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Article Open Access

Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection

  • Authors:
    • Fatemeh Adiliaghdam
    • Marianna Almpani
    • Mohammad Hadi Gharedaghi
    • Mehran Najibi
    • Richard A. Hodin
    • Laurence G. Rahme
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Copyright: © Adiliaghdam et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4057-4066
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    Published online on: March 21, 2019
       https://doi.org/10.3892/mmr.2019.10071
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Abstract

Burn‑site infections, commonly due to Pseudomonas aeruginosa, have been associated with deranged intestinal integrity, allowing bacteria and their products to translocate from the gut to the circulatory system. The P. aeruginosa quorum sensing (QS) transcription factor MvfR (PqsR) controls the expression of numerous virulence factors, and the synthesis of several toxic products. However, the role of QS in intestinal integrity alterations, to the best of our knowledge, has not been previously investigated. Using a proven anti‑MvfR, anti‑virulence agent, the in vivo results of the present study revealed that inhibition of MvfR function significantly decreased Fluorescein Isothiocyanate‑Dextran (FITC‑Dextran) flow from the intestine to the systemic circulation, diminished bacterial translocation from the intestine to mesenteric lymph nodes (MLNs), and improved tight junction integrity in thermally injured and infected mice. In addition, the MvfR antagonist administration alleviates the intestinal inflammation, as demonstrated by reduced ileal TNF‑α and fecal lipocalin‑2 concentrations. In addition, it is associated with lower levels of circulating endotoxin and decreased P. aeruginosa dissemination from the burn wound to the ileum. Collectively, these results hold great promise that the inhibition of this QS system mitigates gut hyperpermeability by attenuating the derangement of morphological and immune aspects of the intestinal barrier, suggesting that MvfR function is crucial in the deterioration of intestinal integrity following P. aeruginosa burn‑site infection. Therefore, an anti‑virulence approach targeting MvfR, could potentially offer a novel therapeutic approach against multi‑drug resistant P. aeruginosa infections following thermal injuries. Since this approach is targeting virulence pathways that are non‑essential for growth or viability, our strategy is hypothesized to minimize the development of bacterial resistance, and preserve the beneficial enteric microbes, while improving intestinal integrity that is deranged as a result of burn and infection.
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View References

1 

Groschwitz KR and Hogan SP: Intestinal barrier function: Molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 124:3–20. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Muniz LR, Knosp C and Yeretssian G: Intestinal antimicrobial peptides during homeostasis, infection, and disease. Front Immunol. 3:3102012. View Article : Google Scholar : PubMed/NCBI

3 

Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG and De Winter BY: Regulation of intestinal permeability: The role of proteases. World J Gastroenterol. 23:2106–2123. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Forjuoh SN: Burns in low- and middle-income countries: A review of available literature on descriptive epidemiology, risk factors, treatment, and prevention. Burns. 32:529–537. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Ryan CM, Yarmush ML, Burke JF and Tompkins RG: Increased gut permeability early after burns correlates with the extent of burn injury. Crit Care Med. 20:1508–1512. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Nielson CB, Duethman NC, Howard JM, Moncure M and Wood JG: Burns: Pathophysiology of systemic complications and current management. J Burn Care Res. 38:e469–ee481. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Wolf SE, Ikeda H, Matin S, Debroy MA, Rajaraman S, Herndon DN and Thompson JC: Cutaneous burn increases apoptosis in the gut epithelium of mice. J Am Coll Surg. 188:10–16. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Costantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, Wolf P, Baird A, Eliceiri B, Bansal V and Coimbra R: Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: Effects on tight junction structural proteins. Shock. 31:416–422. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Fazal N, Shelip A and Alzahrani AJ: Burn-injury affects gut-associated lymphoid tissues derived CD4+ T cells. Results Immunol. 3:85–94. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, et al: Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS One. 10:e01299962015. View Article : Google Scholar : PubMed/NCBI

11 

Noble EE, Hsu TM and Kanoski SE: Gut to brain dysbiosis: Mechanisms linking western diet consumption, the microbiome, and cognitive impairment. Front Behav Neurosci. 11:92017. View Article : Google Scholar : PubMed/NCBI

12 

Li N, Hu X, Liu Y, Wang Y, Wang Y, Liu J, Cai W, Bai X, Zhu X, Han J and Hu D: Systemic inflammatory responses and multiple organ dysfunction syndrome following skin burn wound and Pseudomonas aeruginosa infection in mice. Shock. 40:152–159. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Ryan CM, Bailey SH, Carter EA, Schoenfeld DA and Tompkins RG: Additive effects of thermal injury and infection on gut permeability. Arch Surg. 129:325–328. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Ziegler TR, Smith RJ, O'Dwyer ST, Demling RH and Wilmore DW: Increased intestinal permeability associated with infection in burn patients. Arch Surg. 123:1313–1319. 1988. View Article : Google Scholar : PubMed/NCBI

15 

Jones WG II, Barber AE, Minei JP, Fahey TJ III, Shires GT III and Shires GT: Differential pathophysiology of bacterial translocation after thermal injury and sepsis. Ann Surg. 214:24–30. 1991. View Article : Google Scholar : PubMed/NCBI

16 

Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG and Rahme LG: Prediction of multiple infections after severe burn trauma: A prospective cohort study. Ann Surg. 261:781–792. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Alp E, Coruh A, Gunay GK, Yontar Y and Doganay M: Risk factors for nosocomial infection and mortality in burn patients: 10 years of experience at a university hospital. J Burn Care Res. 33:379–385. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lister PD, Wolter DJ and Hanson ND: Antibacterial-resistant Pseudomonas aeruginosa: Clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 22:582–610. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Déziel E, Gopalan S, Tampakaki AP, Lépine F, Padfield KE, Saucier M, Xiao G and Rahme LG: The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: Multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones. Mol Microbiol. 55:998–1014. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Maura D, Hazan R, Kitao T, Ballok AE and Rahme LG: Evidence for direct control of virulence and defense gene circuits by the Pseudomonas aeruginosa quorum sensing regulator, MvfR. Sci Rep. 6:340832016. View Article : Google Scholar : PubMed/NCBI

21 

Allegretta G, Maurer CK, Eberhard J, Maura D, Hartmann RW, Rahme L and Empting M: In-depth profiling of MvfR-regulated small molecules in Pseudomonas aeruginosa after quorum sensing inhibitor treatment. Front Microbiol. 8:9242017. View Article : Google Scholar : PubMed/NCBI

22 

Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Déziel E, Zahler R, et al: Polypharmacology approaches against the Pseudomonas aeruginosa MvfR regulon and their application in blocking virulence and antibiotic tolerance. ACS Chem Biol. 12:1435–1443. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Maura D and Rahme LG: Pharmacological inhibition of the Pseudomonas aeruginosa MvfR Quorum-sensing system interferes with biofilm formation and potentiates antibiotic-mediated biofilm disruption. Antimicrob Agents Chemother. 61(pii): e01362–17. 2017.PubMed/NCBI

24 

Starkey M, Lepine F, Maura D, Bandyopadhaya A, Lesic B, He J, Kitao T, Righi V, Milot S, Tzika A and Rahme L: Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity. PLoS Pathog. 10:e10043212014. View Article : Google Scholar : PubMed/NCBI

25 

Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG and Ausubel FM: Common virulence factors for bacterial pathogenicity in plants and animals. Science. 268:1899–1902. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Walker HL and Mason AD Jr: A standard animal burn. J Trauma. 8:1049–1051. 1968. View Article : Google Scholar : PubMed/NCBI

27 

Pasternak AJ, Hamonic GM, Van Kessel A and Wilson HL: Postnatal regulation of MAMDC4 in the porcine intestinal epithelium is influenced by bacterial colonization. Physiol Rep. 4(pii): e130182016. View Article : Google Scholar : PubMed/NCBI

28 

Yu L, Zhai Q, Tian F, Liu X, Wang G, Zhao J, Zhang H, Narbad A and Chen W: Potential of Lactobacillus plantarum CCFM639 in protecting against aluminum toxicity mediated by intestinal barrier function and oxidative stress. Nutrients. 8(pii): E7832016. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM and Burcelin R: Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 57:1470–1481. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Volynets V, Reichold A, Bardos G, Rings A, Bleich A and Bischoff SC: Assessment of the intestinal barrier with five different permeability tests in healthy C57BL/6J and BALB/cJ mice. Dig Dis Sci. 61:737–746. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Gunzel D and Yu AS: Claudins and the modulation of tight junction permeability. Physiol Rev. 93:525–569. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Markov AG, Veshnyakova A, Fromm M, Amasheh M and Amasheh S: Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J Comp Physiol B. 180:591–598. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Michielan A and D'Inca R: Intestinal permeability in inflammatory bowel disease: Pathogenesis, clinical evaluation, and therapy of leaky gut. Mediators Inflamm. 2015:6281572015. View Article : Google Scholar : PubMed/NCBI

35 

Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM and Nusrat A: Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol. 171:6164–6172. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT and Vijay-Kumar M: Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One. 7:e443282012. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K and Hauser CJ: Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 464:104–107. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Teplitz C, Davis D, Mason AD Jr and Moncrief JA: Pseudomonas burn wound sepsis. I pathogenesis of experimental Pseudomonas burn wound sepsis. J Surg Res. 4:200–216. 1964. View Article : Google Scholar : PubMed/NCBI

39 

Teplitz C, Davis D, Walker HL, Raulston GL, Mason AD Jr and Moncrief JA: Pseudomonas burn wound sepsis. Ii hematogenous infection at the junction of the burn wound and the unburned hypodermis. J Surg Res. 4:217–222. 1964. View Article : Google Scholar : PubMed/NCBI

40 

Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, et al: Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog. 3:1229–1239. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Williams JM, Duckworth CA, Burkitt MD, Watson AJ, Campbell BJ and Pritchard DM: Epithelial cell shedding and barrier function: A matter of life and death at the small intestinal villus tip. Vet Pathol. 52:445–455. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Williams JM, Duckworth CA, Watson AJ, Frey MR, Miguel JC, Burkitt MD, Sutton R, Hughes KR, Hall LJ, Caamaño JH, et al: A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Dis Model Mech. 6:1388–1399. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Cannon AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, Kennedy RH, Gamelli RL and Choudhry MA: Effects of mesalamine treatment on gut barrier integrity after burn injury. J Burn Care Res. 37:283–292. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Samonte VA, Goto M, Ravindranath TM, Fazal N, Holloway VM, Goyal A, Gamelli RL and Sayeed MM: Exacerbation of intestinal permeability in rats after a two-hit injury: Burn and Enterococcus faecalis infection. Crit Care Med. 32:2267–2273. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Capaldo CT and Nusrat A: Cytokine regulation of tight junctions. Biochim Biophys Acta. 1788:864–871. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA and Said HM: TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 286:G367–G376. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Adiliaghdam F, Almpani M, Gharedaghi MH, Najibi M, Hodin RA and Rahme LG: Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection. Mol Med Rep 19: 4057-4066, 2019.
APA
Adiliaghdam, F., Almpani, M., Gharedaghi, M.H., Najibi, M., Hodin, R.A., & Rahme, L.G. (2019). Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection. Molecular Medicine Reports, 19, 4057-4066. https://doi.org/10.3892/mmr.2019.10071
MLA
Adiliaghdam, F., Almpani, M., Gharedaghi, M. H., Najibi, M., Hodin, R. A., Rahme, L. G."Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection". Molecular Medicine Reports 19.5 (2019): 4057-4066.
Chicago
Adiliaghdam, F., Almpani, M., Gharedaghi, M. H., Najibi, M., Hodin, R. A., Rahme, L. G."Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection". Molecular Medicine Reports 19, no. 5 (2019): 4057-4066. https://doi.org/10.3892/mmr.2019.10071
Copy and paste a formatted citation
x
Spandidos Publications style
Adiliaghdam F, Almpani M, Gharedaghi MH, Najibi M, Hodin RA and Rahme LG: Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection. Mol Med Rep 19: 4057-4066, 2019.
APA
Adiliaghdam, F., Almpani, M., Gharedaghi, M.H., Najibi, M., Hodin, R.A., & Rahme, L.G. (2019). Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection. Molecular Medicine Reports, 19, 4057-4066. https://doi.org/10.3892/mmr.2019.10071
MLA
Adiliaghdam, F., Almpani, M., Gharedaghi, M. H., Najibi, M., Hodin, R. A., Rahme, L. G."Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection". Molecular Medicine Reports 19.5 (2019): 4057-4066.
Chicago
Adiliaghdam, F., Almpani, M., Gharedaghi, M. H., Najibi, M., Hodin, R. A., Rahme, L. G."Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection". Molecular Medicine Reports 19, no. 5 (2019): 4057-4066. https://doi.org/10.3892/mmr.2019.10071
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