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FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition

  • Authors:
    • Ya‑Dong Luo
    • Xu Ding
    • Hong‑Ming Du
    • Yu‑Nong Wu
    • Huai‑Qi Li
    • He‑Ming Wu
    • Xiao‑Min Zhang
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4101-4108
    |
    Published online on: March 27, 2019
       https://doi.org/10.3892/mmr.2019.10094
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Abstract

Although forkhead box protein M1 (FOXM1) is markedly upregulated in human premalignant and oral squamous cell carcinoma (OSCC) tissues and cultured cells, the association of FOXM1 expression with OSCC prognosis is not well understood. The present study investigated the possible association of FOXM1 expression in patients with OSCC with their clinicopathological characteristics and clinical outcomes. The expression of FOXM1 protein in OSCC tissues from 119 patients was evaluated by immunohistochemistry, and the results demonstrated that FOXM1 overexpression in patients with OSCC was associated with tumour recurrence and poor prognosis. To study the in vitro effects of FOXM1, its expression was decreased by small interfering RNA (siRNA) in OSCC cell lines, and FOXM1 knockdown decreased the proliferative, migratory and invasive capacities of cells. FOXM1 inhibition by siRNA gave rise to reduced expression of vimentin and increased expression of E‑cadherin. The present study reported FOXM1 as a novel predictor of tumour recurrence in patients with OSCC and its potential involvement in epithelial‑mesenchymal transition in OSCC cells.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Jerjes W, Upile T, Petrie A, Riskalla A, Hamdoon Z, Vourvachis M, Karavidas K, Jay A, Sandison A, Thomas GJ, et al: Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head Neck Oncol. 2:92010. View Article : Google Scholar : PubMed/NCBI

3 

Carvalho AL, Nishimoto IN, Califano JA and Kowalski LP: Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database. Int J Cancer. 114:806–816. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Ahmad A, Wang Z, Kong D, Ali S, Li Y, Banerjee S, Ali R and Sarkar FH: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors. Breast Cancer Res Treat. 122:337–346. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK, Cheong SC, Teo SH, et al: FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One. 4:e48492009. View Article : Google Scholar : PubMed/NCBI

6 

Lam EW, Brosens JJ, Gomes AR and Koo CY: Forkhead box proteins: Tuning forks for transcriptional harmony. Nat Rev Cancer. 13:482–495. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Tian S, Wang C and An MW: Test on existence of histology subtype-specific prognostic signatures among early stage lung adenocarcinoma and squamous cell carcinoma patients using a Cox-model based filter. Biol Direct. 10:152015. View Article : Google Scholar : PubMed/NCBI

9 

Yu CP, Yu S, Shi L, Wang S, Li ZX, Wang YH, Sun CJ and Liang J: FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1. Mol Med Rep. 16:5181–5188. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Park HJ, Costa RH, Lau LF, Tyner AL and Raychaudhuri P: Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol. 28:5162–5171. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Raychaudhuri P and Park HJ: FoxM1: A master regulator of tumor metastasis. Cancer Res. 71:4329–4333. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Leung TW, Lin SS, Tsang AC, Tong CS, Ching JC, Leung WY, Gimlich R, Wong GG and Yao KM: Over-expression of FoxM1 stimulates cyclin B1 expression. FEBS Lett. 507:59–66. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Myatt SS and Lam EW: The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 7:847–859. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Koo CY, Muir KW and Lam EW: FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 1819:28–37. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Ma J, Qi G, Xu J, Ni H, Xu W, Ru G, Zhao Z, Xu W and He X: Overexpression of forkhead box M1 and urokinase-type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis. Oncol Lett. 14:7288–7296. 2017.PubMed/NCBI

16 

Jiang LZ, Wang P, Deng B, Huang C, Tang WX, Lu HY and Chen HY: Overexpression of Forkhead Box M1 transcription factor and nuclear factor-κB in laryngeal squamous cell carcinoma: A potential indicator for poor prognosis. Hum Pathol. 42:1185–1193. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Abdeljaoued S, Bettaieb I, Nasri M, Adouni O, Goucha A, El Amine O, Boussen H, Rahal K and Gamoudi A: Overexpression of FOXM1 Is a potential prognostic marker in male breast cancer. Oncol Res Treat. 40:167–172. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Wittekind C and Oberschmid B: TNM classification of malignant tumors 2010: General aspects and amendments in the general section. Pathologe. 31:333–334, 336-338. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

19 

Kim HE, Krug MA, Han I, Ensley J, Yoo GH, Forman JD and Kim HR: Neutron radiation enhances cisplatin cytotoxicity independently of apoptosis in human head and neck carcinoma cells. Clin Cancer Res. 6:4142–4147. 2000.PubMed/NCBI

20 

Patel V, Ramesh A, Traicoff JL, Baibakov G, Emmert-Buck MR, Gutkind JS and Knezevic V: Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. Oral Oncol. 41:503–508. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Xiao C, Wang L, Zhu L, Zhang C and Zhou J: Secreted frizzledrelated protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma. Mol Med Rep. 10:2293–2298. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zhu J, Wu YN, Zhang W, Zhang XM, Ding X, Li HQ, Geng M, Xie ZQ and Wu HM: Monocarboxylate transporter 4 facilitates cell proliferation and migration and is associated with poor prognosis in oral squamous cell carcinoma patients. PLoS One. 9:e879042014. View Article : Google Scholar : PubMed/NCBI

23 

Zhu Z, Xu X, Yu Y, Graham M, Prince ME, Carey TE and Sun D: Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro. Mol Pharm. 7:1283–1290. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T and Costa RH: Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol. 25:10875–10894. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Nandi D, Cheema PS, Jaiswal N and Nag A: FoxM1: Repurposing an oncogene as a biomarker. Semin Cancer Bilo. 52:74–84. 2018. View Article : Google Scholar

26 

Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A and Teh MT: Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer. 119:4249–4258. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Teh MT, Gemenetzidis E, Chaplin T, Young BD and Philpott MP: Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol Cancer. 9:452010. View Article : Google Scholar : PubMed/NCBI

28 

Tosi GM, Marigliani D, Romeo N and Toti P: Disease pathways in proliferative vitreoretinopathy: An ongoing challenge. J Cell Physiol. 229:1577–1583. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Casaroli-Marano RP, Pagan R and Vilaró S: Epithelial-mesenchymal transition in proliferative vitreoretinopathy: Intermediate filament protein expression in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 40:2062–2072. 1999.PubMed/NCBI

30 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Chen W, Yi JK, Shimane T, Mehrazarin S, Lin YL, Shin H, Kim RH, Park NH and Kang MK: Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells. Carcinogenesis. 37:500–510. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Thierauf J, Veit JA and Hess J: Epithelial-to-mesenchymal transition in the pathogenesis and therapy of head and neck cancer. Cancers (Basel). 9(pii): E762017. View Article : Google Scholar : PubMed/NCBI

33 

Bao B, Wang Z, Ali S, Kong D, Banerjee S, Ahmad A, Li Y, Azmi AS, Miele L and Sarkar FH: Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. J Cell Biochem. 112:2296–2306. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Ishida T, Hijioka H, Kume K, Miyawaki A and Nakamura N: Notch signaling induces EMT in OSCC cell lines in a hypoxic environment. Oncol Lett. 6:1201–1206. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S and Ohnishi K: The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis. 31:2012–2021. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo YD, Ding X, Du HM, Wu YN, Li HQ, Wu HM and Zhang XM: FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Mol Med Rep 19: 4101-4108, 2019.
APA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., & Zhang, X. (2019). FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Molecular Medicine Reports, 19, 4101-4108. https://doi.org/10.3892/mmr.2019.10094
MLA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19.5 (2019): 4101-4108.
Chicago
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19, no. 5 (2019): 4101-4108. https://doi.org/10.3892/mmr.2019.10094
Copy and paste a formatted citation
x
Spandidos Publications style
Luo YD, Ding X, Du HM, Wu YN, Li HQ, Wu HM and Zhang XM: FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Mol Med Rep 19: 4101-4108, 2019.
APA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., & Zhang, X. (2019). FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Molecular Medicine Reports, 19, 4101-4108. https://doi.org/10.3892/mmr.2019.10094
MLA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19.5 (2019): 4101-4108.
Chicago
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19, no. 5 (2019): 4101-4108. https://doi.org/10.3892/mmr.2019.10094
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