Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2019 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection

  • Authors:
    • Xiaoguang Xu
    • Yong Han
    • Haiyan Huang
    • Lili Bi
    • Xiangrui Kong
    • Xihui Ma
    • Bingyi Shi
    • Li Xiao
  • View Affiliations / Copyright

    Affiliations: Beijing Key Laboratory of Organ Transplant and Immune Regulation, Transplant Research Laboratory of Organ Transplantation Institute, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4238-4248
    |
    Published online on: March 27, 2019
       https://doi.org/10.3892/mmr.2019.10091
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Emerging evidence indicates that natural killer (NK) cells and NKT‑like cells may affect allograft outcomes following solid organ transplantation. However, the roles of these cells in allograft acceptance and dysfunction are controversial. To assess the changes in NK cell and CD3+CD56+ NKT‑like cell frequency and phenotype in renal allograft recipients and to explore their associations with acute T‑cell‑mediated renal allograft rejection (ACR), longitudinal changes in NK and NKT‑like cell frequency and phenotype were characterized using flow cytometry and immunohistochemistry in the peripheral blood and kidney allograft tissues in 142 recipients undergoing kidney transplantation. The serum concentrations of NK cell‑associated cytokines were also detected by cytokine multiplex immunoassay. In contrast to the healthy controls, recipients with stable graft function exhibited increased proportions of CD56brightCD16dim subsets and decreased proportions of NKT‑like cells in their peripheral blood mononuclear cells (PBMCs). Patients with ACR demonstrated increased proportions of NK cells, which were associated with increased CD3‑CD56bright subsets and decreased CD3‑CD56dim subsets, an increase in the CD56bright/CD56dim ratio in PBMCs and increased CD56+ NK cell infiltration in the kidney allograft, compared with the stable controls. In addition, there was a decreased proportion of NKT‑like cells in patients with ACR, and an increased ratio of CD56bright/NKT‑like cells compared with the stable controls. These differences appeared to be consistent with the increase in the serum concentrations of C‑C motif chemokine 19 and the decrease in the serum concentrations of interleukin‑15. These data indicate that CD56bright NK cells may promote the development of ACR, and that NKT‑like cells may have immunoregulatory function. The results also imply that the CD56bright/CD56dim ratio may affect the ACR signatures.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Kitchens WH, Uehara S, Chase CM, Colvin RB, Russell PS and Madsen JC: The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 81:811–817. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Pratschke J, Stauch D and Kotsch K: Role of NK and NKT cells in solid organ transplantation. Transpl Int. 22:859–868. 2009. View Article : Google Scholar : PubMed/NCBI

3 

López-Botet M, Vilches C, Redondo-Pachón D, Muntasell A, Pupuleku A, Yélamos J, Pascual J and Crespo M: Dual role of natural killer cells on graft rejection and control of cytomegalovirus infection in renal transplantation. Front Immunol. 8:1662017. View Article : Google Scholar : PubMed/NCBI

4 

Yu G, Xu X, Vu MD, Kilpatrick ED and Li XC: NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med. 203:1851–1858. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Michel T, Poli A, Cuapio A, Briquemont B, Iserentant G, Ollert M and Zimmer J: Human CD56bright NK cells: An update. J Immunol. 196:2923–2931. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Crespo M, Yelamos J, Redondo D, Muntasell A, Perez-Saéz MJ, López-Montañés M, García C, Torio A, Mir M, Hernández JJ, et al: Circulating NK-cell subsets in renal allograft recipients with anti-HLA donor-specific antibodies. Am J Transplant. 15:806–814. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Assadiasl S, Sepanjnia A, Aghili B, Nafar M, Ahmadpoor P, Pourrezagholi F, Parvin M, Shahlaee A, Nicknam MH and Amirzargar A: Natural killer cell subsets and IL-2, IL-15 and IL-18 genes expressions in chronic kidney allograft dysfunction and graft function in kidney allograft recipients. Int J Organ Transplant Med. 7:212–217. 2016.PubMed/NCBI

8 

Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, Cipollone G, Navarra G, Mingari MC, Moretta L and Ferlazzo G: CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol. 192:3805–3815. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Melsen JE, Lugthart G, Lankester AC and Schilham MW: Human circulating and tissue-resident CD56 (bright) natural killer cell populations. Front Immunol. 7:2622016. View Article : Google Scholar : PubMed/NCBI

10 

Shin S, Kim YH, Cho YM, Park Y, Han S, Choi BH, Choi JY and Han DJ: Interpreting CD56+ and CD163+ infiltrates in early versus late renal transplant biopsies. Am J Nephrol. 41:362–369. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hongo D, Tang X, Dutt S, Nador RG and Strober S: Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants. Blood. 119:1581–1589. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Jiang X, Kojo S, Harada M, Ohkohchi N, Taniguchi M and Seino KI: Mechanism of NKT cell-mediated transplant tolerance. Am J Transplant. 7:1482–1490. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ and Van Kaer L: NKT cells: What's in a name. Nat Rev Immunol. 4:231–237. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Peng LS, Mao FY, Zhao YL, Wang TT, Chen N, Zhang JY, Cheng P, Li WH, Lv YP, Teng YS, et al: Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer. Oncotarget. 7:55222–55230. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Golden-Mason L, Castelblanco N, O'Farrelly C and Rosen HR: Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol. 81:9292–9298. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Diao H, He J, Zheng Q, Chen J, Cui G, Wei Y, Ye P, Kohanawa M and Li L: A possible role for NKT-like cells in patients with chronic hepatitis B during telbivudine treatment. Immunol Lett. 160:65–71. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Haas M, Sis B, Racusen LC, Solez K, Glotz D, Colvin RB, Castro MC, David DS, David-Neto E, Bagnasco SM, et al: Banff 2013 meeting report: Inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant. 14:272–283. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, et al: The banff 2017 kidney meeting report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 18:293–307. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Fehniger TA, Shah MH, Turner MJ, VanDeusen JB, Whitman SP, Cooper MA, Suzuki K, Wechser M, Goodsaid F and Caligiuri MA: Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response. J Immunol. 162:4511–4520. 1999.PubMed/NCBI

20 

Márquez ME, Millet C, Stekman H, Conesa A, Deglesne PA, Toro F, Sanctis JD and Blanca I: CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells. Cell Immunol. 264:86–92. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Bendelac A, Savage PB and Teyton L: The biology of NKT cells. Annu Rev Immunol. 25:297–336. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Lin SJ, Huang YC, Cheng PJ, Lee PT, Hsiao HS and Kuo ML: Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood. Cytokine. 76:348–355. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Xu X, Huang H, Wang Q, Cai M, Qian Y, Han Y, Wang X, Gao Y, Yuan M, Xu L, et al: IFN-γ-producing Th1-like regulatory T cells may limit acute cellular renal allograft rejection: Paradoxical post-transplantation effects of IFN-γ. Immunobiology. 222:280–290. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Poli A, Michel T, Thérésine M, Andrès E, Hentges F and Zimmer J: CD56bright natural killer (NK) cells: An important NK cell subset. Immunology. 126:458–465. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Xu X, Huang H, Cai M, Qian Y, Li Z, Bai H, Han Y, Xiao L, Zhou W, Wang X and Shi B: Combination of IL-1 receptor antagonist, IL-20 and CD40 ligand for the prediction of acute cellular renal allograft rejection. J Clin Immunol. 33:280–287. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Cassano P, Bui E, Rogers AH, Walton ZE, Ross R, Zeng M, Nadal-Vicens M, Mischoulon D, Baker AW, Keshaviah A, et al: Inflammatory cytokines in major depressive disorder: A case-control study. Aust N Z J Psychiatry. 51:23–31. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Curran-Everett D: Multiple comparisons: Philosophies and illustrations. Am J Physiol Regul Integr Comp Physiol. 279:R1–R8. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Maghazachi AA: Role of chemokines in the biology of natural killer cells. Curr Top Microbiol Immunol. 341:37–58. 2010.PubMed/NCBI

29 

Zhou HL, Wang YT, Gao T, Wang WG and Wang YS: Distribution and expression of fibroblast-specific protein chemokine CCL21 and chemokine receptor CCR7 in renal allografts. Transplant Proc. 45:538–545. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Huang H, Xu X, Yao C, Cai M, Qian Y, Wang X and Shi B: Serum levels of CXCR3 ligands predict T cell-mediated acute rejection after kidney transplantation. Mol Med Rep. 9:45–50. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Oh K, Kim S, Park SH, Gu H, Roopenian D, Chung DH, Kim YS and Lee DS: Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity. J Immunol. 174:2030–2036. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Yang SH, Jin JZ, Lee SH, Park H, Kim CH, Lee DS, Kim S, Chung NH and Kim YS: Role of NKT cells in allogeneic islet graft survival. Clin Immunol. 124:258–266. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu X, Han Y, Huang H, Bi L, Kong X, Ma X, Shi B and Xiao L: Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection. Mol Med Rep 19: 4238-4248, 2019.
APA
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X. ... Xiao, L. (2019). Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection. Molecular Medicine Reports, 19, 4238-4248. https://doi.org/10.3892/mmr.2019.10091
MLA
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X., Shi, B., Xiao, L."Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection". Molecular Medicine Reports 19.5 (2019): 4238-4248.
Chicago
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X., Shi, B., Xiao, L."Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection". Molecular Medicine Reports 19, no. 5 (2019): 4238-4248. https://doi.org/10.3892/mmr.2019.10091
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Han Y, Huang H, Bi L, Kong X, Ma X, Shi B and Xiao L: Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection. Mol Med Rep 19: 4238-4248, 2019.
APA
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X. ... Xiao, L. (2019). Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection. Molecular Medicine Reports, 19, 4238-4248. https://doi.org/10.3892/mmr.2019.10091
MLA
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X., Shi, B., Xiao, L."Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection". Molecular Medicine Reports 19.5 (2019): 4238-4248.
Chicago
Xu, X., Han, Y., Huang, H., Bi, L., Kong, X., Ma, X., Shi, B., Xiao, L."Circulating NK cell subsets and NKT‑like cells in renal transplant recipients with acute T‑cell‑mediated renal allograft rejection". Molecular Medicine Reports 19, no. 5 (2019): 4238-4248. https://doi.org/10.3892/mmr.2019.10091
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team