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Molecular Medicine Reports
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May-2019 Volume 19 Issue 5

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Article

lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway

  • Authors:
    • Zhan Song
    • Junfeng Du
    • Lirong Zhou
    • Baohua Sun
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
  • Pages: 4425-4432
    |
    Published online on: March 27, 2019
       https://doi.org/10.3892/mmr.2019.10089
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Abstract

AWPPH is a newly discovered long non‑coding (lnc)RNA that serves an oncogenic role in the development of several types of cancer; however, its involvement in non‑small cell lung cancer (NSCLC) is unknown. Therefore, the aim of the present study was to investigate the function of AWPPH in NSCLC. The results demonstrated that AWPPH expression levels were significantly upregulated in the lung tissues and serum samples of patients with NSCLC compared with in healthy controls. High expression levels of AWPPH effectively distinguished NSCLC patients from healthy controls. In addition, patients with high expression levels of AWPPH had significantly shorter survival time. AWPPH overexpression in NSCLC cells promoted proliferation and inhibited apoptosis, and activated the Wnt/β‑catenin signaling pathway, which is a classic signaling pathway involved in the development and progression of different types of cancers. Treatment with a Wnt/β‑catenin signaling pathway activator produced no significant effect on AWPPH expression. Therefore, it was concluded that lcRNA AWPPH could promote the growth of NSCLCs by activating the Wnt/β‑catenin signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Song Z, Du J, Zhou L and Sun B: lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway. Mol Med Rep 19: 4425-4432, 2019.
APA
Song, Z., Du, J., Zhou, L., & Sun, B. (2019). lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 19, 4425-4432. https://doi.org/10.3892/mmr.2019.10089
MLA
Song, Z., Du, J., Zhou, L., Sun, B."lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 19.5 (2019): 4425-4432.
Chicago
Song, Z., Du, J., Zhou, L., Sun, B."lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 19, no. 5 (2019): 4425-4432. https://doi.org/10.3892/mmr.2019.10089
Copy and paste a formatted citation
x
Spandidos Publications style
Song Z, Du J, Zhou L and Sun B: lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway. Mol Med Rep 19: 4425-4432, 2019.
APA
Song, Z., Du, J., Zhou, L., & Sun, B. (2019). lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 19, 4425-4432. https://doi.org/10.3892/mmr.2019.10089
MLA
Song, Z., Du, J., Zhou, L., Sun, B."lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 19.5 (2019): 4425-4432.
Chicago
Song, Z., Du, J., Zhou, L., Sun, B."lncRNA AWPPH promotes proliferation and inhibits apoptosis of non‑small cell lung cancer cells by activating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 19, no. 5 (2019): 4425-4432. https://doi.org/10.3892/mmr.2019.10089
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