Gultekin SH and Baehrecke EH: Autophagy in human tumors: Cell survival or death? CellDeath Differ. 11:1046–1048. 2004.

48 

Platini F, Pérez-tomás R, Ambrosio S and Tessitore L: Understanding autophagy in cell death control. Curr Pharm Des. 16:101–113. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Denton D, Xu T and Kumar S: Autophagy as a pro-death pathway. Immunol Cell Biol. 93:35–42. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Mariño G, Madeo F and Kroemer G: Autophagy for tissue homeostasis and neuroprotection. Curr Opin Cell Biol. 23:198–206. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Annabi B, Lee YT, Turcotte S, Naud E, Desrosiers RR, Champagne M, Eliopoulos N, Galipeau J and Béliveau R: Hypoxia Promotes Murine Bone-Marrow-Derived Stromal Cell Migration and Tube Formation. Stem Cells. 21:337–347. 2010. View Article : Google Scholar

52 

Wang S, Zhou SL, Min FY, Ma JJ, Shi XJ, Bereczki E and Wu J: mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metab Brain Dis. 29:729–736. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Ronsisvalle N, Di Benedetto G, Parenti C, Amoroso S, Bernardini R and Cantarella G: CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25–35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. Current Alzheimer Res. 11:714–724. 2014. View Article : Google Scholar

54 

Caccamo A, Majumder S, Richardson A, Strong R and Oddo S: Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-beta, and Tau: Effects On Cognitive Impairments. J Biol Chem. 285:13107–13120. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang B, Cai Z, Zhang W, Yin D, Zhao W and Yang M: Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway. Mol Med Rep 19: 4091-4100, 2019.
APA
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., & Yang, M. (2019). Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway. Molecular Medicine Reports, 19, 4091-4100. https://doi.org/10.3892/mmr.2019.10069
MLA
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., Yang, M."Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway". Molecular Medicine Reports 19.5 (2019): 4091-4100.
Chicago
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., Yang, M."Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway". Molecular Medicine Reports 19, no. 5 (2019): 4091-4100. https://doi.org/10.3892/mmr.2019.10069
Copy and paste a formatted citation
x
Spandidos Publications style
Yang B, Cai Z, Zhang W, Yin D, Zhao W and Yang M: Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway. Mol Med Rep 19: 4091-4100, 2019.
APA
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., & Yang, M. (2019). Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway. Molecular Medicine Reports, 19, 4091-4100. https://doi.org/10.3892/mmr.2019.10069
MLA
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., Yang, M."Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway". Molecular Medicine Reports 19.5 (2019): 4091-4100.
Chicago
Yang, B., Cai, Z., Zhang, W., Yin, D., Zhao, W., Yang, M."Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway". Molecular Medicine Reports 19, no. 5 (2019): 4091-4100. https://doi.org/10.3892/mmr.2019.10069
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